JP5349335B2 - 高い安定性を有する組換えxrgd富化ゼラチン - Google Patents

高い安定性を有する組換えxrgd富化ゼラチン Download PDF

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Publication number
JP5349335B2
JP5349335B2 JP2009550598A JP2009550598A JP5349335B2 JP 5349335 B2 JP5349335 B2 JP 5349335B2 JP 2009550598 A JP2009550598 A JP 2009550598A JP 2009550598 A JP2009550598 A JP 2009550598A JP 5349335 B2 JP5349335 B2 JP 5349335B2
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gelatin
xrgd
recombinant
polypeptide
recombinant gelatin
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Japanese (ja)
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JP2010518833A5 (enExample
JP2010518833A (ja
Inventor
デ・ボーア,アルジョ・リサンダー
ヴァン・ユルク,ヘンドリク
ヴァン・アステン,ペーター・フランシスクス・テレシウス
ボウストラ,ジャン・バスティアン
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Fujifilm Manufacturing Europe BV
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Fujifilm Manufacturing Europe BV
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Priority claimed from EP07102838A external-priority patent/EP1961411A1/en
Priority claimed from EP07102839A external-priority patent/EP1961414A1/en
Application filed by Fujifilm Manufacturing Europe BV filed Critical Fujifilm Manufacturing Europe BV
Publication of JP2010518833A publication Critical patent/JP2010518833A/ja
Publication of JP2010518833A5 publication Critical patent/JP2010518833A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009550598A 2007-02-21 2008-02-21 高い安定性を有する組換えxrgd富化ゼラチン Active JP5349335B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP07102838A EP1961411A1 (en) 2007-02-21 2007-02-21 A controlled release composition
EP07102838.5 2007-02-21
EP07102839.3 2007-02-21
EP07102839A EP1961414A1 (en) 2007-02-21 2007-02-21 A controlled release composition comprising a recombinant gelatin
EP07116193.9 2007-09-12
EP07116189 2007-09-12
EP07116189.7 2007-09-12
EP07116193 2007-09-12
EP08100556 2008-01-16
EP08100556.3 2008-01-16
PCT/NL2008/050100 WO2008103042A1 (en) 2007-02-21 2008-02-21 Recombinant xrgd-enriched gelatins having high stability

Publications (3)

Publication Number Publication Date
JP2010518833A JP2010518833A (ja) 2010-06-03
JP2010518833A5 JP2010518833A5 (enExample) 2011-02-03
JP5349335B2 true JP5349335B2 (ja) 2013-11-20

Family

ID=39503383

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009550598A Active JP5349335B2 (ja) 2007-02-21 2008-02-21 高い安定性を有する組換えxrgd富化ゼラチン
JP2009550599A Active JP5349336B2 (ja) 2007-02-21 2008-02-21 Rgdを含有する組換えゼラチン
JP2009550817A Active JP5548984B2 (ja) 2007-02-21 2008-02-21 機能性が増大した非天然の組換えゼラチン
JP2009550597A Active JP5548983B2 (ja) 2007-02-21 2008-02-21 組換えゼラチン

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2009550599A Active JP5349336B2 (ja) 2007-02-21 2008-02-21 Rgdを含有する組換えゼラチン
JP2009550817A Active JP5548984B2 (ja) 2007-02-21 2008-02-21 機能性が増大した非天然の組換えゼラチン
JP2009550597A Active JP5548983B2 (ja) 2007-02-21 2008-02-21 組換えゼラチン

Country Status (5)

Country Link
US (5) US8158756B2 (enExample)
EP (4) EP2112998B1 (enExample)
JP (4) JP5349335B2 (enExample)
AT (2) ATE554103T1 (enExample)
WO (4) WO2008103043A1 (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008103043A1 (en) * 2007-02-21 2008-08-28 Fujifilm Manufacturing Europe B.V. Rgd containing recombinant gelatin
JP2011507507A (ja) * 2007-12-21 2011-03-10 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ マルチマー性前駆体のinvivoタンパク質分解的プロセシングによる関心対象のタンパク質の分泌収量の改善
JP2011518782A (ja) * 2008-04-10 2011-06-30 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ ヘパリン結合部位および/またはヘパラン硫酸結合部位を富化した組換えタンパク質
WO2010001149A2 (en) * 2008-07-04 2010-01-07 Fujifilm Manufacturing Europe Bv Coating method for medical devices
WO2010038059A2 (en) * 2008-10-02 2010-04-08 Fujifilm Manufacturing Europe Bv Antimicrobial coating
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
WO2010128672A1 (ja) 2009-05-07 2010-11-11 富士フイルム株式会社 遺伝子組み換えゼラチンを含む血管新生誘導剤
WO2010143708A1 (ja) * 2009-06-12 2010-12-16 富士フイルム株式会社 新生血管に対する標的化剤
WO2010147109A1 (ja) * 2009-06-15 2010-12-23 富士フイルム株式会社 遺伝子組み換えゼラチン及び塩基性線維芽細胞増殖因子を含む血管新生誘導剤
EP2460541B1 (en) * 2009-07-30 2018-01-17 FUJIFILM Corporation Kidney-imaging agent comprising recombinant gelatin
WO2011013791A1 (ja) 2009-07-30 2011-02-03 富士フイルム株式会社 遺伝子組み換えゼラチンを含む腎臓標的ドラッグデリバリー剤
US8987204B2 (en) 2009-09-04 2015-03-24 Fujifilm Coporation Bone regeneration agent comprising gelatin
WO2011060583A1 (zh) * 2009-11-19 2011-05-26 浙江大学 非天然的胶原样蛋白及其应用
GB0921460D0 (en) * 2009-12-08 2010-01-20 Fujifilm Mfg Europe Bv Anti-fibrotic hydrogel compositions
EP2522366B1 (en) * 2010-01-08 2018-10-31 FUJIFILM Corporation Targeting agent for tumor site
KR101744040B1 (ko) * 2010-03-01 2017-06-07 후지필름 가부시키가이샤 생체 친화성을 갖는 고분자 블록과 세포로 이루어지는 세포 구조체
US9101686B2 (en) 2010-03-02 2015-08-11 Fujifilm Corporation Cell support and bone regeneration material
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
GB201014388D0 (en) 2010-08-31 2010-10-13 Fujifilm Mfg Europe Bv Biocompatible compositions for tissue augmentation
GB201018044D0 (en) 2010-10-26 2010-12-08 Fujifilm Mfg Europe Bv Non-natural gelatin-like proteins with enhanced functionality
JP5847418B2 (ja) * 2011-03-30 2016-01-20 富士フイルム株式会社 細胞接着性タンパク質
US20120263681A1 (en) * 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
JP2012244909A (ja) * 2011-05-25 2012-12-13 Nagoya City Univ 組み換え蛋白質の製造方法及び蛋白質の導入方法
JP5990298B2 (ja) * 2011-08-31 2016-09-14 富士フイルム株式会社 細胞移植用細胞構造体および細胞移植用細胞集合体
JP5876787B2 (ja) * 2011-08-31 2016-03-02 富士フイルム株式会社 細胞移植用細胞構造体および細胞移植用細胞集合体
JP5808631B2 (ja) * 2011-09-29 2015-11-10 富士フイルム株式会社 血管新生用足場、及び再生医療用の血管の製造方法
GB201119182D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
GB201119173D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
WO2013137268A1 (ja) 2012-03-12 2013-09-19 富士フイルム株式会社 組織修復材の製造方法
WO2014050908A1 (ja) 2012-09-26 2014-04-03 富士フイルム株式会社 ポリペプチド、足場組成物、軟骨組織修復用組成物、軟骨細胞培養用組成物及びグリコサミノグリカン産生促進用組成物
WO2014115732A1 (ja) * 2013-01-25 2014-07-31 富士フイルム株式会社 移植用人工真皮およびその製造方法
CN107033383B (zh) 2013-02-27 2020-07-24 富士胶片株式会社 制造生物亲和性高分子的多孔体的方法
JP5981025B2 (ja) 2013-03-12 2016-08-31 富士フイルム株式会社 組織修復材
GB201304947D0 (en) * 2013-03-18 2013-05-01 Cass Anthony E G Biomimetic collagen
JP6145511B2 (ja) 2013-09-25 2017-06-14 富士フイルム株式会社 生体親和性高分子多孔質体の製造方法、生体親和性高分子多孔質体、生体親和性高分子ブロック並びに細胞構造体
WO2015194494A1 (ja) 2014-06-16 2015-12-23 富士フイルム株式会社 脳損傷治療用細胞構造体、その製造方法、及び脳損傷治療剤
US10851152B2 (en) 2015-06-25 2020-12-01 Kola-Gen Pharma, Inc. Polymerized peptide and gel having collagen-like structure
WO2017043489A1 (ja) 2015-09-11 2017-03-16 富士フイルム株式会社 ゼラチン構造体製造方法、及びゼラチン構造体製造システム
EP3397753B1 (en) 2015-12-30 2021-10-27 FUJIFILM Cellular Dynamics, Inc. Microtissue formation using stem cell-derived human hepatocytes
JP6820912B2 (ja) * 2016-03-28 2021-01-27 富士フイルム株式会社 製剤、製剤用部材およびそれらの製造方法
EP3438124A4 (en) * 2016-03-29 2019-03-13 FUJIFILM Corporation CELL LAYER INSERTION, CELL LAYER INSERTION COMPOSITION AND KIT
EP3438246B1 (en) * 2016-03-29 2020-08-26 FUJIFILM Corporation Laminate containing cell sheet, agent for treating cardiac diseases, and film for being laminated on cell sheet
WO2017200039A1 (ja) * 2016-05-19 2017-11-23 富士フイルム株式会社 細胞培養方法、培地及び培地キット
CN109219587B (zh) 2016-05-30 2021-09-14 富士胶片株式会社 磷酸钙成型体的制造方法、磷酸钙成型体及移植用材料
JP6637598B2 (ja) 2016-06-08 2020-01-29 富士フイルム株式会社 ゼラチン成形体の製造方法及びゼラチン成形体
EP3590952A4 (en) * 2017-03-02 2020-03-11 Fujifilm Corporation EMBEDDING AGENTS FOR CELL MASS OR CELL STRUCTURE AND CELL MASS OR CELL STRUCTURAL COMPOSITION AND KIT
JP6854879B2 (ja) 2017-03-16 2021-04-07 富士フイルム株式会社 巨核球と血小板とを分離する方法および巨核球と血小板とを分離するための器具
EP3597731B1 (en) 2017-03-17 2022-06-29 FUJIFILM Corporation Method for producing cell structures
CN110869495B (zh) * 2017-05-12 2023-06-20 富士胶片株式会社 间充质干细胞的制造方法及其应用
WO2019004446A1 (ja) 2017-06-30 2019-01-03 富士フイルム株式会社 ライソゾーム病処置剤
JP6941175B2 (ja) 2017-08-30 2021-09-29 富士フイルム株式会社 細胞移植用デバイスおよびその製造方法
WO2019044991A1 (ja) 2017-08-30 2019-03-07 富士フイルム株式会社 血管新生剤およびその製造方法
KR102476632B1 (ko) * 2017-11-06 2022-12-09 후지필름 가부시키가이샤 진주 양식용 재료 및 코팅용 조성물
CN111344393A (zh) 2017-11-10 2020-06-26 富士胶片株式会社 从间充质干细胞制造胰岛素产生细胞的方法、胰岛素产生细胞、细胞构建体及医药组合物
EP3747475A4 (en) * 2018-01-30 2021-06-02 FUJIFILM Corporation COMPOSITION OF FIBRIN, BASIC MATERIAL FOR REGENERATIVE MEDICINE, PROCESS FOR THE PRODUCTION OF FIBRIN COMPOSITION AND KIT
EP3848063A4 (en) * 2018-09-03 2021-10-27 FUJIFILM Corporation GEL FORMATION KIT, GEL AND METHOD FOR MANUFACTURING GEL
CN121605944A (zh) 2018-10-12 2026-03-06 富士胶片株式会社 珍珠养殖用材料、插核方法及珍珠养殖用材料组合物
JP7385664B2 (ja) 2019-07-26 2023-11-22 富士フイルム株式会社 生体移植材料
EP4019025B1 (en) 2019-08-23 2026-05-06 FUJIFILM Corporation Composition comprising microcapsule and cell structure
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EP4296598A4 (en) 2021-03-24 2024-08-07 FUJIFILM Corporation HEAT TREATMENT DEVICE AND METHOD FOR PRODUCING A HEAT TREATMENT OBJECT
WO2022202938A1 (ja) 2021-03-26 2022-09-29 富士フイルム株式会社 凍結乾燥用容器
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WO2023053710A1 (ja) 2021-09-30 2023-04-06 富士フイルム株式会社 組織修復材キット及び組織修復方法
EP4480509A1 (en) 2022-03-30 2024-12-25 FUJIFILM Corporation Tissue restoration material and tissue restoration material production method
EP4726051A1 (en) 2023-06-06 2026-04-15 FUJIFILM Corporation Recombinant yeast, method for producing target protein, and kit and method for producing recombinant yeast
AU2024393859A1 (en) * 2023-12-08 2026-06-04 Bolt Threads, Inc. Recombinant silk polypeptides and compositions made thereof

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US208141A (en) * 1878-09-17 Improvement in harvester guard-fingers
US204551A (en) * 1878-06-04 Improvement in bee-hives
US31501A (en) * 1861-02-19 Fracture apparatus
US9580A (en) * 1853-02-08 Improvement in gas-meters
US68013A (en) * 1867-08-20 Es ait t aeeaft
US119170A (en) * 1871-09-19 Improvement in harvester-cutters
US28243A (en) * 1860-05-08 williams
US114078A (en) * 1871-04-25 Improvement in valves and steam-chests for engines
US241032A (en) * 1881-05-03 Machine for making curved lead pipe
US147690A (en) * 1874-02-17 Improvement in belt-fastenings
US106410A (en) * 1870-08-16 William f
US237663A (en) * 1881-02-08 Hydrocarbon-gas generator
US58703A (en) * 1866-10-09 Improved mop-head
US107666A (en) * 1870-09-27 Improvement in rollers for sewing-machines
US121609A (en) * 1871-12-05 Improvement in tremolos for reed organs
US113910A (en) * 1871-04-18 Improvement in door-locks
US196496A (en) * 1877-10-23 Improvement in elevator-cups
US143568A (en) * 1873-10-14 Improvement in stays for ships sails
US229264A (en) * 1880-06-29 Recovering soda from spent liquors after treating vegetable fiber
US4034A (en) * 1845-05-07 Improvement in machines for breaking and cleaning hemp
US251719A (en) * 1882-01-03 Crucible
US24346A (en) * 1859-06-07 Lock attachment
US167446A (en) * 1875-09-07 Improvement in refrigerators
US177492A (en) * 1876-05-16 Improvement in anchors
US7991A (en) * 1851-03-18 Of beehives
US24361A (en) * 1859-06-07 Jacob j
US64074A (en) * 1867-04-23 Thesraphic oo
US274957A (en) * 1883-04-03 Punch for nut-machines
US190153A (en) * 1877-05-01 Improvement in processes of making shoes
US147501A (en) * 1874-02-17 Improvement in eooklnq-stoves
US4855134A (en) * 1983-10-14 1989-08-08 Sumitomo Pharmaceuticals Company, Limited Sustained-release preparation
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5514581A (en) 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
US5002769A (en) 1987-03-13 1991-03-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for the sustained-release of chlorhexidine
US4994388A (en) 1988-04-15 1991-02-19 Solohill Engineering, Inc. Collagen-coated polystyrene microcarrier beads
DE68928532T2 (de) * 1988-11-09 1998-05-28 Protein Polymer Tech Inc Funktionelles, durch ein rekombinantes verfahren hergestelltes synthetisches proteinpolymer
IL95500A (en) * 1989-09-11 1997-03-18 Matrix Pharma ANTI-PROLIFERATIVE COMPOSITIONS CONTAINING TGF-b PROTEIN IN A VISCOUS MATRIX AND THEIR USE
JPH07501443A (ja) * 1991-11-12 1995-02-16 プロテイン ポリマー テクノロジーズ,インコーポレイティド 高分子量のコラーゲン様タンパク質ポリマー
DE4140192C2 (de) 1991-12-05 1996-02-29 Alfatec Pharma Gmbh Sol-gesteuerte Thermokolloidmatrix auf Gelatinebasis für perorale Retardformen
DE4210334A1 (de) * 1992-03-30 1993-10-07 Stoess & Co Gelatine Biologisch abbaubares, wasserresistentes Polymer-Material
IL105529A0 (en) 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
US5512474A (en) 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
JP3639593B2 (ja) 1993-05-31 2005-04-20 科研製薬株式会社 塩基性線維芽細胞増殖因子含有架橋ゼラチンゲル製剤
IL109539A0 (en) 1994-05-03 1994-08-26 Yissum Res Dev Co Substained-release pharmaceutical system for the delivery of antioxidants
AU736784B2 (en) * 1997-06-03 2001-08-02 Celltran Limited New medicaments based on polymers composed of methacrylamide-modified gelatin
US6342250B1 (en) * 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
NL1007908C2 (nl) * 1997-12-24 1999-06-25 Fuji Photo Film Bv Zilverhalide-emulsies met recombinant collageen die geschikt zijn voor fotografische toediening alsmede de bereiding daarvan.
US6150081A (en) 1997-12-24 2000-11-21 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
US20030007991A1 (en) * 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20050147690A1 (en) 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
DE69940802D1 (de) 1998-12-23 2009-06-10 Fujifilm Mfg Europe Bv Silberhalogenidemulsionen, die rekombinante gelatineartige Proteine enthalten
AU1591701A (en) 1999-11-12 2001-06-06 Fibrogen, Inc. Recombinant gelatins
US6992172B1 (en) * 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
EP1238675A1 (en) 2001-03-06 2002-09-11 Fuji Photo Film B.V. Recombinant gelatin-like proteins for use as plasma expanders
US20060024346A1 (en) 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
US7067150B2 (en) 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
US20070196496A1 (en) 2002-04-16 2007-08-23 Michael Farber Delivery systems for functional ingredients
AU2003295270A1 (en) * 2002-12-23 2004-07-14 Fuji Photo Film B.V. Process for coating cell-culture support
JP2006519086A (ja) 2003-02-28 2006-08-24 ファイブローゲン、インコーポレーテッド コラーゲン組成物および生体材料
JP4459543B2 (ja) 2003-03-17 2010-04-28 株式会社メドジェル 徐放性ハイドロゲル製剤
WO2004085473A2 (en) * 2003-03-28 2004-10-07 Fuji Photo Film B.V. Rgd-enriched gelatine-like proteins with enhanced cell binding
US20050058703A1 (en) * 2003-08-01 2005-03-17 Chang Robert C. Gelatin capsules
WO2005011740A1 (en) * 2003-08-05 2005-02-10 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin-like proteins as stabiliser in lyophilized pharmaceutical compositions
WO2005011739A1 (en) * 2003-08-05 2005-02-10 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin as a stabiliser in vaccines
EP1713440A4 (en) * 2004-01-23 2009-10-28 California Inst Of Techn GENETICALLY MANUFACTURED PROTEINS AND MANUFACTURING AND USE METHOD
JP2005211477A (ja) 2004-01-30 2005-08-11 Gunze Ltd 再生医療用支持体
EP1723974A4 (en) 2004-02-25 2010-09-01 Ihara & Company Ltd COLLAGENGEL AND METHOD FOR ITS MANUFACTURE
US20070190153A1 (en) * 2004-03-05 2007-08-16 Jonathan Farber Delivery systems for non-steroidal anti-inflammatory drugs (nsaids)
AU2005259789A1 (en) 2004-06-30 2006-01-12 Covalon Technologies Inc. Non-adhesive hydrogels
US20060024361A1 (en) * 2004-07-28 2006-02-02 Isa Odidi Disintegrant assisted controlled release technology
WO2006034365A2 (en) * 2004-09-21 2006-03-30 Massachusetts Institute Of Technology Gradient scaffolding and methods of producing the same
JP5047797B2 (ja) 2004-09-30 2012-10-10 コヴァロン・テクノロジーズ・インコーポレーテッド 非接着性の弾性ゼラチンマトリックス
WO2006091099A2 (en) 2005-02-23 2006-08-31 Fujifilm Manufacturing Europe B.V. Non-glycosylated recombinant collagen-like polypeptides
EP1863466B1 (en) * 2005-03-03 2017-08-09 Takasago International Corporation (USA) Synergistic salivation components
EP1801122A1 (en) 2005-12-23 2007-06-27 FUJIFILM Manufacturing Europe B.V. Recombinant gelatin particles for cell adhesion
WO2008103043A1 (en) * 2007-02-21 2008-08-28 Fujifilm Manufacturing Europe B.V. Rgd containing recombinant gelatin

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