JP5315056B2 - 固結抑制粒状製剤 - Google Patents
固結抑制粒状製剤 Download PDFInfo
- Publication number
- JP5315056B2 JP5315056B2 JP2008541029A JP2008541029A JP5315056B2 JP 5315056 B2 JP5315056 B2 JP 5315056B2 JP 2008541029 A JP2008541029 A JP 2008541029A JP 2008541029 A JP2008541029 A JP 2008541029A JP 5315056 B2 JP5315056 B2 JP 5315056B2
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- JP
- Japan
- Prior art keywords
- acid
- pullulan
- granular
- caking
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000012453 solvate Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229960005137 succinic acid Drugs 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- YZMCKZRAOLZXAZ-UHFFFAOYSA-N sulfisomidine Chemical compound CC1=NC(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 YZMCKZRAOLZXAZ-UHFFFAOYSA-N 0.000 description 1
- 229960001975 sulfisomidine Drugs 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
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- 229960000278 theophylline Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 229960003386 triazolam Drugs 0.000 description 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 229960004699 valsartan Drugs 0.000 description 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 description 1
- 229960000744 vinpocetine Drugs 0.000 description 1
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- 229940088594 vitamin Drugs 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
- 229960001729 voglibose Drugs 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008541029A JP5315056B2 (ja) | 2006-10-25 | 2007-10-25 | 固結抑制粒状製剤 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006290561 | 2006-10-25 | ||
| JP2006290561 | 2006-10-25 | ||
| PCT/JP2007/070854 WO2008050847A1 (fr) | 2006-10-25 | 2007-10-25 | Préparation granulaire non agglutinante |
| JP2008541029A JP5315056B2 (ja) | 2006-10-25 | 2007-10-25 | 固結抑制粒状製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2008050847A1 JPWO2008050847A1 (ja) | 2010-02-25 |
| JP5315056B2 true JP5315056B2 (ja) | 2013-10-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541029A Expired - Fee Related JP5315056B2 (ja) | 2006-10-25 | 2007-10-25 | 固結抑制粒状製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100093875A1 (ko) |
| EP (1) | EP2095812A4 (ko) |
| JP (1) | JP5315056B2 (ko) |
| KR (1) | KR20090081407A (ko) |
| CN (1) | CN101541311B (ko) |
| WO (1) | WO2008050847A1 (ko) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5055391B2 (ja) * | 2010-01-19 | 2012-10-24 | 株式会社浜乙女 | 酢顆粒の製造方法及び酢顆粒、酢顆粒付き海苔 |
| CN102240270B (zh) * | 2010-05-13 | 2013-01-02 | 丽珠医药集团股份有限公司 | 布南色林片剂及其制备方法 |
| WO2012063246A1 (en) * | 2010-11-11 | 2012-05-18 | Mapi Pharma Ltd. | Amorphous form of lurasidone hydrochloride |
| JP5860480B2 (ja) | 2011-01-11 | 2016-02-16 | キャプシュゲル・ベルジウム・エヌ・ヴィ | プルランを含む新しい硬カプセル |
| JP5935976B2 (ja) * | 2011-01-26 | 2016-06-15 | 日産化学工業株式会社 | 安定化される農薬固型製剤 |
| JP2012201597A (ja) * | 2011-03-23 | 2012-10-22 | Nihon Generic Co Ltd | モサプリドを含有する固形製剤 |
| KR101267834B1 (ko) * | 2011-05-19 | 2013-05-27 | 씨제이제일제당 (주) | 고화 방지 감미 소재 조성물 및 그의 제조 방법 |
| US8981095B2 (en) | 2011-07-28 | 2015-03-17 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of lurasidone and salts thereof |
| JP5756727B2 (ja) * | 2011-09-30 | 2015-07-29 | ハウス食品グループ本社株式会社 | 顆粒 |
| CN103130794B (zh) * | 2011-12-02 | 2016-06-22 | 苏州二叶制药有限公司 | 卢拉西酮盐酸盐的晶体a的制备方法 |
| WO2013132511A1 (en) * | 2012-03-09 | 2013-09-12 | Hetero Research Foundation | Novel polymorph of lurasidone hydrochloride |
| TWI594765B (zh) * | 2012-04-30 | 2017-08-11 | 大塚製藥股份有限公司 | 口服調製劑 |
| CN102688210A (zh) * | 2012-06-21 | 2012-09-26 | 李兴惠 | 鲁拉西酮的药物组合物和制备方法 |
| EP2942052A4 (en) * | 2013-01-07 | 2016-06-08 | Sam A Pharm Co Ltd | NEW FORMULATION OF RAPID DISSOLUTION PELLETS WITH ENHANCED SOLUBILITY |
| CN103420887B (zh) * | 2013-08-30 | 2014-12-10 | 孙威 | 一种左舒必利化合物及其制备方法 |
| US20170290775A1 (en) * | 2014-10-07 | 2017-10-12 | Therakine Bio Delivery GmbH | Micronized delivery material and methods for manufacturing thereof |
| EP3206671B1 (en) * | 2014-10-16 | 2024-06-12 | Cargill, Incorporated | Process for preparing a directly compressible erythritol and uses thereof |
| JP6546788B2 (ja) * | 2015-06-04 | 2019-07-17 | ユニテックフーズ株式会社 | 咀嚼・嚥下困難者に適したゼリープレミックス |
| CN108210465A (zh) * | 2016-12-14 | 2018-06-29 | 河南后羿实业集团有限公司 | 防结块复方卡巴匹林钙粉剂及其制备方法 |
| JP7222911B2 (ja) | 2017-04-14 | 2023-02-15 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | プルランを作製する方法 |
| CN110678170A (zh) | 2017-04-14 | 2020-01-10 | 比利时胶囊公司 | 普鲁兰多糖胶囊 |
| CN110477377A (zh) * | 2019-08-02 | 2019-11-22 | 大连医诺生物股份有限公司 | 含非脂溶性成分的口溶型直饮粉及其制备方法 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57189672A (en) * | 1981-05-18 | 1982-11-22 | Meiji Milk Prod Co Ltd | Preparation of low caking powder drink |
| JPS58164683A (ja) * | 1982-03-25 | 1983-09-29 | Takeda Chem Ind Ltd | 安定化された固体組成物 |
| JPH04210926A (ja) * | 1990-02-14 | 1992-08-03 | Takeda Chem Ind Ltd | 発泡組成物 |
| JPH07157431A (ja) * | 1993-12-06 | 1995-06-20 | Taiyo Yakuhin Kogyo Kk | 安定なプロスタグランジンｅ製剤 |
| JP2002524535A (ja) * | 1998-09-14 | 2002-08-06 | インヘール セラピューティック システムズ， インコーポレイテッド | 乾燥粉末活性薬剤肺性送達 |
| JP2004244353A (ja) * | 2003-02-13 | 2004-09-02 | Sankyo Agro Kk | 固結性が改善された農薬粒状組成物 |
| JP2004244359A (ja) * | 2003-02-13 | 2004-09-02 | Shirako:Kk | 血管拡張性医薬及び健康食品組成物 |
| JP2005314413A (ja) * | 2004-04-02 | 2005-11-10 | Ono Pharmaceut Co Ltd | 経口投与用医薬組成物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE108649T1 (de) * | 1990-02-14 | 1994-08-15 | Takeda Chemical Industries Ltd | Brausemischung, deren herstellung sowie verwendung. |
| TW202450B (ko) | 1991-06-26 | 1993-03-21 | Dainippon Pharmaceutical Co | |
| JP3583166B2 (ja) | 1994-06-27 | 2004-10-27 | 興和株式会社 | 損傷皮膚修復用粉末製剤 |
| JPH09316006A (ja) | 1996-05-29 | 1997-12-09 | Yatsuken:Kk | 口腔内溶解性固形製剤 |
| ZA985870B (en) | 1997-07-15 | 1999-01-27 | Dainippon Pharmaceutical Co | 5-substituted-3-oxadiazolyl-1, 6-naphthyridin-2(1H)-one derivatives |
| TW527195B (en) * | 1997-10-09 | 2003-04-11 | Ssp Co Ltd | Fast-soluble solid pharmaceutical combinations |
| JPH11116464A (ja) * | 1997-10-09 | 1999-04-27 | Ss Pharmaceut Co Ltd | 迅速溶解性固形製剤およびその製造法 |
| JP2006290561A (ja) | 2005-04-12 | 2006-10-26 | Shin Caterpillar Mitsubishi Ltd | クレーン作業制御装置 |
| PT1878426E (pt) * | 2005-04-26 | 2010-06-28 | Dainippon Sumitomo Pharma Co | Preparação granulada contendo um composto de biguanida |
| EP1875915A4 (en) | 2005-04-28 | 2010-11-17 | Dainippon Sumitomo Pharma Co | THERAPEUTIC AGENT FOR TREATING CHRONIC OBSTRUCTIVE RESPIRATORY DISEASE |
-
2007
- 2007-10-25 US US12/446,783 patent/US20100093875A1/en not_active Abandoned
- 2007-10-25 EP EP07830588A patent/EP2095812A4/en not_active Withdrawn
- 2007-10-25 WO PCT/JP2007/070854 patent/WO2008050847A1/ja active Application Filing
- 2007-10-25 JP JP2008541029A patent/JP5315056B2/ja not_active Expired - Fee Related
- 2007-10-25 KR KR1020097010551A patent/KR20090081407A/ko not_active Application Discontinuation
- 2007-10-25 CN CN2007800443366A patent/CN101541311B/zh not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57189672A (en) * | 1981-05-18 | 1982-11-22 | Meiji Milk Prod Co Ltd | Preparation of low caking powder drink |
| JPS58164683A (ja) * | 1982-03-25 | 1983-09-29 | Takeda Chem Ind Ltd | 安定化された固体組成物 |
| JPH04210926A (ja) * | 1990-02-14 | 1992-08-03 | Takeda Chem Ind Ltd | 発泡組成物 |
| JPH07157431A (ja) * | 1993-12-06 | 1995-06-20 | Taiyo Yakuhin Kogyo Kk | 安定なプロスタグランジンｅ製剤 |
| JP2002524535A (ja) * | 1998-09-14 | 2002-08-06 | インヘール セラピューティック システムズ， インコーポレイテッド | 乾燥粉末活性薬剤肺性送達 |
| JP2004244353A (ja) * | 2003-02-13 | 2004-09-02 | Sankyo Agro Kk | 固結性が改善された農薬粒状組成物 |
| JP2004244359A (ja) * | 2003-02-13 | 2004-09-02 | Shirako:Kk | 血管拡張性医薬及び健康食品組成物 |
| JP2005314413A (ja) * | 2004-04-02 | 2005-11-10 | Ono Pharmaceut Co Ltd | 経口投与用医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101541311A (zh) | 2009-09-23 |
| WO2008050847A1 (fr) | 2008-05-02 |
| CN101541311B (zh) | 2013-01-23 |
| KR20090081407A (ko) | 2009-07-28 |
| JPWO2008050847A1 (ja) | 2010-02-25 |
| EP2095812A1 (en) | 2009-09-02 |
| EP2095812A4 (en) | 2011-07-13 |
| US20100093875A1 (en) | 2010-04-15 |
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