JP5702396B2 - ベンゾジアゼピンブロモドメイン阻害剤 - Google Patents

ベンゾジアゼピンブロモドメイン阻害剤 Download PDF

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Publication number
JP5702396B2
JP5702396B2 JP2012537381A JP2012537381A JP5702396B2 JP 5702396 B2 JP5702396 B2 JP 5702396B2 JP 2012537381 A JP2012537381 A JP 2012537381A JP 2012537381 A JP2012537381 A JP 2012537381A JP 5702396 B2 JP5702396 B2 JP 5702396B2
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methyl
alkyl
compound
chlorophenyl
methyloxy
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Japanese (ja)
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JP2013510123A (ja
JP2013510123A5 (enExample
Inventor
ベイリー，ジェイムズ
ゴスミニ，ロマン，リュック，マリー
ミルゲ，オリヴィエ
ウィザーリントン，ジェイソン
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グラクソスミスクライン エルエルシー
グラクソスミスクライン エルエルシー
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Priority claimed from GB0919433A external-priority patent/GB0919433D0/en
Priority claimed from GBGB1010509.6A external-priority patent/GB201010509D0/en
Priority claimed from PCT/EP2010/061518 external-priority patent/WO2011054553A1/en
Priority claimed from GBGB1014231.3A external-priority patent/GB201014231D0/en
Application filed by グラクソスミスクライン エルエルシー, グラクソスミスクライン エルエルシー filed Critical グラクソスミスクライン エルエルシー
Publication of JP2013510123A publication Critical patent/JP2013510123A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012537381A 2009-11-05 2010-11-03 ベンゾジアゼピンブロモドメイン阻害剤 Expired - Fee Related JP5702396B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0919433.3 2009-11-05
GB0919433A GB0919433D0 (en) 2009-11-05 2009-11-05 Novel compounds
GBGB1010509.6A GB201010509D0 (en) 2010-06-22 2010-06-22 Novel compounds
GB1010509.6 2010-06-22
EPPCT/EP2010/061518 2010-08-06
PCT/EP2010/061518 WO2011054553A1 (en) 2009-11-05 2010-08-06 Benzodiazepine bromodomain inhibitor
GB1014231.3 2010-08-25
GBGB1014231.3A GB201014231D0 (en) 2010-08-25 2010-08-25 Novel compounds
PCT/EP2010/066697 WO2011054845A1 (en) 2009-11-05 2010-11-03 Benzodiazepine bromodomain inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015030132A Division JP2015143232A (ja) 2009-11-05 2015-02-19 ベンゾジアゼピンブロモドメイン阻害剤

Publications (3)

Publication Number Publication Date
JP2013510123A JP2013510123A (ja) 2013-03-21
JP2013510123A5 JP2013510123A5 (enExample) 2013-11-21
JP5702396B2 true JP5702396B2 (ja) 2015-04-15

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JP2012537381A Expired - Fee Related JP5702396B2 (ja) 2009-11-05 2010-11-03 ベンゾジアゼピンブロモドメイン阻害剤
JP2015030132A Pending JP2015143232A (ja) 2009-11-05 2015-02-19 ベンゾジアゼピンブロモドメイン阻害剤
JP2016185487A Pending JP2017039738A (ja) 2009-11-05 2016-09-23 ベンゾジアゼピンブロモドメイン阻害剤

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JP2015030132A Pending JP2015143232A (ja) 2009-11-05 2015-02-19 ベンゾジアゼピンブロモドメイン阻害剤
JP2016185487A Pending JP2017039738A (ja) 2009-11-05 2016-09-23 ベンゾジアゼピンブロモドメイン阻害剤

Country Status (23)

Country Link
US (3) US9102677B2 (enExample)
EP (2) EP2496582B1 (enExample)
JP (3) JP5702396B2 (enExample)
KR (1) KR20120097508A (enExample)
CN (1) CN102781943B (enExample)
AU (1) AU2010317096B2 (enExample)
BR (1) BR112012010705A2 (enExample)
CA (1) CA2779423C (enExample)
CY (1) CY1117424T1 (enExample)
DK (1) DK2496582T3 (enExample)
EA (1) EA023441B1 (enExample)
ES (2) ES2654423T3 (enExample)
HK (1) HK1221221A1 (enExample)
HR (1) HRP20160253T1 (enExample)
HU (1) HUE026967T2 (enExample)
IL (2) IL219253A (enExample)
ME (1) ME02356B (enExample)
MX (1) MX341212B (enExample)
PL (1) PL2496582T3 (enExample)
RS (1) RS54645B1 (enExample)
SI (1) SI2496582T1 (enExample)
SM (1) SMT201600104B (enExample)
WO (1) WO2011054845A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015143232A (ja) * 2009-11-05 2015-08-06 グラクソスミスクライン エルエルシー ベンゾジアゼピンブロモドメイン阻害剤

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