JP4683988B2 - 再石灰化作用を有する液体口腔用組成物 - Google Patents
再石灰化作用を有する液体口腔用組成物 Download PDFInfo
- Publication number
- JP4683988B2 JP4683988B2 JP2005119646A JP2005119646A JP4683988B2 JP 4683988 B2 JP4683988 B2 JP 4683988B2 JP 2005119646 A JP2005119646 A JP 2005119646A JP 2005119646 A JP2005119646 A JP 2005119646A JP 4683988 B2 JP4683988 B2 JP 4683988B2
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- Prior art keywords
- phosphate
- calcium
- salts
- liquid oral
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 63
- 239000007788 liquid Substances 0.000 title claims description 51
- 230000009471 action Effects 0.000 title description 25
- 229910019142 PO4 Inorganic materials 0.000 claims description 98
- 239000010452 phosphate Substances 0.000 claims description 95
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 75
- -1 phosphate oligosaccharides Chemical class 0.000 claims description 57
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 45
- 229920002472 Starch Polymers 0.000 claims description 33
- 150000003839 salts Chemical class 0.000 claims description 33
- 235000019698 starch Nutrition 0.000 claims description 33
- 239000008107 starch Substances 0.000 claims description 31
- 239000002324 mouth wash Substances 0.000 claims description 29
- 159000000007 calcium salts Chemical class 0.000 claims description 27
- 229920001542 oligosaccharide Polymers 0.000 claims description 26
- 229940051866 mouthwash Drugs 0.000 claims description 23
- 239000005913 Maltodextrin Substances 0.000 claims description 21
- 229920002774 Maltodextrin Polymers 0.000 claims description 21
- 229940035034 maltodextrin Drugs 0.000 claims description 21
- 210000000214 mouth Anatomy 0.000 claims description 19
- 150000007524 organic acids Chemical class 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 13
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 11
- 239000001488 sodium phosphate Substances 0.000 claims description 11
- 150000005846 sugar alcohols Chemical class 0.000 claims description 9
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 9
- 150000002222 fluorine compounds Chemical class 0.000 claims description 8
- 235000005985 organic acids Nutrition 0.000 claims description 8
- 239000000551 dentifrice Substances 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 7
- 239000004359 castor oil Substances 0.000 claims description 6
- 235000019438 castor oil Nutrition 0.000 claims description 6
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 6
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 6
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 6
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 5
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 5
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims description 5
- 229940085605 saccharin sodium Drugs 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229960001777 castor oil Drugs 0.000 claims description 4
- 239000004137 magnesium phosphate Substances 0.000 claims description 4
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims description 4
- 229960002261 magnesium phosphate Drugs 0.000 claims description 4
- 235000010994 magnesium phosphates Nutrition 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
- 235000011008 sodium phosphates Nutrition 0.000 claims description 4
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 4
- 239000004254 Ammonium phosphate Substances 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical group [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 3
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims description 3
- 235000019289 ammonium phosphates Nutrition 0.000 claims description 3
- 150000003863 ammonium salts Chemical class 0.000 claims description 3
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229960002713 calcium chloride Drugs 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 235000011148 calcium chloride Nutrition 0.000 claims description 3
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 3
- 239000001354 calcium citrate Substances 0.000 claims description 3
- 229960004256 calcium citrate Drugs 0.000 claims description 3
- 239000004227 calcium gluconate Substances 0.000 claims description 3
- 235000013927 calcium gluconate Nutrition 0.000 claims description 3
- 229960004494 calcium gluconate Drugs 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 3
- 239000001527 calcium lactate Substances 0.000 claims description 3
- 235000011086 calcium lactate Nutrition 0.000 claims description 3
- 229960002401 calcium lactate Drugs 0.000 claims description 3
- 229960002079 calcium pantothenate Drugs 0.000 claims description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
- 235000019800 disodium phosphate Nutrition 0.000 claims description 3
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 3
- 159000000003 magnesium salts Chemical class 0.000 claims description 3
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 3
- 235000011009 potassium phosphates Nutrition 0.000 claims description 3
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 3
- 150000003751 zinc Chemical class 0.000 claims description 3
- 239000005696 Diammonium phosphate Substances 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 claims description 2
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 claims description 2
- 229910000388 diammonium phosphate Inorganic materials 0.000 claims description 2
- 235000019838 diammonium phosphate Nutrition 0.000 claims description 2
- MHJAJDCZWVHCPF-UHFFFAOYSA-L dimagnesium phosphate Chemical compound [Mg+2].OP([O-])([O-])=O MHJAJDCZWVHCPF-UHFFFAOYSA-L 0.000 claims description 2
- 229910000395 dimagnesium phosphate Inorganic materials 0.000 claims description 2
- 235000019820 disodium diphosphate Nutrition 0.000 claims description 2
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 claims description 2
- 229940005740 hexametaphosphate Drugs 0.000 claims description 2
- 235000019837 monoammonium phosphate Nutrition 0.000 claims description 2
- 239000006012 monoammonium phosphate Substances 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 2
- 235000015424 sodium Nutrition 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical group [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 2
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 2
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 2
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 2
- 235000019801 trisodium phosphate Nutrition 0.000 claims description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 2
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims 2
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims 2
- 229940095618 calcium glycerophosphate Drugs 0.000 claims 2
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims 2
- 159000000014 iron salts Chemical class 0.000 claims 1
- BRFMYUCUGXFMIO-UHFFFAOYSA-N phosphono dihydrogen phosphate phosphoric acid Chemical compound OP(O)(O)=O.OP(O)(=O)OP(O)(O)=O BRFMYUCUGXFMIO-UHFFFAOYSA-N 0.000 claims 1
- 235000007686 potassium Nutrition 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 description 81
- 239000000243 solution Substances 0.000 description 50
- 239000011575 calcium Substances 0.000 description 38
- 238000006243 chemical reaction Methods 0.000 description 25
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 24
- 229960005069 calcium Drugs 0.000 description 24
- 229910052791 calcium Inorganic materials 0.000 description 24
- 230000000694 effects Effects 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 239000001506 calcium phosphate Substances 0.000 description 16
- 229910000389 calcium phosphate Inorganic materials 0.000 description 16
- 235000011010 calcium phosphates Nutrition 0.000 description 16
- 239000003795 chemical substances by application Substances 0.000 description 16
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 14
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 14
- 230000008021 deposition Effects 0.000 description 12
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 12
- 235000014113 dietary fatty acids Nutrition 0.000 description 11
- 239000000194 fatty acid Substances 0.000 description 11
- 229930195729 fatty acid Natural products 0.000 description 11
- 230000000395 remineralizing effect Effects 0.000 description 10
- 229940093915 gynecological organic acid Drugs 0.000 description 7
- 239000004310 lactic acid Substances 0.000 description 6
- 235000014655 lactic acid Nutrition 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 238000000691 measurement method Methods 0.000 description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
- 150000002482 oligosaccharides Chemical class 0.000 description 4
- 239000011574 phosphorus Substances 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 229920001592 potato starch Polymers 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 230000007928 solubilization Effects 0.000 description 4
- 238000005063 solubilization Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 239000000811 xylitol Substances 0.000 description 4
- 235000010447 xylitol Nutrition 0.000 description 4
- 229960002675 xylitol Drugs 0.000 description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 150000005215 alkyl ethers Chemical class 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 230000002308 calcification Effects 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229940099112 cornstarch Drugs 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 108010075550 termamyl Proteins 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
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- 241000894006 Bacteria Species 0.000 description 2
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
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- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
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- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
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Landscapes
- Cosmetics (AREA)
Description
再石灰化試験測定法:
(i) 再石灰化促進剤試料液の調製
再石灰化促進剤試料液は、最終濃度の調整直前に、希NaOH溶液又は希HCl溶液で試料液のpHを6.5〜7.0に調整する。調製した試料液は反応当日に使用して、ヒドロキシアパタイト無添加反応とヒドロキシアパタイト添加反応を同時進行で行う。なお、水は全て精製水を使用する。
JIS検定に合格した標準温度計で正確に36℃を表示し、温度変化が±0.3℃以内となる恒温槽を用意する。ガラス製の反応用バイアル瓶(容量13.5mL)に、再石灰化促進剤、並びに再石灰化剤であるカルシウム塩及びリン酸塩を除いて最終濃度の2倍に調製した液体口腔用組成物5mL、HEPES緩衝液(200mM,pH7.0)1mL、最終濃度の10倍濃度に調製したリン酸塩溶液1mL、最終濃度の10倍濃度に調製した再石灰化促進剤試料液1mLの順に入れる。このバイアル瓶を前記恒温槽に10分間以上静置してから、反応液のpHを7.00±0.02に調整する。pH調整に用いる希NaOH溶液又は希HCl溶液の添加量は100μL以内とする。pHの調整を終えた反応液は前記恒温槽に戻して10分間以上静置する。次いで、反応液に水1mLを投入してから直ちに最終濃度の10倍濃度に調製したカルシウム塩溶液1mLを投入し、前記恒温槽に静置して24時間反応する。反応終了後、反応液の一部を採取して、12,000rpm、3分間遠心分離した後、上清を回収して、可溶性のカルシウム濃度を測定する。可溶性のカルシウム濃度はカルシウム測定キットで測定し、ppm単位で表示する。
最終濃度の10倍濃度に調製したカルシウム塩溶液1mLを投入する前に、水1mLの代わりにヒドロキシアパタイト(5mg/mL)溶液1mLを加えることを除いて、(ii)のヒドロキシアパタイト無添加反応の場合と同様に、反応を行い、可溶性のカルシウム濃度を測定する。
ヒドロキシアパタイト無添加の24時間反応終了液における可溶性のカルシウム濃度を測定し、下記式からCa可溶化率を求める。
カルシウム可溶化率(%)=[ヒドロキシアパタイト無添加反応終了液上清の可溶性カルシウム(ppm)/反応液に添加したカルシウム(ppm)]×100
反応系に存在するヒドロキシアパタイトに対する、ヒドロキシアパタイト無添加の24時間反応終了液における可溶性のカルシウム濃度からヒドロキシアパタイト添加の24時間反応終了液における可溶性のカルシウム濃度を差し引いた値の比率をカルシウム沈着率と設定し、下記式で求める。
カルシウム沈着率(%)={[ヒドロキシアパタイト無添加反応終了液上清の可溶性カルシウム(ppm)−ヒドロキシアパタイト添加反応終了液上清の可溶性カルシウム(ppm)]/反応液に添加したヒドロキシアパタイト(500ppm)}×100
(b)リン酸塩1〜7mM、並びに
(c)リン酸塩の1〜2倍molのカルシウム塩
を含み、使用時のアルコール含有量が0〜3v/v%である液体口腔用組成物。
(b)リン酸塩1〜15mM、好ましくは1〜7mM、並びに
(c)リン酸塩の1〜2倍molのカルシウム塩
を含み、使用時のアルコール含有量が0〜20v/v%である液体口腔用組成物。
(9)前記(1)〜(8)のいずれかに記載の液体口腔用組成物を含む洗口剤。
(10)エタノール、グリセリン、ポリオキシエチレン硬化ヒマシ油、サッカリンナトリウム及び塩化セチルピリジニウムから選ばれる少なくとも1種を含む基本処方に、前記(1)〜(8)のいずれかに記載の液体口腔用組成物を配合してなる洗口剤。
(11)前記(1)〜(8)のいずれかに記載の液体口腔用組成物を含む液体歯磨き剤。
(12)エタノール、グリセリン、ポリオキシエチレン硬化ヒマシ油、サッカリンナトリウム及び塩化セチルピリジニウムから選ばれる少なくとも1種を含む基本処方に、前記(1)〜(8)のいずれかに記載の液体口腔用組成物を配合してなる液体歯磨き剤。
(a)PMD、還元PMD及びそれらの塩から選ばれる少なくとも1種0.00001〜1w/w%、又はPOS、還元POS、リン酸澱粉及びそれらの塩から選ばれる少なくとも1種0.001〜5w/w%、
(b)リン酸塩1〜7mM、並びに
(c)リン酸塩の1〜2倍molのカルシウム塩
を含み、使用時のアルコール含有量が0〜3v/v%である液体口腔用組成物。
(a)有機酸及びその塩から選ばれる少なくとも1種0.005〜5w/w%、
(b)リン酸塩1〜15mM、好ましくは1〜7mM、並びに
(c)リン酸塩の1〜2倍molのカルシウム塩
を含み、使用時のアルコール含有量が0〜20v/v%である液体口腔用組成物。
前記組成物Bに、更に、PMD、還元PMD及びそれらの塩から選ばれる少なくとも1種0.00001〜1w/w%、又はPOS、還元POS、リン酸澱粉及びそれらの塩から選ばれる少なくとも1種0.001〜5w/w%を配合した液体口腔用組成物。
<リン酸澱粉>
コーンスターチ(王子コーンスターチ株式会社製、水分13重量%)1200kgを一定の流速でタービュライザに導入し、同時に第一リン酸ナトリウム・2水塩176kgと無水第二リン酸ナトリウム32kgを水に溶解して全量655kgのリン酸溶液(溶液中のリン含量6.4重量%、pH6.0)を一定の流速で添加して均一に混合した。このリン酸混合澱粉をフラッシュ・ドライヤーで水分6重量%となるまで乾燥し、得られたリン酸含浸澱粉(リン含量3.5重量%、pH5.6)750kgを流動層加熱機(王子コーンスターチ株式会社製)に投入した。加熱した熱風を供給して流動加熱し、排気される熱風は流動層の系外に排出した。加熱開始後、30分で175℃まで昇温し、熱風の排気はそのまま系外に排出し続けて、175℃で120分加熱反応した。加熱反応終了後、送風を冷風に切り替え、更に熱風の排気を系外に排出し続けて、品温を100℃以下にまで冷却した。回収されたリン酸エステル澱粉は700kgであり、その結合リン含量は2.8重量%、リン酸化率は81%であった。
70℃の水71Lに塩化カルシウム二水和物34gを溶解した後、攪拌しながら前述のリン酸澱粉8kgを徐々に添加しながら溶解した。水酸化ナトリウムでpH6.0とした後、超耐熱性α−アミラーゼ(ターマミル クラッシック、ノボザイムズ社製)を対澱粉0.05重量%添加し、5分間保持した。粘度が下がり始めるとリン酸澱粉45kgを徐々に追加添加した。水酸化ナトリウムでpH6.0に再調整後、追加した澱粉に対してターマミル クラッシックを0.05重量%添加して10分保持した。次に、調製したリン酸澱粉分散液をジェットクッカーにて入口温度110℃、滞留時間5分の条件で処理した。ジェットクッカー処理した液をタンクに集め、ターマミル クラッシックを対澱粉0.05重量%追加添加し、60℃、3時間反応させた。酵素反応は塩酸でpH3.5に調整し、終了とした。
還元デキストリン100kg(東和化成(株)製PO−10)とリン酸ナトリウム溶液(リン酸1ナトリウム・2水塩15kgとリン酸2ナトリウム2.7kgを水400kgに溶解したものをスプレードライヤーで乾燥粉末化した。これを流動層に投入し、170℃まで昇温後2時間焙焼し、得られた試料を20%水溶液とし粉末活性炭を対固形分10重量%添加し、60℃、2時間攪拌保持した。その後、セラミック濾過機で残渣と活性炭を除去した。濾過供給液が減少したら純水を添加して透過液のBrixが1以下になるまで濾過を行った。NF膜で脱塩・濃縮処理を行い、さらに10重量%の水酸化ナトリウムでpH6.2に調整した。0.45μmのポリスルフォンのメンブレンフィルターで濾過後、スプレードライヤーで乾燥粉末化し還元PMDを得た。
特開2002−325556号公報の実施例1の方法に準じてPOSを得た。
上記で得たPOSを出発物質として特開2002−325556号公報の実施例10の方法に準じて還元POSを得た。
以下の基本処方洗口剤を調製した。
基本処方洗口剤
グリセリン10.0g
ポリオキシエチレン(60)硬化ヒマシ油1g
サッカリンナトリウム0.01g
塩化セチルピリジニウム0.02g
精製水(蒸留水の脱塩精製水をMILLIPORE社製MILLI-Q Labo で再精製した水) 残
計50.0mL(最終濃度の2倍に調製)
再石灰化剤であるKH2PO4、CaCl2、再石灰化促進剤等を何も加えず洗口剤のみで再石灰化作用を評価した。
(試験2)
再石灰化剤である18mMKH2PO4溶液1mLと30mMCaCl2溶液1mLのみを添加し、再石灰化促進剤等は何も加えず洗口剤の再石灰化作用を評価した。
(試験3)
再石灰化剤である18mMKH2PO4溶液1mLと30mMCaCl2溶液1mLと再石灰化促進剤である0.002%PMD溶液1mLを加え、洗口剤の再石灰化作用を評価した。
(試験4)
0.002%PMD溶液を0.2%POS溶液に換えた以外は試験3と同様に洗口剤の再石灰化作用を評価した。
(試験5)
0.002%PMD溶液を0.002%還元PMD溶液に換えた以外は試験3と同様に洗口剤の再石灰化作用を評価した。
(試験6)
0.002%PMD溶液を0.2%還元POS溶液に換えた以外は試験3と同様に洗口剤の再石灰化作用を評価した。
(試験7)
0.002%PMD溶液を10%リン酸澱粉溶液に換えた以外は試験3と同様に洗口剤の再石灰化作用を評価した。
(試験8)
再石灰化剤である18mMKH2PO4溶液1mLと30mMCaCl2溶液1mLと再石灰化促進剤である0.004%PMD溶液0.5mLと4%乳酸溶液0.5mLを加え、洗口剤の再石灰化作用を評価した。
(試験9)
4%乳酸溶液を40%キシリトール溶液に換えた以外は試験8と同様に洗口剤の再石灰化作用を評価した。
(試験10)
4%乳酸溶液を0.02%フッ化ナトリウム溶液に換えた以外は試験8と同様に洗口剤の再石灰化作用を評価した。
(試験11)
再石灰化剤である18mMKH2PO4溶液1mLと30mMCaCl2溶液1mLと再石灰化促進剤である0.008%PMD溶液0.25mL、40%キシリトール溶液0.5mL及び8%乳酸溶液0.25mLを加え、洗口剤の再石灰化作用を評価した。
(実施例1〜6)
Claims (8)
- (a)リン酸マルトデキストリン、還元リン酸マルトデキストリン及びそれらの塩から選ばれる少なくとも1種0.00001〜1w/w%、又はリン酸オリゴ糖、還元リン酸オリゴ糖、リン酸澱粉及びそれらの塩から選ばれる少なくとも1種0.001〜5w/w%、
(b)リン酸塩1〜7mM、並びに
(c)リン酸塩の1〜2倍molのカルシウム塩
を含み、使用時のエタノール含有量が0〜3v/v%であり、
前記リン酸塩がリン酸ナトリウム塩、リン酸カリウム塩、リン酸アンモニウム塩及びリン酸マグネシウム塩から選ばれ、
前記カルシウム塩が塩化カルシウム、乳酸カルシウム、グルコン酸カルシウム、パントテン酸カルシウム、クエン酸カルシウム、第一リン酸水素カルシウム及びグリセロリン酸カルシウムから選ばれる液体口腔用組成物。 - (a)有機酸及びそのアルカリ金属塩、マグネシウム塩、アンモニウム塩、鉄塩、亜鉛塩又はアルミニウム塩から選ばれる少なくとも1種0.005〜5w/w%、
(b)リン酸塩1〜15mM、
(c)リン酸塩の1〜2倍molのカルシウム塩、並びに
(d)リン酸マルトデキストリン、還元リン酸マルトデキストリン及びそれらの塩から選ばれる少なくとも1種0.00001〜1w/w%、又はリン酸オリゴ糖、還元リン酸オリゴ糖、リン酸澱粉及びそれらの塩から選ばれる少なくとも1種0.001〜5w/w%
を含み、使用時のエタノール含有量が0〜20v/v%であり、
前記リン酸塩がリン酸ナトリウム塩、リン酸カリウム塩、リン酸アンモニウム塩及びリン酸マグネシウム塩から選ばれ、
前記カルシウム塩が塩化カルシウム、乳酸カルシウム、グルコン酸カルシウム、パントテン酸カルシウム、クエン酸カルシウム、第一リン酸水素カルシウム及びグリセロリン酸カルシウムから選ばれる液体口腔用組成物。 - 更に、糖アルコール及びフッ素化合物から選ばれる少なくとも1種を含む請求項1又は2に記載の液体口腔用組成物。
- 前記リン酸塩がリン酸一ナトリウム、リン酸二ナトリウム、リン酸三ナトリウム、トリポリリン酸ナトリウム、ピロリン酸ナトリウム、酸性ピロリン酸ナトリウム、ヘキサメタリン酸ナトリウム、酸性ヘキサメタリン酸ナトリウム、リン酸一カリウム、リン酸二カリウム、リン酸一アンモニウム、リン酸二アンモニウム、リン酸水素マグネシウム及びリン酸マグネシウムから選ばれる請求項1〜3のいずれか1項に記載の液体口腔用組成物。
- 請求項1〜4のいずれか1項に記載の液体口腔用組成物を含む洗口剤。
- エタノール、グリセリン、ポリオキシエチレン硬化ヒマシ油、サッカリンナトリウム及び塩化セチルピリジニウムから選ばれる少なくとも1種を含む基本処方に、請求項1〜4のいずれか1項に記載の液体口腔用組成物を配合してなる洗口剤。
- 請求項1〜4のいずれか1項に記載の液体口腔用組成物を含む液体歯磨き剤。
- エタノール、グリセリン、ポリオキシエチレン硬化ヒマシ油、サッカリンナトリウム及び塩化セチルピリジニウムから選ばれる少なくとも1種を含む基本処方に、請求項1〜4のいずれか1項に記載の液体口腔用組成物を配合してなる液体歯磨き剤。
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