JP5122142B2 - 安定化させたαヘリックスペプチドおよびその使用法 - Google Patents

安定化させたαヘリックスペプチドおよびその使用法 Download PDF

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JP5122142B2
JP5122142B2 JP2006540005A JP2006540005A JP5122142B2 JP 5122142 B2 JP5122142 B2 JP 5122142B2 JP 2006540005 A JP2006540005 A JP 2006540005A JP 2006540005 A JP2006540005 A JP 2006540005A JP 5122142 B2 JP5122142 B2 JP 5122142B2
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polypeptide
bid
compound
bcl
sahb3 bid
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JP2008501623A (ja
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ローレン ディー． ワレンスキー
スタンリー ジェイ． コースマイアー
グレゴリー バーダイン
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デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

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JP2006540005A 2003-11-05 2004-11-05 安定化させたαヘリックスペプチドおよびその使用法 Expired - Fee Related JP5122142B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US51784803P 2003-11-05 2003-11-05
US60/517,848 2003-11-05
US59154804P 2004-07-27 2004-07-27
US60/591,548 2004-07-27
PCT/US2004/038403 WO2005044839A2 (en) 2003-11-05 2004-11-05 Stabilized alpha helical peptides and uses thereof

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JP2011266427A Division JP2012116836A (ja) 2003-11-05 2011-12-06 安定化させたαヘリックスペプチドおよびその使用法

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JP2008501623A JP2008501623A (ja) 2008-01-24
JP5122142B2 true JP5122142B2 (ja) 2013-01-16

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JP2006540005A Expired - Fee Related JP5122142B2 (ja) 2003-11-05 2004-11-05 安定化させたαヘリックスペプチドおよびその使用法
JP2011266427A Withdrawn JP2012116836A (ja) 2003-11-05 2011-12-06 安定化させたαヘリックスペプチドおよびその使用法
JP2015033319A Withdrawn JP2015163608A (ja) 2003-11-05 2015-02-23 安定化させたαヘリックスペプチドおよびその使用法
JP2017079231A Withdrawn JP2017197522A (ja) 2003-11-05 2017-04-12 安定化させたαヘリックスペプチドおよびその使用法
JP2019105614A Pending JP2019189622A (ja) 2003-11-05 2019-06-05 安定化させたαヘリックスペプチドおよびその使用法

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JP2011266427A Withdrawn JP2012116836A (ja) 2003-11-05 2011-12-06 安定化させたαヘリックスペプチドおよびその使用法
JP2015033319A Withdrawn JP2015163608A (ja) 2003-11-05 2015-02-23 安定化させたαヘリックスペプチドおよびその使用法
JP2017079231A Withdrawn JP2017197522A (ja) 2003-11-05 2017-04-12 安定化させたαヘリックスペプチドおよびその使用法
JP2019105614A Pending JP2019189622A (ja) 2003-11-05 2019-06-05 安定化させたαヘリックスペプチドおよびその使用法

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US (6) US7723469B2 (enExample)
EP (4) EP2332968B1 (enExample)
JP (5) JP5122142B2 (enExample)
CN (3) CN103467588B (enExample)
AU (1) AU2004287884C1 (enExample)
BR (1) BRPI0416258A (enExample)
CA (2) CA2830063C (enExample)
CY (1) CY1114944T1 (enExample)
DK (2) DK1680443T5 (enExample)
ES (2) ES2586387T3 (enExample)
IL (3) IL175152A (enExample)
PL (2) PL1680443T3 (enExample)
PT (2) PT2332968T (enExample)
SI (1) SI1680443T1 (enExample)
WO (1) WO2005044839A2 (enExample)
ZA (1) ZA200603565B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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WO2016085280A1 (ko) * 2014-11-28 2016-06-02 서울대학교산학협력단 세포 투과성 스테이플 펩타이드, 이의 제조방법 및 그 용도

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WO2004022580A2 (en) 2002-09-09 2004-03-18 Dana-Farber Cancer Institute, Inc. Bh3 peptides and method of use thereof
PL1680443T3 (pl) 2003-11-05 2014-02-28 Dana Farber Cancer Inst Inc Stabilizowane alfa-helikalne peptydy i ich zastosowanie
WO2005118620A2 (en) 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
FR2881430B1 (fr) * 2005-02-01 2010-10-22 Servier Lab Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
EP2008106A2 (en) 2006-03-31 2008-12-31 Dana-Farber Cancer Institute Methods of determining cellular chemosensitivity
US8937154B2 (en) 2006-10-05 2015-01-20 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
AU2007307254A1 (en) * 2006-10-05 2008-04-17 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
EP2489360A1 (en) * 2006-11-15 2012-08-22 Dana-Farber Cancer Institute, Inc. Stabilized MAML peptides and uses thereof
US7960506B2 (en) * 2006-12-14 2011-06-14 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US7981998B2 (en) * 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
AU2016210709B2 (en) * 2007-01-31 2018-04-19 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
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AU2013231104B2 (en) * 2007-01-31 2016-05-12 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
WO2008104000A2 (en) * 2007-02-23 2008-08-28 Aileron Therapeutics, Inc. Triazole macrocycle systems
CA2682174C (en) 2007-03-28 2021-04-06 President And Fellows Of Harvard College Stitched polypeptides
EP2152294B1 (en) * 2007-05-02 2017-07-26 Dana-Farber Cancer Institute, Inc. A bad bh3 domain peptide for use in treating or delaying the onset of diabetes.
WO2009042237A2 (en) 2007-09-26 2009-04-02 Dana Farber Cancer Institute Methods and compositions for modulating bcl-2 family polypeptides
US8871899B2 (en) * 2007-12-31 2014-10-28 New York University Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices
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EP2242503A4 (en) * 2008-02-08 2012-04-25 Aileron Therapeutics Inc THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
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EP2334317B1 (en) * 2008-09-16 2017-06-14 The Research Foundation Of State University Of New York Stapled peptides and method of synthesis
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