PE20070109A1 - Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina - Google Patents
Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenaminaInfo
- Publication number
- PE20070109A1 PE20070109A1 PE2006000628A PE2006000628A PE20070109A1 PE 20070109 A1 PE20070109 A1 PE 20070109A1 PE 2006000628 A PE2006000628 A PE 2006000628A PE 2006000628 A PE2006000628 A PE 2006000628A PE 20070109 A1 PE20070109 A1 PE 20070109A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- imidazol
- trifluoromethyl
- benzenamine
- synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- XLSZMDLNRCVEIJ-UHFFFAOYSA-N 4-methylimidazole Chemical compound CC1=CNC=N1 XLSZMDLNRCVEIJ-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- JMLCVCGQBRZYOZ-UHFFFAOYSA-N 4-methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]imidazole Chemical compound C1=NC(C)=CN1C1=CC([N+]([O-])=O)=CC(C(F)(F)F)=C1 JMLCVCGQBRZYOZ-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical group N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 229940054066 benzamide antipsychotics Drugs 0.000 abstract 1
- 229910052792 caesium Inorganic materials 0.000 abstract 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 abstract 1
- 229910052808 lithium carbonate Inorganic materials 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 abstract 1
- 229910000105 potassium hydride Inorganic materials 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
- C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68897605P | 2005-06-09 | 2005-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070109A1 true PE20070109A1 (es) | 2007-04-02 |
Family
ID=37149980
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010000467A PE20100715A1 (es) | 2005-06-09 | 2006-06-07 | Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina |
| PE2006000628A PE20070109A1 (es) | 2005-06-09 | 2006-06-07 | Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina |
| PE2010000468A PE20100716A1 (es) | 2005-06-09 | 2006-06-07 | Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010000467A PE20100715A1 (es) | 2005-06-09 | 2006-06-07 | Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010000468A PE20100716A1 (es) | 2005-06-09 | 2006-06-07 | Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7781597B2 (enExample) |
| EP (3) | EP2292607B1 (enExample) |
| JP (2) | JP5225078B2 (enExample) |
| KR (2) | KR101249199B1 (enExample) |
| CN (6) | CN102174021B (enExample) |
| AR (1) | AR057056A1 (enExample) |
| AT (1) | ATE540931T1 (enExample) |
| AU (3) | AU2006258050B2 (enExample) |
| BR (1) | BRPI0611683A2 (enExample) |
| CA (4) | CA2942046A1 (enExample) |
| DK (2) | DK2266961T3 (enExample) |
| ES (3) | ES2465522T3 (enExample) |
| GT (1) | GT200600202AA (enExample) |
| HU (1) | HUE028024T2 (enExample) |
| IN (2) | IN2014DN08588A (enExample) |
| JO (1) | JO2758B1 (enExample) |
| MX (1) | MX2007015609A (enExample) |
| MY (1) | MY146795A (enExample) |
| PE (3) | PE20100715A1 (enExample) |
| PL (3) | PL2266961T3 (enExample) |
| PT (3) | PT2292607E (enExample) |
| RU (1) | RU2446162C2 (enExample) |
| SI (2) | SI2266961T1 (enExample) |
| TW (1) | TWI380981B (enExample) |
| WO (1) | WO2006135640A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1930136B (zh) | 2004-03-05 | 2012-02-08 | 日产化学工业株式会社 | 异*唑啉取代苯甲酰胺化合物及有害生物防除剂 |
| MY146795A (en) * | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| BRPI0809770B8 (pt) | 2007-06-13 | 2022-12-06 | Du Pont | Composto e composição para controlar uma praga de invertebrados |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| DK2957284T3 (en) | 2007-06-27 | 2018-02-05 | Du Pont | PROCEDURE TO CHECK ANIMALS FOR ANIMALS |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物 |
| KR20100075996A (ko) | 2007-10-03 | 2010-07-05 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물 |
| TWI583664B (zh) | 2008-04-09 | 2017-05-21 | 杜邦股份有限公司 | 羰基化合物及其製備方法 |
| US20100016590A1 (en) * | 2008-07-17 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Nilotinib intermediates and preparation thereof |
| EP2530081A3 (en) | 2008-11-05 | 2013-04-10 | Teva Pharmaceutical Industries, Ltd. | Nilotinib HCI crystalline forms |
| WO2010060074A1 (en) * | 2008-11-24 | 2010-05-27 | Teva Pharmaceutical Industries Ltd. | Preparation of nilotinib and intermediates thereof |
| US20110053968A1 (en) | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| MX2012013758A (es) | 2010-05-27 | 2013-01-24 | Du Pont | Forma cristalina de 4-[5-[3-cloro-5-trifluorometil)fenil]-4,5-dihi dro-5-(trifluorometil)-3-isoxazolil]-n-[2-oxo-2-[(2,2,2-trifluoro etil)amino]etil]-1-naftalenocarboxamida. |
| BR112014015720B1 (pt) | 2011-12-30 | 2020-03-17 | Hanmi Pharm. Co., Ltd. | Derivados de tieno[3,2-d]pirimidina, composição farmacêutica e uso dos mesmos para a prevenção ou tratamento de uma doença causada por ativação anormal de uma proteína quinase |
| CN102592837B (zh) * | 2012-03-12 | 2014-01-15 | 河北师范大学 | 制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法 |
| CN103694176B (zh) * | 2014-01-07 | 2015-02-18 | 苏州立新制药有限公司 | 尼洛替尼中间体的制备方法 |
| CN104592122B (zh) * | 2014-12-09 | 2018-01-23 | 凯莱英医药集团（天津）股份有限公司 | 3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法 |
| CN105985293B (zh) * | 2015-03-04 | 2018-04-03 | 埃斯特维华义制药有限公司 | 尼洛替尼中间体的制备方法 |
| EP3095782A1 (en) | 2015-05-18 | 2016-11-23 | Esteve Química, S.A. | New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine |
| CN107201532B (zh) * | 2017-05-09 | 2019-08-27 | 吉林凯莱英医药化学有限公司 | 芳香化合物的硝化方法 |
| WO2019130254A1 (en) * | 2018-01-01 | 2019-07-04 | Laurus Labs Ltd | An improved process for 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl) aniline |
| CN108530364B (zh) * | 2018-04-10 | 2020-01-21 | 江苏创诺制药有限公司 | 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用 |
| EP3806858A4 (en) | 2018-06-15 | 2022-03-09 | Handa Pharmaceuticals, Inc. | KINA INHIBITOR SALTS AND COMPOSITIONS THEREOF |
| US11014945B2 (en) * | 2019-04-06 | 2021-05-25 | Trinapco, Inc. | Sulfonyldiazoles and N-(fluorosulfonyl)azoles, and methods of making the same |
| EP3904342A1 (en) | 2020-04-28 | 2021-11-03 | Grindeks, A Joint Stock Company | Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride |
| CN114751836B (zh) * | 2021-02-23 | 2024-05-31 | 四川青木制药有限公司 | 3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体 |
| CN114853734A (zh) * | 2022-06-14 | 2022-08-05 | 海南鑫开源医药科技有限公司 | 一种尼洛替尼游离碱的制备方法 |
| CN116478319B (zh) * | 2022-11-07 | 2025-07-01 | 华北电力大学 | 一种离子共价有机聚合物的制备方法及其在碱性环境吸附ReO4-的应用 |
| CN115626880B (zh) * | 2022-11-15 | 2023-11-14 | 常州大学 | 3-硝基-5-氰基三氟甲苯的合成方法 |
| CN118108670B (zh) * | 2023-12-28 | 2025-07-01 | 江苏希迪制药有限公司 | 尼罗替尼中间体3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺的精制纯化方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1051076A1 (ru) * | 1982-04-09 | 1983-10-30 | Алтайский политехнический институт | Способ получени производных имидазола |
| CA1292234C (en) * | 1984-05-29 | 1991-11-19 | Simon Fraser Campbell | Heterocyclic-substituted quinolone inotropic agents |
| GB8413685D0 (en) * | 1984-05-29 | 1984-07-04 | Pfizer Ltd | Quinolone inotropic agents |
| GB8502267D0 (en) * | 1985-01-30 | 1985-02-27 | Pfizer Ltd | Quinolone inotropic agents |
| HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| GB0023383D0 (en) * | 2000-09-23 | 2000-11-08 | Synprotec Ltd | 3,5-Bis (Trifluormethyl)Benzene derivatives |
| PE20040522A1 (es) * | 2002-05-29 | 2004-09-28 | Novartis Ag | Derivados de diarilurea dependientes de la cinasa de proteina |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| GB0222514D0 (en) | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
| CN1939910A (zh) * | 2004-12-31 | 2007-04-04 | 孙飘扬 | 氨基嘧啶类化合物及其盐和其制备方法与药物用途 |
| GT200600207A (es) * | 2005-06-09 | 2007-01-15 | Novartis Ag | Proceso para la síntesis de compuestos orgánicos |
| MY146795A (en) * | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
-
2006
- 2006-05-31 MY MYPI20062506A patent/MY146795A/en unknown
- 2006-06-06 JO JO2006161A patent/JO2758B1/en active
- 2006-06-07 PT PT101719425T patent/PT2292607E/pt unknown
- 2006-06-07 DK DK10171941.7T patent/DK2266961T3/en active
- 2006-06-07 EP EP10171942.5A patent/EP2292607B1/en active Active
- 2006-06-07 PT PT06772447T patent/PT1896426E/pt unknown
- 2006-06-07 KR KR1020077028642A patent/KR101249199B1/ko not_active Expired - Fee Related
- 2006-06-07 PE PE2010000467A patent/PE20100715A1/es not_active Application Discontinuation
- 2006-06-07 SI SI200632010T patent/SI2266961T1/sl unknown
- 2006-06-07 PE PE2006000628A patent/PE20070109A1/es not_active Application Discontinuation
- 2006-06-07 US US11/915,691 patent/US7781597B2/en active Active
- 2006-06-07 CA CA2942046A patent/CA2942046A1/en not_active Abandoned
- 2006-06-07 EP EP10171941.7A patent/EP2266961B1/en active Active
- 2006-06-07 PE PE2010000468A patent/PE20100716A1/es not_active Application Discontinuation
- 2006-06-07 CN CN2011100581788A patent/CN102174021B/zh not_active Expired - Fee Related
- 2006-06-07 AT AT06772447T patent/ATE540931T1/de active
- 2006-06-07 DK DK10171942.5T patent/DK2292607T3/da active
- 2006-06-07 BR BRPI0611683-3A patent/BRPI0611683A2/pt active Search and Examination
- 2006-06-07 EP EP06772447A patent/EP1896426B1/en active Active
- 2006-06-07 HU HUE10171941A patent/HUE028024T2/en unknown
- 2006-06-07 CN CN200680019924XA patent/CN101189212B/zh not_active Expired - Fee Related
- 2006-06-07 ES ES10171942.5T patent/ES2465522T3/es active Active
- 2006-06-07 IN IN8588DEN2014 patent/IN2014DN08588A/en unknown
- 2006-06-07 PL PL10171941T patent/PL2266961T3/pl unknown
- 2006-06-07 RU RU2007148238/04A patent/RU2446162C2/ru active
- 2006-06-07 CN CN2011100572469A patent/CN102174019B/zh not_active Expired - Fee Related
- 2006-06-07 KR KR1020127011979A patent/KR101283109B1/ko not_active Expired - Fee Related
- 2006-06-07 PL PL06772447T patent/PL1896426T3/pl unknown
- 2006-06-07 ES ES06772447T patent/ES2380489T3/es active Active
- 2006-06-07 AR ARP060102367A patent/AR057056A1/es unknown
- 2006-06-07 IN IN8578DEN2014 patent/IN2014DN08578A/en unknown
- 2006-06-07 WO PCT/US2006/022154 patent/WO2006135640A2/en not_active Ceased
- 2006-06-07 CN CN2011100581769A patent/CN102180796A/zh active Pending
- 2006-06-07 AU AU2006258050A patent/AU2006258050B2/en not_active Ceased
- 2006-06-07 CN CN2011100574125A patent/CN102180836B/zh not_active Expired - Fee Related
- 2006-06-07 CA CA2611280A patent/CA2611280C/en active Active
- 2006-06-07 CA CA2886482A patent/CA2886482C/en active Active
- 2006-06-07 CN CN2011100581773A patent/CN102174020B/zh not_active Expired - Fee Related
- 2006-06-07 PT PT101719417T patent/PT2266961E/pt unknown
- 2006-06-07 MX MX2007015609A patent/MX2007015609A/es active IP Right Grant
- 2006-06-07 PL PL10171942T patent/PL2292607T3/pl unknown
- 2006-06-07 ES ES10171941.7T patent/ES2558696T3/es active Active
- 2006-06-07 JP JP2008515880A patent/JP5225078B2/ja not_active Expired - Fee Related
- 2006-06-07 SI SI200631789T patent/SI2292607T1/sl unknown
- 2006-06-07 CA CA2833394A patent/CA2833394C/en active Active
- 2006-06-08 TW TW095120304A patent/TWI380981B/zh not_active IP Right Cessation
-
2010
- 2010-07-12 US US12/834,295 patent/US8008504B2/en not_active Expired - Fee Related
- 2010-11-11 AU AU2010241374A patent/AU2010241374B2/en not_active Ceased
-
2011
- 2011-03-09 AU AU2011201044A patent/AU2011201044A1/en not_active Abandoned
-
2012
- 2012-05-17 GT GT200600202AK patent/GT200600202AA/es unknown
- 2012-09-21 JP JP2012208775A patent/JP2013035855A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20070109A1 (es) | Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina | |
| Jalani et al. | Synthesis of substituted 1, 2, 3-triazoles via metal-free click cycloaddition reactions and alternative cyclization methods | |
| MX2007003377A (es) | Agonistas del receptor de trombopoyetina. | |
| EA200870586A1 (ru) | 3-(1,3-бензодиоксол-5-ил)-6-(4-циклопропилпиперазин-1-ил)пиридазин, его соли и сольваты и его применение в качестве антагониста н3 рецептора гистамина | |
| PE20131086A1 (es) | Proceso para preparar compuestos antivirales | |
| YU44898A (sh) | Postupak za dobijanje magnezijumove soli supstituisanog heterocikličnog sulfinila | |
| CZ198598A3 (cs) | Způsob přípravy imidazolových derivátů a meziprodukty tohoto postupu | |
| WO2011019799A3 (en) | Copper catalyzed cycloaddition of organic azides and 1-haloalkynes | |
| Liu et al. | Copper-catalyzed annulation of α-substituted diazoacetates with 2-ethynylanilines: the direct synthesis of C2-functionalized indoles | |
| Tran et al. | Copper-catalyzed domino three-component approach for the assembly of 2-Aminated benzimidazoles and quinazolines | |
| PE20070015A1 (es) | Proceso para la sintesis de compuestos pirimidinilaminobenzamidas | |
| Khalili et al. | KF/Al2O3: an efficient solid heterogeneous base catalyst in one-pot synthesis of benzimidazoles and bis-benzimidazoles at room temperature | |
| Yi et al. | Synthesis of 1, 2-Fused/Disubstituted Benzimidazoles and Benzimidazolium Salts by I2-Mediated sp3 C–H Amination | |
| UY32242A (es) | Ácidos de 2-[(1-cianopropil)carbamoil]-5-metoximetil nicotínico y su uso para la fabricación de imidazolinonas herbicidas | |
| FR2843114B1 (fr) | Procede de monomethylation d'heterocycles azotes | |
| EA200701470A1 (ru) | Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений | |
| CA2482466A1 (en) | Process for 5-[[2(r)-[1(r)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(s)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3h-1,2,4-triazol-3-one | |
| Talukdar et al. | Ullmann-Type N-, S-, and O-Arylation Using a Well-Defined 7-Azaindole-N-oxide (7-AINO)-Based Copper (II) Catalyst: Scope and Application to Drug Synthesis | |
| Łukasik et al. | Aryliminophosphoranes as key intermediates in the one-pot synthesis of 1-aryl-1, 3-dihydro-2H-benzimidazol-2-ones from N-aryl-2-nitrosoanilines and carbon dioxide under mild metal-free conditions | |
| ES8706116A1 (es) | Un procedimiento para la preparacion de oxindol-carboxamidas triciclicas | |
| YU52303A (sh) | Postupak karbamoilacije alkohola | |
| DE602006010584D1 (de) | Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole | |
| Rostamizadeh et al. | Aqueous 1 M glucose solution as a novel and fully green reaction medium and catalyst for the oxidant-free synthesis of 2-arylbenzimidazoles | |
| WO2009012201A3 (en) | Process for the preparation of trifluoroalkyl-phenyl and heterocyclic sulfonamides | |
| PE20070084A1 (es) | Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-bencenamina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |