CA2976671C - Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) - Google Patents
Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) Download PDFInfo
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- CA2976671C CA2976671C CA2976671A CA2976671A CA2976671C CA 2976671 C CA2976671 C CA 2976671C CA 2976671 A CA2976671 A CA 2976671A CA 2976671 A CA2976671 A CA 2976671A CA 2976671 C CA2976671 C CA 2976671C
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Classifications
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
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- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Filtering Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3101298A CA3101298A1 (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
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| US30929010P | 2010-03-01 | 2010-03-01 | |
| US61/309,290 | 2010-03-01 | ||
| CA2791685A CA2791685C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2791685A Division CA2791685C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
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| CA3101298A Division CA3101298A1 (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
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| CA2976671A1 CA2976671A1 (en) | 2011-09-09 |
| CA2976671C true CA2976671C (en) | 2021-01-12 |
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| CA2976671A Expired - Fee Related CA2976671C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| CA3101298A Abandoned CA3101298A1 (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| CA2791685A Expired - Fee Related CA2791685C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
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| CA3101298A Abandoned CA3101298A1 (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| CA2791685A Expired - Fee Related CA2791685C (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Country Status (37)
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| UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| DK2379600T4 (da) † | 2008-12-22 | 2021-01-04 | Novo Nordisk As | Antistoffer mod tissue factor pathway inhibitor |
| PH12012501742A1 (en) * | 2010-03-01 | 2022-03-21 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| CN103080135B (zh) * | 2010-06-30 | 2017-06-13 | 诺沃—诺迪斯克有限公司 | 能够特异性结合组织因子途径抑制剂的抗体 |
| DK2694544T3 (en) * | 2011-04-01 | 2019-04-15 | Bayer Healthcare Llc | MONOCLONAL ANTIBODIES AGAINST TIBI FACTOR ACTIVITY INHIBITOR (TFPI) |
| CN104185474B (zh) * | 2012-03-30 | 2017-08-25 | 拜尔健康护理有限责任公司 | 蛋白酶调节的抗体 |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| HUE037907T2 (hu) | 2013-03-15 | 2018-09-28 | Bayer Healthcare Llc | TFPI elleni, pH-tartományon belül különbözõ kötõdésû antitestváltozatok javított farmakokinetika érdekében |
| TW201522368A (zh) * | 2013-03-15 | 2015-06-16 | Bayer Healthcare Llc | 抗組織因子路徑抑制劑之前藥抗體 |
| CN112225812B (zh) * | 2015-02-25 | 2024-08-13 | 财团法人牧岩生命科学研究所 | 结合tfpi的新型抗体以及包含所述抗体的组合物 |
| KR102438650B1 (ko) | 2015-08-19 | 2022-08-31 | 화이자 인코포레이티드 | 조직 인자 경로 억제제 항체 및 그의 용도 |
| KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
| BR112021006223A2 (pt) * | 2018-10-11 | 2021-07-06 | Pfizer | regime de dosagem para antagonistas de inibidor da via de fator tecidual (tfpi) |
| KR102692277B1 (ko) * | 2019-03-11 | 2024-08-05 | 현대자동차주식회사 | 상용 전기차용 모터 마운트 |
| CN112442127A (zh) * | 2019-08-29 | 2021-03-05 | 苏州康宁杰瑞生物科技有限公司 | 针对tfpi的单克隆抗体 |
| WO2022103221A1 (ko) * | 2020-11-13 | 2022-05-19 | 한미약품 주식회사 | 치료학적 효소 융합단백질의 파브리병에 기인하거나 동반되는 신장질환 예방 및 치료 용도 |
| CN117285632A (zh) * | 2022-06-17 | 2023-12-26 | 安源医药科技（上海）有限公司 | 针对tfpi的单克隆抗体及其用途 |
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