CA2976671C - Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) - Google Patents
Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) Download PDFInfo
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- CA2976671C CA2976671C CA2976671A CA2976671A CA2976671C CA 2976671 C CA2976671 C CA 2976671C CA 2976671 A CA2976671 A CA 2976671A CA 2976671 A CA2976671 A CA 2976671A CA 2976671 C CA2976671 C CA 2976671C
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
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- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Filtering Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3101298A CA3101298A1 (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Applications Claiming Priority (3)
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| US30929010P | 2010-03-01 | 2010-03-01 | |
| US61/309,290 | 2010-03-01 | ||
| CA2791685A CA2791685C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2791685A Division CA2791685C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA3101298A Division CA3101298A1 (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
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| CA2976671A1 CA2976671A1 (en) | 2011-09-09 |
| CA2976671C true CA2976671C (en) | 2021-01-12 |
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| CA3101298A Abandoned CA3101298A1 (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| CA2791685A Expired - Fee Related CA2791685C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| CA2976671A Expired - Fee Related CA2976671C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
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| CA3101298A Abandoned CA3101298A1 (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| CA2791685A Expired - Fee Related CA2791685C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Country Status (37)
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| UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| PT2379600E (pt) * | 2008-12-22 | 2014-04-29 | Novo Nordisk As | Anticorpos contra inibidor da via de fator tecidual |
| DK3345615T3 (da) * | 2010-03-01 | 2020-01-20 | Bayer Healthcare Llc | Optimerede monoklonale antistoffer mod inhibitor af vævsfaktoraktiveringsvejen (tfpi) |
| EP2588499B1 (en) * | 2010-06-30 | 2020-04-08 | Novo Nordisk A/S | Antibodies that are capable of specifically binding tissue factor pathway inhibitor |
| MX2013011218A (es) * | 2011-04-01 | 2013-10-17 | Bayer Healthcare Llc | Anticuerpos monoclonales frente al inhibidor de la ruta del factor tisular (tfpi). |
| BR112014024373A2 (pt) * | 2012-03-30 | 2017-08-08 | Bayer Healthcare Llc | anticorpos regulados por protease |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| CN105452298B (zh) * | 2013-03-15 | 2021-08-31 | 拜尔健康护理有限责任公司 | 改善药代动力学的具有跨pH范围差异结合的抗TFPI抗体变体 |
| HK1215262A1 (zh) * | 2013-03-15 | 2016-08-19 | Bayer Healthcare Llc | 針對組織因子途徑抑制劑的前體藥物抗體 |
| EA036490B1 (ru) * | 2015-02-25 | 2020-11-17 | Могам Инститьют Фор Байомедикал Рисерч | Антитела, связывающиеся с tfpi, и содержащая их композиция |
| SG10201912817YA (en) | 2015-08-19 | 2020-02-27 | Pfizer | Tissue factor pathway inhibitor antibodies and uses thereof |
| KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
| US20210395391A1 (en) * | 2018-10-11 | 2021-12-23 | Pfizer Inc. | Dosage Regimen for TFPI Antagonists |
| KR102692277B1 (ko) * | 2019-03-11 | 2024-08-05 | 현대자동차주식회사 | 상용 전기차용 모터 마운트 |
| CN112442127A (zh) * | 2019-08-29 | 2021-03-05 | 苏州康宁杰瑞生物科技有限公司 | 针对tfpi的单克隆抗体 |
| CN116419760A (zh) * | 2020-11-13 | 2023-07-11 | 韩美药品株式会社 | 治疗酶融合蛋白在预防和治疗由法布里病引起或伴有法布里病的肾病中的用途 |
| CN117285632A (zh) * | 2022-06-17 | 2023-12-26 | 安源医药科技（上海）有限公司 | 针对tfpi的单克隆抗体及其用途 |
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