JP5280366B2 - 抗菌剤及び宿主反応調節剤の組み合わせを含有する口腔ケア組成物 - Google Patents
抗菌剤及び宿主反応調節剤の組み合わせを含有する口腔ケア組成物 Download PDFInfo
- Publication number
- JP5280366B2 JP5280366B2 JP2009535253A JP2009535253A JP5280366B2 JP 5280366 B2 JP5280366 B2 JP 5280366B2 JP 2009535253 A JP2009535253 A JP 2009535253A JP 2009535253 A JP2009535253 A JP 2009535253A JP 5280366 B2 JP5280366 B2 JP 5280366B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- oral
- agents
- inflammatory
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
2)動脈の脂肪線条、アテローム斑、斑形成の進行、アテローム斑上の繊維性被膜の菲薄化、アテローム斑の破裂、及びその結果生じる血液凝固症状の発生の軽減;
3)頸動脈(内膜)壁の厚み(例えば超音波技術によって評価した場合の厚み)の縮小;
4)血液循環及び体循環の口腔病原体及び/又はその毒性成分への曝露の軽減(具体的には、口腔細菌、リポ多糖体(LPS)の血中濃度、並びに/又は動脈プラーク、動脈構造、及び/若しくは遠隔臓器(例えば心臓、肝臓、膵臓、腎臓)内に見られる口腔病原体及び/若しくはその成分の発生率の低下をもたらす);
5)下部呼吸器の病原菌吸入への曝露、並びにそれに伴う肺炎の発生及び/又は慢性閉塞性肺疾患の悪化の軽減;
6)循環ヘマトクリット、ヘモグロビン、白血球数、及び/又は血小板数の変化の軽減;
7)炎症性メディエータ/サイトカイン、例えばTNF−α、IL−1、IL−6、及びCD−14の血中/血清及び唾液濃度の調節障害の発生率の低下;
8)C反応性タンパク質、フィブリノゲン、α1−抗トリプシン、及びハプトグロビンなどの急性期反応物質の血流/血清及び唾液レベルの調節障害の発生率の低下;
9)ホモシステイン、グリコシル化ヘモグロビン、8−イソ−PGF−2α、及び尿酸などの代謝調節障害の血中/血清及び唾液マーカーの調節障害の発生率の低下;
10)典型的には耐糖能障害試験によって評価するようなグルコース代謝の調節障害、空腹時に上昇する血糖濃度、及び空腹時インスリン濃度異常の、発生率の低下;並びに
11)血中若しくは血清コレステロール、トリグリセリド、LDL、HDL、VLDL、アポリポタンパク質B、及び/又はアポリポタンパク質A−1などの血中脂質の濃度の調節障害の軽減。
(a)マトリックスメタロプロテイナーゼ(MMP)、シクロオキシゲナーゼ(COX)、PGE2、インターロイキン1(IL−1)、IL−1β変換酵素(ICE)、トランスフォーミング増殖因子β1(TGF−β1)、誘導型一酸化窒素シンターゼ(iNOS)、ヒアルロニダーゼ、カテプシン、核因子κB(NF−κB)、及びIL−1受容体関連キナーゼ(IRAK)から選択される少なくとも1つの宿主炎症促進性因子に対して阻害活性を有する1つ以上の第1の活性剤と;
(b)バイオフィルム形成と、バイオフィルム定着と、ジンジパイン、METアーゼ及びシスタリシン(Cystalysin)から選択される細菌酵素とから選択される細菌性病原因子の少なくとも1つに対して阻害活性を有する1つ以上の第2の活性剤との組み合わせを含む。
2オレオレジン
本発明の組成物は、任意に、最適な効果を得るために追加の治療薬を含んでいてもよい。故に、例えば、本発明の組成物は、抗菌/抗歯垢剤、バイオフィルム阻害剤、抗生物質;鎮痛剤及び局所麻酔剤;象牙質減感剤;悪臭マスキング剤、及び他の宿主反応調節剤などの追加の薬剤を含んでいてもよい。
ヒスタミン−2(H−2又はH2)受容体拮抗化合物(H−2拮抗物質)が、本発明の口腔ケア組成物に使用されてもよい。本明細書で使用するとき、選択的H−2拮抗物質は、H−2受容体を遮断するが、ヒスタミン−1(H−1又はH1)受容体の遮断に関して有意な活性の無い化合物である。選択的H−2拮抗物質は、消化管や気管支などの様々な臓器の平滑筋の収縮を刺激するが、この作用は、典型的な抗ヒスタミン剤である低濃度のメピラミンで抑制することができる。これらメピラミン感受性のヒスタミン応答に関与する薬理学的受容体は、H−1受容体と定義されている(A.S.F.アッシュ(Ash, A.S.F.)及びH.O.シルド(H.O. Schild)、「ブリティッシュ・ジャーナル・オブ・ファーマコロジー・アンド・ケモセラピー(Brit. J. Pharmacol Chemother.)」27巻、1966年、427頁)。ヒスタミンはまた、胃による酸の分泌を刺激し(E.R.ロウ(Loew, E.R.)及びO.チッカーリング(O. Chickerin)、「プロシーディングス・フォー・ザ・エクスペアリメンタル・バイオロジー・アンド・メディシン(Proc. Soc. Exp. Biol. Med.)」48巻、1941年、65頁)、心拍数を上昇させ(U.トレンデレンバーグ(Trendelenburg, U.)、「ジャーナル・オブ・ファーマコロジー(J. Pharmacol)」130巻、1960年、450頁)、ラットの子宮収縮を阻害する(P.B.デュー(Dews, P.B.)及びJ.D.P.グラハム(J.D.P. Graham)、「ブリティッシュ・ジャーナル・オブ・ファーマコロジー・アンド・ケモセラピー(Brit. J. Pharmacol Chemother.)」1巻、1946年、278頁)が、これらの作用はメピルアミン及び関連薬物によっては拮抗できない。口腔ケア組成物又は物質に有用なH−2拮抗物質は、メピラミン非感受性の非H−1(H−2)ヒスタミン応答に関与する受容体を遮断するものであり、メピラミン感受性のヒスタミン応答に関与する受容体を遮断しないものである。
他の抗炎症剤も本発明の口腔組成物に存在してもよい。これらの薬剤には、リポキシゲナーゼ阻害剤、例えばノルジヒドログアイアレチン酸;シクロオキシゲナーゼ阻害物質、例えばフルルビプロフェン;及び非ステロイド性抗炎症剤、例えばアスピリン、ケトロラク、フルルビプロフェン、イブプロフェン、ナプロキセン、インドメタシン、ケトプロフェン、ピロキシカム、メクロフェナム酸、ロフェコキシブ、セレコキシブ、及びこれらの混合物が挙げられるが、これらに限定されない。存在する場合、他の抗炎症剤は一般に、本発明の組成物の約0.001重量%〜約5重量%を構成する。ケトロラクは、米国再発行特許第036,419号(1999年11月30日発行);米国特許第5,785,951号(1998年7月28日発行)及び同第5,464,609号(1995年11月7日発行)に記載されている。
他のマトリックスメタロプロテイナーゼ阻害物質も本発明の口腔組成物に存在してもよい。メタロプロテイナーゼ(MP)は、しばしば細胞間マトリックスに作用する酵素であり、したがって組織の破壊及び再形成に関与する。MPの例には、ヒト皮膚線維芽細胞コラゲナーゼ、ヒト皮膚線維芽細胞ゼラチナーゼ、ヒト喀痰コラゲナーゼ、アグリカナーゼ及びゼラチナーゼ、並びにヒトストロメリシンが挙げられる。コラゲナーゼ、ストロメリシン、アグリカナーゼ及び関連酵素は、歯周病などの多くの症候学的疾患の媒介に重要であると考えられている。MP阻害物質の潜在的な治療上の指標については、リウマチ様関節炎(D.E.ミューリン(Mullins, D. E.)ら(「バイオキミカ・エト・バイオフィジカ・アクタ(Biochim. Biophys. Acta.)」(1983年、695巻:117〜214頁)所収);変形性関節症(B.ヘンダーソン(Henderson, B.)ら(「ドラッグス・アンド・フューチャー(Drugs of the Future)」(1990年、15巻:495〜508頁)所収);腫瘍細胞の転移(前掲論文、M.J.ブロードハースト(Broadhurst, M. J.)ら(欧州特許出願第276,436号(1987年公開))、R.ライヒ(Reich, R.)ら(「キャンサー・リサーチ(Cancer Res.)」(48巻、3307〜3312頁、1988年)所収);及び組織の様々な潰瘍形成又は潰瘍状態の治療を包含する文献中に記載されている。例えば、アルカリ火傷の結果として、又は緑膿菌、アカントアメーバ、単純ヘルペス及びワクシニア・ウイルスによる感染の結果として、角膜に潰瘍状態が起こる可能性がある。望ましくないメタロプロテアーゼ活性を特徴とする状態の他の例とには、歯周病、表皮水疱症、発熱、炎症、及び強膜炎が挙げられる(デチッコ(DeCicco)ら、PCT国際公開特許第95/29892号(1995年11月9日公開))。
細胞の酸化還元状態の調整剤には、酸化防止剤(例えば、N−アセチルシステイン及び没食子酸)、酸化防止酵素誘発因子(例えば、アネトール−ジチオチオン、オルチプラッツ、ピロリジンジチオカルバメート(PDTC)及びインドール−3−カルビノール)、栄養素及びビタミン(例えば、補酵素Q10、ピロロキノリンキノン(PQQ)、ビタミンA、C、及びE、セレン及びこれらの組み合わせ)が挙げられる。
口腔に許容可能なキャリアは、局所的口腔投与に好適な1種以上の混和性のある固体若しくは液体賦形剤、又は希釈剤を含む。本明細書で使用するとき、「混和性のある」とは、組成物の成分が、実質的に組成物の安定性及び/又は効果を低下させるような方法で相互作用することなく混合し得ることを意味する。これらの物質は、当該技術分野において周知であり、組成物が調製されるのに望ましい物理的、審美的及び性能特性に基づいて当業者によって容易に選択される。これらのキャリアは、典型的には、口腔用組成物の約50重量%〜約99重量%、好ましくは約70重量%〜約98重量%、より好ましくは約90重量%〜約95重量%の濃度で含まれてもよい。
本発明の口腔用組成物は、任意に、生物学的に利用可能で有効なフッ化物イオンを提供することができる可溶性フッ化物源を包含する。可溶性フッ化物イオン源には、フッ化ナトリウム、フッ化第一スズ、フッ化インジウム、フッ化アミン及びモノフルオロリン酸ナトリウムが挙げられる。フッ化第一スズは好ましい可溶性フッ化物源である。この成分は、第一スズイオン源及びフッ化物源の両方として作用できる。米国特許第2,946,725号(ノリス(Norris)ら、1960年7月26日発行)及び同第3,678,154号(ウィダー(Widder)ら、1972年7月18日発行)は、このようなフッ化物源、並びにその他の物質を開示している。
本発明は、組成物中に過酸化物源を含んでいてもよい。白化に加えて、過酸化物はまた口腔に他の効果も提供する。過酸化水素及び他の過酸素化合物は、虫歯、歯垢、歯肉炎、歯周炎、口臭、慢性再発性アフター性潰瘍、義歯の炎症、歯列矯正装置の損傷、抜歯後及び歯根膜手術後、外傷性口腔病変、並びに粘膜感染、ヘルペス口内炎などに対する治療的及び/又は予防的処置に有効であると長い間認められてきた。口腔内の過酸化物含有剤は、組織及び唾液酵素との相互作用によって生じる何千もの小さな酸素の泡を生成する化学機械的作用を及ぼす。口内洗浄剤の激しい動き(swishing action)が、この特有の化学機械的作用を増強する。そのような作用は、その他の剤を感染した歯肉のクレバスに送達するために推奨されてきた。故に、過酸化物は、歯周病と関連することが知られている嫌気性細菌のコロニー形成及び増殖を防ぎ、本明細書で使用するのに好ましい抗菌剤の1つである。
本発明はまたアルカリ金属重炭酸塩を包含してもよい。重曹としても知られている重炭酸ナトリウムは、好ましいアルカリ金属重炭酸塩である。上記で示したように、重曹はある程度の抗菌及び抗炎症活性を有し、故に活性成分として使用されてもよい。アルカリ金属重炭酸塩はまた緩衝剤としても機能する。本組成物は、口腔用組成物の約0.5重量%〜約50重量%、好ましくは約0.5重量%〜約30重量%、より好ましくは約2重量%〜約20重量%、最も好ましくは約5重量%〜約18重量%のアルカリ金属重炭酸塩を含有してもよい。
本組成物は、任意に、キレート化活性を有する物質であり、歯石形成に関連する鉱物の沈着を低減するのに有効な抗結石剤を含んでいてもよい。このようなキレート剤は、細菌の細胞壁に見られるカルシウムを錯化でき、更にこのバイオマスをそのまま保持するのに役立つカルシウム架橋からカルシウムを除去することによって歯垢を分解できる。しかしながら、カルシウムに対する親和性が高すぎるキレート剤を用いることは、結果として歯の脱ミネラル化(demineralization)をもたらす可能性があり、これは本発明の目的及び意図に反するために、望ましくない。好適なキレート剤は、通常はカルシウム結合定数が約101〜105であり、洗浄を改善し、歯垢及び結石の形成を減少させる。キレート剤はまた、金属イオンと錯化することができ、故に組成物に存在する場合に第一スズを安定化するために使用することができる。
本発明の組成物の局所口腔キャリアにおいて有用な歯科用研磨剤には、多くの様々な物質が含まれる。選択される物質は、目的の組成物中で混和性があり、象牙質を過度に削らないものでなければならない。好適な研磨剤には、例えば、ゲル及び沈殿物を包含するシリカ、不溶性ポリメタリン酸ナトリウム、水和アルミナ、炭酸カルシウム、オルトリン酸二カルシウム二水和物、ピロリン酸カルシウム、リン酸三カルシウム、ポリメタリン酸カルシウム、及び尿素とホルムアルデヒドとの粒子状縮合生成物のような樹脂性研磨剤物質が挙げられる。
商業的に好適な口腔用組成物の調製に用いる水は、好ましくは、イオン含量が少なく、有機不純物を含まないものであるべきである。口腔用組成物において、水は、本明細書の組成物の0重量%〜約95重量%、好ましくは約5重量%〜約50重量%を占めてもよい。水の量には、添加される遊離水に加えてソルビトール、シリカ、界面活性剤溶液、及び/又は着色剤溶液など他の物質と共に導入される水が包含される。
本組成物は緩衝剤を含有してもよい。本明細書で使用するとき、緩衝剤とは、組成物のpHをpH約3.0〜pH約10の範囲に調整するために用いることができる薬剤を指す。
練り歯磨き又はゲルを調製する際には、組成物の望ましい稠度を提供し、使用に際した望ましい活性剤放出特性を提供し、貯蔵安定性を提供し、組成物などの安定性を提供するために、いくつかの増粘物質を加えることが必要である。好ましい増粘剤は、カルボキシビニルポリマー、カラギーナン、ヒドロキシエチルセルロース、ラポナイト、並びにカルボキシメチルセルロースナトリウム及びカルボキシメチルヒドロキシエチルセルロースナトリウムのようなセルロースエーテルの水溶性塩である。カラヤゴム、キサンタンガム、アラビアゴム、及びトラガカントゴムのような天然ゴムを使用することもできる。更に質感を改善するために、コロイド状ケイ酸アルミニウムマグネシウム又は超微粒子状シリカを増粘剤の一部として使用することができる。
本発明の組成物の局所的な口腔キャリアの別の任意成分は、保湿剤である。保湿剤は、練り歯磨き組成物が空気への曝露時に硬化するのを防ぎ、組成物に口への潤い感を付与し、特定の保湿剤では、練り歯磨き組成物に望ましい甘い香味を付与するのに役立つ。保湿剤は、純保湿剤を基準にすると、一般に本明細書の組成物の約0重量%〜約70重量%、好ましくは約5重量%〜約25重量%を構成する。本発明の組成物における使用に好適な保湿剤には、グリセリン、ソルビトール、キシリトール、ブチレングリコール、ポリエチレングリコール及びプロピレングリコールのような食用多価アルコール、特にソルビトール及びグリセリンが挙げられる。
着香剤もまた、組成物に添加してもよい。好適な着香剤には、ウインターグリーン油、ペパーミント油、スペアミント油、クローブ芽油、メンソール、アネトール、サリチル酸メチル、オイカリプトール、カッシア、1−メンチルアセテート、セージ、オイゲノール、パセリ油、オキサノン(oxanone)、α−イリソン、マジョラム、レモン、オレンジ、プロペニルグエトール、シナモン、バニリン、チモール、リナロール、CGAとして知られるシンナムアルデヒドグリセロールアセタール、及びこれらの混合物が挙げられる。着香剤は、一般に組成物中で、組成物の約0.001重量%〜約5重量%の濃度で用いられる。
本組成物はまた、一般的に起泡剤とも呼ばれる界面活性剤を含んでもよい。好適な界面活性剤は、広いpH範囲にわたって適度に安定かつ発泡性であるものである。界面活性剤は、アニオン性、非イオン性、両性、双性イオン性、カチオン性、又はこれらの混合物であってよい。
本組成物に使用してよい他の乳化剤としては、B.F.グッドリッチ(B.F.Goodrich)から入手可能なペミュレン(Pemulen)(登録商標)シリーズのようなポリマー性乳化剤が挙げられ、これは、主に、疎水性物質用の乳化剤として有用な高分子量のポリアクリル酸ポリマーである。
1つ以上の抗菌剤及び抗炎症剤の組み合わせを含む安全で有効な量の本発明の組成物は、患者の口腔の上述した疾患及び状態の治療又は予防のために、いくつかの従来の方法で、口腔の粘膜組織、口腔の歯肉組織、及び/又は歯の表面に局所適用してもよい。患者は、歯垢、歯肉炎及び歯周炎を包含する口腔状態の治療又は予防の必要なヒト又は動物であってもよい。「動物」とは、特に家庭用ペット若しくは他の家畜、又は捕獲されている動物を包含することを意味する。
調査は、イヌ科動物モデルにてリボフラビン+塩化セチルピリジニウム(CPC)リンスの生体内効果を評価するために行われた。調査の初めに、ビーグル犬披検体は予防処置を受けた。約1週間後、ビーグル犬は基準歯肉炎指数(GI)及び歯垢指数について類別された。歯肉炎指数は、0〜3の等級である(0=炎症なし;1=炎症が存在し、歯肉は赤色である;2=プロービング時に出血;3=自然に出血)。歯垢指数は各歯の歯垢被覆%である。SASランダム化プログラムを用いて基準炎症指数(II)スコアのバランスをとった治療群に犬をランダムに振り分けた。治療は振り分け後の次の日に開始した。動物は、歯/歯肉をスプレーミストボトルを用いて、30日間平日は1日2回、週末には1日1回局所治療された(30mL/治療)。30日の終わりに、動物は最終的な臨床類別を行われた。
Claims (4)
- リボフラビンと、塩化セチルピリジニウムと、口腔に許容可能なキャリアとを含む、口内洗浄剤の形態である局所口腔用組成物であって、口腔細菌感染及び全身系疾患を有する又は発生する危険性のある患者にて、口腔細菌感染を治療又は予防し、口腔細菌感染によって媒介される全身系疾患を阻害するための、局所口腔用組成物。
- アスピリン、ケトロラク、フルルビプロフェン、イブプロフェン、ナプロキセン、インドメタシン、ケトプロフェン、ピロキシカム、メクロフェナム酸、ノルジヒドログアイアレチン酸、及びこれらの混合物から選択される抗炎症剤を更に含む、請求項1に記載の局所口腔用組成物。
- 補酵素Q10、PQQ、ビタミンC、ビタミンE、ビタミンA、アネトール−ジチオチオン、及びこれらの混合物からなる群から選択される細胞酸化還元状態調整剤である宿主反応調節剤を更に含む、請求項1に記載の局所口腔用組成物。
- 前記組成物が、抗菌/抗歯垢剤、バイオフィルム阻害剤、抗生物質、鎮痛剤、局所用麻酔剤、象牙質減感剤、悪臭マスキング剤、及びこれらの混合物から選択される追加の治療活性物質を含む、請求項1に記載の局所口腔用組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/595,530 US8283135B2 (en) | 2000-06-30 | 2006-11-10 | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
US11/595,530 | 2006-11-10 | ||
PCT/US2007/007972 WO2008057136A1 (en) | 2006-11-10 | 2007-03-30 | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010508346A JP2010508346A (ja) | 2010-03-18 |
JP5280366B2 true JP5280366B2 (ja) | 2013-09-04 |
Family
ID=38461711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009535253A Expired - Fee Related JP5280366B2 (ja) | 2006-11-10 | 2007-03-30 | 抗菌剤及び宿主反応調節剤の組み合わせを含有する口腔ケア組成物 |
Country Status (12)
Country | Link |
---|---|
US (1) | US8283135B2 (ja) |
EP (2) | EP2415473B1 (ja) |
JP (1) | JP5280366B2 (ja) |
CN (2) | CN101534823A (ja) |
AU (1) | AU2007318251B2 (ja) |
BR (1) | BRPI0718699A2 (ja) |
CA (1) | CA2669019C (ja) |
ES (1) | ES2395854T3 (ja) |
MX (1) | MX2009004973A (ja) |
MY (1) | MY157928A (ja) |
RU (1) | RU2448711C2 (ja) |
WO (1) | WO2008057136A1 (ja) |
Families Citing this family (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060141039A1 (en) * | 2004-12-23 | 2006-06-29 | Colgate-Palmolive Company | Oral compositions containing oxidized camellia |
JP2009541345A (ja) | 2006-06-20 | 2009-11-26 | イズン ファーマシューティカルズ コーポレイション | 抗炎症可溶フィルム |
US9155769B2 (en) | 2006-07-07 | 2015-10-13 | The Procter & Gamble Co | Flavor oils with reduced dimethyl sulfoxide content and use in oral compositions |
US8007771B2 (en) † | 2006-07-07 | 2011-08-30 | The Procter & Gamble Company | Flavors for oral compositions |
WO2008011556A2 (en) * | 2006-07-20 | 2008-01-24 | Izun Pharmaceuticals Corporation | Film-delivering rinse |
WO2008021088A2 (en) * | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
WO2008042944A2 (en) * | 2006-10-05 | 2008-04-10 | The Trustees Of Columbia University In The City Of New York | Non-irritating oral care formulations |
US8338352B2 (en) * | 2007-05-07 | 2012-12-25 | Ecolab Usa Inc. | Solidification matrix |
CA2684150C (en) | 2007-05-14 | 2016-10-04 | Research Foundation Of State University Of New York | Decenoic acid dispersion inducers in the treatment of biofilms |
US8759269B2 (en) * | 2007-07-02 | 2014-06-24 | Ecolab Usa Inc. | Solidification matrix including a salt of a straight chain saturated mono-, di-, and tri- carboxylic acid |
US9616006B2 (en) | 2007-10-10 | 2017-04-11 | DermaMedics, LLC | Methods and compositions for treating dermatological diseases and conditions |
CA2740200C (en) * | 2007-10-10 | 2015-01-13 | Therametics, Llc | Methods and compositions for treating dermatological diseases and conditions |
US8198228B2 (en) * | 2008-01-04 | 2012-06-12 | Ecolab Usa Inc. | Solidification matrix using an aminocarboxylate |
US8138138B2 (en) * | 2008-01-04 | 2012-03-20 | Ecolab Usa Inc. | Solidification matrix using a polycarboxylic acid polymer |
US8772221B2 (en) | 2008-01-04 | 2014-07-08 | Ecolab Usa Inc. | Solidification matrices using phosphonocarboxylic acid copolymers and phosphonopolyacrylic acid homopolymers |
AR070356A1 (es) * | 2008-02-08 | 2010-03-31 | Colgate Palmolive Co | Producto para cuidado oral y metodos de uso del mismo |
MX357344B (es) * | 2008-02-08 | 2018-07-05 | Colgate Palmolive Co | Producto para el cuidado oral y métodos de uso y fabricación del mismo. |
BRPI0906462A2 (pt) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Método para tratar, melhorar, inibir ou evitar boca seca, saliva artificial, uso de um aminoácido básico em forma livre ou de sal, e, aminoácido básico em forma livre ou de sal |
CN102124337B (zh) * | 2008-06-13 | 2015-06-10 | Alt生物科学有限责任公司 | 用于疾病相关的硫醇化合物的快速测定的设备 |
WO2010006192A1 (en) * | 2008-07-09 | 2010-01-14 | Board Of Regents Of The University Of Nebraska | Functional micelles for hard tissue targeted delivery of chemicals |
PL219098B1 (pl) * | 2008-08-28 | 2015-03-31 | Akademia Medyczna Im Piastów Śląskich We Wrocławiu | Kompozycja farmaceutyczna do leczenia chorób przyzębia |
US8273385B1 (en) * | 2008-10-17 | 2012-09-25 | Thres Flo, LLC | Oral rinse composition and method |
MX2011004155A (es) * | 2008-10-20 | 2011-05-23 | Unilever Nv | Una composicion antimicrobiana. |
GB0905864D0 (en) * | 2009-04-03 | 2009-05-20 | Glaxo Group Ltd | Novel use |
GB0905863D0 (en) | 2009-04-03 | 2009-05-20 | Glaxo Group Ltd | Novel composition |
US8962057B2 (en) * | 2009-04-29 | 2015-02-24 | The Procter & Gamble Company | Methods for improving taste and oral care compositions with improved taste |
US8222192B2 (en) * | 2009-06-19 | 2012-07-17 | R&W Medical LLC | Alcohol-based skin cleanser |
JP5844260B2 (ja) | 2009-09-24 | 2016-01-13 | ユニリーバー・ナームローゼ・ベンノートシヤープ | オイゲノール、テルピネオールおよびチモールを含む殺菌剤 |
TR200907338A1 (tr) * | 2009-09-28 | 2011-04-21 | Yedi̇tepe Üni̇versi̇tesi̇ | Doğal bileşenler içeren bir film şeridi. |
BR112012007399A2 (pt) * | 2009-09-29 | 2016-08-09 | United Technologies Ut Ag | composição de cuidado oral, usos da interleucina-1 recombinante humana e métodos para reduzir o mau hálito e para o tratamento ou prevenção de doença periodontal. |
US20110117515A1 (en) * | 2009-11-03 | 2011-05-19 | Jennifer Jablow | Device and method for tooth and gum cleaning for pets using a pen delivery and tooth gel |
US8530403B2 (en) * | 2009-11-20 | 2013-09-10 | Ecolab Usa Inc. | Solidification matrix using a maleic-containing terpolymer binding agent |
EP2504025A4 (en) * | 2009-11-23 | 2013-05-01 | Stephen F Olmstead | COMPOSITIONS AND METHODS USING SERRATIA PEPTIDASE FOR INHIBITING AND TREATING BIOFILMS ASSOCIATED WITH PARTICULAR SUFFERING |
US20110124547A1 (en) * | 2009-11-23 | 2011-05-26 | Ecolab Inc. | Solidification matrix using a sulfonated/carboxylated polymer binding agent |
TWI492744B (zh) * | 2009-12-04 | 2015-07-21 | Abbott Lab | 使用類胡蘿蔔素調節早產兒發炎症之方法 |
US20120308488A1 (en) * | 2010-01-29 | 2012-12-06 | Colgate-Palmolive Company | Oral care product for sensitive enamel care |
MY179976A (en) * | 2010-01-29 | 2020-11-19 | Colgate Palmolive Co | Oral care product for sensitive enamel care |
CN101962651B (zh) * | 2010-02-05 | 2012-06-13 | 中山大学 | 一种来自深海宏基因组的l-蛋氨酸裂解酶基因及其表达产物 |
MY162557A (en) * | 2010-02-26 | 2017-06-15 | Oral Health Australia Pty Ltd | Treatment or prevention of infection |
GB201004981D0 (en) | 2010-03-24 | 2010-05-12 | Glaxo Group Ltd | Novel use |
BR112012025488B1 (pt) * | 2010-04-09 | 2020-12-29 | Unilever N.V | composição de cuidados orais e uso de uma fonte de íons de zinco |
AT509777B1 (de) * | 2010-04-30 | 2012-03-15 | Orphanidis Pharma Res Gmbh | Adhesive retardformulierungen zur lokalen verabreichung von curcumin |
US9579269B2 (en) | 2010-06-23 | 2017-02-28 | Colgate-Palmolive Company | Therapeutic oral composition |
GB2481630A (en) * | 2010-07-01 | 2012-01-04 | Robert Taylor | Composition for dental health |
CN103153272A (zh) | 2010-07-19 | 2013-06-12 | 宝洁公司 | 包含精油化合物的衍生物的组合物以及在个人护理产品中的用途 |
JP5884731B2 (ja) * | 2010-08-09 | 2016-03-15 | 三菱瓦斯化学株式会社 | ピロロキノリンキノンのゲル |
EP2621457B1 (en) | 2010-10-01 | 2017-08-23 | Swissdent Cosmetics AG | Oxidative stable micellar compositions |
MX345131B (es) * | 2010-11-04 | 2017-01-17 | Colgate Palmolive Co | Composicion dentifrica con astringencia reducida. |
CA2816635A1 (en) * | 2010-11-05 | 2012-05-10 | Idemitsu Kosan Co., Ltd. | Cashew nut shell liquid with improved stability |
CN102166171A (zh) * | 2010-11-29 | 2011-08-31 | 吴克 | 漱口泡腾片及其制备工艺 |
GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
EA022986B1 (ru) | 2010-12-07 | 2016-04-29 | Юнилевер Нв | Композиция для ухода за полостью рта |
SG190974A1 (en) | 2010-12-23 | 2013-07-31 | Colgate Palmolive Co | Aqueous oral care composition comprising xanthan gum, cellulose gum and carbomer |
US11147751B2 (en) | 2010-12-23 | 2021-10-19 | Colgate-Palmolive Company | Fluid compositions comprising a structuring agent |
JP6291151B2 (ja) * | 2011-03-31 | 2018-03-14 | 小林製薬株式会社 | 口腔用組成物 |
WO2013015979A2 (en) * | 2011-07-26 | 2013-01-31 | Wm. Wrigley Jr. Company | Compositions containing zinc salts and isothiocyanates for reduction of oral volatile sulfur compounds (vscs) |
US9421180B2 (en) | 2011-09-30 | 2016-08-23 | Perio Sciences, Llc | Antioxidant compositions for treatment of inflammation or oxidative damage |
BR112014009479B8 (pt) | 2011-11-03 | 2019-01-29 | Unilever Nv | composição líquida de limpeza pessoal e método de desinfecção da superfície externa |
EP2782550A2 (en) * | 2011-11-25 | 2014-10-01 | Unilever N.V. | An oral care composition comprising polyphenol |
US20130149359A1 (en) * | 2011-12-12 | 2013-06-13 | Eric M. Sanders | Effervescent Mouthwash |
CN102631373B (zh) * | 2012-04-17 | 2014-04-16 | 周佐石 | 一种快速治疗口腔溃疡的药物香口胶 |
KR101450098B1 (ko) | 2012-05-04 | 2014-10-14 | 동의대학교 산학협력단 | 푸코이단을 유효성분으로 포함하는 구강 세정용 조성물 |
US20130344120A1 (en) | 2012-06-21 | 2013-12-26 | Douglas Craig Scott | Mouth Rinse Emulsions |
US10123953B2 (en) | 2012-06-21 | 2018-11-13 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
US20150297490A1 (en) * | 2012-11-26 | 2015-10-22 | Apollonia Health Inc. | Compositions, uses and methods for treating or preventing dental caries |
WO2014124950A1 (en) | 2013-02-14 | 2014-08-21 | Glaxo Group Limited | Novel composition |
US11007143B2 (en) | 2013-03-15 | 2021-05-18 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body |
US11318089B2 (en) | 2013-03-15 | 2022-05-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body |
US11000545B2 (en) | 2013-03-15 | 2021-05-11 | Cda Research Group, Inc. | Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza |
US11083750B2 (en) | 2013-03-15 | 2021-08-10 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
US10398733B2 (en) | 2013-03-15 | 2019-09-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
CN103301064B (zh) * | 2013-06-04 | 2016-04-20 | 北京四环生物制药有限公司 | 一种白介素-2或其衍生物鼻喷剂及其制备方法 |
US9757209B2 (en) * | 2013-07-03 | 2017-09-12 | Essential Dental Systems, Inc. | Compositions and methods for dental applications involving zinc-oxide cements |
US9326922B2 (en) * | 2014-01-15 | 2016-05-03 | The Procter & Gamble Company | Oral care compositions containing high purity barium sulfate particles |
AU2015208739B2 (en) * | 2014-01-27 | 2020-04-16 | Aidance Skincare & Topical Solutions Llc | Topical antibiotic formulations |
US10154948B2 (en) * | 2014-06-20 | 2018-12-18 | Colgate-Palmolive Company | Oral compositions containing zinc, stannous and fluoride ion sources |
CA2952630A1 (en) * | 2014-06-28 | 2015-12-30 | Relevance Health | System for assessing global wellness |
WO2016004597A1 (en) * | 2014-07-10 | 2016-01-14 | The Procter & Gamble Company | Anti-calculus oral compositions |
MX2017003599A (es) | 2014-09-24 | 2017-07-13 | Colgate Palmolive Co | Biodisponibilidad de iones de metal. |
US10524488B2 (en) | 2014-12-17 | 2020-01-07 | Colgate-Palmolive Company | Composition and method for reducing or treating oral inflammation |
US20180153779A1 (en) * | 2015-04-14 | 2018-06-07 | Kenneth Davin Fine | Dental Hygiene Systems |
JP6551924B2 (ja) * | 2015-05-25 | 2019-07-31 | 学校法人近畿大学 | 歯周病改善剤及びその製造方法 |
RU2602684C1 (ru) * | 2015-06-10 | 2016-11-20 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Нижегородская государственная медицинская академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО НижГМА Минздрава России) | Способ лечения хронического рецидивирующего афтозного стоматита |
WO2016208582A1 (ja) * | 2015-06-22 | 2016-12-29 | 株式会社明治 | がん患者のための口腔ケア用組成物 |
CN104940194A (zh) * | 2015-06-24 | 2015-09-30 | 安徽四正医药科技有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗顽固性牙周炎药物的应用 |
BR112018009609B1 (pt) | 2015-11-13 | 2021-03-16 | The Procter & Gamble Company | composições dentifrícias com absorção melhorada de fluoreto |
CN108348414A (zh) | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有双氟化物源与改善的氟化物摄取的牙粉组合物 |
CN108348442A (zh) * | 2015-11-13 | 2018-07-31 | 宝洁公司 | 具有抗牙垢和抗菌有益效果的牙粉组合物 |
WO2017079953A1 (en) | 2015-11-13 | 2017-05-18 | The Procter & Gamble Company | Dentifrice compositions with improved fluoride stability |
US10702571B2 (en) | 2015-12-03 | 2020-07-07 | The University Of North Carolina At Pembroke | Materials for cathepsin B enhancement and methods of use |
WO2017106763A1 (en) * | 2015-12-17 | 2017-06-22 | Colgate-Palmolive Company | Oral care compositions comprising at least one phosphate/acrylate copolymer and at least one cationic active ingredient |
CN108463208B (zh) | 2015-12-30 | 2021-12-07 | 高露洁-棕榄公司 | 口腔护理组合物 |
CN109069391B (zh) | 2015-12-30 | 2022-02-11 | 高露洁-棕榄公司 | 口腔护理组合物 |
EP3380064B1 (en) | 2015-12-30 | 2020-05-06 | Colgate-Palmolive Company | Personal care compositions |
CN108472209B (zh) | 2015-12-30 | 2021-06-25 | 高露洁-棕榄公司 | 个人护理组合物 |
US11020441B2 (en) * | 2016-01-19 | 2021-06-01 | Symrise Ag | Probiotics for use as anti-inflammatory agents in the oral cavity |
GB201607518D0 (en) | 2016-04-29 | 2016-06-15 | Andalay Technologies Ltd | Mouthwash composition |
BR112018075900B1 (pt) * | 2016-06-24 | 2022-07-19 | Colgate-Palmolive Company | Composições para higiene bucal |
CN106074192B (zh) * | 2016-07-01 | 2019-08-06 | 好来化工(中山)有限公司 | 抗氧化的口腔护理组合物 |
WO2018058498A1 (en) | 2016-09-30 | 2018-04-05 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
BR112019018084A2 (pt) * | 2017-03-03 | 2020-03-24 | The Procter & Gamble Company | Métodos para quantificar íons em um biofilme dental |
JP2018184362A (ja) * | 2017-04-25 | 2018-11-22 | 株式会社R−good | 殺菌性組成物 |
IE87094B1 (en) * | 2017-08-04 | 2020-05-13 | Laboratorios Kin S A | Gel comprising chlorhexidine |
KR102010691B1 (ko) * | 2018-01-05 | 2019-08-13 | 제주대학교 산학협력단 | 프라톨을 이용한 항염증용 조성물 |
CN111936114B (zh) | 2018-03-29 | 2023-11-17 | 宝洁公司 | 用于促进牙龈健康的口腔护理组合物 |
AU2018415261B2 (en) | 2018-03-29 | 2021-11-04 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
JP7058343B2 (ja) | 2018-03-29 | 2022-04-21 | ザ プロクター アンド ギャンブル カンパニー | 歯肉健康を促進するための口腔ケア組成物 |
CN111989083B (zh) | 2018-03-29 | 2024-02-13 | 宝洁公司 | 用于促进牙龈健康的口腔护理组合物 |
CN108834889B (zh) * | 2018-05-31 | 2021-11-30 | 贵州盛达生植物发展有限公司 | 一种提升铁皮石斛抗病性的组培苗培育方法 |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
WO2020005841A1 (en) | 2018-06-25 | 2020-01-02 | Triumph Pharmaceuticals Inc. | Methods of inhibiting microbial infections using zinc-containing compositions |
CN112770740B (zh) * | 2018-08-17 | 2023-01-17 | 纳米智能生物医学工程有限公司 | 用于治疗和预防龈牙周炎或种植体周围炎的组合物以及涂覆有该组合物的牙间刷 |
US11865107B2 (en) * | 2018-11-21 | 2024-01-09 | Asclepius Pharmaceutical, LLC | Pharmaceutical composition |
US20220071868A1 (en) * | 2018-12-26 | 2022-03-10 | Colgate-Palmolive Company | Methods of Inhibiting Neutrophil Recruitment to the Gingival Crevice |
EP3883529A1 (en) * | 2018-12-26 | 2021-09-29 | Colgate-Palmolive Company | Oral care compositions |
US20220071867A1 (en) * | 2018-12-26 | 2022-03-10 | Colgate-Palmolive Company | Methods of Inhibiting Neutrophil Recruitment to the Gingival Crevice |
US11193184B2 (en) | 2019-02-22 | 2021-12-07 | Cda Research Group, Inc. | System for use in producing a metal ion suspension and process of using same |
JP2019142863A (ja) * | 2019-02-28 | 2019-08-29 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 口内炎症を減少または治療するための組成物および方法 |
US20200338016A1 (en) * | 2019-04-26 | 2020-10-29 | Mark Edward Fenzl | Combination broad-spectrum antibiotic preparations for drug-resistant pathogens |
CN113747948B (zh) | 2019-04-26 | 2023-12-15 | 宝洁公司 | 减少来源于阳离子抗微生物剂的牙齿变色 |
US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
JP7414973B2 (ja) | 2019-09-30 | 2024-01-16 | ザ プロクター アンド ギャンブル カンパニー | 歯科バイオフィルムの処置のための歯磨剤組成物 |
WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
CN114466651A (zh) | 2019-09-30 | 2022-05-10 | 宝洁公司 | 使用包含啤酒花的口腔护理组合物的方法 |
AU2019468797A1 (en) | 2019-09-30 | 2022-03-17 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
JP6871555B2 (ja) * | 2019-10-04 | 2021-05-12 | 国立大学法人大阪大学 | 歯周病菌細胞侵入抑制用組成物 |
CA3164386A1 (en) | 2020-02-18 | 2021-08-26 | Kana Hashimoto | Oral care composition |
CN111329875B (zh) * | 2020-02-26 | 2023-07-21 | 好维股份有限公司 | 用于修复口腔软组织细胞的口腔护理组合物及应用 |
CN113384479B (zh) * | 2020-03-13 | 2023-07-21 | 好维股份有限公司 | 一种口腔护理组合物 |
EP4018196A1 (en) * | 2020-04-02 | 2022-06-29 | Colgate-Palmolive Company | Compositions for and methods of neutralizing lipopolysaccharide toxicity and methods of identifying the same |
JP2021183584A (ja) * | 2020-05-22 | 2021-12-02 | 小林製薬株式会社 | オートインデューサー−2阻害剤 |
WO2021242461A1 (en) * | 2020-05-27 | 2021-12-02 | Brilliant Lab LLC | Nutrient composition able to inhibit quorum sensing |
CN111888531A (zh) * | 2020-08-14 | 2020-11-06 | 广州润虹医药科技股份有限公司 | 一种引导性组织再生膜及其制备方法 |
US11458220B2 (en) | 2020-11-12 | 2022-10-04 | Singletto Inc. | Microbial disinfection for personal protection equipment |
AU2022277813A1 (en) * | 2021-05-21 | 2024-01-18 | Cancer Research And Biotechnology Ag | Compounds inhibiting the synergistic carsinogenic effect of heavy metals in the presence of other carcinogens for use in the treatment of cancer |
CN114469911A (zh) * | 2022-04-14 | 2022-05-13 | 南方科技大学 | 结核萘醌或其类似物在制备铜绿假单胞菌抑制药物中的应用 |
WO2023200910A2 (en) * | 2022-04-15 | 2023-10-19 | Creighton University | Accelerated tooth remineralization technology |
CN114917320A (zh) * | 2022-04-18 | 2022-08-19 | 重庆功存科技有限公司 | 三七总皂苷与茶多酚合成的口腔抑菌喷剂 |
CN115518005B (zh) * | 2022-10-24 | 2023-06-20 | 海南省人民医院 | 一种口腔护理凝胶及其制备方法 |
Family Cites Families (169)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL46892C (ja) | 1936-02-15 | |||
BE519897A (ja) | 1952-05-13 | |||
US2946725A (en) | 1957-03-25 | 1960-07-26 | Procter & Gamble | Dentifrice compositions |
US3070510A (en) | 1959-11-03 | 1962-12-25 | Procter & Gamble | Dentifrice containing resinous cleaning agents |
US3538230A (en) | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
US3678154A (en) | 1968-07-01 | 1972-07-18 | Procter & Gamble | Oral compositions for calculus retardation |
US4136163A (en) | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
US3737533A (en) | 1971-04-28 | 1973-06-05 | Upjohn Co | Compositions and methods of combatting insects using 1'-variable-1',1'-dihalohalobenzeneazomethanes |
US3864472A (en) | 1972-11-06 | 1975-02-04 | Colgate Palmolive Co | Clear lemon-flavored mouthwash |
US3959458A (en) | 1973-02-09 | 1976-05-25 | The Procter & Gamble Company | Oral compositions for calculus retardation |
US3862307A (en) | 1973-04-09 | 1975-01-21 | Procter & Gamble | Dentifrices containing a cationic therapeutic agent and improved silica abrasive |
US3988433A (en) | 1973-08-10 | 1976-10-26 | The Procter & Gamble Company | Oral compositions for preventing or removing stains from teeth |
US4089880A (en) | 1975-03-13 | 1978-05-16 | Sullivan Systems Inc. | Proces for refining fatty oils |
US4083955A (en) | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
US4051234A (en) | 1975-06-06 | 1977-09-27 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
US4137303A (en) | 1975-06-18 | 1979-01-30 | Colgate Palmolive Company | Antibacterial oral composition |
US4118776A (en) * | 1975-07-17 | 1978-10-03 | Nippon Electric Company, Ltd. | Numerically controlled machine comprising a microprogrammable computer operable with microprograms for macroinstructions and for inherent functions of the machine |
US4042679A (en) | 1975-11-07 | 1977-08-16 | Colgate-Palmolive Company | Antibacterial oral composition |
US4370314A (en) | 1975-12-08 | 1983-01-25 | Colgate-Palmolive Company | Oral composition containing antibacterial agent |
US4206215A (en) | 1976-02-25 | 1980-06-03 | Sterling Drug Inc. | Antimicrobial bis-[4-(substituted-amino)-1-pyridinium]alkanes |
US4138477A (en) | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
US4118474A (en) | 1976-08-16 | 1978-10-03 | Colgate-Palmolive Company | Antibacterial oral composition |
US4118475A (en) | 1976-08-16 | 1978-10-03 | Colgate-Palmolive Company | Antibacterial oral composition |
US4118476A (en) | 1976-08-16 | 1978-10-03 | Colgate-Palmolive Company | Antibacterial oral composition |
US4118473A (en) | 1976-08-16 | 1978-10-03 | Colgate-Palmolive Company | Antibacterial oral composition |
US4118472A (en) | 1976-08-16 | 1978-10-03 | Colgate-Palmolive Company | Antibacterial oral composition |
US4080441A (en) | 1976-12-27 | 1978-03-21 | Colgate-Palmolive Company | Antibacterial oral composition |
US4188372A (en) | 1976-12-27 | 1980-02-12 | Colgate-Palmolive Company | Antibacterial oral composition |
US4110429A (en) | 1976-12-30 | 1978-08-29 | Colgate-Palmolive Company | Antibacterial oral composition |
US4183914A (en) | 1977-12-19 | 1980-01-15 | Abdul Gaffar | Magnesium polycarboxylate complexes and anticalculus agents |
US4256730A (en) | 1978-08-24 | 1981-03-17 | The Procter & Gamble Company | Oral compositions |
US4273759A (en) | 1979-05-18 | 1981-06-16 | Colgate-Palmolive Company | Antibacterial oral composition |
US4340583A (en) | 1979-05-23 | 1982-07-20 | J. M. Huber Corporation | High fluoride compatibility dentifrice abrasives and compositions |
US4224309A (en) | 1979-08-24 | 1980-09-23 | Colgate-Palmolive Company | Antibacterial oral composition |
US4325939A (en) | 1980-09-22 | 1982-04-20 | Richardson-Vicks Inc. | Zinc derivatives and their use in dental compositions |
US4339430A (en) | 1980-12-31 | 1982-07-13 | Colgate-Palmolive Company | Antibacterial oral composition |
US4599228A (en) | 1981-01-19 | 1986-07-08 | Vipont Laboratories, Inc. | Antimicrobial agent |
US4323551A (en) | 1981-02-19 | 1982-04-06 | The Procter & Gamble Company | Mouthwash compositions |
JPS5888334A (ja) | 1981-11-20 | 1983-05-26 | Takasago Corp | 3−l−メントキシプロパン−1、2−ジオ−ル |
US4443430A (en) | 1982-11-16 | 1984-04-17 | Ethicon, Inc. | Synthetic absorbable hemostatic agent |
US4528180A (en) | 1983-03-01 | 1985-07-09 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
US4849213A (en) | 1983-03-01 | 1989-07-18 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery therof |
US4663154A (en) | 1983-05-09 | 1987-05-05 | The Procter & Gamble Company | Oral compositions |
US4472373A (en) | 1983-05-09 | 1984-09-18 | The Procter & Gamble Company | Oral compositions |
US4959204A (en) | 1983-05-09 | 1990-09-25 | The Proctor & Gamble Company | Oral compositions |
US4661341A (en) | 1984-10-30 | 1987-04-28 | The Procter & Gamble Company | Oral compositions |
US4775525A (en) | 1985-12-16 | 1988-10-04 | Ivo Pera | Oral hygiene formulation containing sodium alginate |
US4659204A (en) * | 1985-12-26 | 1987-04-21 | Polaroid Corporation | Latching mechanism for photographic apparatus |
ZW23187A1 (en) | 1986-12-15 | 1988-06-29 | Hoffmann La Roche | Phosphinic acid derivatives |
US4894220A (en) | 1987-01-30 | 1990-01-16 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
US5004597A (en) | 1987-09-14 | 1991-04-02 | The Procter & Gamble Company | Oral compositions comprising stannous flouride and stannous gluconate |
US4847070A (en) | 1987-10-08 | 1989-07-11 | The Procter & Gamble Company | Anticalculus compositions |
LU87089A1 (fr) * | 1987-12-22 | 1989-07-07 | Oreal | Nouveaux sulfonamides du benzylidene camphre derivant d'aminoacides et leur application en cosmetique,notamment en tant que filtres solaires |
US4994262A (en) | 1988-10-14 | 1991-02-19 | The Procter & Gamble Company | Oral compositions |
US5198220A (en) | 1989-11-17 | 1993-03-30 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
US5256396A (en) | 1990-01-24 | 1993-10-26 | Colgate-Palmolive Company | Topical composition |
US5464609A (en) | 1990-03-16 | 1995-11-07 | The Procter & Gamble Company | Use of ketorolac for treatment of oral diseases and conditions |
US5015466A (en) | 1990-06-26 | 1991-05-14 | The Procter & Gamble Company | Anticalculus compositions using tartrate-succinates |
US5015467A (en) | 1990-06-26 | 1991-05-14 | The Procter & Gamble Company | Combined anticalculus and antiplaque compositions |
US5158763A (en) | 1990-10-09 | 1992-10-27 | Colgate-Palmolive Company | Non-staining anti-bacterial oral composition |
US5356615A (en) | 1991-01-30 | 1994-10-18 | Colgate Palmolive Company | Antiplaque oral compositions |
GB9110721D0 (en) | 1991-05-17 | 1991-07-10 | Unilever Plc | Dentifrice compositions |
US5213790A (en) | 1991-10-23 | 1993-05-25 | The Procter & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
US5281410A (en) | 1991-10-23 | 1994-01-25 | The Proctor & Gamble Company | Methods of reducing plaque and gingivitis with reduced staining |
US5145666A (en) | 1991-10-23 | 1992-09-08 | The Proctor & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
US5286479A (en) | 1991-12-10 | 1994-02-15 | The Dow Chemical Company | Oral compositions for suppressing mouth odors |
EP0629347B1 (en) | 1992-01-23 | 1997-07-02 | Morinaga Milk Industry Co., Ltd. | Antibacterial agent and treatment of article therewith |
US5374418A (en) | 1992-02-13 | 1994-12-20 | Kao Corporation | Composition for use in oral cavity |
GB9204414D0 (en) | 1992-02-29 | 1992-04-15 | Smithkline Beecham Plc | Method of treatment |
CN1075868A (zh) | 1992-03-02 | 1993-09-08 | 池洁 | 一种保健牙签 |
US5294433A (en) | 1992-04-15 | 1994-03-15 | The Procter & Gamble Company | Use of H-2 antagonists for treatment of gingivitis |
US5370865A (en) | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
US5431927A (en) | 1992-06-16 | 1995-07-11 | Colgate-Palmolive Company | Pet food product having oral care properties |
US6440395B1 (en) | 1992-06-22 | 2002-08-27 | Barry M. Libin | Antiplaque mouth rinse |
US6004587A (en) | 1992-06-25 | 1999-12-21 | Bioxy Inc. | Therapeutic, production and immunostimulatory uses of biocidal compositions |
US5830511A (en) | 1992-06-25 | 1998-11-03 | Bioxy Inc. | Therapeutic, production and immunostimulatory uses of biocidal compositions |
US5292527A (en) | 1992-07-02 | 1994-03-08 | Bausch & Lomb Incorporated | Non-alcoholic aqueous mouthwash |
US5242910A (en) | 1992-10-13 | 1993-09-07 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
US5405604A (en) | 1992-10-16 | 1995-04-11 | The Procter & Gamble Company | Concentrated mouthrinse for efficient delivery of antimicrobials |
WO1994013254A1 (en) | 1992-12-16 | 1994-06-23 | Colgate-Palmolive Company | Antiplaque, antigingivitis, anticaries oral composition |
ZA94438B (en) | 1993-02-19 | 1994-08-29 | Warner Lambert Co | Pre-brushing rinse composition |
WO1994027566A1 (en) | 1993-05-20 | 1994-12-08 | Warner-Lambert Company | Improved peppermint flavor for oral hygiene products |
KR100304064B1 (ko) | 1993-08-12 | 2001-11-22 | 다카하시 미치나오 | 구강용조성물 |
CN1086995A (zh) | 1993-08-24 | 1994-05-25 | 苏州牙膏厂 | 一种含维生素的牙膏 |
US5451401A (en) | 1993-09-29 | 1995-09-19 | The Procter & Gamble Company | Diphosphonic acid esters as tartar control agents |
US5338537A (en) | 1993-10-05 | 1994-08-16 | The Procter & Gamble Company | Oral compositions |
JPH09510186A (ja) * | 1993-12-22 | 1997-10-14 | ザ、プロクター、エンド、ギャンブル、カンパニー | 抗菌剤の効率的デリバリー用の濃縮マウスリンス |
WO1995029892A1 (en) | 1994-04-28 | 1995-11-09 | The Du Pont Merck Pharmaceutical Company | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
US5560905A (en) | 1994-05-13 | 1996-10-01 | The Proctor & Gamble Company | Oral compositions |
GB2290233B (en) | 1994-05-21 | 1998-06-17 | Medical Express | Tooth-whitening compositions containing both chlorite and chlorate salts |
JPH10501266A (ja) | 1994-06-10 | 1998-02-03 | ザ、プロクター、エンド、ギャンブル、カンパニー | マウスリンス組成物 |
EP0691124A1 (en) | 1994-07-07 | 1996-01-10 | Sara Lee/DE N.V. | Mouth care products |
US5603920A (en) | 1994-09-26 | 1997-02-18 | The Proctor & Gamble Company | Dentifrice compositions |
WO1996015770A1 (en) | 1994-11-17 | 1996-05-30 | Warner-Lambert Company | Antimicrobial oral compositions |
DE9418448U1 (de) * | 1994-11-18 | 1995-01-12 | Schroff Gmbh, 75334 Straubenhardt | Gestell für einen Geräteschrank |
US5578293A (en) | 1994-12-06 | 1996-11-26 | Colgate Palmolive Company | Oral compositions containing stabilized stannous compounds having antiplaque and antitartar efficacy |
US5639746A (en) | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
FR2729077A1 (fr) | 1995-01-05 | 1996-07-12 | Oreal | Composition cosmetique sous forme d'une pate souple et procede de preparation |
US5626838A (en) | 1995-03-13 | 1997-05-06 | The Procter & Gamble Company | Use of ketorolac for treatment of squamous cell carcinomas of the oral cavity or oropharynx |
US5672598A (en) | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
US5560906A (en) | 1995-03-27 | 1996-10-01 | Oral Technology Laboratories, Inc. | Non-alcoholic antimicrobial mouthwash for removal of dental plaque |
US5651958A (en) | 1995-05-02 | 1997-07-29 | The Procter & Gamble Company | Dentifrice compositions |
US5589160A (en) | 1995-05-02 | 1996-12-31 | The Procter & Gamble Company | Dentifrice compositions |
US5658553A (en) | 1995-05-02 | 1997-08-19 | The Procter & Gamble Company | Dentifrice compositions |
US5849271A (en) | 1995-06-07 | 1998-12-15 | The Procter & Gamble Company | Oral compositions |
TW442287B (en) | 1995-06-13 | 2001-06-23 | American Home Produits Corp | Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac) |
DE69618786T2 (de) * | 1995-07-10 | 2002-11-07 | Unilever N.V., Rotterdam | Wärmeerzeugende zahnpasta |
DE69719834T2 (de) | 1996-04-24 | 2003-11-20 | Pfizer Inc., New York | Dentalwerkstoffe enthaltend Cyclodextrine und phenolische Verbindungen |
GB9611364D0 (en) | 1996-05-31 | 1996-08-07 | Smithkline Beecham Plc | Composition |
KR20000022497A (ko) | 1996-07-01 | 2000-04-25 | 플레믹 크리스티안 | 키랄성 도펀트 |
US5753217A (en) | 1996-08-14 | 1998-05-19 | William C. Christopfel | Method of reducing oral malodor |
ATE272062T1 (de) | 1996-08-28 | 2004-08-15 | Procter & Gamble | Spirocyclisch metalloprotease inhibitoren |
BR9712792A (pt) | 1996-08-28 | 1999-12-14 | Procter & Gamble | Inibidores de metaloprotease bidentada. |
AU731319B2 (en) | 1996-08-28 | 2001-03-29 | Procter & Gamble Company, The | Heterocyclic metalloprotease inhibitors |
HUP0000210A3 (en) | 1996-08-28 | 2001-07-30 | Procter And Gamble Co Cincinna | Heterocyclic compounds as metalloprotease inhibitors and use of them for producing pharmaceutical compisitions |
CZ62899A3 (cs) | 1996-08-28 | 1999-07-14 | The Procter & Gamble Company | 1,3-Diheterocyklické metaloproteázové inhibitory |
JP3539736B2 (ja) | 1996-08-28 | 2004-07-07 | ザ プロクター アンド ギャンブル カンパニー | 基質メタロプロテアーゼインヒビターとしてのホスフィン酸アミド |
ATE226193T1 (de) | 1996-08-28 | 2002-11-15 | Procter & Gamble | Substituierte zyklische amine als metalloproteaseinhibitoren |
US5939052A (en) | 1996-11-21 | 1999-08-17 | The Procter & Gamble Company | Dentifrice compositions containing polyphosphate and fluoride |
US6190644B1 (en) | 1996-11-21 | 2001-02-20 | The Procter & Gamble Company | Dentifrice compositions containing polyphosphate and monofluorophosphate |
US6713049B1 (en) | 1999-11-12 | 2004-03-30 | The Procter & Gamble Company | Oral compositions providing optimal surface conditioning |
US6350436B1 (en) | 1996-11-21 | 2002-02-26 | The Procter & Gamble Company | Method of reducing staining of stannous in dentifrice compositions |
US20030206874A1 (en) | 1996-11-21 | 2003-11-06 | The Proctor & Gamble Company | Promoting whole body health |
US6241974B1 (en) | 1997-04-22 | 2001-06-05 | The Procter & Gamble Company | Dentifrice compositions containing β-phase calcium pyrophosphate an anticalculus agent, and fluoride |
EP1009737A2 (en) | 1997-07-31 | 2000-06-21 | The Procter & Gamble Company | Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors |
US5948390A (en) | 1997-08-25 | 1999-09-07 | Pfizer Inc. | Stable zinc/citrate/CPC oral rinse formulations |
WO1999012517A1 (en) | 1997-09-09 | 1999-03-18 | Smithkline Beecham Corporation | Tooth whitening preparations |
US5875799A (en) | 1997-09-23 | 1999-03-02 | Advanced Medical Instruments, Inc. | Therapeutic dental floss for treating systemic diseases |
US5875798A (en) | 1997-09-23 | 1999-03-02 | Advanced Medical Instruments, Inc. | Therapeutic toothpick for treating oral and systemic diseases |
CN1213534A (zh) | 1997-10-06 | 1999-04-14 | 陈创 | 口体舒治疗保健系统牙膏 |
US5980925A (en) | 1997-12-30 | 1999-11-09 | Ethicon, Inc. | High glycerin containing anti-microbial cleansers |
US6846478B1 (en) * | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
US6350438B1 (en) * | 1998-02-27 | 2002-02-26 | The Procter & Gamble Company | Oral care compositions comprising chlorite and methods |
US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
JP3763075B2 (ja) | 1998-04-24 | 2006-04-05 | サンスター株式会社 | 歯周病の予防又は治療用の食品組成物、口腔用組成物及び医薬組成物 |
AU3765999A (en) * | 1998-06-29 | 2000-01-17 | Warner-Lambert Company | Improved oral compositions for control and prevention of tartar, oral malodor, plaque and gingivitis |
JP2000063250A (ja) | 1998-08-18 | 2000-02-29 | Lion Corp | 口腔用組成物 |
US6861047B1 (en) | 1999-01-27 | 2005-03-01 | Victor Carnell | Oral hygiene preparations; associated methods and kit |
ES2225260T3 (es) | 1999-11-12 | 2005-03-16 | THE PROCTER & GAMBLE COMPANY | Composiciones bucales estannosas de doble fase mejoradas. |
CA2389174C (en) | 1999-11-12 | 2007-01-23 | The Procter & Gamble Company | Improved stannous oral compositions |
JP2003526649A (ja) | 2000-03-14 | 2003-09-09 | ザ、プロクター、エンド、ギャンブル、カンパニー | ポリホスフェート、フッ化物及びスズ(ii)塩を含む安定な歯磨き組成物 |
CN1109742C (zh) | 2000-03-28 | 2003-05-28 | 广东省农业科学院蚕业研究所 | 一种桑椹酒的生产方法 |
DE60134855D1 (de) | 2000-06-30 | 2008-08-28 | Procter & Gamble | Orale zubereitungen, die antimikrobielle wirkstoffe enthalten zur prävention von systemischen erkrankungen |
AU2001271544A1 (en) * | 2000-06-30 | 2002-01-14 | The Procter And Gamble Company | Oral compositions comprising host-response modulating agent |
US20020068039A1 (en) | 2000-07-28 | 2002-06-06 | Pan Pauline C. | Oral care compositions containing grapefruit seed extract |
US6685921B2 (en) | 2000-10-25 | 2004-02-03 | The Procter & Gamble Company | Dental care compositions |
WO2002045611A2 (en) | 2000-12-08 | 2002-06-13 | Brown, Dale, G. | Biofilm therapy process and elements |
JP3957195B2 (ja) | 2001-01-24 | 2007-08-15 | ブライトスマイル プロフェッショナル インク. | 局所用口腔ケア組成物 |
CA2445591A1 (en) | 2001-04-27 | 2002-11-07 | The Procter & Gamble Company | Nitrogen heterocyclic compounds and compositions for controlling biofilms |
CZ20033403A3 (cs) | 2001-06-25 | 2004-10-13 | Theáprocterá@Ágambleácompany | Abrazivní přípravky na čištění zubů |
US6355229B1 (en) | 2001-06-27 | 2002-03-12 | Church & Dwight Co., Inc. | Oral composition containing cetylpyridinium chloride and guar hydroxypropyltrimonium chloride and method of using the same |
ATE469633T1 (de) | 2001-11-28 | 2010-06-15 | Procter & Gamble | Zahnpflegezusammensetzungen |
US20060034782A1 (en) | 2001-12-04 | 2006-02-16 | Brown Dale G | Biofilm therapy interproximal devices |
US6579513B1 (en) * | 2002-01-03 | 2003-06-17 | Playtex Products, Inc. | Hygiene mouthspray composition |
US6723305B2 (en) | 2002-03-04 | 2004-04-20 | Colgate Palmolive Company | Anti-microbial breath freshening mouthrinse |
BR0202927B1 (pt) | 2002-07-18 | 2014-12-02 | Antonio Carlos Pereira Coelho | Composição fitoterápica a base de extratos vegetais, processo de obtenção da dita composição, e uso de extratos vegetais para preparação de composição fitoterápica. |
AU2003265688A1 (en) * | 2002-08-27 | 2004-03-19 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product using citral |
WO2004019802A2 (en) * | 2002-08-27 | 2004-03-11 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product using carvacrol |
US6746681B1 (en) | 2002-12-20 | 2004-06-08 | Preventive Dental Specialties, Inc. | Pet tooth care preparation |
JP4721630B2 (ja) * | 2003-09-30 | 2011-07-13 | サンスター株式会社 | 抗内毒素剤、及びこれを含有する歯周病抑制用口腔用組成物 |
JP4496429B2 (ja) * | 2004-03-05 | 2010-07-07 | ライオン株式会社 | 歯磨剤組成物及び歯磨剤製品 |
JP2006124289A (ja) * | 2004-10-27 | 2006-05-18 | Kowa Co | 新規な口腔内溶解用固形製剤 |
JP2006124288A (ja) * | 2004-10-27 | 2006-05-18 | Kowa Co | 新規口腔内溶解用固形製剤 |
TW200621315A (en) * | 2004-10-28 | 2006-07-01 | Kowa Co | Orally dissolving solid preparation |
JP2006182699A (ja) * | 2004-12-27 | 2006-07-13 | Lion Corp | 口腔用組成物 |
JP2006182669A (ja) * | 2004-12-27 | 2006-07-13 | Lion Corp | 口腔内貼付剤 |
JP2006206465A (ja) * | 2005-01-26 | 2006-08-10 | Kowa Co | 持続性口腔内溶解用固形製剤 |
WO2006105196A2 (en) * | 2005-03-28 | 2006-10-05 | Bioresponse, L.L.C. | Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health |
US8007771B2 (en) * | 2006-07-07 | 2011-08-30 | The Procter & Gamble Company | Flavors for oral compositions |
-
2006
- 2006-11-10 US US11/595,530 patent/US8283135B2/en not_active Expired - Fee Related
-
2007
- 2007-03-30 CA CA2669019A patent/CA2669019C/en not_active Expired - Fee Related
- 2007-03-30 WO PCT/US2007/007972 patent/WO2008057136A1/en active Application Filing
- 2007-03-30 CN CNA2007800411810A patent/CN101534823A/zh active Pending
- 2007-03-30 MY MYPI20091726A patent/MY157928A/en unknown
- 2007-03-30 EP EP11187748.6A patent/EP2415473B1/en not_active Not-in-force
- 2007-03-30 JP JP2009535253A patent/JP5280366B2/ja not_active Expired - Fee Related
- 2007-03-30 AU AU2007318251A patent/AU2007318251B2/en not_active Ceased
- 2007-03-30 RU RU2009114589/15A patent/RU2448711C2/ru not_active IP Right Cessation
- 2007-03-30 ES ES07754488T patent/ES2395854T3/es active Active
- 2007-03-30 EP EP07754488A patent/EP2079468B1/en not_active Not-in-force
- 2007-03-30 CN CN201510387948.1A patent/CN104958187A/zh active Pending
- 2007-03-30 BR BRPI0718699-1A patent/BRPI0718699A2/pt not_active IP Right Cessation
- 2007-03-30 MX MX2009004973A patent/MX2009004973A/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP2415473B1 (en) | 2014-09-17 |
RU2009114589A (ru) | 2010-12-20 |
JP2010508346A (ja) | 2010-03-18 |
RU2448711C2 (ru) | 2012-04-27 |
EP2079468B1 (en) | 2012-09-19 |
CN101534823A (zh) | 2009-09-16 |
US8283135B2 (en) | 2012-10-09 |
MX2009004973A (es) | 2009-05-19 |
EP2415473A1 (en) | 2012-02-08 |
WO2008057136A1 (en) | 2008-05-15 |
EP2079468A1 (en) | 2009-07-22 |
CA2669019A1 (en) | 2008-05-15 |
CA2669019C (en) | 2014-01-14 |
US20070053849A1 (en) | 2007-03-08 |
ES2395854T3 (es) | 2013-02-15 |
BRPI0718699A2 (pt) | 2013-01-15 |
AU2007318251B2 (en) | 2013-05-02 |
CN104958187A (zh) | 2015-10-07 |
MY157928A (en) | 2016-08-15 |
AU2007318251A1 (en) | 2008-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5280366B2 (ja) | 抗菌剤及び宿主反応調節剤の組み合わせを含有する口腔ケア組成物 | |
EP1294383B1 (en) | Oral compositions comprising antimicrobial agents for the prevention of systemic diseases | |
US6846478B1 (en) | Promoting whole body health | |
US8277782B2 (en) | Topical oral care compositions comprising host response modulating agents | |
US20030206874A1 (en) | Promoting whole body health | |
US6350438B1 (en) | Oral care compositions comprising chlorite and methods | |
US6696047B2 (en) | Stable oral care compositions comprising chlorite | |
AU2006305772B2 (en) | Oral composition containing morin | |
US20120263657A1 (en) | Promoting Whole Body Health |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111021 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120123 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120130 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120203 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120629 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121001 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121009 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121029 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121105 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121129 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121206 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121228 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130423 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130522 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |