CN104122191B - 细胞分析仪及细胞分析方法 - Google Patents

细胞分析仪及细胞分析方法 Download PDF

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CN104122191B
CN104122191B CN201410379120.7A CN201410379120A CN104122191B CN 104122191 B CN104122191 B CN 104122191B CN 201410379120 A CN201410379120 A CN 201410379120A CN 104122191 B CN104122191 B CN 104122191B
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cell
cells
value
agglutinated
measurement sample
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CN104122191A (zh
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石坂正树
岸和希
福田正和
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Sysmex Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201410379120.7A 2007-10-29 2008-10-24 细胞分析仪及细胞分析方法 Active CN104122191B (zh)

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JP2007280738 2007-10-29
JP2007-280738 2007-10-29
CN200880113752.1A CN101842688B (zh) 2007-10-29 2008-10-24 细胞分析仪及细胞分析方法

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EP (1) EP2204643B1 (enExample)
JP (4) JP5378228B2 (enExample)
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WO (1) WO2009057525A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104122191B (zh) * 2007-10-29 2020-02-18 希森美康株式会社 细胞分析仪及细胞分析方法
US20120136584A1 (en) * 2009-08-04 2012-05-31 Kazuo Ban Detection apparatus and detection method for detecting microorganisms
JP2011095182A (ja) * 2009-10-30 2011-05-12 Sysmex Corp 細胞分析装置及び細胞分析方法
JP2011095181A (ja) 2009-10-30 2011-05-12 Sysmex Corp 粒子分析装置
US8767069B2 (en) * 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
JP5693894B2 (ja) 2010-08-26 2015-04-01 日本光電工業株式会社 細胞解析装置及び細胞解析方法
CN102446353B (zh) * 2010-09-30 2016-01-06 广州阳普医疗科技股份有限公司 用于血型分析的机器视觉判读方法与装置
JP5937780B2 (ja) * 2010-11-11 2016-06-22 ソニー株式会社 蛍光スペクトル補正方法及び蛍光スペクトル測定装置
US10011884B2 (en) 2010-11-12 2018-07-03 Incelldx, Inc. Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion from a suspension sample of cervical cells
CN102539300B (zh) 2010-12-31 2016-01-20 深圳迈瑞生物医疗电子股份有限公司 低值样本粒子测量方法及粒子分析仪
CN103649717B (zh) * 2011-06-27 2016-09-07 希森美康株式会社 细胞分析装置
KR20160103175A (ko) * 2011-07-19 2016-08-31 오비지오 이미징 시스템스 엔.브이. 세포 샘플에서의 암 세포들의 검출 및/또는 분류를 위한 방법 및 시스템
JP5876359B2 (ja) 2012-03-30 2016-03-02 シスメックス株式会社 癌化情報提供方法および癌化情報提供装置
CN104297213B (zh) * 2013-07-16 2017-10-03 成都深迈瑞医疗电子技术研究院有限公司 血液细胞分析仪及其异常细胞的识别方法与系统
JP6227425B2 (ja) * 2014-01-17 2017-11-08 アズビル株式会社 複数種類の粒子の蛍光強度の比較方法及び蛍光検出装置の評価方法
JP6116502B2 (ja) * 2014-02-28 2017-04-19 シスメックス株式会社 検体分析装置および検体分析方法
JP6317976B2 (ja) * 2014-03-31 2018-04-25 シスメックス株式会社 尿検体分析方法及び尿検体分析装置
JP6238856B2 (ja) 2014-08-25 2017-11-29 シスメックス株式会社 尿中異型細胞の分析方法、尿分析装置および体液中異型細胞の分析方法
JP6228085B2 (ja) * 2014-08-27 2017-11-08 シスメックス株式会社 検体分析装置及び検体分析方法
CN104483300B (zh) * 2014-12-18 2017-06-13 苏州大学 一种检测循环肿瘤细胞的装置
JP2015083994A (ja) * 2015-02-03 2015-04-30 日本光電工業株式会社 細胞解析装置及び細胞解析方法
CN106662572B (zh) 2015-02-12 2019-07-05 深圳迈瑞生物医疗电子股份有限公司 细胞分析仪、粒子分类方法及装置
JP6680492B2 (ja) 2015-09-11 2020-04-15 シスメックス株式会社 細胞分析装置および細胞分析方法
JP6719773B2 (ja) * 2015-12-25 2020-07-08 国立大学法人大阪大学 分類分析方法、分類分析装置および分類分析用記憶媒体
CN106990232B (zh) * 2016-01-01 2019-05-28 海南欣泰康医药科技有限公司 血液试剂分析系统以及分析方法
JP6286455B2 (ja) * 2016-01-20 2018-02-28 シスメックス株式会社 細胞分析方法、癌化情報提供方法、細胞分析装置および癌化情報提供装置
EP3465226B1 (en) * 2016-06-07 2021-04-28 Essen Instruments, Inc. d/b/a Essen BioScience, Inc. Method for air bubble detection between samples using flow cytometry scatter waveform analysis
CN108931463B (zh) * 2018-05-29 2020-12-25 迈克医疗电子有限公司 基于鞘流阻抗原理的血细胞脉冲识别方法及识别装置
AU2019368519B2 (en) * 2018-10-26 2022-11-03 Shandong University System and method for real-time screening and measurement of cellular specific photosensitive effect
US20200200671A1 (en) * 2018-12-20 2020-06-25 Sony Corporation Information processing apparatus, information processing method, and program
WO2020133285A1 (zh) * 2018-12-28 2020-07-02 深圳迈瑞生物医疗电子股份有限公司 一种血液细胞参数修正方法、血液样本检测仪和存储介质
CN113544490B (zh) * 2019-03-29 2024-07-02 贝克顿·迪金森公司 用于颗粒辨别的参数
JP2021124397A (ja) * 2020-02-05 2021-08-30 日本光電工業株式会社 粒子分析方法および粒子分析装置
CN112881268B (zh) * 2021-01-26 2024-05-31 桂林优利特医疗电子有限公司 一种基于流式细胞术的尿液有形成分波形信号的处理方法
CN112798769B (zh) * 2021-01-28 2022-02-18 深圳市科曼医疗设备有限公司 一种细胞分析仪的细胞分析方法、装置和细胞分析仪

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4750837A (en) * 1986-04-11 1988-06-14 Sclavo Inc. Fluorometer with reference light source
EP1496349A1 (en) * 2003-07-09 2005-01-12 Aisin Seiki Kabushiki Kaisha Light irradiating apparatus for cell sorter
CN1880942A (zh) * 2005-07-12 2006-12-20 希森美康株式会社 粒子分析仪用参照物
CN1970788A (zh) * 2005-11-23 2007-05-30 郑芳 流式细胞仪－细胞内分子探针技术

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826899A (en) * 1969-08-15 1974-07-30 Nuclear Res Ass Inc Biological cell analyzing system
JPS5832145A (ja) 1981-08-20 1983-02-25 Kyoto Giken:Kk 細胞診断装置
JPS5981539A (ja) 1982-10-30 1984-05-11 Nippon Steel Corp 溶融金属の直接発光分光分析装置
JPS5981536A (ja) * 1982-11-01 1984-05-11 Japan Spectroscopic Co 微小粒子分離装置
JPH0619349B2 (ja) * 1983-11-22 1994-03-16 東亜医用電子株式会社 体液成分分析方法およびその装置
US4660971A (en) * 1984-05-03 1987-04-28 Becton, Dickinson And Company Optical features of flow cytometry apparatus
US5109429A (en) 1985-11-04 1992-04-28 Cell Analysis Systems,Inc. Apparatus and method for analyses of biological specimens
US5275787A (en) * 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
JP2675895B2 (ja) * 1990-04-25 1997-11-12 キヤノン株式会社 検体処理方法及び検体測定方法及び検体測定装置
US5488469A (en) * 1991-08-30 1996-01-30 Omron Corporation Cell analyzing apparatus
JPH0619349A (ja) 1992-07-03 1994-01-28 Ricoh Co Ltd 画像形成装置
JP3290786B2 (ja) 1993-11-26 2002-06-10 シスメックス株式会社 粒子分析装置
US7450229B2 (en) * 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US6608682B2 (en) * 1999-01-25 2003-08-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
JP4554810B2 (ja) * 2000-12-21 2010-09-29 シスメックス株式会社 粒子分析装置および粒子分析方法
US6594009B2 (en) * 2001-02-27 2003-07-15 Honeywell International Inc. Flow cytometer and ultraviolet light disinfecting systems
US20030190602A1 (en) * 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
JP4659242B2 (ja) 2001-03-21 2011-03-30 シスメックス株式会社 粒子分析装置
EP1245944B1 (en) * 2001-03-29 2007-02-14 Sysmex Corporation Flow cytometer
US20040071328A1 (en) * 2001-09-07 2004-04-15 Vaisberg Eugeni A. Classifying cells based on information contained in cell images
ATE425456T1 (de) * 2002-06-24 2009-03-15 Sysmex Corp Verfahren zur klassifizierung und zählung von leukozyten
JP4299597B2 (ja) * 2002-07-29 2009-07-22 シスメックス株式会社 血液分析装置及び方法
DK2308419T3 (da) 2003-03-28 2016-06-06 Inguran Llc Fremgangsmåde til bedømmelse af farvningstilstandene for dyresperm, som skal sorteres.
JP2007533971A (ja) * 2003-09-30 2007-11-22 シンギュレックス・インコーポレイテッド 粒子検出の分析精度を改善する方法
JP2005315862A (ja) 2004-03-30 2005-11-10 Sysmex Corp 子宮頸癌のスクリーニング方法及び子宮頸癌診断薬
US20050221399A1 (en) * 2004-03-30 2005-10-06 Sysmex Corporation Method for screening cervical cancer
US9243993B2 (en) * 2005-03-17 2016-01-26 Sysmex Corporation Sample analyzer and sample analyzing method
US20060211009A1 (en) * 2005-03-18 2006-09-21 Sungwhan An System for biomarker discovery
WO2006103920A1 (ja) 2005-03-29 2006-10-05 Sysmex Corporation 癌・異型細胞および凝集粒子を弁別する方法および細胞分析装置
JP4745030B2 (ja) * 2005-11-15 2011-08-10 シスメックス株式会社 血液分析装置
JP4417936B2 (ja) 2006-08-01 2010-02-17 シスメックス株式会社 尿中赤血球の鑑別装置および方法
CN104122191B (zh) * 2007-10-29 2020-02-18 希森美康株式会社 细胞分析仪及细胞分析方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4750837A (en) * 1986-04-11 1988-06-14 Sclavo Inc. Fluorometer with reference light source
EP1496349A1 (en) * 2003-07-09 2005-01-12 Aisin Seiki Kabushiki Kaisha Light irradiating apparatus for cell sorter
CN1880942A (zh) * 2005-07-12 2006-12-20 希森美康株式会社 粒子分析仪用参照物
CN1970788A (zh) * 2005-11-23 2007-05-30 郑芳 流式细胞仪－细胞内分子探针技术

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Publication number Publication date
JP5599927B2 (ja) 2014-10-01
JP2014002170A (ja) 2014-01-09
EP2204643B1 (en) 2019-08-21
EP2204643A1 (en) 2010-07-07
US20100196917A1 (en) 2010-08-05
CN101842688A (zh) 2010-09-22
US9625388B2 (en) 2017-04-18
JP5378228B2 (ja) 2013-12-25
JP2014211453A (ja) 2014-11-13
WO2009057525A1 (ja) 2009-05-07
EP2204643A4 (en) 2017-08-02
CN101842688B (zh) 2017-02-08
JP5739959B2 (ja) 2015-06-24
US20170322159A1 (en) 2017-11-09
US20140154677A1 (en) 2014-06-05
JP5859613B2 (ja) 2016-02-10
CN104122191A (zh) 2014-10-29
JPWO2009057525A1 (ja) 2011-03-10
JP2014029342A (ja) 2014-02-13
US9733186B2 (en) 2017-08-15

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