JP5378228B2 - 細胞分析装置及び細胞分析方法 - Google Patents
細胞分析装置及び細胞分析方法 Download PDFInfo
- Publication number
- JP5378228B2 JP5378228B2 JP2009539037A JP2009539037A JP5378228B2 JP 5378228 B2 JP5378228 B2 JP 5378228B2 JP 2009539037 A JP2009539037 A JP 2009539037A JP 2009539037 A JP2009539037 A JP 2009539037A JP 5378228 B2 JP5378228 B2 JP 5378228B2
- Authority
- JP
- Japan
- Prior art keywords
- cell
- value
- fluorescence
- cells
- measurement sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0092—Monitoring flocculation or agglomeration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1497—Particle shape
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009539037A JP5378228B2 (ja) | 2007-10-29 | 2008-10-24 | 細胞分析装置及び細胞分析方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007280738 | 2007-10-29 | ||
| JP2007280738 | 2007-10-29 | ||
| JP2009539037A JP5378228B2 (ja) | 2007-10-29 | 2008-10-24 | 細胞分析装置及び細胞分析方法 |
| PCT/JP2008/069338 WO2009057525A1 (ja) | 2007-10-29 | 2008-10-24 | 細胞分析装置及び細胞分析方法 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013196526A Division JP5599927B2 (ja) | 2007-10-29 | 2013-09-24 | 細胞分析装置及び細胞分析方法 |
| JP2013196525A Division JP5739959B2 (ja) | 2007-10-29 | 2013-09-24 | 細胞分析装置及び細胞分析方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2009057525A1 JPWO2009057525A1 (ja) | 2011-03-10 |
| JP5378228B2 true JP5378228B2 (ja) | 2013-12-25 |
Family
ID=40590916
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539037A Active JP5378228B2 (ja) | 2007-10-29 | 2008-10-24 | 細胞分析装置及び細胞分析方法 |
| JP2013196526A Active JP5599927B2 (ja) | 2007-10-29 | 2013-09-24 | 細胞分析装置及び細胞分析方法 |
| JP2013196525A Active JP5739959B2 (ja) | 2007-10-29 | 2013-09-24 | 細胞分析装置及び細胞分析方法 |
| JP2014164986A Active JP5859613B2 (ja) | 2007-10-29 | 2014-08-13 | 細胞分析装置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013196526A Active JP5599927B2 (ja) | 2007-10-29 | 2013-09-24 | 細胞分析装置及び細胞分析方法 |
| JP2013196525A Active JP5739959B2 (ja) | 2007-10-29 | 2013-09-24 | 細胞分析装置及び細胞分析方法 |
| JP2014164986A Active JP5859613B2 (ja) | 2007-10-29 | 2014-08-13 | 細胞分析装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9625388B2 (enExample) |
| EP (1) | EP2204643B1 (enExample) |
| JP (4) | JP5378228B2 (enExample) |
| CN (2) | CN104122191B (enExample) |
| WO (1) | WO2009057525A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104122191B (zh) * | 2007-10-29 | 2020-02-18 | 希森美康株式会社 | 细胞分析仪及细胞分析方法 |
| US20120136584A1 (en) * | 2009-08-04 | 2012-05-31 | Kazuo Ban | Detection apparatus and detection method for detecting microorganisms |
| JP2011095182A (ja) * | 2009-10-30 | 2011-05-12 | Sysmex Corp | 細胞分析装置及び細胞分析方法 |
| JP2011095181A (ja) | 2009-10-30 | 2011-05-12 | Sysmex Corp | 粒子分析装置 |
| US8767069B2 (en) * | 2010-06-30 | 2014-07-01 | Luminex Corporation | Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution |
| JP5693894B2 (ja) | 2010-08-26 | 2015-04-01 | 日本光電工業株式会社 | 細胞解析装置及び細胞解析方法 |
| CN102446353B (zh) * | 2010-09-30 | 2016-01-06 | 广州阳普医疗科技股份有限公司 | 用于血型分析的机器视觉判读方法与装置 |
| JP5937780B2 (ja) * | 2010-11-11 | 2016-06-22 | ソニー株式会社 | 蛍光スペクトル補正方法及び蛍光スペクトル測定装置 |
| US10011884B2 (en) | 2010-11-12 | 2018-07-03 | Incelldx, Inc. | Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion from a suspension sample of cervical cells |
| CN102539300B (zh) | 2010-12-31 | 2016-01-20 | 深圳迈瑞生物医疗电子股份有限公司 | 低值样本粒子测量方法及粒子分析仪 |
| CN103649717B (zh) * | 2011-06-27 | 2016-09-07 | 希森美康株式会社 | 细胞分析装置 |
| KR20160103175A (ko) * | 2011-07-19 | 2016-08-31 | 오비지오 이미징 시스템스 엔.브이. | 세포 샘플에서의 암 세포들의 검출 및/또는 분류를 위한 방법 및 시스템 |
| JP5876359B2 (ja) | 2012-03-30 | 2016-03-02 | シスメックス株式会社 | 癌化情報提供方法および癌化情報提供装置 |
| CN104297213B (zh) * | 2013-07-16 | 2017-10-03 | 成都深迈瑞医疗电子技术研究院有限公司 | 血液细胞分析仪及其异常细胞的识别方法与系统 |
| JP6227425B2 (ja) * | 2014-01-17 | 2017-11-08 | アズビル株式会社 | 複数種類の粒子の蛍光強度の比較方法及び蛍光検出装置の評価方法 |
| JP6116502B2 (ja) * | 2014-02-28 | 2017-04-19 | シスメックス株式会社 | 検体分析装置および検体分析方法 |
| JP6317976B2 (ja) * | 2014-03-31 | 2018-04-25 | シスメックス株式会社 | 尿検体分析方法及び尿検体分析装置 |
| JP6238856B2 (ja) | 2014-08-25 | 2017-11-29 | シスメックス株式会社 | 尿中異型細胞の分析方法、尿分析装置および体液中異型細胞の分析方法 |
| JP6228085B2 (ja) * | 2014-08-27 | 2017-11-08 | シスメックス株式会社 | 検体分析装置及び検体分析方法 |
| CN104483300B (zh) * | 2014-12-18 | 2017-06-13 | 苏州大学 | 一种检测循环肿瘤细胞的装置 |
| JP2015083994A (ja) * | 2015-02-03 | 2015-04-30 | 日本光電工業株式会社 | 細胞解析装置及び細胞解析方法 |
| CN106662572B (zh) | 2015-02-12 | 2019-07-05 | 深圳迈瑞生物医疗电子股份有限公司 | 细胞分析仪、粒子分类方法及装置 |
| JP6680492B2 (ja) | 2015-09-11 | 2020-04-15 | シスメックス株式会社 | 細胞分析装置および細胞分析方法 |
| JP6719773B2 (ja) * | 2015-12-25 | 2020-07-08 | 国立大学法人大阪大学 | 分類分析方法、分類分析装置および分類分析用記憶媒体 |
| CN106990232B (zh) * | 2016-01-01 | 2019-05-28 | 海南欣泰康医药科技有限公司 | 血液试剂分析系统以及分析方法 |
| JP6286455B2 (ja) * | 2016-01-20 | 2018-02-28 | シスメックス株式会社 | 細胞分析方法、癌化情報提供方法、細胞分析装置および癌化情報提供装置 |
| EP3465226B1 (en) * | 2016-06-07 | 2021-04-28 | Essen Instruments, Inc. d/b/a Essen BioScience, Inc. | Method for air bubble detection between samples using flow cytometry scatter waveform analysis |
| CN108931463B (zh) * | 2018-05-29 | 2020-12-25 | 迈克医疗电子有限公司 | 基于鞘流阻抗原理的血细胞脉冲识别方法及识别装置 |
| AU2019368519B2 (en) * | 2018-10-26 | 2022-11-03 | Shandong University | System and method for real-time screening and measurement of cellular specific photosensitive effect |
| US20200200671A1 (en) * | 2018-12-20 | 2020-06-25 | Sony Corporation | Information processing apparatus, information processing method, and program |
| WO2020133285A1 (zh) * | 2018-12-28 | 2020-07-02 | 深圳迈瑞生物医疗电子股份有限公司 | 一种血液细胞参数修正方法、血液样本检测仪和存储介质 |
| CN113544490B (zh) * | 2019-03-29 | 2024-07-02 | 贝克顿·迪金森公司 | 用于颗粒辨别的参数 |
| JP2021124397A (ja) * | 2020-02-05 | 2021-08-30 | 日本光電工業株式会社 | 粒子分析方法および粒子分析装置 |
| CN112881268B (zh) * | 2021-01-26 | 2024-05-31 | 桂林优利特医疗电子有限公司 | 一种基于流式细胞术的尿液有形成分波形信号的处理方法 |
| CN112798769B (zh) * | 2021-01-28 | 2022-02-18 | 深圳市科曼医疗设备有限公司 | 一种细胞分析仪的细胞分析方法、装置和细胞分析仪 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3826899A (en) * | 1969-08-15 | 1974-07-30 | Nuclear Res Ass Inc | Biological cell analyzing system |
| JPS5832145A (ja) | 1981-08-20 | 1983-02-25 | Kyoto Giken:Kk | 細胞診断装置 |
| JPS5981539A (ja) | 1982-10-30 | 1984-05-11 | Nippon Steel Corp | 溶融金属の直接発光分光分析装置 |
| JPS5981536A (ja) * | 1982-11-01 | 1984-05-11 | Japan Spectroscopic Co | 微小粒子分離装置 |
| JPH0619349B2 (ja) * | 1983-11-22 | 1994-03-16 | 東亜医用電子株式会社 | 体液成分分析方法およびその装置 |
| US4660971A (en) * | 1984-05-03 | 1987-04-28 | Becton, Dickinson And Company | Optical features of flow cytometry apparatus |
| US5109429A (en) | 1985-11-04 | 1992-04-28 | Cell Analysis Systems,Inc. | Apparatus and method for analyses of biological specimens |
| US4750837A (en) * | 1986-04-11 | 1988-06-14 | Sclavo Inc. | Fluorometer with reference light source |
| US5275787A (en) * | 1989-10-04 | 1994-01-04 | Canon Kabushiki Kaisha | Apparatus for separating or measuring particles to be examined in a sample fluid |
| JP2675895B2 (ja) * | 1990-04-25 | 1997-11-12 | キヤノン株式会社 | 検体処理方法及び検体測定方法及び検体測定装置 |
| US5488469A (en) * | 1991-08-30 | 1996-01-30 | Omron Corporation | Cell analyzing apparatus |
| JPH0619349A (ja) | 1992-07-03 | 1994-01-28 | Ricoh Co Ltd | 画像形成装置 |
| JP3290786B2 (ja) | 1993-11-26 | 2002-06-10 | シスメックス株式会社 | 粒子分析装置 |
| US7450229B2 (en) * | 1999-01-25 | 2008-11-11 | Amnis Corporation | Methods for analyzing inter-cellular phenomena |
| US6608682B2 (en) * | 1999-01-25 | 2003-08-19 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
| JP4554810B2 (ja) * | 2000-12-21 | 2010-09-29 | シスメックス株式会社 | 粒子分析装置および粒子分析方法 |
| US6594009B2 (en) * | 2001-02-27 | 2003-07-15 | Honeywell International Inc. | Flow cytometer and ultraviolet light disinfecting systems |
| US20030190602A1 (en) * | 2001-03-12 | 2003-10-09 | Monogen, Inc. | Cell-based detection and differentiation of disease states |
| JP4659242B2 (ja) | 2001-03-21 | 2011-03-30 | シスメックス株式会社 | 粒子分析装置 |
| EP1245944B1 (en) * | 2001-03-29 | 2007-02-14 | Sysmex Corporation | Flow cytometer |
| US20040071328A1 (en) * | 2001-09-07 | 2004-04-15 | Vaisberg Eugeni A. | Classifying cells based on information contained in cell images |
| ATE425456T1 (de) * | 2002-06-24 | 2009-03-15 | Sysmex Corp | Verfahren zur klassifizierung und zählung von leukozyten |
| JP4299597B2 (ja) * | 2002-07-29 | 2009-07-22 | シスメックス株式会社 | 血液分析装置及び方法 |
| DK2308419T3 (da) | 2003-03-28 | 2016-06-06 | Inguran Llc | Fremgangsmåde til bedømmelse af farvningstilstandene for dyresperm, som skal sorteres. |
| JP2005030831A (ja) * | 2003-07-09 | 2005-02-03 | Aisin Seiki Co Ltd | セルソータ用光照射装置 |
| JP2007533971A (ja) * | 2003-09-30 | 2007-11-22 | シンギュレックス・インコーポレイテッド | 粒子検出の分析精度を改善する方法 |
| JP2005315862A (ja) | 2004-03-30 | 2005-11-10 | Sysmex Corp | 子宮頸癌のスクリーニング方法及び子宮頸癌診断薬 |
| US20050221399A1 (en) * | 2004-03-30 | 2005-10-06 | Sysmex Corporation | Method for screening cervical cancer |
| US9243993B2 (en) * | 2005-03-17 | 2016-01-26 | Sysmex Corporation | Sample analyzer and sample analyzing method |
| US20060211009A1 (en) * | 2005-03-18 | 2006-09-21 | Sungwhan An | System for biomarker discovery |
| WO2006103920A1 (ja) | 2005-03-29 | 2006-10-05 | Sysmex Corporation | 癌・異型細胞および凝集粒子を弁別する方法および細胞分析装置 |
| ES2547643T3 (es) * | 2005-07-12 | 2015-10-07 | Sysmex Corporation | Material de referencia para un analizador de partículas |
| JP4745030B2 (ja) * | 2005-11-15 | 2011-08-10 | シスメックス株式会社 | 血液分析装置 |
| CN1970788A (zh) * | 2005-11-23 | 2007-05-30 | 郑芳 | 流式细胞仪-细胞内分子探针技术 |
| JP4417936B2 (ja) | 2006-08-01 | 2010-02-17 | シスメックス株式会社 | 尿中赤血球の鑑別装置および方法 |
| CN104122191B (zh) * | 2007-10-29 | 2020-02-18 | 希森美康株式会社 | 细胞分析仪及细胞分析方法 |
-
2008
- 2008-10-24 CN CN201410379120.7A patent/CN104122191B/zh active Active
- 2008-10-24 WO PCT/JP2008/069338 patent/WO2009057525A1/ja not_active Ceased
- 2008-10-24 CN CN200880113752.1A patent/CN101842688B/zh active Active
- 2008-10-24 JP JP2009539037A patent/JP5378228B2/ja active Active
- 2008-10-24 EP EP08844313.0A patent/EP2204643B1/en active Active
-
2010
- 2010-04-19 US US12/762,703 patent/US9625388B2/en active Active
-
2013
- 2013-09-24 JP JP2013196526A patent/JP5599927B2/ja active Active
- 2013-09-24 JP JP2013196525A patent/JP5739959B2/ja active Active
-
2014
- 2014-01-27 US US14/164,773 patent/US9733186B2/en active Active
- 2014-08-13 JP JP2014164986A patent/JP5859613B2/ja active Active
-
2017
- 2017-07-14 US US15/650,105 patent/US20170322159A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5599927B2 (ja) | 2014-10-01 |
| JP2014002170A (ja) | 2014-01-09 |
| EP2204643B1 (en) | 2019-08-21 |
| EP2204643A1 (en) | 2010-07-07 |
| US20100196917A1 (en) | 2010-08-05 |
| CN101842688A (zh) | 2010-09-22 |
| US9625388B2 (en) | 2017-04-18 |
| JP2014211453A (ja) | 2014-11-13 |
| CN104122191B (zh) | 2020-02-18 |
| WO2009057525A1 (ja) | 2009-05-07 |
| EP2204643A4 (en) | 2017-08-02 |
| CN101842688B (zh) | 2017-02-08 |
| JP5739959B2 (ja) | 2015-06-24 |
| US20170322159A1 (en) | 2017-11-09 |
| US20140154677A1 (en) | 2014-06-05 |
| JP5859613B2 (ja) | 2016-02-10 |
| CN104122191A (zh) | 2014-10-29 |
| JPWO2009057525A1 (ja) | 2011-03-10 |
| JP2014029342A (ja) | 2014-02-13 |
| US9733186B2 (en) | 2017-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5378228B2 (ja) | 細胞分析装置及び細胞分析方法 | |
| JP5259305B2 (ja) | 細胞分析装置及び細胞分析方法 | |
| JP5537347B2 (ja) | 粒子分析装置 | |
| US7800742B2 (en) | Cell analyzer and cell analyzing method | |
| JP6100658B2 (ja) | 血球分析装置および血球分析方法 | |
| US20110104744A1 (en) | Cell analyzing apparatus and cell analyzing method | |
| JP2010085194A (ja) | 試料分析装置 | |
| JP6076801B2 (ja) | 血球分析装置および血球分析方法 | |
| US10208352B2 (en) | Providing cervical or oral mucosa canceration information from measurement of cells located toward the basal membrane side of epithelial tissue | |
| JP2011069696A (ja) | 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム | |
| US9354161B2 (en) | Sample analyzing method and sample analyzer | |
| EP2843409B1 (en) | Urine sample analyzing method and sample analyzer | |
| US9719123B2 (en) | Urine sample analyzer and urine sample analyzing method | |
| EP2889379A1 (en) | Method of detecting filarial larvae in blood, and blood analyzer | |
| JP5258350B2 (ja) | 試料分析装置及び試料分析方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111004 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20111004 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20121002 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121121 |
|
| TRDD | Decision of grant or rejection written | ||
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20130820 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130827 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130925 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5378228 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |