CN1906209A - 稳定的α螺旋肽及其用途 - Google Patents

稳定的α螺旋肽及其用途 Download PDF

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Publication number
CN1906209A
CN1906209A CNA2004800399459A CN200480039945A CN1906209A CN 1906209 A CN1906209 A CN 1906209A CN A2004800399459 A CNA2004800399459 A CN A2004800399459A CN 200480039945 A CN200480039945 A CN 200480039945A CN 1906209 A CN1906209 A CN 1906209A
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Prior art keywords
polypeptide
alkyl
general formula
compound
alkynyl
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Pending
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CNA2004800399459A
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English (en)
Chinese (zh)
Inventor
洛伦·D·沃伦斯基
斯坦利·J·科斯迈耶
格雷戈里·弗迪恩
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Dana Farber Cancer Institute Inc
Harvard University
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Dana Farber Cancer Institute Inc
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Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Priority to CN201610944586.6A priority Critical patent/CN107090025A/zh
Priority to CN201310178526.4A priority patent/CN103467588B/zh
Publication of CN1906209A publication Critical patent/CN1906209A/zh
Pending legal-status Critical Current

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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
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CNA2004800399459A 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途 Pending CN1906209A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610944586.6A CN107090025A (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途
CN201310178526.4A CN103467588B (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51784803P 2003-11-05 2003-11-05
US60/517,848 2003-11-05
US59154804P 2004-07-27 2004-07-27
US60/591,548 2004-07-27

Related Child Applications (2)

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CN201610944586.6A Division CN107090025A (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途
CN201310178526.4A Division CN103467588B (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途

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CN1906209A true CN1906209A (zh) 2007-01-31

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CNA2004800399459A Pending CN1906209A (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途
CN201310178526.4A Expired - Fee Related CN103467588B (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途
CN201610944586.6A Pending CN107090025A (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途

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CN201310178526.4A Expired - Fee Related CN103467588B (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途
CN201610944586.6A Pending CN107090025A (zh) 2003-11-05 2004-11-05 稳定的α螺旋肽及其用途

Country Status (16)

Country Link
US (6) US7723469B2 (enExample)
EP (4) EP1680443B9 (enExample)
JP (5) JP5122142B2 (enExample)
CN (3) CN1906209A (enExample)
AU (1) AU2004287884C1 (enExample)
BR (1) BRPI0416258A (enExample)
CA (2) CA2544223C (enExample)
CY (1) CY1114944T1 (enExample)
DK (2) DK1680443T5 (enExample)
ES (2) ES2437567T3 (enExample)
IL (3) IL175152A (enExample)
PL (2) PL1680443T3 (enExample)
PT (2) PT2332968T (enExample)
SI (1) SI1680443T1 (enExample)
WO (1) WO2005044839A2 (enExample)
ZA (1) ZA200603565B (enExample)

Cited By (25)

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CN102203126A (zh) * 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
CN102482336A (zh) * 2008-09-22 2012-05-30 爱勒让治疗公司 拟肽大环化合物
CN102655875A (zh) * 2009-10-14 2012-09-05 爱勒让治疗公司 改善的拟肽大环化合物
CN103649113A (zh) * 2011-04-15 2014-03-19 达纳-法伯癌症研究所有限公司 使用BCL-9的安定的α螺旋将癌症中失调WNT信号传递订为目标
CN104474529A (zh) * 2008-02-08 2015-04-01 爱勒让治疗公司 治疗性的拟肽大环化合物
CN105307667A (zh) * 2013-03-13 2016-02-03 哈佛大学的校长及成员们 钉合且缝合的多肽及其用途
US9845287B2 (en) 2012-11-01 2017-12-19 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CN107540737A (zh) * 2016-06-29 2018-01-05 香港理工大学 用于促进内体及溶酶体生物降解的碳氢订书肽
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9957299B2 (en) 2010-08-13 2018-05-01 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN108026146A (zh) * 2015-07-02 2018-05-11 达纳-法伯癌症研究所股份有限公司 稳定的抗微生物肽
CN108368161A (zh) * 2015-09-10 2018-08-03 艾瑞朗医疗公司 作为mcl-1调节剂的拟肽大环化合物
US10202431B2 (en) 2007-01-31 2019-02-12 Aileron Therapeutics, Inc. Stabilized P53 peptides and uses thereof
US10213477B2 (en) 2012-02-15 2019-02-26 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10227390B2 (en) 2013-06-14 2019-03-12 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
US10227380B2 (en) 2012-02-15 2019-03-12 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10301351B2 (en) 2007-03-28 2019-05-28 President And Fellows Of Harvard College Stitched polypeptides
US10308699B2 (en) 2011-10-18 2019-06-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10471120B2 (en) 2014-09-24 2019-11-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US11198713B2 (en) 2017-09-07 2021-12-14 Fog Pharmaceuticals, Inc. Agents modulating beta-catenin functions and methods thereof
US11325955B2 (en) 2017-07-19 2022-05-10 Dana-Farber Cancer Institute, Inc. Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections
US12391733B2 (en) 2016-02-29 2025-08-19 Dana-Farber Cancer Institute, Inc. Stapled intracellular-targeting antimicrobial peptides to treat infection

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Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
CA2496400A1 (en) 2002-09-09 2004-03-18 Dana-Farber Cancer Institute, Inc. Bh3 peptides and method of use thereof
EP1680443B9 (en) * 2003-11-05 2014-09-03 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
FR2881430B1 (fr) * 2005-02-01 2010-10-22 Servier Lab Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
US8221966B2 (en) 2006-03-31 2012-07-17 Dana Farber Cancer Institute Methods of determining cellular chemosensitivity
WO2008045238A2 (en) 2006-10-05 2008-04-17 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
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