CN102939098B - 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体 - Google Patents

针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体 Download PDF

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Publication number
CN102939098B
CN102939098B CN201180022078.8A CN201180022078A CN102939098B CN 102939098 B CN102939098 B CN 102939098B CN 201180022078 A CN201180022078 A CN 201180022078A CN 102939098 B CN102939098 B CN 102939098B
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China
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substitutions
antibody
heavy chain
light chain
tfpi
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Expired - Fee Related
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CN201180022078.8A
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English (en)
Chinese (zh)
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CN102939098A (zh
Inventor
王卓智
潘俊亮
J.格鲁德津斯卡
C.沃特斯梅尔
J.特贝
J.伯肯菲尔德
N.沃布斯特
S.布吕克纳
S.施泰尼希
P.肖尔茨
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Bayer Healthcare LLC
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Bayer Healthcare LLC
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Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Priority to CN201510319455.4A priority Critical patent/CN105001335B/zh
Priority to CN201610539997.7A priority patent/CN106188301A/zh
Priority to CN201911010357.7A priority patent/CN110835373A/zh
Priority to CN201711202426.5A priority patent/CN107987166A/zh
Publication of CN102939098A publication Critical patent/CN102939098A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Filtering Materials (AREA)
CN201180022078.8A 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体 Expired - Fee Related CN102939098B (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201510319455.4A CN105001335B (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201610539997.7A CN106188301A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201911010357.7A CN110835373A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201711202426.5A CN107987166A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01
US61/309,290 2010-03-01
PCT/US2011/026766 WO2011109452A1 (en) 2010-03-01 2011-03-01 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Related Child Applications (4)

Application Number Title Priority Date Filing Date
CN201610539997.7A Division CN106188301A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201711202426.5A Division CN107987166A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201510319455.4A Division CN105001335B (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201911010357.7A Division CN110835373A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体

Publications (2)

Publication Number Publication Date
CN102939098A CN102939098A (zh) 2013-02-20
CN102939098B true CN102939098B (zh) 2016-08-03

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Application Number Title Priority Date Filing Date
CN201610539997.7A Pending CN106188301A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201711202426.5A Pending CN107987166A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201510319455.4A Expired - Fee Related CN105001335B (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201180022078.8A Expired - Fee Related CN102939098B (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201911010357.7A Pending CN110835373A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CN201610539997.7A Pending CN106188301A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201711202426.5A Pending CN107987166A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体
CN201510319455.4A Expired - Fee Related CN105001335B (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体

Family Applications After (1)

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CN201911010357.7A Pending CN110835373A (zh) 2010-03-01 2011-03-01 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体

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US (3) US9309324B2 (enExample)
EP (2) EP2542257B1 (enExample)
JP (4) JP6025570B2 (enExample)
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CL (2) CL2012002415A1 (enExample)
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CR (1) CR20120453A (enExample)
CU (1) CU23982B1 (enExample)
CY (2) CY1119410T1 (enExample)
DK (2) DK3345615T3 (enExample)
DO (1) DOP2012000239A (enExample)
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EC (2) ECSP12012134A (enExample)
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HU (2) HUE036655T2 (enExample)
IL (3) IL221551B (enExample)
LT (2) LT3345615T (enExample)
ME (2) ME03578B (enExample)
MX (2) MX2012010198A (enExample)
MY (1) MY174760A (enExample)
NZ (2) NZ602115A (enExample)
PE (1) PE20160538A1 (enExample)
PH (4) PH12012501742A1 (enExample)
PL (2) PL2542257T3 (enExample)
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RS (2) RS59830B1 (enExample)
SG (3) SG10201502587SA (enExample)
SI (2) SI3345615T1 (enExample)
SM (1) SMT201700454T1 (enExample)
WO (1) WO2011109452A1 (enExample)

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UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
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EA201892184A1 (ru) * 2010-03-01 2019-03-29 БАЙЕР ХЕЛЬСКЕР ЛЛСи Оптимизированные моноклональные антитела против ингибитора пути тканевого фактора
CN103080135B (zh) * 2010-06-30 2017-06-13 诺沃—诺迪斯克有限公司 能够特异性结合组织因子途径抑制剂的抗体
PT2694544T (pt) * 2011-04-01 2019-04-02 Bayer Healthcare Llc Anticorpos monoclonais contra inibidor da via do fator tecidual (tfpi)
JP6283017B2 (ja) * 2012-03-30 2018-02-21 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ プロテアーゼ制御抗体
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UY35459A (es) * 2013-03-15 2014-10-31 Bayer Healthcare Llc Anticuerpos profármaco contra el inhibidor de la vía del factor tisular
JP6660957B2 (ja) * 2015-02-25 2020-03-11 モガム インスティチュート フォー バイオメディカル リサーチＭＯＧＡＭ Ｉｎｓｔｉｔｕｔｅ ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ 新規の抗−ｔｆｐｉ抗体及びこれを含む組成物
AU2016307967C9 (en) * 2015-08-19 2025-02-20 Pfizer Inc. Tissue factor pathway inhibitor antibodies and uses thereof
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
KR20240135884A (ko) * 2018-10-11 2024-09-12 화이자 인코포레이티드 Tfpi 길항제의 투여량 섭생법
KR102692277B1 (ko) * 2019-03-11 2024-08-05 현대자동차주식회사 상용 전기차용 모터 마운트
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JP2017035100A (ja) 2017-02-16
KR20190047135A (ko) 2019-05-07
ME03578B (me) 2020-07-20
CN102939098A (zh) 2013-02-20
AU2011223710A1 (en) 2012-09-20
CA2976671C (en) 2021-01-12
IL262444B (en) 2021-01-31
JP6684369B2 (ja) 2020-04-22
KR101974980B1 (ko) 2019-05-07
RS59830B1 (sr) 2020-02-28
CO6620068A2 (es) 2013-02-15
EP2542257A4 (en) 2013-11-13

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