PT2473527T - Formulações estáveis de polipéptidos e seus usos - Google Patents
Formulações estáveis de polipéptidos e seus usosInfo
- Publication number
- PT2473527T PT2473527T PT107478950T PT10747895T PT2473527T PT 2473527 T PT2473527 T PT 2473527T PT 107478950 T PT107478950 T PT 107478950T PT 10747895 T PT10747895 T PT 10747895T PT 2473527 T PT2473527 T PT 2473527T
- Authority
- PT
- Portugal
- Prior art keywords
- polypeptides
- stable formulations
- formulations
- stable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27581609P | 2009-09-03 | 2009-09-03 | |
| US28450209P | 2009-12-18 | 2009-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2473527T true PT2473527T (pt) | 2017-02-27 |
Family
ID=42797362
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT181857723T PT3438126T (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
| PT107478950T PT2473527T (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
| PT10747896T PT2473528E (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT181857723T PT3438126T (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT10747896T PT2473528E (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9884117B2 (pt) |
| EP (5) | EP3438126B1 (pt) |
| CY (1) | CY1121411T1 (pt) |
| DK (2) | DK2473527T3 (pt) |
| ES (3) | ES2617180T3 (pt) |
| HK (1) | HK1204284A1 (pt) |
| HR (1) | HRP20190137T1 (pt) |
| LT (1) | LT2805731T (pt) |
| PL (2) | PL3438126T3 (pt) |
| PT (3) | PT3438126T (pt) |
| SI (1) | SI2805731T1 (pt) |
| WO (2) | WO2011026945A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| RU2481355C2 (ru) | 2007-05-24 | 2013-05-10 | Аблинкс Н.В. | Аминокислотные последовательности, направленные на rank-l, и полипептиды, включающие их, для лечения заболеваний и нарушений костей |
| MX345226B (es) | 2008-10-29 | 2017-01-20 | Ablynx Nv | Formulaciones de moleculas de union a antigeno de dominio sencillo. |
| MX2011004558A (es) | 2008-10-29 | 2011-06-01 | Wyeth Llc | Procedimientos para la purificacion de moleculas de union a antigeno de un unico dominio. |
| US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| US10005830B2 (en) | 2009-03-05 | 2018-06-26 | Ablynx N.V. | Antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| WO2010115995A2 (en) | 2009-04-10 | 2010-10-14 | Ablynx Nv | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
| JP5647222B2 (ja) | 2009-04-10 | 2014-12-24 | アブリンクス エン．ヴェー． | Ｉｌ−６ｒ関連疾患及び障害の治療のためのｉｌ−６ｒに指向性を有する改善されたアミノ酸配列及びこれを含むポリペプチド |
| US9884117B2 (en) * | 2009-09-03 | 2018-02-06 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| WO2011028962A1 (en) * | 2009-09-04 | 2011-03-10 | Xoma Technology Ltd. | Antibody coformulations |
| PL2533761T3 (pl) | 2010-02-11 | 2019-09-30 | Ablynx N.V. | Sposoby i kompozycje do wytwarzania aerozoli |
| SI3345615T1 (sl) | 2010-03-01 | 2020-03-31 | Bayer Healthcare Llc | Optimizirana monoklonska protitelesa proti zaviralcu poti tkivnega faktorja (TFPI) |
| WO2011161263A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Pharmaceutical compositions for cutaneous administration |
| KR102023207B1 (ko) | 2010-12-02 | 2019-11-25 | 온콜리틱스 바이오테크 인코포레이티드 | 동결건조 바이러스 제형 |
| EA201390810A1 (ru) * | 2010-12-02 | 2013-09-30 | Онколитикс Байотек Инк. | Жидкие вирусные составы |
| CN103732625A (zh) * | 2011-05-27 | 2014-04-16 | 埃博灵克斯股份有限公司 | 使用rankl结合肽抑制骨质吸收 |
| CN103945862A (zh) * | 2011-07-07 | 2014-07-23 | Lfb美国股份有限公司 | 使蛋白质稳定的制剂 |
| WO2013041722A1 (en) * | 2011-09-23 | 2013-03-28 | Ablynx Nv | Prolonged inhibition of interleukin-6 mediated signaling |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| WO2014193821A1 (en) * | 2013-05-28 | 2014-12-04 | Momenta Pharmaceuticals, Inc. | Pharmaceutical compositions comprising pyrophosphate |
| WO2016062766A1 (en) | 2014-10-21 | 2016-04-28 | Ablynx Nv | Treatment of il-6r related diseases |
| WO2018007442A1 (en) | 2016-07-06 | 2018-01-11 | Ablynx N.V. | Treatment of il-6r related diseases |
| WO2018029182A1 (en) | 2016-08-08 | 2018-02-15 | Ablynx N.V. | Il-6r single variable domain antibodies for treatment of il-6r related diseases |
| BR112019017853A2 (pt) * | 2017-02-28 | 2021-04-27 | Vib Vzw | Meios e métodos para liberação oral de proteína |
| AU2018277343A1 (en) | 2017-06-02 | 2020-01-02 | Ablynx N.V. | Adamts binding immunoglobulins |
| WO2020185479A1 (en) * | 2019-03-08 | 2020-09-17 | Boehringer Ingelheim International Gmbh | Anti-il-36r antibody formulations |
| CN114681592A (zh) * | 2020-12-31 | 2022-07-01 | 天境生物科技(杭州)有限公司 | 包含可溶性gp130二聚体的制剂和使用方法 |
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| KR20110091777A (ko) | 2008-11-26 | 2011-08-12 | 글락소 그룹 리미티드 | 폴리펩티드, 항체 가변 도메인 및 길항제 |
| CN102387814A (zh) * | 2009-01-29 | 2012-03-21 | 米迪缪尼有限公司 | 延长体内半衰期的人抗il-6抗体及其在治疗肿瘤、自身免疫性疾病和炎症性疾病中的应用 |
| US10005830B2 (en) | 2009-03-05 | 2018-06-26 | Ablynx N.V. | Antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| US9884117B2 (en) * | 2009-09-03 | 2018-02-06 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
-
2010
- 2010-09-03 US US13/393,679 patent/US9884117B2/en active Active
- 2010-09-03 EP EP18185772.3A patent/EP3438126B1/en active Active
- 2010-09-03 DK DK10747895.0T patent/DK2473527T3/en active
- 2010-09-03 ES ES10747895.0T patent/ES2617180T3/es active Active
- 2010-09-03 EP EP20176028.7A patent/EP3725330A1/en active Pending
- 2010-09-03 EP EP10747896.8A patent/EP2473528B1/en active Active
- 2010-09-03 PT PT181857723T patent/PT3438126T/pt unknown
- 2010-09-03 US US13/393,636 patent/US20120244158A1/en not_active Abandoned
- 2010-09-03 LT LTEP14171120.0T patent/LT2805731T/lt unknown
- 2010-09-03 PT PT107478950T patent/PT2473527T/pt unknown
- 2010-09-03 EP EP10747895.0A patent/EP2473527B1/en active Active
- 2010-09-03 SI SI201031846T patent/SI2805731T1/sl unknown
- 2010-09-03 ES ES10747896T patent/ES2531083T3/es active Active
- 2010-09-03 DK DK10747896T patent/DK2473528T3/en active
- 2010-09-03 WO PCT/EP2010/062972 patent/WO2011026945A1/en active Application Filing
- 2010-09-03 PT PT10747896T patent/PT2473528E/pt unknown
- 2010-09-03 EP EP14171120.0A patent/EP2805731B1/en active Active
- 2010-09-03 WO PCT/EP2010/062975 patent/WO2011026948A1/en active Application Filing
- 2010-09-03 PL PL18185772T patent/PL3438126T3/pl unknown
- 2010-09-03 ES ES18185772T patent/ES2831323T3/es active Active
- 2010-09-03 PL PL10747896T patent/PL2473528T3/pl unknown
-
2015
- 2015-05-22 HK HK15104885.3A patent/HK1204284A1/xx not_active IP Right Cessation
-
2019
- 2019-01-21 HR HRP20190137TT patent/HRP20190137T1/hr unknown
- 2019-01-31 CY CY20191100137T patent/CY1121411T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3438126A1 (en) | 2019-02-06 |
| EP3438126B1 (en) | 2020-08-19 |
| EP2805731B1 (en) | 2018-10-31 |
| DK2473527T3 (en) | 2017-03-06 |
| EP2473528B1 (en) | 2014-12-03 |
| HK1204284A1 (en) | 2015-11-13 |
| DK2473528T3 (en) | 2015-03-02 |
| PT2473528E (pt) | 2015-03-04 |
| ES2831323T3 (es) | 2021-06-08 |
| HRP20190137T1 (hr) | 2019-03-22 |
| US20120244158A1 (en) | 2012-09-27 |
| PL3438126T3 (pl) | 2021-03-08 |
| SI2805731T1 (sl) | 2019-02-28 |
| PT3438126T (pt) | 2020-11-09 |
| US9884117B2 (en) | 2018-02-06 |
| WO2011026945A1 (en) | 2011-03-10 |
| PL2473528T3 (pl) | 2015-05-29 |
| CY1121411T1 (el) | 2020-05-29 |
| EP3725330A1 (en) | 2020-10-21 |
| EP2473528A1 (en) | 2012-07-11 |
| ES2617180T3 (es) | 2017-06-15 |
| WO2011026948A1 (en) | 2011-03-10 |
| ES2531083T3 (es) | 2015-03-10 |
| EP2473527A1 (en) | 2012-07-11 |
| EP2473527B1 (en) | 2016-11-30 |
| LT2805731T (lt) | 2019-02-11 |
| EP2805731A3 (en) | 2015-04-01 |
| US20120201812A1 (en) | 2012-08-09 |
| EP2805731A2 (en) | 2014-11-26 |
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