JP5861194B2 - 選択的グルコシダーゼインヒビターおよびその使用 - Google Patents

選択的グルコシダーゼインヒビターおよびその使用 Download PDF

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Publication number
JP5861194B2
JP5861194B2 JP2013544980A JP2013544980A JP5861194B2 JP 5861194 B2 JP5861194 B2 JP 5861194B2 JP 2013544980 A JP2013544980 A JP 2013544980A JP 2013544980 A JP2013544980 A JP 2013544980A JP 5861194 B2 JP5861194 B2 JP 5861194B2
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Japan
Prior art keywords
mmol
pyrano
tetrahydro
compound
dcm
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Expired - Fee Related
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JP2013544980A
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Japanese (ja)
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JP2014501740A (ja
JP2014501740A5 (enExample
Inventor
ラメシュ コール，
ラメシュ コール，
アーネスト ジェイ． マケーチャン，
アーネスト ジェイ． マケーチャン，
ハロルド ジー． セルニック，
ハロルド ジー． セルニック，
デイビッド ジェイ． ヴォカドゥロ，
デイビッド ジェイ． ヴォカドゥロ，
ユアンシ ジョウ，
ユアンシ ジョウ，
ヨンバオ ジュー，
ヨンバオ ジュー，
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Priority claimed from PCT/CN2011/074569 external-priority patent/WO2012159262A1/en
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Publication of JP2014501740A publication Critical patent/JP2014501740A/ja
Publication of JP2014501740A5 publication Critical patent/JP2014501740A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • G—PHYSICS
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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JP2013544980A 2010-12-23 2011-12-21 選択的グルコシダーゼインヒビターおよびその使用 Expired - Fee Related JP5861194B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201061426773P 2010-12-23 2010-12-23
US61/426,773 2010-12-23
PCT/CN2011/074569 WO2012159262A1 (en) 2011-05-24 2011-05-24 Selective glycosidase inhibitors and uses thereof
CNPCT/CN2011/074569 2011-05-24
US201161507684P 2011-07-14 2011-07-14
US61/507,684 2011-07-14
PCT/CA2011/001397 WO2012083435A1 (en) 2010-12-23 2011-12-21 Selective glycosidase inhibitors and uses thereof

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JP2014501740A JP2014501740A (ja) 2014-01-23
JP2014501740A5 JP2014501740A5 (enExample) 2015-10-15
JP5861194B2 true JP5861194B2 (ja) 2016-02-16

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US (2) US9243020B2 (enExample)
EP (1) EP2655388B1 (enExample)
JP (2) JP5861194B2 (enExample)
KR (1) KR101979036B1 (enExample)
CN (1) CN103339138B (enExample)
AR (1) AR085004A1 (enExample)
AU (1) AU2011349021B2 (enExample)
BR (1) BR112013016179A2 (enExample)
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CO (1) CO6821931A2 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524911A (ja) * 2011-06-27 2014-09-25 アレクトス・セラピューティクス・インコーポレイテッド 選択的グリコシダーゼ阻害剤およびその使用

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CA2599843C (en) * 2005-03-01 2013-08-27 Simon Fraser University Selective glycosidase inhibitors, methods of making inhibitors, and uses thereof
JP5380293B2 (ja) 2006-08-31 2014-01-08 サイモン・フレーザー・ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
WO2010012107A1 (en) * 2008-08-01 2010-02-04 Simon Fraser University Selective glycosidase inhibitors and uses thereof
US9120781B2 (en) 2010-05-11 2015-09-01 Simon Fraser University Selective glycosidase inhibitors and uses thereof
WO2012061927A1 (en) 2010-11-08 2012-05-18 Alectos Therapeutics, Inc. Selective glycosidase inhibitors and uses thereof
RU2609210C2 (ru) * 2010-12-23 2017-01-31 Алектос Терапьютикс Инк. Селективные ингибиторы гликозидазы и их применение
WO2012126091A1 (en) 2011-03-24 2012-09-27 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2012129651A1 (en) 2011-03-31 2012-10-04 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2726468B1 (en) 2011-06-27 2017-04-12 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US9701693B2 (en) 2011-06-27 2017-07-11 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013028715A1 (en) 2011-08-25 2013-02-28 Merck Patent Gmbh Pyrano [3, 2 - d] [1, 3] thiazole as glycosidase inhibitors
EP2890676B1 (en) 2012-08-31 2018-12-05 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2890675A4 (en) 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
KR20150079711A (ko) * 2012-10-31 2015-07-08 알렉토스 테라퓨틱스 인크. 글리코시다아제 저해제 및 이의 용도
WO2014100934A1 (en) 2012-12-24 2014-07-03 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
SG11201701315VA (en) 2014-08-28 2017-03-30 Asceneuron Sa Glycosidase inhibitors
KR101777164B1 (ko) 2015-07-20 2017-09-11 순천향대학교 산학협력단 O-GlcNAc 트랜스퍼레즈 억제제용 UDP-GlcNAc의 C1-포스포네이트 유도체
US9994589B2 (en) * 2015-12-14 2018-06-12 Amicus Therapeutics, Inc. Compounds and methods for the treatment of alzheimer's disease and/or cerebral amyloid angiopathy
JP2019506430A (ja) 2016-02-25 2019-03-07 エースニューロン・ソシエテ・アノニム グリコシダーゼ阻害剤
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