AU2004287884C1 - Stabilized alpha helical peptides and uses thereof - Google Patents

Stabilized alpha helical peptides and uses thereof Download PDF

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Publication number
AU2004287884C1
AU2004287884C1 AU2004287884A AU2004287884A AU2004287884C1 AU 2004287884 C1 AU2004287884 C1 AU 2004287884C1 AU 2004287884 A AU2004287884 A AU 2004287884A AU 2004287884 A AU2004287884 A AU 2004287884A AU 2004287884 C1 AU2004287884 C1 AU 2004287884C1
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Australia
Prior art keywords
polypeptide
alkyl
formula
xaa
compound
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Ceased
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AU2004287884A
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AU2004287884A1 (en
AU2004287884B2 (en
Inventor
Stanley J. Korsmeyer
Gregory Verdine
Loren D. Walensky
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Dana Farber Cancer Institute Inc
Harvard University
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Dana Farber Cancer Institute Inc
Harvard University
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Publication of AU2004287884A1 publication Critical patent/AU2004287884A1/en
Publication of AU2004287884B2 publication Critical patent/AU2004287884B2/en
Priority to AU2012207048A priority Critical patent/AU2012207048C1/en
Application granted granted Critical
Publication of AU2004287884C1 publication Critical patent/AU2004287884C1/en
Assigned to DANA-FARBER CANCER INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE reassignment DANA-FARBER CANCER INSTITUTE, INC. Request for Assignment Assignors: DANA-FARBER CANCER INSTITUTE, INC.
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
AU2004287884A 2003-11-05 2004-11-05 Stabilized alpha helical peptides and uses thereof Ceased AU2004287884C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012207048A AU2012207048C1 (en) 2003-11-05 2012-07-25 Stabilized alpha helical peptides and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US51784803P 2003-11-05 2003-11-05
US60/517,848 2003-11-05
US59154804P 2004-07-27 2004-07-27
US60/591,548 2004-07-27
PCT/US2004/038403 WO2005044839A2 (en) 2003-11-05 2004-11-05 Stabilized alpha helical peptides and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012207048A Division AU2012207048C1 (en) 2003-11-05 2012-07-25 Stabilized alpha helical peptides and uses thereof

Publications (3)

Publication Number Publication Date
AU2004287884A1 AU2004287884A1 (en) 2005-05-19
AU2004287884B2 AU2004287884B2 (en) 2012-04-26
AU2004287884C1 true AU2004287884C1 (en) 2012-11-29

Family

ID=34576814

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AU2004287884A Ceased AU2004287884C1 (en) 2003-11-05 2004-11-05 Stabilized alpha helical peptides and uses thereof

Country Status (16)

Country Link
US (6) US7723469B2 (enExample)
EP (4) EP1680443B9 (enExample)
JP (5) JP5122142B2 (enExample)
CN (3) CN1906209A (enExample)
AU (1) AU2004287884C1 (enExample)
BR (1) BRPI0416258A (enExample)
CA (2) CA2544223C (enExample)
CY (1) CY1114944T1 (enExample)
DK (2) DK1680443T5 (enExample)
ES (2) ES2437567T3 (enExample)
IL (3) IL175152A (enExample)
PL (2) PL1680443T3 (enExample)
PT (2) PT2332968T (enExample)
SI (1) SI1680443T1 (enExample)
WO (1) WO2005044839A2 (enExample)
ZA (1) ZA200603565B (enExample)

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