JP5379347B2 - ４’−チオヌクレオシドおよびオリゴマー化合物 - Google Patents

４’−チオヌクレオシドおよびオリゴマー化合物 Download PDF

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JP5379347B2
JP5379347B2 JP2006527130A JP2006527130A JP5379347B2 JP 5379347 B2 JP5379347 B2 JP 5379347B2 JP 2006527130 A JP2006527130 A JP 2006527130A JP 2006527130 A JP2006527130 A JP 2006527130A JP 5379347 B2 JP5379347 B2 JP 5379347B2
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compound
oligonucleotide
group
oligonucleotides
nucleoside
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JP2007514643A5 (https=
JP2007514643A (ja
Inventor
バット、バルクリシェン
ダンデ、プラサッド
プラカッシュ、ターザ、ピー．
アラーソン、チャールズ
スウェイジ、エリック、イー．
グリッフィー、リチャード、エイチ．
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
Isis Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
JP2006527130A 2003-09-18 2004-09-20 ４’−チオヌクレオシドおよびオリゴマー化合物 Expired - Fee Related JP5379347B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50399703P 2003-09-18 2003-09-18
US60/503,997 2003-09-18
PCT/US2004/030874 WO2005027962A1 (en) 2003-09-18 2004-09-20 4’-thionucleosides and oligomeric compounds

Publications (3)

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JP2007514643A JP2007514643A (ja) 2007-06-07
JP2007514643A5 JP2007514643A5 (https=) 2013-10-10
JP5379347B2 true JP5379347B2 (ja) 2013-12-25

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US (2) US7875733B2 (https=)
EP (1) EP1677822B1 (https=)
JP (1) JP5379347B2 (https=)
AU (2) AU2004274021B2 (https=)
CA (1) CA2538252C (https=)
WO (1) WO2005027962A1 (https=)

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US20050130923A1 (en) 2005-06-16
US20100324277A1 (en) 2010-12-23
EP1677822A2 (en) 2006-07-12
US7939677B2 (en) 2011-05-10
WO2005027962A3 (en) 2007-07-12
AU2009222605B2 (en) 2010-12-09
EP1677822B1 (en) 2014-04-23
AU2009222605A1 (en) 2009-11-12
AU2004274021B2 (en) 2009-08-13
WO2005027962A9 (en) 2006-08-10
CA2538252C (en) 2014-02-25
EP1677822A4 (en) 2009-08-19
US7875733B2 (en) 2011-01-25
AU2004274021A1 (en) 2005-03-31
WO2005027962A1 (en) 2005-03-31
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