AU2006258050B2 - Process for the synthesis of organic compounds - Google Patents

Process for the synthesis of organic compounds Download PDF

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Publication number
AU2006258050B2
AU2006258050B2 AU2006258050A AU2006258050A AU2006258050B2 AU 2006258050 B2 AU2006258050 B2 AU 2006258050B2 AU 2006258050 A AU2006258050 A AU 2006258050A AU 2006258050 A AU2006258050 A AU 2006258050A AU 2006258050 B2 AU2006258050 B2 AU 2006258050B2
Authority
AU
Australia
Prior art keywords
methyl
trifluoromethyl
imidazol
benzenamine
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006258050A
Other languages
English (en)
Other versions
AU2006258050A1 (en
Inventor
Stephan Abel
Murat Acemoglu
Bernhard Erb
Christoph Krell
Mark Meisenbach
Mahavir Prashad
Joseph Sclafani
Wen-Chung Shieh
Song Xue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37149980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2006258050(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2006258050A1 publication Critical patent/AU2006258050A1/en
Priority to AU2010241374A priority Critical patent/AU2010241374B2/en
Application granted granted Critical
Publication of AU2006258050B2 publication Critical patent/AU2006258050B2/en
Priority to AU2011201044A priority patent/AU2011201044A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2006258050A 2005-06-09 2006-06-07 Process for the synthesis of organic compounds Ceased AU2006258050B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2010241374A AU2010241374B2 (en) 2005-06-09 2010-11-11 Process for the synthesis of organic compounds
AU2011201044A AU2011201044A1 (en) 2005-06-09 2011-03-09 Process for the synthesis of organic compounds

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68897605P 2005-06-09 2005-06-09
US60/688,976 2005-06-09
PCT/US2006/022154 WO2006135640A2 (en) 2005-06-09 2006-06-07 Process for the synthesis of organic compounds

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2010241374A Division AU2010241374B2 (en) 2005-06-09 2010-11-11 Process for the synthesis of organic compounds
AU2011201044A Division AU2011201044A1 (en) 2005-06-09 2011-03-09 Process for the synthesis of organic compounds

Publications (2)

Publication Number Publication Date
AU2006258050A1 AU2006258050A1 (en) 2006-12-21
AU2006258050B2 true AU2006258050B2 (en) 2010-12-09

Family

ID=37149980

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2006258050A Ceased AU2006258050B2 (en) 2005-06-09 2006-06-07 Process for the synthesis of organic compounds
AU2010241374A Ceased AU2010241374B2 (en) 2005-06-09 2010-11-11 Process for the synthesis of organic compounds
AU2011201044A Abandoned AU2011201044A1 (en) 2005-06-09 2011-03-09 Process for the synthesis of organic compounds

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2010241374A Ceased AU2010241374B2 (en) 2005-06-09 2010-11-11 Process for the synthesis of organic compounds
AU2011201044A Abandoned AU2011201044A1 (en) 2005-06-09 2011-03-09 Process for the synthesis of organic compounds

Country Status (25)

Country Link
US (2) US7781597B2 (enExample)
EP (3) EP2292607B1 (enExample)
JP (2) JP5225078B2 (enExample)
KR (2) KR101249199B1 (enExample)
CN (6) CN102174021B (enExample)
AR (1) AR057056A1 (enExample)
AT (1) ATE540931T1 (enExample)
AU (3) AU2006258050B2 (enExample)
BR (1) BRPI0611683A2 (enExample)
CA (4) CA2942046A1 (enExample)
DK (2) DK2266961T3 (enExample)
ES (3) ES2465522T3 (enExample)
GT (1) GT200600202AA (enExample)
HU (1) HUE028024T2 (enExample)
IN (2) IN2014DN08588A (enExample)
JO (1) JO2758B1 (enExample)
MX (1) MX2007015609A (enExample)
MY (1) MY146795A (enExample)
PE (3) PE20100715A1 (enExample)
PL (3) PL2266961T3 (enExample)
PT (3) PT2292607E (enExample)
RU (1) RU2446162C2 (enExample)
SI (2) SI2266961T1 (enExample)
TW (1) TWI380981B (enExample)
WO (1) WO2006135640A2 (enExample)

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CN1930136B (zh) 2004-03-05 2012-02-08 日产化学工业株式会社 异*唑啉取代苯甲酰胺化合物及有害生物防除剂
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
BRPI0809770B8 (pt) 2007-06-13 2022-12-06 Du Pont Composto e composição para controlar uma praga de invertebrados
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
DK2957284T3 (en) 2007-06-27 2018-02-05 Du Pont PROCEDURE TO CHECK ANIMALS FOR ANIMALS
TWI600639B (zh) 2007-08-17 2017-10-01 杜邦股份有限公司 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物
KR20100075996A (ko) 2007-10-03 2010-07-05 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물
TWI583664B (zh) 2008-04-09 2017-05-21 杜邦股份有限公司 羰基化合物及其製備方法
US20100016590A1 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
EP2530081A3 (en) 2008-11-05 2013-04-10 Teva Pharmaceutical Industries, Ltd. Nilotinib HCI crystalline forms
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
MX2012013758A (es) 2010-05-27 2013-01-24 Du Pont Forma cristalina de 4-[5-[3-cloro-5-trifluorometil)fenil]-4,5-dihi dro-5-(trifluorometil)-3-isoxazolil]-n-[2-oxo-2-[(2,2,2-trifluoro etil)amino]etil]-1-naftalenocarboxamida.
BR112014015720B1 (pt) 2011-12-30 2020-03-17 Hanmi Pharm. Co., Ltd. Derivados de tieno[3,2-d]pirimidina, composição farmacêutica e uso dos mesmos para a prevenção ou tratamento de uma doença causada por ativação anormal de uma proteína quinase
CN102592837B (zh) * 2012-03-12 2014-01-15 河北师范大学 制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法
CN103694176B (zh) * 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
CN104592122B (zh) * 2014-12-09 2018-01-23 凯莱英医药集团（天津）股份有限公司 3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
CN105985293B (zh) * 2015-03-04 2018-04-03 埃斯特维华义制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN107201532B (zh) * 2017-05-09 2019-08-27 吉林凯莱英医药化学有限公司 芳香化合物的硝化方法
WO2019130254A1 (en) * 2018-01-01 2019-07-04 Laurus Labs Ltd An improved process for 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl) aniline
CN108530364B (zh) * 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
EP3806858A4 (en) 2018-06-15 2022-03-09 Handa Pharmaceuticals, Inc. KINA INHIBITOR SALTS AND COMPOSITIONS THEREOF
US11014945B2 (en) * 2019-04-06 2021-05-25 Trinapco, Inc. Sulfonyldiazoles and N-(fluorosulfonyl)azoles, and methods of making the same
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
CN114751836B (zh) * 2021-02-23 2024-05-31 四川青木制药有限公司 3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体
CN114853734A (zh) * 2022-06-14 2022-08-05 海南鑫开源医药科技有限公司 一种尼洛替尼游离碱的制备方法
CN116478319B (zh) * 2022-11-07 2025-07-01 华北电力大学 一种离子共价有机聚合物的制备方法及其在碱性环境吸附ReO4-的应用
CN115626880B (zh) * 2022-11-15 2023-11-14 常州大学 3-硝基-5-氰基三氟甲苯的合成方法
CN118108670B (zh) * 2023-12-28 2025-07-01 江苏希迪制药有限公司 尼罗替尼中间体3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺的精制纯化方法

Citations (6)

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EP0166533A1 (en) * 1984-05-29 1986-01-02 Pfizer Limited Quinolone inotropic agents
WO2001053274A1 (en) * 2000-01-21 2001-07-26 Agouron Pharmaceuticals, Inc. Amide compounds for inhibiting protein kinases
WO2003099771A2 (en) * 2002-05-29 2003-12-04 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
WO2004005281A1 (en) * 2002-07-05 2004-01-15 Novartis Ag Inhibitors of tyrosine kinases
WO2004029038A1 (en) * 2002-09-27 2004-04-08 Novartis Ag Novel pyrimidineamide derivatives and the use thereof
WO2006069525A1 (en) * 2004-12-31 2006-07-06 Piaoyang Sun Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof

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SU1051076A1 (ru) * 1982-04-09 1983-10-30 Алтайский политехнический институт Способ получени производных имидазола
GB8413685D0 (en) * 1984-05-29 1984-07-04 Pfizer Ltd Quinolone inotropic agents
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
GB0023383D0 (en) * 2000-09-23 2000-11-08 Synprotec Ltd 3,5-Bis (Trifluormethyl)Benzene derivatives
GT200600207A (es) * 2005-06-09 2007-01-15 Novartis Ag Proceso para la síntesis de compuestos orgánicos
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
EP0166533A1 (en) * 1984-05-29 1986-01-02 Pfizer Limited Quinolone inotropic agents
WO2001053274A1 (en) * 2000-01-21 2001-07-26 Agouron Pharmaceuticals, Inc. Amide compounds for inhibiting protein kinases
WO2003099771A2 (en) * 2002-05-29 2003-12-04 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
WO2004005281A1 (en) * 2002-07-05 2004-01-15 Novartis Ag Inhibitors of tyrosine kinases
WO2004029038A1 (en) * 2002-09-27 2004-04-08 Novartis Ag Novel pyrimidineamide derivatives and the use thereof
WO2006069525A1 (en) * 2004-12-31 2006-07-06 Piaoyang Sun Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof

Also Published As

Publication number Publication date
HUE028024T2 (en) 2016-11-28
CN102174020A (zh) 2011-09-07
ES2558696T3 (es) 2016-02-08
PT1896426E (pt) 2012-04-12
CN102180796A (zh) 2011-09-14
MX2007015609A (es) 2008-02-25
PE20070109A1 (es) 2007-04-02
PL2266961T3 (pl) 2016-04-29
CN102174021B (zh) 2013-02-27
US7781597B2 (en) 2010-08-24
KR101249199B1 (ko) 2013-04-03
CA2611280A1 (en) 2006-12-21
JP5225078B2 (ja) 2013-07-03
TW200716563A (en) 2007-05-01
RU2446162C2 (ru) 2012-03-27
JP2013035855A (ja) 2013-02-21
SI2292607T1 (sl) 2014-09-30
CN102180836A (zh) 2011-09-14
US20080200692A1 (en) 2008-08-21
PE20100715A1 (es) 2010-10-25
SI2266961T1 (sl) 2016-02-29
EP2292607A3 (en) 2011-04-27
JO2758B1 (en) 2014-03-15
ATE540931T1 (de) 2012-01-15
PL1896426T3 (pl) 2012-06-29
PE20100716A1 (es) 2010-10-25
CN102174019A (zh) 2011-09-07
ES2380489T8 (es) 2012-06-22
CN102174021A (zh) 2011-09-07
EP2266961A2 (en) 2010-12-29
ES2380489T3 (es) 2012-05-14
TWI380981B (zh) 2013-01-01
US8008504B2 (en) 2011-08-30
WO2006135640A3 (en) 2007-08-02
DK2292607T3 (da) 2014-06-30
EP1896426A2 (en) 2008-03-12
US20100280257A1 (en) 2010-11-04
PT2266961E (pt) 2016-02-05
AU2011201044A1 (en) 2011-03-31
CA2611280C (en) 2014-01-28
AU2010241374A1 (en) 2010-12-02
EP2292607A2 (en) 2011-03-09
AU2010241374B2 (en) 2011-11-03
IN2014DN08588A (enExample) 2015-07-10
IN2014DN08578A (enExample) 2015-07-10
CN101189212B (zh) 2011-05-18
CA2942046A1 (en) 2006-12-21
AU2006258050A1 (en) 2006-12-21
CN102174020B (zh) 2012-11-07
KR20080014010A (ko) 2008-02-13
EP2292607B1 (en) 2014-04-09
PL2292607T3 (pl) 2014-09-30
EP2266961A3 (en) 2011-07-27
KR20120099028A (ko) 2012-09-06
EP2266961B1 (en) 2015-10-21
EP1896426B1 (en) 2012-01-11
DK2266961T3 (en) 2016-01-25
CA2886482A1 (en) 2006-12-21
KR101283109B1 (ko) 2013-07-05
ES2465522T3 (es) 2014-06-06
CA2886482C (en) 2017-09-05
CA2833394C (en) 2016-03-29
WO2006135640A2 (en) 2006-12-21
GT200600202AA (es) 2014-06-09
RU2007148238A (ru) 2009-07-20
CN102174019B (zh) 2013-02-13
PT2292607E (pt) 2014-06-24
MY146795A (en) 2012-09-28
BRPI0611683A2 (pt) 2010-09-28
CA2833394A1 (en) 2006-12-21
CN101189212A (zh) 2008-05-28
CN102180836B (zh) 2012-11-21
AR057056A1 (es) 2007-11-14
JP2008546645A (ja) 2008-12-25

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired