JP5315056B2 - 固結抑制粒状製剤 - Google Patents

固結抑制粒状製剤 Download PDF

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Publication number
JP5315056B2
JP5315056B2 JP2008541029A JP2008541029A JP5315056B2 JP 5315056 B2 JP5315056 B2 JP 5315056B2 JP 2008541029 A JP2008541029 A JP 2008541029A JP 2008541029 A JP2008541029 A JP 2008541029A JP 5315056 B2 JP5315056 B2 JP 5315056B2
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JP
Japan
Prior art keywords
acid
pullulan
granular
caking
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008541029A
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English (en)
Japanese (ja)
Other versions
JPWO2008050847A1 (ja
Inventor
康博 松井
友紀 池田
康 落合
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
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Application filed by Sumitomo Dainippon Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Priority to JP2008541029A priority Critical patent/JP5315056B2/ja
Publication of JPWO2008050847A1 publication Critical patent/JPWO2008050847A1/ja
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
JP2008541029A 2006-10-25 2007-10-25 固結抑制粒状製剤 Expired - Fee Related JP5315056B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008541029A JP5315056B2 (ja) 2006-10-25 2007-10-25 固結抑制粒状製剤

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006290561 2006-10-25
JP2006290561 2006-10-25
JP2008541029A JP5315056B2 (ja) 2006-10-25 2007-10-25 固結抑制粒状製剤
PCT/JP2007/070854 WO2008050847A1 (fr) 2006-10-25 2007-10-25 Préparation granulaire non agglutinante

Publications (2)

Publication Number Publication Date
JPWO2008050847A1 JPWO2008050847A1 (ja) 2010-02-25
JP5315056B2 true JP5315056B2 (ja) 2013-10-16

Family

ID=39324631

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008541029A Expired - Fee Related JP5315056B2 (ja) 2006-10-25 2007-10-25 固結抑制粒状製剤

Country Status (6)

Country Link
US (1) US20100093875A1 (ko)
EP (1) EP2095812A4 (ko)
JP (1) JP5315056B2 (ko)
KR (1) KR20090081407A (ko)
CN (1) CN101541311B (ko)
WO (1) WO2008050847A1 (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5055391B2 (ja) * 2010-01-19 2012-10-24 株式会社浜乙女 酢顆粒の製造方法及び酢顆粒、酢顆粒付き海苔
CN102240270B (zh) * 2010-05-13 2013-01-02 丽珠医药集团股份有限公司 布南色林片剂及其制备方法
WO2012063246A1 (en) * 2010-11-11 2012-05-18 Mapi Pharma Ltd. Amorphous form of lurasidone hydrochloride
EP2663294B1 (en) 2011-01-11 2015-09-30 Capsugel Belgium NV New hard capsules comprising pullulan
JP5935976B2 (ja) * 2011-01-26 2016-06-15 日産化学工業株式会社 安定化される農薬固型製剤
JP2012201597A (ja) * 2011-03-23 2012-10-22 Nihon Generic Co Ltd モサプリドを含有する固形製剤
KR101267834B1 (ko) * 2011-05-19 2013-05-27 씨제이제일제당 (주) 고화 방지 감미 소재 조성물 및 그의 제조 방법
US8981095B2 (en) 2011-07-28 2015-03-17 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of lurasidone and salts thereof
JP5756727B2 (ja) * 2011-09-30 2015-07-29 ハウス食品グループ本社株式会社 顆粒
CN103130794B (zh) * 2011-12-02 2016-06-22 苏州二叶制药有限公司 卢拉西酮盐酸盐的晶体a的制备方法
WO2013132511A1 (en) * 2012-03-09 2013-09-12 Hetero Research Foundation Novel polymorph of lurasidone hydrochloride
AR091349A1 (es) * 2012-04-30 2015-01-28 Otsuka Pharma Co Ltd Formulacion oral
CN102688210A (zh) * 2012-06-21 2012-09-26 李兴惠 鲁拉西酮的药物组合物和制备方法
WO2014106962A1 (ko) * 2013-01-07 2014-07-10 삼아제약 주식회사 향상된 용해도를 갖는 신규한 속용성 과립제형
CN103420887B (zh) * 2013-08-30 2014-12-10 孙威 一种左舒必利化合物及其制备方法
EP3204044A4 (en) * 2014-10-07 2018-10-03 Andreas Voigt Micronized delivery material, method for manufacturing thereof and methods for application
CA2963706C (en) * 2014-10-16 2023-10-03 Cargill, Incorporated Process for preparing a directly compressible erythritol & uses thereof
JP6546788B2 (ja) * 2015-06-04 2019-07-17 ユニテックフーズ株式会社 咀嚼・嚥下困難者に適したゼリープレミックス
CN108210465A (zh) * 2016-12-14 2018-06-29 河南后羿实业集团有限公司 防结块复方卡巴匹林钙粉剂及其制备方法
JP7222911B2 (ja) 2017-04-14 2023-02-15 カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ プルランを作製する方法
AU2018251256B2 (en) 2017-04-14 2023-10-05 Capsugel Belgium Nv Pullulan capsules
CN110477377A (zh) * 2019-08-02 2019-11-22 大连医诺生物股份有限公司 含非脂溶性成分的口溶型直饮粉及其制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57189672A (en) * 1981-05-18 1982-11-22 Meiji Milk Prod Co Ltd Preparation of low caking powder drink
JPS58164683A (ja) * 1982-03-25 1983-09-29 Takeda Chem Ind Ltd 安定化された固体組成物
JPH04210926A (ja) * 1990-02-14 1992-08-03 Takeda Chem Ind Ltd 発泡組成物
JPH07157431A (ja) * 1993-12-06 1995-06-20 Taiyo Yakuhin Kogyo Kk 安定なプロスタグランジンｅ製剤
JP2002524535A (ja) * 1998-09-14 2002-08-06 インヘール セラピューティック システムズ， インコーポレイテッド 乾燥粉末活性薬剤肺性送達
JP2004244353A (ja) * 2003-02-13 2004-09-02 Sankyo Agro Kk 固結性が改善された農薬粒状組成物
JP2004244359A (ja) * 2003-02-13 2004-09-02 Shirako:Kk 血管拡張性医薬及び健康食品組成物
JP2005314413A (ja) * 2004-04-02 2005-11-10 Ono Pharmaceut Co Ltd 経口投与用医薬組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69102900T3 (de) * 1990-02-14 1998-04-09 Takeda Chemical Industries Ltd Brausemischung, deren Herstellung sowie Verwendung.
TW202450B (ko) 1991-06-26 1993-03-21 Dainippon Pharmaceutical Co
JP3583166B2 (ja) 1994-06-27 2004-10-27 興和株式会社 損傷皮膚修復用粉末製剤
JPH09316006A (ja) 1996-05-29 1997-12-09 Yatsuken:Kk 口腔内溶解性固形製剤
TW486479B (en) 1997-07-15 2002-05-11 Dainippon Pharmaceutical Co 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivatives
JPH11116464A (ja) * 1997-10-09 1999-04-27 Ss Pharmaceut Co Ltd 迅速溶解性固形製剤およびその製造法
TW527195B (en) * 1997-10-09 2003-04-11 Ssp Co Ltd Fast-soluble solid pharmaceutical combinations
JP2006290561A (ja) 2005-04-12 2006-10-26 Shin Caterpillar Mitsubishi Ltd クレーン作業制御装置
ES2343432T3 (es) * 2005-04-26 2010-07-30 Dainippon Sumitomo Pharma Co., Ltd. Preparado granular que contiene un compuesto de biguanida.
CN101166534B (zh) 2005-04-28 2011-09-21 大日本住友制药株式会社 用于慢性阻塞性肺部疾病的治疗剂

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57189672A (en) * 1981-05-18 1982-11-22 Meiji Milk Prod Co Ltd Preparation of low caking powder drink
JPS58164683A (ja) * 1982-03-25 1983-09-29 Takeda Chem Ind Ltd 安定化された固体組成物
JPH04210926A (ja) * 1990-02-14 1992-08-03 Takeda Chem Ind Ltd 発泡組成物
JPH07157431A (ja) * 1993-12-06 1995-06-20 Taiyo Yakuhin Kogyo Kk 安定なプロスタグランジンｅ製剤
JP2002524535A (ja) * 1998-09-14 2002-08-06 インヘール セラピューティック システムズ， インコーポレイテッド 乾燥粉末活性薬剤肺性送達
JP2004244353A (ja) * 2003-02-13 2004-09-02 Sankyo Agro Kk 固結性が改善された農薬粒状組成物
JP2004244359A (ja) * 2003-02-13 2004-09-02 Shirako:Kk 血管拡張性医薬及び健康食品組成物
JP2005314413A (ja) * 2004-04-02 2005-11-10 Ono Pharmaceut Co Ltd 経口投与用医薬組成物

Also Published As

Publication number Publication date
JPWO2008050847A1 (ja) 2010-02-25
US20100093875A1 (en) 2010-04-15
CN101541311A (zh) 2009-09-23
WO2008050847A1 (fr) 2008-05-02
KR20090081407A (ko) 2009-07-28
EP2095812A1 (en) 2009-09-02
CN101541311B (zh) 2013-01-23
EP2095812A4 (en) 2011-07-13

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