NZ702494A - Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) - Google Patents
Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)Info
- Publication number
- NZ702494A NZ702494A NZ702494A NZ70249411A NZ702494A NZ 702494 A NZ702494 A NZ 702494A NZ 702494 A NZ702494 A NZ 702494A NZ 70249411 A NZ70249411 A NZ 70249411A NZ 702494 A NZ702494 A NZ 702494A
- Authority
- NZ
- New Zealand
- Prior art keywords
- tissue factor
- pathway inhibitor
- amino acid
- factor pathway
- antibody
- Prior art date
Links
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 title 1
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 title 1
- 101150070659 tfpI gene Proteins 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 101000653189 Homo sapiens Tissue factor pathway inhibitor Proteins 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 102220475408 Acyl-coenzyme A thioesterase MBLAC2_S89A_mutation Human genes 0.000 abstract 1
- 102220523550 C-C motif chemokine 2_D91L_mutation Human genes 0.000 abstract 1
- 102220600740 Calmodulin-binding transcription activator 1_Q1E_mutation Human genes 0.000 abstract 1
- 102220640918 Cell division control protein 6 homolog_S54D_mutation Human genes 0.000 abstract 1
- 102220466999 EH domain-binding protein 1-like protein 1_G33K_mutation Human genes 0.000 abstract 1
- 102220606828 Gap junction beta-1 protein_M34K_mutation Human genes 0.000 abstract 1
- 102220500396 Neutral and basic amino acid transport protein rBAT_S31P_mutation Human genes 0.000 abstract 1
- 102220467388 Otoancorin_Y48F_mutation Human genes 0.000 abstract 1
- 102220572773 RNA-binding protein FUS_D91Q_mutation Human genes 0.000 abstract 1
- 102220476285 Retinaldehyde-binding protein 1_P54L_mutation Human genes 0.000 abstract 1
- 102220476297 Retinaldehyde-binding protein 1_S21T_mutation Human genes 0.000 abstract 1
- 102220600976 Syndecan-4_N26A_mutation Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 102220352372 c.148T>G Human genes 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 102200153431 rs1060501000 Human genes 0.000 abstract 1
- 102220004991 rs121912517 Human genes 0.000 abstract 1
- 102200068095 rs121913658 Human genes 0.000 abstract 1
- 102220283790 rs1555932413 Human genes 0.000 abstract 1
- 102220276093 rs1555932427 Human genes 0.000 abstract 1
- 102200108151 rs17683011 Human genes 0.000 abstract 1
- 102200079914 rs193302884 Human genes 0.000 abstract 1
- 102220012970 rs199742269 Human genes 0.000 abstract 1
- 102200069953 rs28931601 Human genes 0.000 abstract 1
- 102220272824 rs563079629 Human genes 0.000 abstract 1
- 102220057210 rs730880391 Human genes 0.000 abstract 1
- 102220308785 rs749697322 Human genes 0.000 abstract 1
- 102220088091 rs768851540 Human genes 0.000 abstract 1
- 102220106607 rs773955198 Human genes 0.000 abstract 1
- 102220250470 rs774802052 Human genes 0.000 abstract 1
- 102220147551 rs781230154 Human genes 0.000 abstract 1
- 102220072337 rs794728990 Human genes 0.000 abstract 1
- 102200040542 rs80356524 Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Filtering Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30929010P | 2010-03-01 | 2010-03-01 | |
| NZ602115A NZ602115A (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ702494A true NZ702494A (en) | 2016-09-30 |
Family
ID=44542552
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ702494A NZ702494A (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| NZ602115A NZ602115A (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ602115A NZ602115A (en) | 2010-03-01 | 2011-03-01 | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Country Status (37)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| JP5714505B2 (ja) | 2008-12-22 | 2015-05-07 | ノヴォ ノルディスク アー／エス | 組織因子経路阻害因子に対する抗体 |
| CN110835373A (zh) * | 2010-03-01 | 2020-02-25 | 拜耳医药保健有限公司 | 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体 |
| JP2013533871A (ja) * | 2010-06-30 | 2013-08-29 | ノヴォ ノルディスク アー／エス | 組織因子経路インヒビターに特異的に結合することが可能な抗体 |
| EA034214B1 (ru) * | 2011-04-01 | 2020-01-17 | Байер Хелфкеа Ллк | Выделенное моноклональное антитело или его антигенсвязывающий фрагмент, который связывается с эпитопом ингибитора пути тканевого фактора человека, содержащая его фармацевтическая композиция, способ применения этой композиции и кодирующая антитело молекула нуклеиновой кислоты |
| KR20150030639A (ko) | 2012-03-30 | 2015-03-20 | 바이엘 헬스케어 엘엘씨 | 프로테아제로 조절된 항체 |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| UY35459A (es) * | 2013-03-15 | 2014-10-31 | Bayer Healthcare Llc | Anticuerpos profármaco contra el inhibidor de la vía del factor tisular |
| HRP20180078T1 (hr) * | 2013-03-15 | 2018-03-09 | Bayer Healthcare Llc | VARIJANTE ANTI-TFPI PROTUTIJELA S DIFERENCIJALNIM VEZANJEM U ŠIROKOM RASPONU pH RADI POBOLJŠANE FARMAKOKINETIKE |
| EP4279128A3 (en) * | 2015-02-25 | 2024-02-28 | Mogam Institute for Biomedical Research | Novel antibody binding to tfpi and composition comprising the same |
| KR102068915B1 (ko) | 2015-08-19 | 2020-01-22 | 화이자 인코포레이티드 | 조직 인자 경로 억제제 항체 및 그의 용도 |
| KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
| MX2021004120A (es) * | 2018-10-11 | 2021-09-10 | Pfizer | Regimen de dosificacion para antagonistas de tfpi. |
| KR102692277B1 (ko) * | 2019-03-11 | 2024-08-05 | 현대자동차주식회사 | 상용 전기차용 모터 마운트 |
| CN112442127A (zh) * | 2019-08-29 | 2021-03-05 | 苏州康宁杰瑞生物科技有限公司 | 针对tfpi的单克隆抗体 |
| KR20220065719A (ko) * | 2020-11-13 | 2022-05-20 | 한미약품 주식회사 | 치료학적 효소 융합단백질의 파브리병에 기인하거나 동반되는 신장질환 예방 및 치료 용도 |
| CN117285632A (zh) * | 2022-06-17 | 2023-12-26 | 安源医药科技（上海）有限公司 | 针对tfpi的单克隆抗体及其用途 |
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