PL3129378T3 - Związki hamujące bromodomenę i zawierająca je kompozycja farmaceutyczna do zapobiegania lub leczenia nowotworu - Google Patents
Związki hamujące bromodomenę i zawierająca je kompozycja farmaceutyczna do zapobiegania lub leczenia nowotworuInfo
- Publication number
- PL3129378T3 PL3129378T3 PL15776821T PL15776821T PL3129378T3 PL 3129378 T3 PL3129378 T3 PL 3129378T3 PL 15776821 T PL15776821 T PL 15776821T PL 15776821 T PL15776821 T PL 15776821T PL 3129378 T3 PL3129378 T3 PL 3129378T3
- Authority
- PL
- Poland
- Prior art keywords
- bromodomain
- cancer
- treating
- preventing
- pharmaceutical composition
- Prior art date
Links
- 102000001805 Bromodomains Human genes 0.000 title 1
- 108050009021 Bromodomains Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461977370P | 2014-04-09 | 2014-04-09 | |
| EP15776821.9A EP3129378B1 (en) | 2014-04-09 | 2015-04-08 | Bromodomain-inhibiting compounds and pharmaceutical composition comprising same for preventing or treating a cancer |
| PCT/KR2015/003530 WO2015156601A1 (en) | 2014-04-09 | 2015-04-08 | Bromodomain-inhibiting compounds and pharmaceutical composition comprising same for preventing or treating a cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3129378T3 true PL3129378T3 (pl) | 2020-03-31 |
Family
ID=54288110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15776821T PL3129378T3 (pl) | 2014-04-09 | 2015-04-08 | Związki hamujące bromodomenę i zawierająca je kompozycja farmaceutyczna do zapobiegania lub leczenia nowotworu |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9884874B2 (pl) |
| EP (1) | EP3129378B1 (pl) |
| JP (1) | JP6333996B2 (pl) |
| KR (1) | KR101928521B1 (pl) |
| CN (1) | CN106132968B (pl) |
| DK (1) | DK3129378T3 (pl) |
| ES (1) | ES2751642T3 (pl) |
| PL (1) | PL3129378T3 (pl) |
| WO (1) | WO2015156601A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN107629057B (zh) * | 2016-07-19 | 2020-03-27 | 上海勋和医药科技有限公司 | Bet蛋白抑制剂及其应用 |
| CA3041949A1 (en) * | 2016-12-16 | 2018-06-21 | F. Hoffmann-La Roche Ag | Process for the manufacture of diazepine derivatives |
| WO2019238557A1 (en) | 2018-06-13 | 2019-12-19 | Dybly Ag | Preparation of condensed triazepine derivatives and their use as bet inhibitors |
| CN114671887A (zh) * | 2021-10-29 | 2022-06-28 | 四川大学华西医院 | 一种二氢吲哚酮类化合物的制备及其抗肿瘤应用 |
| CN114702451B (zh) * | 2022-03-29 | 2024-05-14 | 国药集团国瑞药业有限公司 | 一种氯硝西泮及其中间体的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2120939A1 (en) * | 1991-10-11 | 1993-04-15 | Tetsuya Tahara | Therapeutic agent for osteoporosis and diazepine compound |
| WO1994006802A1 (fr) * | 1992-09-18 | 1994-03-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thienodiazepine et son utilisation medicinale |
| WO2009050469A1 (en) | 2007-10-17 | 2009-04-23 | Kudos Pharmaceuticals Limited | 4- [3- (4-cyclopropanecarbonyl-piperazine-i-carbonyl) -4 -fluoro-benzyl] -2h-phthalaz in-1-one |
| JP5478262B2 (ja) * | 2007-12-28 | 2014-04-23 | 田辺三菱製薬株式会社 | 抗癌剤 |
| HUE026967T2 (en) * | 2009-11-05 | 2016-07-28 | Glaxosmithkline Llc | Benzodiazepine Bromodomain inhibitor |
| DK2722334T3 (en) | 2009-11-05 | 2016-03-07 | Glaxosmithkline Llc | benzodiazepine bromdomæneinhibitor |
| GB0919426D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| JP5913292B2 (ja) * | 2010-05-14 | 2016-04-27 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 代謝を調節する組成物および方法 |
| DK2571503T3 (en) * | 2010-05-14 | 2015-04-20 | Dana Farber Cancer Inst Inc | COMPOSITIONS AND THEIR USE IN THE TREATMENT OF NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2013033270A2 (en) | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same |
-
2015
- 2015-04-08 EP EP15776821.9A patent/EP3129378B1/en active Active
- 2015-04-08 CN CN201580016461.0A patent/CN106132968B/zh active Active
- 2015-04-08 KR KR1020167030835A patent/KR101928521B1/ko active Active
- 2015-04-08 JP JP2016561662A patent/JP6333996B2/ja active Active
- 2015-04-08 WO PCT/KR2015/003530 patent/WO2015156601A1/en not_active Ceased
- 2015-04-08 US US15/129,657 patent/US9884874B2/en active Active
- 2015-04-08 ES ES15776821T patent/ES2751642T3/es active Active
- 2015-04-08 DK DK15776821.9T patent/DK3129378T3/da active
- 2015-04-08 PL PL15776821T patent/PL3129378T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN106132968A (zh) | 2016-11-16 |
| WO2015156601A1 (en) | 2015-10-15 |
| JP6333996B2 (ja) | 2018-05-30 |
| CN106132968B (zh) | 2019-04-05 |
| KR20160133006A (ko) | 2016-11-21 |
| KR101928521B1 (ko) | 2018-12-13 |
| DK3129378T3 (da) | 2019-10-07 |
| ES2751642T3 (es) | 2020-04-01 |
| JP2017510605A (ja) | 2017-04-13 |
| EP3129378B1 (en) | 2019-06-26 |
| US9884874B2 (en) | 2018-02-06 |
| US20170174702A1 (en) | 2017-06-22 |
| EP3129378A1 (en) | 2017-02-15 |
| EP3129378A4 (en) | 2017-08-23 |
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