JP5225078B2 - 有機化合物の合成方法 - Google Patents

有機化合物の合成方法 Download PDF

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Publication number
JP5225078B2
JP5225078B2 JP2008515880A JP2008515880A JP5225078B2 JP 5225078 B2 JP5225078 B2 JP 5225078B2 JP 2008515880 A JP2008515880 A JP 2008515880A JP 2008515880 A JP2008515880 A JP 2008515880A JP 5225078 B2 JP5225078 B2 JP 5225078B2
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Japan
Prior art keywords
methyl
trifluoromethyl
imidazol
formula
compound
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Expired - Fee Related
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JP2008515880A
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English (en)
Japanese (ja)
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JP2008546645A5 (enExample
JP2008546645A (ja
Inventor
シュテファン・アベル
ムラット・アツェモグル
ベルンハルト・エアプ
クリストフ・クレル
ジョゼフ・スクラファーニ
マルク・マイゼンバッハ
マハバー・プラシャド
ウェン−チュン・シー
ソン・シュエ
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2008515880A 2005-06-09 2006-06-07 有機化合物の合成方法 Expired - Fee Related JP5225078B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68897605P 2005-06-09 2005-06-09
US60/688,976 2005-06-09
PCT/US2006/022154 WO2006135640A2 (en) 2005-06-09 2006-06-07 Process for the synthesis of organic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012208775A Division JP2013035855A (ja) 2005-06-09 2012-09-21 有機化合物の合成方法

Publications (3)

Publication Number Publication Date
JP2008546645A JP2008546645A (ja) 2008-12-25
JP2008546645A5 JP2008546645A5 (enExample) 2009-07-23
JP5225078B2 true JP5225078B2 (ja) 2013-07-03

Family

ID=37149980

Family Applications (2)

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JP2008515880A Expired - Fee Related JP5225078B2 (ja) 2005-06-09 2006-06-07 有機化合物の合成方法
JP2012208775A Pending JP2013035855A (ja) 2005-06-09 2012-09-21 有機化合物の合成方法

Family Applications After (1)

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JP2012208775A Pending JP2013035855A (ja) 2005-06-09 2012-09-21 有機化合物の合成方法

Country Status (25)

Country Link
US (2) US7781597B2 (enExample)
EP (3) EP1896426B1 (enExample)
JP (2) JP5225078B2 (enExample)
KR (2) KR101249199B1 (enExample)
CN (6) CN102174020B (enExample)
AR (1) AR057056A1 (enExample)
AT (1) ATE540931T1 (enExample)
AU (3) AU2006258050B2 (enExample)
BR (1) BRPI0611683A2 (enExample)
CA (4) CA2942046A1 (enExample)
DK (2) DK2266961T3 (enExample)
ES (3) ES2465522T3 (enExample)
GT (1) GT200600202AA (enExample)
HU (1) HUE028024T2 (enExample)
IN (2) IN2014DN08578A (enExample)
JO (1) JO2758B1 (enExample)
MX (1) MX2007015609A (enExample)
MY (1) MY146795A (enExample)
PE (3) PE20070109A1 (enExample)
PL (3) PL2266961T3 (enExample)
PT (3) PT2292607E (enExample)
RU (1) RU2446162C2 (enExample)
SI (2) SI2266961T1 (enExample)
TW (1) TWI380981B (enExample)
WO (1) WO2006135640A2 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013035855A (ja) * 2005-06-09 2013-02-21 Novartis Ag 有機化合物の合成方法

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RS53639B1 (sr) 2004-03-05 2015-04-30 Nissan Chemical Industries Ltd. Izoksazolinom supstituisano benzamidno jedinjenje i sredstvo za kontrolu štetnih organizama
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
MX2009013469A (es) 2007-06-13 2010-01-20 Du Pont Insecticidas de isoxazolina.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
HUE037127T2 (hu) 2007-06-27 2018-08-28 Du Pont Állati károkozó irtására szolgáló eljárás
TWI461411B (zh) 2007-08-17 2014-11-21 Du Pont 製備５－鹵烷基－４，５－二氫異唑衍生物之方法
US8367584B2 (en) 2007-10-03 2013-02-05 E.I. Du Pont De Nemours And Company Naphthalene isoxazoline compounds for control of invertebrate pests
TWI583664B (zh) 2008-04-09 2017-05-21 杜邦股份有限公司 羰基化合物及其製備方法
WO2010009402A2 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
EP2530081A3 (en) 2008-11-05 2013-04-10 Teva Pharmaceutical Industries, Ltd. Nilotinib HCI crystalline forms
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
SI2576523T1 (sl) 2010-05-27 2016-05-31 E.I. du Pont de Nemours and Company Chestnut Run Plaza 974 Center Road Kristalinične oblike 4-(5-(3-kloro-5-(trifluorometil)fenil)-4,5-dihidro 5-(trifluorometil)-3-izoksazolil)-N-(2-okso-2-((2,2,2-trifluoroetil) amino)etil)-1 naftalenkarboksamida
BR122019019582B1 (pt) 2011-12-30 2021-07-13 Hanmi Pharm. Co., Ltd. Compostos derivados de tieno[3,2-d]pirimidina, composição farmacêutica contendo os ditos compostos e uso dos mesmos para a prevenção ou tratamento de uma doença causada por ativação anormal de uma proteína quinase
CN102592837B (zh) * 2012-03-12 2014-01-15 河北师范大学 制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法
CN103694176B (zh) * 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
CN104592122B (zh) * 2014-12-09 2018-01-23 凯莱英医药集团（天津）股份有限公司 3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
CN105985293B (zh) * 2015-03-04 2018-04-03 埃斯特维华义制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN107201532B (zh) * 2017-05-09 2019-08-27 吉林凯莱英医药化学有限公司 芳香化合物的硝化方法
WO2019130254A1 (en) * 2018-01-01 2019-07-04 Laurus Labs Ltd An improved process for 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl) aniline
CN108530364B (zh) * 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
KR20210042896A (ko) 2018-06-15 2021-04-20 한다 파마슈티칼스, 인코포레이티드 카이네이스 억제제 염 및 이의 조성물
CA3136189A1 (en) * 2019-04-06 2020-10-15 Trinapco, Inc. Sulfonyldiazoles and n-(fluorosulfonyl)azoles, and methods of making the same
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
CN114751836B (zh) * 2021-02-23 2024-05-31 四川青木制药有限公司 3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体
CN114853734A (zh) * 2022-06-14 2022-08-05 海南鑫开源医药科技有限公司 一种尼洛替尼游离碱的制备方法
CN116478319B (zh) * 2022-11-07 2025-07-01 华北电力大学 一种离子共价有机聚合物的制备方法及其在碱性环境吸附ReO4-的应用
CN115626880B (zh) * 2022-11-15 2023-11-14 常州大学 3-硝基-5-氰基三氟甲苯的合成方法
CN118108670B (zh) * 2023-12-28 2025-07-01 江苏希迪制药有限公司 尼罗替尼中间体3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺的精制纯化方法

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SU1051076A1 (ru) * 1982-04-09 1983-10-30 Алтайский политехнический институт Способ получени производных имидазола
GB8413685D0 (en) * 1984-05-29 1984-07-04 Pfizer Ltd Quinolone inotropic agents
GR851296B (enExample) * 1984-05-29 1985-11-25 Pfizer
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
GB0023383D0 (en) * 2000-09-23 2000-11-08 Synprotec Ltd 3,5-Bis (Trifluormethyl)Benzene derivatives
TW200406374A (en) 2002-05-29 2004-05-01 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0222514D0 (en) * 2002-09-27 2002-11-06 Novartis Ag Organic compounds
CN1939910A (zh) * 2004-12-31 2007-04-04 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
GT200600207A (es) * 2005-06-09 2007-01-15 Novartis Ag Proceso para la síntesis de compuestos orgánicos

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013035855A (ja) * 2005-06-09 2013-02-21 Novartis Ag 有機化合物の合成方法

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Publication number Publication date
CN102174019B (zh) 2013-02-13
CA2886482A1 (en) 2006-12-21
IN2014DN08588A (enExample) 2015-07-10
GT200600202AA (es) 2014-06-09
AU2011201044A1 (en) 2011-03-31
MY146795A (en) 2012-09-28
ES2558696T3 (es) 2016-02-08
PE20100716A1 (es) 2010-10-25
BRPI0611683A2 (pt) 2010-09-28
RU2446162C2 (ru) 2012-03-27
EP2266961A2 (en) 2010-12-29
CN101189212A (zh) 2008-05-28
CN101189212B (zh) 2011-05-18
CA2611280C (en) 2014-01-28
ES2380489T3 (es) 2012-05-14
EP2292607A2 (en) 2011-03-09
PL2266961T3 (pl) 2016-04-29
US8008504B2 (en) 2011-08-30
WO2006135640A3 (en) 2007-08-02
PL1896426T3 (pl) 2012-06-29
CN102174020A (zh) 2011-09-07
WO2006135640A2 (en) 2006-12-21
EP2292607A3 (en) 2011-04-27
SI2266961T1 (sl) 2016-02-29
CA2833394A1 (en) 2006-12-21
KR101249199B1 (ko) 2013-04-03
CA2833394C (en) 2016-03-29
KR20120099028A (ko) 2012-09-06
CA2611280A1 (en) 2006-12-21
JP2013035855A (ja) 2013-02-21
AU2006258050A1 (en) 2006-12-21
AU2006258050B2 (en) 2010-12-09
CN102180796A (zh) 2011-09-14
CN102174020B (zh) 2012-11-07
TW200716563A (en) 2007-05-01
KR20080014010A (ko) 2008-02-13
US20080200692A1 (en) 2008-08-21
AU2010241374A1 (en) 2010-12-02
PL2292607T3 (pl) 2014-09-30
MX2007015609A (es) 2008-02-25
PT1896426E (pt) 2012-04-12
AU2010241374B2 (en) 2011-11-03
CN102180836B (zh) 2012-11-21
PT2266961E (pt) 2016-02-05
ATE540931T1 (de) 2012-01-15
ES2465522T3 (es) 2014-06-06
EP2266961B1 (en) 2015-10-21
US7781597B2 (en) 2010-08-24
EP1896426B1 (en) 2012-01-11
KR101283109B1 (ko) 2013-07-05
PE20070109A1 (es) 2007-04-02
JO2758B1 (en) 2014-03-15
US20100280257A1 (en) 2010-11-04
IN2014DN08578A (enExample) 2015-07-10
EP2266961A3 (en) 2011-07-27
HUE028024T2 (en) 2016-11-28
CN102174021B (zh) 2013-02-27
SI2292607T1 (sl) 2014-09-30
CN102174021A (zh) 2011-09-07
PE20100715A1 (es) 2010-10-25
EP2292607B1 (en) 2014-04-09
RU2007148238A (ru) 2009-07-20
TWI380981B (zh) 2013-01-01
DK2266961T3 (en) 2016-01-25
CA2886482C (en) 2017-09-05
ES2380489T8 (es) 2012-06-22
CA2942046A1 (en) 2006-12-21
PT2292607E (pt) 2014-06-24
EP1896426A2 (en) 2008-03-12
DK2292607T3 (da) 2014-06-30
AR057056A1 (es) 2007-11-14
JP2008546645A (ja) 2008-12-25
CN102180836A (zh) 2011-09-14
CN102174019A (zh) 2011-09-07

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