JP4809228B2 - ヒストンデアセチラーゼの阻害剤 - Google Patents
ヒストンデアセチラーゼの阻害剤 Download PDFInfo
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- JP4809228B2 JP4809228B2 JP2006528279A JP2006528279A JP4809228B2 JP 4809228 B2 JP4809228 B2 JP 4809228B2 JP 2006528279 A JP2006528279 A JP 2006528279A JP 2006528279 A JP2006528279 A JP 2006528279A JP 4809228 B2 JP4809228 B2 JP 4809228B2
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- Prior art keywords
- alkyl
- amino
- hydroxy
- alkyloxy
- substituted
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- 0 C*1*CN(C)CC1 Chemical compound C*1*CN(C)CC1 0.000 description 23
- BJJVGDLTHHTZTF-UHFFFAOYSA-N BC(CC)C(CC1)=CCC=C1c1ccccc1 Chemical compound BC(CC)C(CC1)=CCC=C1c1ccccc1 BJJVGDLTHHTZTF-UHFFFAOYSA-N 0.000 description 1
- RJPKIHBUTGKZSR-UHFFFAOYSA-N C=CC(Nc1cc(-c2ccc[s]2)ccc1N)=O Chemical compound C=CC(Nc1cc(-c2ccc[s]2)ccc1N)=O RJPKIHBUTGKZSR-UHFFFAOYSA-N 0.000 description 1
- MPXAYYWSDIKNTP-UHFFFAOYSA-N CC(Nc(cccc1)c1N)=O Chemical compound CC(Nc(cccc1)c1N)=O MPXAYYWSDIKNTP-UHFFFAOYSA-N 0.000 description 1
- MMSLOZQEMPDGPI-UHFFFAOYSA-N CC(c1ccc(C)cc1)=C Chemical compound CC(c1ccc(C)cc1)=C MMSLOZQEMPDGPI-UHFFFAOYSA-N 0.000 description 1
- JZHZESHIHSFKIF-UHFFFAOYSA-N CONC(c(cc1)ccc1[I](CC1)C=CN1S(C)(=O)=O)=O Chemical compound CONC(c(cc1)ccc1[I](CC1)C=CN1S(C)(=O)=O)=O JZHZESHIHSFKIF-UHFFFAOYSA-N 0.000 description 1
- ILSOQFQZGZSGHT-UHFFFAOYSA-N COc(c(OC)c1)ccc1NCc(cc1)ccc1C(Nc(cc(cc1)C#Cc2ccccc2)c1N)=O Chemical compound COc(c(OC)c1)ccc1NCc(cc1)ccc1C(Nc(cc(cc1)C#Cc2ccccc2)c1N)=O ILSOQFQZGZSGHT-UHFFFAOYSA-N 0.000 description 1
- VOPLBKUSQCHUEI-UHFFFAOYSA-N COc(cc1)ccc1C(Nc(cc(cc1)-c2cc(O)ccc2)c1N)=O Chemical compound COc(cc1)ccc1C(Nc(cc(cc1)-c2cc(O)ccc2)c1N)=O VOPLBKUSQCHUEI-UHFFFAOYSA-N 0.000 description 1
- OFLUOBWXCXWNTN-UHFFFAOYSA-N COc(cc1)ccc1C(Nc(cc(cc1)C(N)=O)c1N)=O Chemical compound COc(cc1)ccc1C(Nc(cc(cc1)C(N)=O)c1N)=O OFLUOBWXCXWNTN-UHFFFAOYSA-N 0.000 description 1
- MMHCNMMRQBGRLF-UHFFFAOYSA-N COc(cc1)ccc1C(Nc1cc(C(O)=O)ccc1N)=O Chemical compound COc(cc1)ccc1C(Nc1cc(C(O)=O)ccc1N)=O MMHCNMMRQBGRLF-UHFFFAOYSA-N 0.000 description 1
- VQDYTXLRRXBRCC-UHFFFAOYSA-N COc(ccc(NCc(cc1)ccc1C(Nc(cc(cc1)Br)c1[N+]([O-])=O)=O)c1)c1OC Chemical compound COc(ccc(NCc(cc1)ccc1C(Nc(cc(cc1)Br)c1[N+]([O-])=O)=O)c1)c1OC VQDYTXLRRXBRCC-UHFFFAOYSA-N 0.000 description 1
- PLBVTOAVEQEGJA-UHFFFAOYSA-N C[n]1c2cc(C(Nc(cc(cc3)-c4ccc[s]4)c3N)=O)ccc2cc1 Chemical compound C[n]1c2cc(C(Nc(cc(cc3)-c4ccc[s]4)c3N)=O)ccc2cc1 PLBVTOAVEQEGJA-UHFFFAOYSA-N 0.000 description 1
- JYLLWXNVYCWUMU-UHFFFAOYSA-N Cc([nH]c1c2)nc1cc(Cl)c2F Chemical compound Cc([nH]c1c2)nc1cc(Cl)c2F JYLLWXNVYCWUMU-UHFFFAOYSA-N 0.000 description 1
- FOVXANGOLMXKES-UHFFFAOYSA-N Cc(cc1)cc(F)c1OC Chemical compound Cc(cc1)cc(F)c1OC FOVXANGOLMXKES-UHFFFAOYSA-N 0.000 description 1
- GYPMBQZAVBFUIZ-UHFFFAOYSA-N Cc(cc1)cc(OC)c1OC Chemical compound Cc(cc1)cc(OC)c1OC GYPMBQZAVBFUIZ-UHFFFAOYSA-N 0.000 description 1
- OLHBKXYPKCHVNW-UHFFFAOYSA-N Cc(cc1)cc2c1OCC2 Chemical compound Cc(cc1)cc2c1OCC2 OLHBKXYPKCHVNW-UHFFFAOYSA-N 0.000 description 1
- AISCQORWBOTWKZ-UHFFFAOYSA-N Cc(cc1)ccc1SNc(cc1)ccc1I Chemical compound Cc(cc1)ccc1SNc(cc1)ccc1I AISCQORWBOTWKZ-UHFFFAOYSA-N 0.000 description 1
- KCIZTNZGSBSSRM-UHFFFAOYSA-N Cc(cc1OC)cc(OC)c1OC Chemical compound Cc(cc1OC)cc(OC)c1OC KCIZTNZGSBSSRM-UHFFFAOYSA-N 0.000 description 1
- XEGDWHHXJDSNLS-ZETCQYMHSA-N NC(C([N+]([O-])=O)=CC1)=C[C@H]1c1ccc[s]1 Chemical compound NC(C([N+]([O-])=O)=CC1)=C[C@H]1c1ccc[s]1 XEGDWHHXJDSNLS-ZETCQYMHSA-N 0.000 description 1
- RJYNRKXEPWUDFL-UHFFFAOYSA-N Nc(c(NC(c([o]c1c2)cc1ccc2OCCN1CCOCC1)=O)c1)ccc1-c1ccc[s]1 Chemical compound Nc(c(NC(c([o]c1c2)cc1ccc2OCCN1CCOCC1)=O)c1)ccc1-c1ccc[s]1 RJYNRKXEPWUDFL-UHFFFAOYSA-N 0.000 description 1
- CREXSUWLTAWAGO-UHFFFAOYSA-N Nc(c(NC(c(cc1)cc(C(N2CCN3CCOCC3)=O)c1C2=O)=O)c1)ccc1-c1ccc[s]1 Chemical compound Nc(c(NC(c(cc1)cc(C(N2CCN3CCOCC3)=O)c1C2=O)=O)c1)ccc1-c1ccc[s]1 CREXSUWLTAWAGO-UHFFFAOYSA-N 0.000 description 1
- RMIFLIVHJLREFJ-UHFFFAOYSA-N Nc1cc(Br)ccc1[N+]([O-])=O Chemical compound Nc1cc(Br)ccc1[N+]([O-])=O RMIFLIVHJLREFJ-UHFFFAOYSA-N 0.000 description 1
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- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
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| US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| JP4648628B2 (ja) | 2002-03-13 | 2011-03-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのカルボニルアミノ誘導体 |
| WO2003076401A1 (en) | 2002-03-13 | 2003-09-18 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
| CA2476583C (en) * | 2002-03-13 | 2011-07-05 | Kristof Van Emelen | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
| CN100396679C (zh) | 2002-03-13 | 2008-06-25 | 詹森药业有限公司 | 用作组蛋白脱乙酰化酶抑制剂的哌嗪基、哌啶基和吗啉基衍生物 |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
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| US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| ME01058B (me) | 2004-07-28 | 2012-10-20 | Janssen Pharmaceutica Nv | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
| HRP20120327T1 (hr) | 2004-07-28 | 2012-05-31 | Janssen Pharmaceutica Nv | Supstituirani indolil alkil amino derivati kao novi inhibitori histonske deacetilaze |
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| US7642275B2 (en) | 2004-12-16 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AU2006240246A1 (en) | 2005-04-20 | 2006-11-02 | Merck Sharp & Dohme Corp. | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions |
| CA2605110A1 (en) | 2005-04-20 | 2006-11-02 | Merck & Co., Inc. | Benzothiophene derivatives |
| JP2008536925A (ja) | 2005-04-20 | 2008-09-11 | メルク エンド カムパニー インコーポレーテッド | ベンゾチオフェンヒドロキサム酸誘導体 |
| GB0509225D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
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| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
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| WO2008041053A2 (en) | 2005-05-20 | 2008-04-10 | Methylgene, Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
| JP4528918B2 (ja) * | 2005-06-21 | 2010-08-25 | 学校法人 関西大学 | カルボキサミド誘導体 |
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2004
- 2004-09-24 AU AU2004276337A patent/AU2004276337B2/en not_active Ceased
- 2004-09-24 JP JP2006528279A patent/JP4809228B2/ja not_active Expired - Fee Related
- 2004-09-24 WO PCT/US2004/031591 patent/WO2005030705A1/en not_active Ceased
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- 2004-09-24 CA CA002539117A patent/CA2539117A1/en not_active Abandoned
- 2004-09-24 KR KR1020067007812A patent/KR101153335B1/ko not_active Expired - Fee Related
- 2004-09-24 EP EP04789074A patent/EP1663953A1/en not_active Withdrawn
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008094847A (ja) * | 2003-09-24 | 2008-04-24 | Methylgene Inc | ヒストンデアセチラーゼの阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005030705A1 (en) | 2005-04-07 |
| JP2008094847A (ja) | 2008-04-24 |
| JP2007506785A (ja) | 2007-03-22 |
| WO2005030705A9 (en) | 2006-04-20 |
| AU2004276337B2 (en) | 2009-11-12 |
| US20080132459A1 (en) | 2008-06-05 |
| JP5127402B2 (ja) | 2013-01-23 |
| WO2005030704A1 (en) | 2005-04-07 |
| KR101153335B1 (ko) | 2012-07-05 |
| AU2004276337A1 (en) | 2005-04-07 |
| EP1663953A1 (en) | 2006-06-07 |
| CA2539117A1 (en) | 2005-04-07 |
| US7868205B2 (en) | 2011-01-11 |
| KR20060065730A (ko) | 2006-06-14 |
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