JP5360751B2 - 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 - Google Patents

非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 Download PDF

Info

Publication number
JP5360751B2
JP5360751B2 JP2008556118A JP2008556118A JP5360751B2 JP 5360751 B2 JP5360751 B2 JP 5360751B2 JP 2008556118 A JP2008556118 A JP 2008556118A JP 2008556118 A JP2008556118 A JP 2008556118A JP 5360751 B2 JP5360751 B2 JP 5360751B2
Authority
JP
Japan
Prior art keywords
salt
lidocaine
eperisone
tolperisone
ionic liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008556118A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2008093686A1 (ja
Inventor
範隆 半間
泰司 三輪
英利 ▲浜▼本
Original Assignee
株式会社 メドレックス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社 メドレックス filed Critical 株式会社 メドレックス
Priority to JP2008556118A priority Critical patent/JP5360751B2/ja
Publication of JPWO2008093686A1 publication Critical patent/JPWO2008093686A1/ja
Application granted granted Critical
Publication of JP5360751B2 publication Critical patent/JP5360751B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/09—Diamines
    • C07C211/11—Diaminopropanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C07C217/10—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008556118A 2007-01-29 2008-01-29 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 Expired - Fee Related JP5360751B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008556118A JP5360751B2 (ja) 2007-01-29 2008-01-29 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP2007018005 2007-01-29
JP2007018005 2007-01-29
JP2007031188 2007-02-09
JP2007031188 2007-02-09
JP2007069620 2007-03-16
JP2007069620 2007-03-16
JP2008556118A JP5360751B2 (ja) 2007-01-29 2008-01-29 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
PCT/JP2008/051326 WO2008093686A1 (ja) 2007-01-29 2008-01-29 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013144711A Division JP2013199502A (ja) 2007-01-29 2013-07-10 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途

Publications (2)

Publication Number Publication Date
JPWO2008093686A1 JPWO2008093686A1 (ja) 2010-05-20
JP5360751B2 true JP5360751B2 (ja) 2013-12-04

Family

ID=39673995

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008556118A Expired - Fee Related JP5360751B2 (ja) 2007-01-29 2008-01-29 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
JP2013144711A Pending JP2013199502A (ja) 2007-01-29 2013-07-10 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013144711A Pending JP2013199502A (ja) 2007-01-29 2013-07-10 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途

Country Status (4)

Country Link
US (1) US20100029704A1 (https=)
EP (1) EP2128123A4 (https=)
JP (2) JP5360751B2 (https=)
WO (1) WO2008093686A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2867194C (en) 2005-10-07 2016-10-04 The University Of Alabama Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
US8920843B2 (en) 2007-11-07 2014-12-30 Svip5 Llc Slow release of organic salts of local anesthetics for pain relief
EP2311498A4 (en) * 2008-08-05 2013-07-24 Medrx Co Ltd EXTERNAL PREPARATION COMPRISING A FATTY ACID SALT OR A BENZOIC ACID SALT OF A PHARMACOLOGICALLY ACTIVE BASIC COMPONENT, AND PROCESS FOR PRODUCTION THEREOF
RU2397975C1 (ru) * 2008-11-27 2010-08-27 Андрей Александрович Иващенко Замещенные 2-(5-гидрокси-2-метил-1н-индол-3-ил)уксусные кислоты и их эфиры, противовирусное активное начало, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
WO2010103845A1 (ja) * 2009-03-11 2010-09-16 興和株式会社 鎮痛・抗炎症剤含有外用剤
JPWO2010103844A1 (ja) * 2009-03-11 2012-09-13 興和株式会社 鎮痛・抗炎症剤含有外用剤
JP2012158521A (ja) * 2009-04-17 2012-08-23 Kureha Corp 外用剤
EP2463263B1 (en) * 2009-08-03 2014-04-23 Riken Isotope labeled 2-arylpropionic acid compounds and process for production of same, and molecular probe for positron emission tomography and method for imaging of cyclooxygenase and the like using same
JP5897804B2 (ja) * 2010-02-26 2016-03-30 興和株式会社 ロキソプロフェン含有の医薬組成物
JP5622410B2 (ja) * 2010-03-12 2014-11-12 帝國製薬株式会社 ケトプロフェン含有水性貼付剤
EP2593096A4 (en) * 2010-07-12 2014-02-26 Yung Shin Pharm Ind Co Ltd DICLOFENAC SALT OF TRAMADOL
ES3034911T3 (en) 2011-05-10 2025-08-26 Itochu Chemical Frontier Corp Non-aqueous patch
BR112013028802B1 (pt) 2011-05-10 2021-10-26 Itochu Chemical Frontier Corporation Curativo adesivo não-aquoso
US11786455B2 (en) 2011-05-10 2023-10-17 Itochu Chemical Frontier Corporation Non-aqueous patch
WO2012172413A1 (en) 2011-06-16 2012-12-20 Abbott Healthcare Pvt. Ltd. Pharmaceutical composition comprising a combination of eperisone and diclofenac and process for preparing thereof
LT2823815T (lt) 2011-09-27 2018-08-27 Itochu Chemical Frontier Corporation Nevandeninis pleistras
CN102526001B (zh) * 2011-12-30 2013-09-25 沈阳药科大学 吲哚美辛盐透皮贴剂及其制备方法
CN102940618A (zh) * 2012-11-29 2013-02-27 沈阳药科大学 洛索洛芬有机胺盐透皮贴剂及其制备方法
EP3395763B1 (en) * 2013-04-30 2020-06-17 Merck Patent GmbH Uses of alumina flakes
WO2015013772A1 (en) * 2013-08-01 2015-02-05 Monash University Compositions and preparation methods of low melting ionic salts of poorly- water soluble drugs
EP3251697A4 (en) * 2015-01-27 2018-08-22 Ajinomoto Co., Inc. Method for controlling skin penetration
ES2863500T3 (es) 2015-04-10 2021-10-11 Capsugel Belgium Nv Formulaciones lipídicas de acetato de abiraterona
CN107613961B (zh) * 2015-05-19 2021-07-13 美德阿利克斯株式会社 经皮吸收型液体制剂
US10064795B2 (en) * 2015-05-22 2018-09-04 Grip Tight Sport Llc Atomizing spray for grip enhancement
WO2017027474A1 (en) * 2015-08-10 2017-02-16 The Trustees Of Princetion University Nano-encapsulation using gras materials and applications thereof
WO2017111167A1 (ja) * 2015-12-25 2017-06-29 興和株式会社 ロキソプロフェンを含有する医薬製剤
WO2020086046A2 (en) * 2018-10-26 2020-04-30 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Topical compositions comprising tolperisone and flurbiprofen combination
CN111494308A (zh) * 2019-01-30 2020-08-07 北京蓝丹医药科技有限公司 一种稳定的氟比洛芬注射液
AU2020362643B2 (en) * 2019-10-11 2024-12-12 Toray Industries, Inc. Pharmaceutical composition containing temperature-responsive ionic liquid
CN112755196B (zh) * 2019-11-01 2024-02-27 华东理工大学 多奈哌齐离子液体
CN110907583B (zh) * 2019-11-13 2021-03-02 湖南九典制药股份有限公司 一种洛索洛芬或其钠盐中有关物质的分离方法
CN111807985A (zh) * 2020-06-17 2020-10-23 西安医学院 一种利多卡因非甾体抗炎药离子液体及其制备方法
JP7525095B2 (ja) * 2020-08-14 2024-07-30 森田薬品工業株式会社 ｐ－ボロノフェニルアラニンを構成成分とするイオン液体
CN112079842A (zh) * 2020-09-18 2020-12-15 哈尔滨工业大学（深圳） 一种依托度酸离子盐及其制备方法与应用
EP4292583A4 (en) * 2021-02-12 2024-12-18 MEDRx Co., Ltd. COMPOSITION WITH IMPROVED ABSORBABILITY OF A POORLY ABSORBABLE MEDICINAL PRODUCT
CN116350577B (zh) * 2023-03-29 2024-09-20 西安医学院 一种非甾体抗炎药离子液体凝胶的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002128699A (ja) * 2000-10-26 2002-05-09 Sankyo Co Ltd 消炎鎮痛外用剤組成物
JP2004514692A (ja) * 2000-11-28 2004-05-20 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング トラマドールとジクロフェナクの塩の懸濁液を含有する非経口投与可能な剤形
JP2005082512A (ja) * 2003-09-05 2005-03-31 Medorekkusu:Kk イオン性の薬物の経皮吸収性を高めた外用剤
JP2005239709A (ja) * 2004-01-29 2005-09-08 Medorekkusu:Kk 消炎鎮痛外用剤

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2104684A1 (en) * 1991-03-04 1992-09-05 Mahdi B. Fawzi Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
CA2200068C (en) 1994-09-16 2005-01-11 Munehiko Hirano A preparation for external use and a patch having the preparation attached thereto
US6191285B1 (en) * 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
EP1043031A4 (en) * 1997-12-26 2007-05-02 Astellas Pharma Inc MEDICINAL COMPOSITIONS WITH PROLONGED RELEASE
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
DE10100455A1 (de) * 2001-01-08 2002-07-11 Creavis Tech & Innovation Gmbh Neuartige Polymerbindersysteme mit ionischen Flüssigkeiten
ATE348712T1 (de) 2001-03-16 2007-01-15 Datalase Ltd Laser markierbare zusammensetzungen und verfahren zur erzeugung eines bildes durch laser
US7166641B2 (en) 2002-10-02 2007-01-23 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same
US20080026077A1 (en) * 2002-11-12 2008-01-31 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
JP2007018005A (ja) 2003-02-17 2007-01-25 Matsushita Electric Ind Co Ltd フォトマスク
JP2005068035A (ja) * 2003-08-20 2005-03-17 Medorekkusu:Kk 慢性疼痛治療用外用剤
JP2005145930A (ja) * 2003-11-19 2005-06-09 Medorekkusu:Kk 非ステロイド系消炎鎮痛剤を含む消炎鎮痛外用剤および組成物の製造方法
JP2005145932A (ja) * 2003-11-19 2005-06-09 Medorekkusu:Kk 消炎鎮痛外用剤
KR20060124724A (ko) * 2004-01-26 2006-12-05 유니버시티 오브 사우스 앨라배마 음이온성―스위트너를 기반으로 하는 이온성 액체 및그것의 사용 방법
ATE534405T1 (de) * 2004-01-29 2011-12-15 Medrx Co Ltd Entzündungshemmendes analgetikum für die äussere anwendung
JP4584620B2 (ja) 2004-04-30 2010-11-24 久光製薬株式会社 消炎鎮痛外用剤
US7592371B2 (en) * 2004-08-18 2009-09-22 Medrx Co., Ltd. External preparation
WO2006018987A1 (ja) 2004-08-18 2006-02-23 Konica Minolta Medical & Graphic, Inc. 画像記録方法及び画像記録装置
US20060210613A1 (en) * 2005-03-15 2006-09-21 Carliss Richard D Therapeutic wound care product
JP4823596B2 (ja) 2005-07-25 2011-11-24 住友大阪セメント株式会社 セメント焼成設備における排ガスの処理方法及び処理装置
CA2867194C (en) * 2005-10-07 2016-10-04 The University Of Alabama Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002128699A (ja) * 2000-10-26 2002-05-09 Sankyo Co Ltd 消炎鎮痛外用剤組成物
JP2004514692A (ja) * 2000-11-28 2004-05-20 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング トラマドールとジクロフェナクの塩の懸濁液を含有する非経口投与可能な剤形
JP2005082512A (ja) * 2003-09-05 2005-03-31 Medorekkusu:Kk イオン性の薬物の経皮吸収性を高めた外用剤
JP2005239709A (ja) * 2004-01-29 2005-09-08 Medorekkusu:Kk 消炎鎮痛外用剤

Also Published As

Publication number Publication date
EP2128123A4 (en) 2011-04-20
JPWO2008093686A1 (ja) 2010-05-20
US20100029704A1 (en) 2010-02-04
WO2008093686A1 (ja) 2008-08-07
EP2128123A1 (en) 2009-12-02
JP2013199502A (ja) 2013-10-03

Similar Documents

Publication Publication Date Title
JP5360751B2 (ja) 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
KR101514342B1 (ko) 지방산계 이온 액체를 유효성분으로 하는 외용제 조성물
WO2010146872A1 (ja) アリピプラゾールと有機酸を有効成分とする外用剤組成物
JP5144658B2 (ja) イブプロフェンの正荷電水溶性プロドラッグ
WO2010016219A1 (ja) 塩基性薬効成分の脂肪酸塩、安息香酸塩を含有する外用剤とその製造方法
BG61676B1 (bg) Фармацевтичен състав, съдържащ сол на ибупрофена
JP2002538142A (ja) 抗炎症、鎮痛性および抗血栓症活性を有するニトロキシ誘導体
JP4684404B2 (ja) 消炎鎮痛外用剤組成物
WO1996004902A1 (en) Composition of external preparation
JP7049258B2 (ja) 水性貼付剤
WO2013035850A1 (ja) 経皮吸収製剤
JP4620168B2 (ja) イオン液体化したエトドラクのテープ剤
US20110184066A1 (en) Ketoprofen Lysine Salt-Containing Aqueous Patch
JP5280472B2 (ja) 外用消炎鎮痛剤組成物
JPWO2007046544A1 (ja) カルボキシル基を有する肥満細胞脱顆粒抑制剤と有機アミンとの塩を含有する外用剤
JP2011037903A (ja) 外用消炎鎮痛剤組成物
CN114502142B (zh) 包含温度响应性离子液体的医药组合物
JP6131523B2 (ja) ロキソプロフェン含有外用剤
WO2003099293A1 (en) Pharmacologically active salts
EP1140197B1 (en) Soluble compositions of toremifene
ES2403130B1 (es) Forma polimórfica de clorhidrato de fexofenadina, compuestos intermedios y procedimiento para su preparación
JP5832856B2 (ja) 局所鎮痛作用増強剤及び局所鎮痛キット
JP2005145930A (ja) 非ステロイド系消炎鎮痛剤を含む消炎鎮痛外用剤および組成物の製造方法
JPH07252213A (ja) 吸収性良好なトシル酸スプラタストおよびその製造方法
JP2024163412A (ja) 含窒素化合物用の可溶化剤

Legal Events

Date Code Title Description
RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20100219

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100728

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20110525

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110525

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130115

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130604

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130710

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130806

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130827

R150 Certificate of patent or registration of utility model

Ref document number: 5360751

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R314531

S804 Written request for registration of cancellation of exclusive licence

Free format text: JAPANESE INTERMEDIATE CODE: R314803

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

LAPS Cancellation because of no payment of annual fees