KR101249199B1 - 유기 화합물의 합성을 위한 공정 - Google Patents

유기 화합물의 합성을 위한 공정 Download PDF

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Publication number
KR101249199B1
KR101249199B1 KR1020077028642A KR20077028642A KR101249199B1 KR 101249199 B1 KR101249199 B1 KR 101249199B1 KR 1020077028642 A KR1020077028642 A KR 1020077028642A KR 20077028642 A KR20077028642 A KR 20077028642A KR 101249199 B1 KR101249199 B1 KR 101249199B1
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KR
South Korea
Prior art keywords
methyl
trifluoromethyl
potassium
sodium
compound
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Expired - Fee Related
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KR1020077028642A
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English (en)
Korean (ko)
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KR20080014010A (ko
Inventor
스테판 아벨
무라트 아체모글루
베른하르트 에르브
크리스토프 크렐
조셉 스클라파니
마르크 마이젠바흐
마하비르 프라샤드
웬-충 시에
송 쉬에
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노파르티스 아게
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Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20080014010A publication Critical patent/KR20080014010A/ko
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020077028642A 2005-06-09 2006-06-07 유기 화합물의 합성을 위한 공정 Expired - Fee Related KR101249199B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68897605P 2005-06-09 2005-06-09
US60/688,976 2005-06-09
PCT/US2006/022154 WO2006135640A2 (en) 2005-06-09 2006-06-07 Process for the synthesis of organic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020127011979A Division KR101283109B1 (ko) 2005-06-09 2006-06-07 유기 화합물의 합성을 위한 공정

Publications (2)

Publication Number Publication Date
KR20080014010A KR20080014010A (ko) 2008-02-13
KR101249199B1 true KR101249199B1 (ko) 2013-04-03

Family

ID=37149980

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077028642A Expired - Fee Related KR101249199B1 (ko) 2005-06-09 2006-06-07 유기 화합물의 합성을 위한 공정
KR1020127011979A Expired - Fee Related KR101283109B1 (ko) 2005-06-09 2006-06-07 유기 화합물의 합성을 위한 공정

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020127011979A Expired - Fee Related KR101283109B1 (ko) 2005-06-09 2006-06-07 유기 화합물의 합성을 위한 공정

Country Status (25)

Country Link
US (2) US7781597B2 (enExample)
EP (3) EP2292607B1 (enExample)
JP (2) JP5225078B2 (enExample)
KR (2) KR101249199B1 (enExample)
CN (6) CN102174021B (enExample)
AR (1) AR057056A1 (enExample)
AT (1) ATE540931T1 (enExample)
AU (3) AU2006258050B2 (enExample)
BR (1) BRPI0611683A2 (enExample)
CA (4) CA2942046A1 (enExample)
DK (2) DK2266961T3 (enExample)
ES (3) ES2465522T3 (enExample)
GT (1) GT200600202AA (enExample)
HU (1) HUE028024T2 (enExample)
IN (2) IN2014DN08588A (enExample)
JO (1) JO2758B1 (enExample)
MX (1) MX2007015609A (enExample)
MY (1) MY146795A (enExample)
PE (3) PE20100715A1 (enExample)
PL (3) PL2266961T3 (enExample)
PT (3) PT2292607E (enExample)
RU (1) RU2446162C2 (enExample)
SI (2) SI2266961T1 (enExample)
TW (1) TWI380981B (enExample)
WO (1) WO2006135640A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1930136B (zh) 2004-03-05 2012-02-08 日产化学工业株式会社 异*唑啉取代苯甲酰胺化合物及有害生物防除剂
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
BRPI0809770B8 (pt) 2007-06-13 2022-12-06 Du Pont Composto e composição para controlar uma praga de invertebrados
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
DK2957284T3 (en) 2007-06-27 2018-02-05 Du Pont PROCEDURE TO CHECK ANIMALS FOR ANIMALS
TWI600639B (zh) 2007-08-17 2017-10-01 杜邦股份有限公司 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物
KR20100075996A (ko) 2007-10-03 2010-07-05 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물
TWI583664B (zh) 2008-04-09 2017-05-21 杜邦股份有限公司 羰基化合物及其製備方法
US20100016590A1 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
EP2530081A3 (en) 2008-11-05 2013-04-10 Teva Pharmaceutical Industries, Ltd. Nilotinib HCI crystalline forms
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
MX2012013758A (es) 2010-05-27 2013-01-24 Du Pont Forma cristalina de 4-[5-[3-cloro-5-trifluorometil)fenil]-4,5-dihi dro-5-(trifluorometil)-3-isoxazolil]-n-[2-oxo-2-[(2,2,2-trifluoro etil)amino]etil]-1-naftalenocarboxamida.
BR112014015720B1 (pt) 2011-12-30 2020-03-17 Hanmi Pharm. Co., Ltd. Derivados de tieno[3,2-d]pirimidina, composição farmacêutica e uso dos mesmos para a prevenção ou tratamento de uma doença causada por ativação anormal de uma proteína quinase
CN102592837B (zh) * 2012-03-12 2014-01-15 河北师范大学 制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法
CN103694176B (zh) * 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
CN104592122B (zh) * 2014-12-09 2018-01-23 凯莱英医药集团（天津）股份有限公司 3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
CN105985293B (zh) * 2015-03-04 2018-04-03 埃斯特维华义制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN107201532B (zh) * 2017-05-09 2019-08-27 吉林凯莱英医药化学有限公司 芳香化合物的硝化方法
WO2019130254A1 (en) * 2018-01-01 2019-07-04 Laurus Labs Ltd An improved process for 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl) aniline
CN108530364B (zh) * 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
EP3806858A4 (en) 2018-06-15 2022-03-09 Handa Pharmaceuticals, Inc. KINA INHIBITOR SALTS AND COMPOSITIONS THEREOF
US11014945B2 (en) * 2019-04-06 2021-05-25 Trinapco, Inc. Sulfonyldiazoles and N-(fluorosulfonyl)azoles, and methods of making the same
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
CN114751836B (zh) * 2021-02-23 2024-05-31 四川青木制药有限公司 3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体
CN114853734A (zh) * 2022-06-14 2022-08-05 海南鑫开源医药科技有限公司 一种尼洛替尼游离碱的制备方法
CN116478319B (zh) * 2022-11-07 2025-07-01 华北电力大学 一种离子共价有机聚合物的制备方法及其在碱性环境吸附ReO4-的应用
CN115626880B (zh) * 2022-11-15 2023-11-14 常州大学 3-硝基-5-氰基三氟甲苯的合成方法
CN118108670B (zh) * 2023-12-28 2025-07-01 江苏希迪制药有限公司 尼罗替尼中间体3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺的精制纯化方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099771A2 (en) * 2002-05-29 2003-12-04 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
WO2004005281A1 (en) * 2002-07-05 2004-01-15 Novartis Ag Inhibitors of tyrosine kinases

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1051076A1 (ru) * 1982-04-09 1983-10-30 Алтайский политехнический институт Способ получени производных имидазола
CA1292234C (en) * 1984-05-29 1991-11-19 Simon Fraser Campbell Heterocyclic-substituted quinolone inotropic agents
GB8413685D0 (en) * 1984-05-29 1984-07-04 Pfizer Ltd Quinolone inotropic agents
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
GB0023383D0 (en) * 2000-09-23 2000-11-08 Synprotec Ltd 3,5-Bis (Trifluormethyl)Benzene derivatives
GB0222514D0 (en) 2002-09-27 2002-11-06 Novartis Ag Organic compounds
CN1939910A (zh) * 2004-12-31 2007-04-04 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
GT200600207A (es) * 2005-06-09 2007-01-15 Novartis Ag Proceso para la síntesis de compuestos orgánicos
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099771A2 (en) * 2002-05-29 2003-12-04 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
WO2004005281A1 (en) * 2002-07-05 2004-01-15 Novartis Ag Inhibitors of tyrosine kinases

Also Published As

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HUE028024T2 (en) 2016-11-28
CN102174020A (zh) 2011-09-07
ES2558696T3 (es) 2016-02-08
PT1896426E (pt) 2012-04-12
CN102180796A (zh) 2011-09-14
MX2007015609A (es) 2008-02-25
PE20070109A1 (es) 2007-04-02
PL2266961T3 (pl) 2016-04-29
AU2006258050B2 (en) 2010-12-09
CN102174021B (zh) 2013-02-27
US7781597B2 (en) 2010-08-24
CA2611280A1 (en) 2006-12-21
JP5225078B2 (ja) 2013-07-03
TW200716563A (en) 2007-05-01
RU2446162C2 (ru) 2012-03-27
JP2013035855A (ja) 2013-02-21
SI2292607T1 (sl) 2014-09-30
CN102180836A (zh) 2011-09-14
US20080200692A1 (en) 2008-08-21
PE20100715A1 (es) 2010-10-25
SI2266961T1 (sl) 2016-02-29
EP2292607A3 (en) 2011-04-27
JO2758B1 (en) 2014-03-15
ATE540931T1 (de) 2012-01-15
PL1896426T3 (pl) 2012-06-29
PE20100716A1 (es) 2010-10-25
CN102174019A (zh) 2011-09-07
ES2380489T8 (es) 2012-06-22
CN102174021A (zh) 2011-09-07
EP2266961A2 (en) 2010-12-29
ES2380489T3 (es) 2012-05-14
TWI380981B (zh) 2013-01-01
US8008504B2 (en) 2011-08-30
WO2006135640A3 (en) 2007-08-02
DK2292607T3 (da) 2014-06-30
EP1896426A2 (en) 2008-03-12
US20100280257A1 (en) 2010-11-04
PT2266961E (pt) 2016-02-05
AU2011201044A1 (en) 2011-03-31
CA2611280C (en) 2014-01-28
AU2010241374A1 (en) 2010-12-02
EP2292607A2 (en) 2011-03-09
AU2010241374B2 (en) 2011-11-03
IN2014DN08588A (enExample) 2015-07-10
IN2014DN08578A (enExample) 2015-07-10
CN101189212B (zh) 2011-05-18
CA2942046A1 (en) 2006-12-21
AU2006258050A1 (en) 2006-12-21
CN102174020B (zh) 2012-11-07
KR20080014010A (ko) 2008-02-13
EP2292607B1 (en) 2014-04-09
PL2292607T3 (pl) 2014-09-30
EP2266961A3 (en) 2011-07-27
KR20120099028A (ko) 2012-09-06
EP2266961B1 (en) 2015-10-21
EP1896426B1 (en) 2012-01-11
DK2266961T3 (en) 2016-01-25
CA2886482A1 (en) 2006-12-21
KR101283109B1 (ko) 2013-07-05
ES2465522T3 (es) 2014-06-06
CA2886482C (en) 2017-09-05
CA2833394C (en) 2016-03-29
WO2006135640A2 (en) 2006-12-21
GT200600202AA (es) 2014-06-09
RU2007148238A (ru) 2009-07-20
CN102174019B (zh) 2013-02-13
PT2292607E (pt) 2014-06-24
MY146795A (en) 2012-09-28
BRPI0611683A2 (pt) 2010-09-28
CA2833394A1 (en) 2006-12-21
CN101189212A (zh) 2008-05-28
CN102180836B (zh) 2012-11-21
AR057056A1 (es) 2007-11-14
JP2008546645A (ja) 2008-12-25

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