RS56814B1 - Varijante anti-tfpi antitela sa diferencijalnim vezivanjem duž ph opsega zarad poboljšanja farmakokinetike - Google Patents
Varijante anti-tfpi antitela sa diferencijalnim vezivanjem duž ph opsega zarad poboljšanja farmakokinetikeInfo
- Publication number
- RS56814B1 RS56814B1 RS20180073A RSP20180073A RS56814B1 RS 56814 B1 RS56814 B1 RS 56814B1 RS 20180073 A RS20180073 A RS 20180073A RS P20180073 A RSP20180073 A RS P20180073A RS 56814 B1 RS56814 B1 RS 56814B1
- Authority
- RS
- Serbia
- Prior art keywords
- range
- antibody variants
- improved pharmacokinetics
- differential binding
- tfpi antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798261P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/029048 WO2014144577A1 (en) | 2013-03-15 | 2014-03-14 | Anti-tfpi antibody variants with differential binding across ph range for improved pharmacokinetics |
| EP14729504.2A EP2970497B1 (en) | 2013-03-15 | 2014-03-14 | Anti-tfpi antibody variants with differential binding across ph range for improved pharmacokinetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS56814B1 true RS56814B1 (sr) | 2018-04-30 |
Family
ID=50928243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20180073A RS56814B1 (sr) | 2013-03-15 | 2014-03-14 | Varijante anti-tfpi antitela sa diferencijalnim vezivanjem duž ph opsega zarad poboljšanja farmakokinetike |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9556280B2 (sr) |
| EP (1) | EP2970497B1 (sr) |
| JP (4) | JP6454678B2 (sr) |
| CN (2) | CN105452298B (sr) |
| CA (1) | CA2906128A1 (sr) |
| CY (1) | CY1120210T1 (sr) |
| DK (1) | DK2970497T3 (sr) |
| ES (1) | ES2657304T3 (sr) |
| HK (1) | HK1218128A1 (sr) |
| HR (1) | HRP20180078T1 (sr) |
| HU (1) | HUE037907T2 (sr) |
| LT (1) | LT2970497T (sr) |
| NO (1) | NO3022387T3 (sr) |
| PL (1) | PL2970497T3 (sr) |
| PT (1) | PT2970497T (sr) |
| RS (1) | RS56814B1 (sr) |
| SI (1) | SI2970497T1 (sr) |
| WO (1) | WO2014144577A1 (sr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201502587SA (en) | 2010-03-01 | 2015-06-29 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| MX352889B (es) | 2011-02-25 | 2017-12-13 | Chugai Pharmaceutical Co Ltd | Anticuerpo de fc especifico para fcyriib. |
| WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| WO2013081143A1 (ja) | 2011-11-30 | 2013-06-06 | 中外製薬株式会社 | 免疫複合体を形成する細胞内への運搬体（キャリア）を含む医薬 |
| SG10201709559PA (en) | 2012-08-24 | 2017-12-28 | Chugai Pharmaceutical Co Ltd | Fcγriib-specific fc region variant |
| DK2940135T5 (da) | 2012-12-27 | 2021-09-20 | Chugai Pharmaceutical Co Ltd | Heterodimeriseret polypeptid |
| US11267868B2 (en) | 2013-04-02 | 2022-03-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| PE20221834A1 (es) | 2014-12-19 | 2022-11-29 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina |
| KR20170110129A (ko) | 2015-02-05 | 2017-10-10 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| CN112225812A (zh) * | 2015-02-25 | 2021-01-15 | 财团法人牧岩生命科学研究所 | 结合tfpi的新型抗体以及包含所述抗体的组合物 |
| PE20240142A1 (es) | 2015-08-19 | 2024-02-01 | Pfizer | Anticuerpos inhibidores via del factor tisular y usos de los mismos |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN116251182A (zh) | 2016-08-05 | 2023-06-13 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| EP3863664A1 (en) | 2018-10-11 | 2021-08-18 | Pfizer Inc. | Dosage regimen for tfpi antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102469853B1 (ko) * | 2008-04-11 | 2022-11-22 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| UA112050C2 (uk) | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| MX2011006501A (es) * | 2008-12-22 | 2011-07-12 | Novo Nordisk As | Anticuerpos contra inhibidor de la via de factor de tejido. |
| SG10201502587SA (en) * | 2010-03-01 | 2015-06-29 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| WO2011111007A2 (en) * | 2010-03-11 | 2011-09-15 | Rinat Neuroscience Corporation | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| AU2012236296A1 (en) | 2011-04-01 | 2013-10-24 | Bayer Healthcare Llc | Monoclonal antibodies against tissue factor pathway inhibitor (TFPI) |
| CN107266574A (zh) * | 2012-03-30 | 2017-10-20 | 拜尔健康护理有限责任公司 | 蛋白酶调节的抗体 |
| WO2014028354A1 (en) * | 2012-08-13 | 2014-02-20 | Regeneron Pharmaceuticals, Inc. | Anti-pcsk9 antibodies with ph-dependent binding characteristics |
| BR112015003464B1 (pt) * | 2012-08-15 | 2022-01-18 | Lucid, Inc | Sistemas e processos para formação de imagens de tecido |
| US8613919B1 (en) * | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
-
2014
- 2014-03-14 PL PL14729504T patent/PL2970497T3/pl unknown
- 2014-03-14 SI SI201430564T patent/SI2970497T1/en unknown
- 2014-03-14 LT LTEP14729504.2T patent/LT2970497T/lt unknown
- 2014-03-14 CN CN201480016248.5A patent/CN105452298B/zh not_active Expired - Fee Related
- 2014-03-14 WO PCT/US2014/029048 patent/WO2014144577A1/en active Application Filing
- 2014-03-14 US US14/213,278 patent/US9556280B2/en active Active
- 2014-03-14 HU HUE14729504A patent/HUE037907T2/hu unknown
- 2014-03-14 CA CA2906128A patent/CA2906128A1/en not_active Abandoned
- 2014-03-14 EP EP14729504.2A patent/EP2970497B1/en active Active
- 2014-03-14 RS RS20180073A patent/RS56814B1/sr unknown
- 2014-03-14 CN CN202110987812.XA patent/CN113788897A/zh active Pending
- 2014-03-14 US US14/772,336 patent/US20160009818A1/en not_active Abandoned
- 2014-03-14 PT PT147295042T patent/PT2970497T/pt unknown
- 2014-03-14 JP JP2016502971A patent/JP6454678B2/ja not_active Expired - Fee Related
- 2014-03-14 DK DK14729504.2T patent/DK2970497T3/da active
- 2014-03-14 ES ES14729504.2T patent/ES2657304T3/es active Active
- 2014-07-03 NO NO14826414A patent/NO3022387T3/no unknown
-
2016
- 2016-06-02 HK HK16106252.2A patent/HK1218128A1/zh unknown
-
2018
- 2018-01-16 HR HRP20180078TT patent/HRP20180078T1/hr unknown
- 2018-01-24 CY CY20181100096T patent/CY1120210T1/el unknown
- 2018-04-25 US US15/962,624 patent/US20180282430A1/en not_active Abandoned
- 2018-12-17 JP JP2018235059A patent/JP6697064B2/ja not_active Expired - Fee Related
-
2020
- 2020-01-24 JP JP2020009685A patent/JP2020079250A/ja active Pending
-
2021
- 2021-04-16 JP JP2021069872A patent/JP2021107436A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN105452298B (zh) | 2021-08-31 |
| CN113788897A (zh) | 2021-12-14 |
| US20160009818A1 (en) | 2016-01-14 |
| CN105452298A (zh) | 2016-03-30 |
| NO3022387T3 (sr) | 2018-08-25 |
| US20140275493A1 (en) | 2014-09-18 |
| JP6697064B2 (ja) | 2020-05-20 |
| JP2016514683A (ja) | 2016-05-23 |
| JP2019069973A (ja) | 2019-05-09 |
| HUE037907T2 (hu) | 2018-09-28 |
| PL2970497T3 (pl) | 2018-05-30 |
| LT2970497T (lt) | 2018-03-12 |
| US20180282430A1 (en) | 2018-10-04 |
| ES2657304T3 (es) | 2018-03-02 |
| CY1120210T1 (el) | 2018-12-12 |
| EP2970497B1 (en) | 2017-10-25 |
| JP6454678B2 (ja) | 2019-01-16 |
| JP2020079250A (ja) | 2020-05-28 |
| SI2970497T1 (en) | 2018-04-30 |
| CA2906128A1 (en) | 2014-09-18 |
| HK1218128A1 (zh) | 2017-02-03 |
| JP2021107436A (ja) | 2021-07-29 |
| US9556280B2 (en) | 2017-01-31 |
| WO2014144577A1 (en) | 2014-09-18 |
| DK2970497T3 (da) | 2018-01-29 |
| HRP20180078T1 (hr) | 2018-03-09 |
| EP2970497A1 (en) | 2016-01-20 |
| PT2970497T (pt) | 2018-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1218128A1 (zh) | 改善藥代動力學的具有跨 範圍差異結合的抗 抗體變體 | |
| HRP20181646T1 (hr) | Konjugati pirolobenzodiazepin - anti-psma protutijela | |
| HK1200271A1 (en) | Mice that produce antigen-binding proteins with ph-dependent binding characteristics ph | |
| HK1217023A1 (zh) | 新型抗體 | |
| IL240045A0 (en) | Antigen-binding molecules activate bi-specific t cells | |
| LT3030581T (lt) | Antikūno surišimo vietos specifiškos egfrviii | |
| EP2956310A4 (en) | Durable card | |
| PL2906251T3 (pl) | Koniugaty pirolobenzodiazepina-przeciwciało anty-CD22 | |
| LT2906252T (lt) | Pirolobenzodiazepino-anti-her2 antikūno konjugatai | |
| EP3083698A4 (en) | Monoclonal anti-tk1 antibodies | |
| IL236524B (en) | Camel antibody libraries | |
| EP3480215B8 (en) | Anti-her2 antibody and conjugate thereof | |
| EP2930240A4 (en) | ANTI-FOLR1 ANTIBODY | |
| HK1217500A1 (zh) | 特異性結合 的抗體 | |
| EP2997787A4 (en) | IMPROVED TECHNIQUES FOR MULTIMEDIA SHARING | |
| EP2837685A4 (en) | ANTI-FGFR2 ANTIBODIES | |
| EP3016980A4 (en) | Egfr antibody conjugates | |
| HK1219963A1 (zh) | 抗體 | |
| DK3611180T3 (da) | Hybrid immunoglobulin indeholdende ikke-peptidyl-binding | |
| IL245488B (en) | Anti- ccl17 antibodies | |
| ZA201507808B (en) | Binding element | |
| HK1217340A1 (zh) | 針對 的單克隆抗體 | |
| HK1218921A1 (zh) | 特異性結合 的抗體 | |
| SG11201604503XA (en) | Cytotoxic antibody | |
| TWM476065U (en) | Dual-power vehicle |