JP5349335B2 - 高い安定性を有する組換えｘｒｇｄ富化ゼラチン - Google Patents

高い安定性を有する組換えｘｒｇｄ富化ゼラチン Download PDF

Info

Publication number
JP5349335B2
JP5349335B2 JP2009550598A JP2009550598A JP5349335B2 JP 5349335 B2 JP5349335 B2 JP 5349335B2 JP 2009550598 A JP2009550598 A JP 2009550598A JP 2009550598 A JP2009550598 A JP 2009550598A JP 5349335 B2 JP5349335 B2 JP 5349335B2
Authority
JP
Japan
Prior art keywords
gelatin
xrgd
recombinant
polypeptide
recombinant gelatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009550598A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010518833A5 (enExample
JP2010518833A (ja
Inventor
デ・ボーア，アルジョ・リサンダー
ヴァン・ユルク，ヘンドリク
ヴァン・アステン，ペーター・フランシスクス・テレシウス
ボウストラ，ジャン・バスティアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Manufacturing Europe BV
Original Assignee
Fujifilm Manufacturing Europe BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07102838A external-priority patent/EP1961411A1/en
Priority claimed from EP07102839A external-priority patent/EP1961414A1/en
Application filed by Fujifilm Manufacturing Europe BV filed Critical Fujifilm Manufacturing Europe BV
Publication of JP2010518833A publication Critical patent/JP2010518833A/ja
Publication of JP2010518833A5 publication Critical patent/JP2010518833A5/ja
Application granted granted Critical
Publication of JP5349335B2 publication Critical patent/JP5349335B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2009550598A 2007-02-21 2008-02-21 高い安定性を有する組換えｘｒｇｄ富化ゼラチン Active JP5349335B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP07102838.5 2007-02-21
EP07102838A EP1961411A1 (en) 2007-02-21 2007-02-21 A controlled release composition
EP07102839.3 2007-02-21
EP07102839A EP1961414A1 (en) 2007-02-21 2007-02-21 A controlled release composition comprising a recombinant gelatin
EP07116189.7 2007-09-12
EP07116189 2007-09-12
EP07116193.9 2007-09-12
EP07116193 2007-09-12
EP08100556 2008-01-16
EP08100556.3 2008-01-16
PCT/NL2008/050100 WO2008103042A1 (en) 2007-02-21 2008-02-21 Recombinant xrgd-enriched gelatins having high stability

Publications (3)

Publication Number Publication Date
JP2010518833A JP2010518833A (ja) 2010-06-03
JP2010518833A5 JP2010518833A5 (enExample) 2011-02-03
JP5349335B2 true JP5349335B2 (ja) 2013-11-20

Family

ID=39503383

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009550598A Active JP5349335B2 (ja) 2007-02-21 2008-02-21 高い安定性を有する組換えｘｒｇｄ富化ゼラチン
JP2009550817A Active JP5548984B2 (ja) 2007-02-21 2008-02-21 機能性が増大した非天然の組換えゼラチン
JP2009550597A Active JP5548983B2 (ja) 2007-02-21 2008-02-21 組換えゼラチン
JP2009550599A Active JP5349336B2 (ja) 2007-02-21 2008-02-21 Ｒｇｄを含有する組換えゼラチン

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2009550817A Active JP5548984B2 (ja) 2007-02-21 2008-02-21 機能性が増大した非天然の組換えゼラチン
JP2009550597A Active JP5548983B2 (ja) 2007-02-21 2008-02-21 組換えゼラチン
JP2009550599A Active JP5349336B2 (ja) 2007-02-21 2008-02-21 Ｒｇｄを含有する組換えゼラチン

Country Status (5)

Country Link
US (5) US8198047B2 (enExample)
EP (4) EP2112998B1 (enExample)
JP (4) JP5349335B2 (enExample)
AT (2) ATE554103T1 (enExample)
WO (4) WO2008103042A1 (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5349335B2 (ja) * 2007-02-21 2013-11-20 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ 高い安定性を有する組換えｘｒｇｄ富化ゼラチン
EP2225375A1 (en) * 2007-12-21 2010-09-08 Fujifilm Manufacturing Europe B.V. Improvement of the secretion yield of a protein of interest by in vivo proteolytic processing of a multimeric precursor
JP2011518782A (ja) * 2008-04-10 2011-06-30 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ ヘパリン結合部位および／またはヘパラン硫酸結合部位を富化した組換えタンパク質
EP2310060B1 (en) * 2008-07-04 2013-02-27 Fujifilm Manufacturing Europe BV Coating method for medical devices
WO2010038059A2 (en) * 2008-10-02 2010-04-08 Fujifilm Manufacturing Europe Bv Antimicrobial coating
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
EP2428215B1 (en) * 2009-05-07 2017-10-18 FUJIFILM Corporation Recombinant gelatin for use in the treatment of ischemic and heart disease and others
WO2010143708A1 (ja) * 2009-06-12 2010-12-16 富士フイルム株式会社 新生血管に対する標的化剤
WO2010147109A1 (ja) * 2009-06-15 2010-12-23 富士フイルム株式会社 遺伝子組み換えゼラチン及び塩基性線維芽細胞増殖因子を含む血管新生誘導剤
EP2460541B1 (en) * 2009-07-30 2018-01-17 FUJIFILM Corporation Kidney-imaging agent comprising recombinant gelatin
WO2011013791A1 (ja) * 2009-07-30 2011-02-03 富士フイルム株式会社 遺伝子組み換えゼラチンを含む腎臓標的ドラッグデリバリー剤
CN105753970B (zh) 2009-09-04 2023-06-23 富士胶片株式会社 包含明胶的骨再生剂
EP2502939B1 (en) * 2009-11-19 2016-01-27 Zhejiang University Nonnatural collagen-like protein and use thereof
GB0921460D0 (en) 2009-12-08 2010-01-20 Fujifilm Mfg Europe Bv Anti-fibrotic hydrogel compositions
EP2522366B1 (en) * 2010-01-08 2018-10-31 FUJIFILM Corporation Targeting agent for tumor site
KR20130005279A (ko) * 2010-03-01 2013-01-15 후지필름 가부시키가이샤 생체 친화성을 갖는 고분자 블록과 세포로 이루어지는 세포 구조체
KR101637431B1 (ko) * 2010-03-02 2016-07-07 후지필름 가부시키가이샤 세포 지지체 및 골재생재
GB201008404D0 (en) 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
GB201014388D0 (en) 2010-08-31 2010-10-13 Fujifilm Mfg Europe Bv Biocompatible compositions for tissue augmentation
GB201018044D0 (en) 2010-10-26 2010-12-08 Fujifilm Mfg Europe Bv Non-natural gelatin-like proteins with enhanced functionality
JP5847418B2 (ja) * 2011-03-30 2016-01-20 富士フイルム株式会社 細胞接着性タンパク質
US20120263681A1 (en) * 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
JP2012244909A (ja) * 2011-05-25 2012-12-13 Nagoya City Univ 組み換え蛋白質の製造方法及び蛋白質の導入方法
JP5990298B2 (ja) * 2011-08-31 2016-09-14 富士フイルム株式会社 細胞移植用細胞構造体および細胞移植用細胞集合体
JP5876787B2 (ja) 2011-08-31 2016-03-02 富士フイルム株式会社 細胞移植用細胞構造体および細胞移植用細胞集合体
JP5808631B2 (ja) 2011-09-29 2015-11-10 富士フイルム株式会社 血管新生用足場、及び再生医療用の血管の製造方法
GB201119173D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
GB201119182D0 (en) 2011-11-07 2011-12-21 Fujifilm Mfg Europe Bv Porous tissue scaffolds
CN104244999B (zh) 2012-03-12 2017-02-22 富士胶片株式会社 组织修复材料的制造方法
WO2014050908A1 (ja) 2012-09-26 2014-04-03 富士フイルム株式会社 ポリペプチド、足場組成物、軟骨組織修復用組成物、軟骨細胞培養用組成物及びグリコサミノグリカン産生促進用組成物
WO2014115732A1 (ja) * 2013-01-25 2014-07-31 富士フイルム株式会社 移植用人工真皮およびその製造方法
EP2962703B1 (en) 2013-02-27 2020-08-19 FUJIFILM Corporation Cell construct for cell transplantation, biocompatible polymer block, and method for producing the same
ES2711672T3 (es) 2013-03-12 2019-05-06 Fujifilm Corp Material para reparación de tejidos
GB201304947D0 (en) * 2013-03-18 2013-05-01 Cass Anthony E G Biomimetic collagen
EP3050580B1 (en) 2013-09-25 2020-02-19 FUJIFILM Corporation Method for producing biocompatible macromolecular porous body, biocompatible macromolecular porous body, biocompatible macromolecular block and cell structure
WO2015194494A1 (ja) 2014-06-16 2015-12-23 富士フイルム株式会社 脳損傷治療用細胞構造体、その製造方法、及び脳損傷治療剤
JP6455862B2 (ja) 2015-06-25 2019-01-23 学校法人早稲田大学 コラーゲン様構造を有する重合ペプチド及びゲル
WO2017043489A1 (ja) 2015-09-11 2017-03-16 富士フイルム株式会社 ゼラチン構造体製造方法、及びゼラチン構造体製造システム
WO2017117333A1 (en) 2015-12-30 2017-07-06 Cellular Dynamics International, Inc. Microtissue formation using stem cell-derived human hepatocytes
EP3437660A4 (en) * 2016-03-28 2019-05-01 Fujifilm Corporation PREPARATION, MATERIAL FOR PREPARATION AND METHOD FOR THE PRODUCTION THEREOF
EP3438124A4 (en) * 2016-03-29 2019-03-13 FUJIFILM Corporation CELL LAYER INSERTION, CELL LAYER INSERTION COMPOSITION AND KIT
EP3438246B1 (en) * 2016-03-29 2020-08-26 FUJIFILM Corporation Laminate containing cell sheet, agent for treating cardiac diseases, and film for being laminated on cell sheet
JPWO2017200039A1 (ja) * 2016-05-19 2019-03-22 富士フイルム株式会社 細胞培養方法、培地及び培地キット
WO2017209136A1 (ja) 2016-05-30 2017-12-07 富士フイルム株式会社 リン酸カルシウム成形体の製造方法、リン酸カルシウム成形体及び移植用材料
KR102179862B1 (ko) 2016-06-08 2020-11-18 후지필름 가부시키가이샤 젤라틴 성형체의 제조 방법 및 젤라틴 성형체
EP3590952A4 (en) * 2017-03-02 2020-03-11 Fujifilm Corporation INCORPORATING AGENT FOR CELLULAR MASS OR CELLULAR STRUCTURE, COMPOSITION AND KIT CONTAINING CELLULAR STRUCTURE OR CELLULAR MASS
EP3597660A4 (en) 2017-03-16 2020-04-01 FUJIFILM Corporation METHOD FOR SEPARATING MEGACARYOCYTES AND PLATES AND INSTRUMENT FOR SEPARATING MEGACARYOCYTES AND PLATES
JP6964313B2 (ja) 2017-03-17 2021-11-10 富士フイルム株式会社 細胞構造体の製造方法
JPWO2018207923A1 (ja) * 2017-05-12 2020-03-12 富士フイルム株式会社 間葉系幹細胞の製造方法、およびその応用
WO2019004446A1 (ja) 2017-06-30 2019-01-03 富士フイルム株式会社 ライソゾーム病処置剤
WO2019044990A1 (ja) 2017-08-30 2019-03-07 富士フイルム株式会社 細胞移植用デバイスおよびその製造方法
WO2019044991A1 (ja) 2017-08-30 2019-03-07 富士フイルム株式会社 血管新生剤およびその製造方法
JPWO2019087650A1 (ja) * 2017-11-06 2020-11-12 富士フイルム株式会社 真珠養殖用材料及びコーティング用組成物
WO2019093468A1 (ja) 2017-11-10 2019-05-16 富士フイルム株式会社 間葉系幹細胞からインスリン産生細胞を製造する方法、インスリン産生細胞、細胞構造体および医薬組成物
WO2019151205A1 (ja) * 2018-01-30 2019-08-08 富士フイルム株式会社 フィブリン組成物、再生医療用基材、フィブリン組成物の製造方法およびキット
WO2020050205A1 (ja) 2018-09-03 2020-03-12 富士フイルム株式会社 ゲル形成キット、ゲルおよびゲルの製造方法
JP6906713B2 (ja) * 2018-10-12 2021-07-21 富士フイルム株式会社 真珠養殖用材料、挿核方法及び真珠養殖用材料組成物
JP7385664B2 (ja) 2019-07-26 2023-11-22 富士フイルム株式会社 生体移植材料
JP7431247B2 (ja) 2019-08-23 2024-02-14 富士フイルム株式会社 ミクロカプセルと細胞構造体とを含む組成物
WO2021241409A1 (ja) 2020-05-25 2021-12-02 富士フイルム株式会社 組成物、シート状成形体、人工皮革およびシート状成形体の製造方法
GB2596525A (en) * 2020-06-26 2022-01-05 Fujifilm Corp Modified gelatins
WO2022202632A1 (ja) 2021-03-24 2022-09-29 富士フイルム株式会社 加熱処理装置及び加熱処理物の製造方法
WO2022202938A1 (ja) 2021-03-26 2022-09-29 富士フイルム株式会社 凍結乾燥用容器
WO2022202633A1 (ja) 2021-03-26 2022-09-29 富士フイルム株式会社 粉体供給装置
EP4299182A4 (en) 2021-03-31 2024-08-28 FUJIFILM Corporation CRUSHING PROCESS, POLYMER BLOCK PRODUCTION PROCESS AND CRUSHING DEVICE
JP7333121B2 (ja) 2021-08-02 2023-08-24 株式会社Rainbow 幹細胞を非凍結で保存または輸送するための方法
WO2023053710A1 (ja) 2021-09-30 2023-04-06 富士フイルム株式会社 組織修復材キット及び組織修復方法
WO2023188492A1 (ja) 2022-03-30 2023-10-05 富士フイルム株式会社 組織修復材及び組織修復材の製造方法
WO2025122874A1 (en) * 2023-12-08 2025-06-12 Bolt Threads, Inc. Recombinant silk polypeptides and compositions made thereof

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034A (en) * 1845-05-07 Improvement in machines for breaking and cleaning hemp
US7991A (en) * 1851-03-18 Of beehives
US58703A (en) * 1866-10-09 Improved mop-head
US208141A (en) * 1878-09-17 Improvement in harvester guard-fingers
US177492A (en) * 1876-05-16 Improvement in anchors
US114078A (en) * 1871-04-25 Improvement in valves and steam-chests for engines
US241032A (en) * 1881-05-03 Machine for making curved lead pipe
US121609A (en) * 1871-12-05 Improvement in tremolos for reed organs
US9580A (en) * 1853-02-08 Improvement in gas-meters
US24346A (en) * 1859-06-07 Lock attachment
US28243A (en) * 1860-05-08 williams
US113910A (en) * 1871-04-18 Improvement in door-locks
US31501A (en) * 1861-02-19 Fracture apparatus
US147501A (en) * 1874-02-17 Improvement in eooklnq-stoves
US167446A (en) * 1875-09-07 Improvement in refrigerators
US64074A (en) * 1867-04-23 Thesraphic oo
US204551A (en) * 1878-06-04 Improvement in bee-hives
US107666A (en) * 1870-09-27 Improvement in rollers for sewing-machines
US251719A (en) * 1882-01-03 Crucible
US274957A (en) * 1883-04-03 Punch for nut-machines
US229264A (en) * 1880-06-29 Recovering soda from spent liquors after treating vegetable fiber
US147690A (en) * 1874-02-17 Improvement in belt-fastenings
US24361A (en) * 1859-06-07 Jacob j
US143568A (en) * 1873-10-14 Improvement in stays for ships sails
US237663A (en) * 1881-02-08 Hydrocarbon-gas generator
US68013A (en) * 1867-08-20 Es ait t aeeaft
US196496A (en) * 1877-10-23 Improvement in elevator-cups
US190153A (en) * 1877-05-01 Improvement in processes of making shoes
US106410A (en) * 1870-08-16 William f
US119170A (en) * 1871-09-19 Improvement in harvester-cutters
US4855134A (en) * 1983-10-14 1989-08-08 Sumitomo Pharmaceuticals Company, Limited Sustained-release preparation
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5514581A (en) * 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
US5002769A (en) 1987-03-13 1991-03-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for the sustained-release of chlorhexidine
US4994388A (en) 1988-04-15 1991-02-19 Solohill Engineering, Inc. Collagen-coated polystyrene microcarrier beads
JP3338441B2 (ja) * 1988-11-09 2002-10-28 プロテイン ポリマー テクノロジーズ，インコーポレイティド 組換え的に調製された官能的な合成タンパク質ポリマー
IL95500A (en) * 1989-09-11 1997-03-18 Matrix Pharma ANTI-PROLIFERATIVE COMPOSITIONS CONTAINING TGF-b PROTEIN IN A VISCOUS MATRIX AND THEIR USE
KR100238715B1 (ko) * 1991-11-12 2000-01-15 존 이. 플라워스 고분자량 콜라겐-유사 단백질 중합체
DE4140192C2 (de) * 1991-12-05 1996-02-29 Alfatec Pharma Gmbh Sol-gesteuerte Thermokolloidmatrix auf Gelatinebasis für perorale Retardformen
DE4210334A1 (de) * 1992-03-30 1993-10-07 Stoess & Co Gelatine Biologisch abbaubares, wasserresistentes Polymer-Material
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
US5512474A (en) 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
DE69427908T2 (de) 1993-05-31 2001-11-22 Kaken Pharmaceutical Co., Ltd. Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält
IL109539A0 (en) * 1994-05-03 1994-08-26 Yissum Res Dev Co Substained-release pharmaceutical system for the delivery of antioxidants
PT986408E (pt) * 1997-06-03 2005-09-30 Innogenetics Nv Novos medicamentos baseados em polimeros compostos por gelatina modificada com metacrilamida
US6342250B1 (en) * 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
US6150081A (en) * 1997-12-24 2000-11-21 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
NL1007908C2 (nl) 1997-12-24 1999-06-25 Fuji Photo Film Bv Zilverhalide-emulsies met recombinant collageen die geschikt zijn voor fotografische toediening alsmede de bereiding daarvan.
US20050147690A1 (en) 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US20030007991A1 (en) 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
EP1014176B1 (en) 1998-12-23 2009-04-29 FUJIFILM Manufacturing Europe B.V. Silver halide emulsions containing recombinant gelatin-like proteins
US6992172B1 (en) * 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
DE60040012D1 (de) 1999-11-12 2008-10-02 Fibrogen Inc Rekombinantes gelatin in impstoffen
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
EP1238675A1 (en) * 2001-03-06 2002-09-11 Fuji Photo Film B.V. Recombinant gelatin-like proteins for use as plasma expanders
US20060024346A1 (en) * 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
US7067150B2 (en) * 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
US20070196496A1 (en) 2002-04-16 2007-08-23 Michael Farber Delivery systems for functional ingredients
AU2003295270A1 (en) 2002-12-23 2004-07-14 Fuji Photo Film B.V. Process for coating cell-culture support
WO2004078120A2 (en) 2003-02-28 2004-09-16 Fibrogen, Inc. Collagen compositions and biomaterials
JP4459543B2 (ja) * 2003-03-17 2010-04-28 株式会社メドジェル 徐放性ハイドロゲル製剤
EP1894945B1 (en) * 2003-03-28 2009-12-02 FUJIFILM Manufacturing Europe B.V. RGD-enriched gelatine-like proteins with enhanced cell binding
US20050058703A1 (en) * 2003-08-01 2005-03-17 Chang Robert C. Gelatin capsules
EP1651272A1 (en) * 2003-08-05 2006-05-03 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin as a stabiliser in vaccines
EP1651275A1 (en) 2003-08-05 2006-05-03 Fuji Photo Film B.V. Use of recombinant or synthetic gelatin-like proteins as stabiliser in lyophilized pharmaceutical compositions
WO2005072223A2 (en) * 2004-01-23 2005-08-11 California Institute Of Technology Engineered proteins, and methods of making and using
JP2005211477A (ja) 2004-01-30 2005-08-11 Gunze Ltd 再生医療用支持体
WO2005079879A1 (ja) * 2004-02-25 2005-09-01 Ihara & Company Ltd. コラーゲンゲルおよびその製造方法
US20070190153A1 (en) 2004-03-05 2007-08-16 Jonathan Farber Delivery systems for non-steroidal anti-inflammatory drugs (nsaids)
EP1773415A1 (en) 2004-06-30 2007-04-18 Covalon Technologies Inc. Non-adhesive hydrogels
US20060024361A1 (en) 2004-07-28 2006-02-02 Isa Odidi Disintegrant assisted controlled release technology
AU2005286755A1 (en) 2004-09-21 2006-03-30 Massachusetts Institute Of Technology Gradient scaffolding and methods of producing the same
EP1793872B1 (en) * 2004-09-30 2016-05-11 Covalon Technologies Inc. Non-adhesive elastic gelatin matrices
DE602006015289D1 (de) * 2005-02-23 2010-08-19 Fujifilm Mfg Europe Bv Nicht-glycosylierte rekombinante collagen-ähnliche polypeptide
WO2006112961A2 (en) 2005-03-03 2006-10-26 Takasago International Corp. (Usa) Synergistic salivation components
EP1801122A1 (en) 2005-12-23 2007-06-27 FUJIFILM Manufacturing Europe B.V. Recombinant gelatin particles for cell adhesion
JP5349335B2 (ja) * 2007-02-21 2013-11-20 フジフィルム・マニュファクチュアリング・ヨーロッパ・ベスローテン・フエンノートシャップ 高い安定性を有する組換えｘｒｇｄ富化ゼラチン

Also Published As

Publication number Publication date
EP2112998B1 (en) 2012-04-18
US20100075902A1 (en) 2010-03-25
EP2112997A1 (en) 2009-11-04
JP5548984B2 (ja) 2014-07-16
US8198047B2 (en) 2012-06-12
US8349588B2 (en) 2013-01-08
WO2008103042A8 (en) 2009-07-23
JP5548983B2 (ja) 2014-07-16
JP2010519252A (ja) 2010-06-03
JP2010519293A (ja) 2010-06-03
WO2008103043A1 (en) 2008-08-28
EP2112997B1 (en) 2012-08-01
US20100119574A1 (en) 2010-05-13
US8349589B2 (en) 2013-01-08
ATE551364T1 (de) 2012-04-15
WO2008103042A1 (en) 2008-08-28
ATE554103T1 (de) 2012-05-15
US20100105618A1 (en) 2010-04-29
US20100062531A1 (en) 2010-03-11
WO2008103044A1 (en) 2008-08-28
JP5349336B2 (ja) 2013-11-20
JP2010518833A (ja) 2010-06-03
EP2112998A1 (en) 2009-11-04
EP2112999A1 (en) 2009-11-04
WO2008103041A1 (en) 2008-08-28
WO2008103044A8 (en) 2010-03-04
WO2008103041A8 (en) 2009-07-23
US8158756B2 (en) 2012-04-17
WO2008103043A8 (en) 2009-07-23
EP2112999B1 (en) 2012-03-28
EP2121749A1 (en) 2009-11-25
US20120107372A1 (en) 2012-05-03
US8173776B1 (en) 2012-05-08
EP2121749B1 (en) 2013-07-03
JP2010519251A (ja) 2010-06-03

Similar Documents

Publication Publication Date Title
JP5349335B2 (ja) 高い安定性を有する組換えｘｒｇｄ富化ゼラチン
US7598347B2 (en) RGD-enriched gelatines
US9023619B2 (en) Non-natural gelatin-like proteins with enhanced functionality
JP5020973B2 (ja) 細胞接着用の組換ゼラチン粒子

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101203

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101203

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121217

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130308

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130722

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130820

R150 Certificate of patent or registration of utility model

Ref document number: 5349335

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250