JP5528789B2 - 液体口腔用組成物 - Google Patents
液体口腔用組成物 Download PDFInfo
- Publication number
- JP5528789B2 JP5528789B2 JP2009292720A JP2009292720A JP5528789B2 JP 5528789 B2 JP5528789 B2 JP 5528789B2 JP 2009292720 A JP2009292720 A JP 2009292720A JP 2009292720 A JP2009292720 A JP 2009292720A JP 5528789 B2 JP5528789 B2 JP 5528789B2
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- JP
- Japan
- Prior art keywords
- oil
- calcium
- soluble
- transparent liquid
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 65
- 239000007788 liquid Substances 0.000 title claims description 44
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 45
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 45
- -1 p-hydroxybenzoic acid ester Chemical class 0.000 claims description 44
- 238000002156 mixing Methods 0.000 claims description 28
- 239000002736 nonionic surfactant Substances 0.000 claims description 26
- 210000000214 mouth Anatomy 0.000 claims description 19
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 18
- 239000004359 castor oil Substances 0.000 claims description 15
- 235000019438 castor oil Nutrition 0.000 claims description 15
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 15
- 239000003205 fragrance Substances 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000004227 calcium gluconate Substances 0.000 claims description 11
- 229960004494 calcium gluconate Drugs 0.000 claims description 11
- 235000013927 calcium gluconate Nutrition 0.000 claims description 11
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 11
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 10
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 8
- 239000001527 calcium lactate Substances 0.000 claims description 8
- 229960002401 calcium lactate Drugs 0.000 claims description 8
- 235000011086 calcium lactate Nutrition 0.000 claims description 8
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 7
- 239000001110 calcium chloride Substances 0.000 claims description 7
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 7
- 229960002713 calcium chloride Drugs 0.000 claims description 7
- 235000011148 calcium chloride Nutrition 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 235000019441 ethanol Nutrition 0.000 claims description 6
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 5
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 5
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 5
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 5
- 239000001639 calcium acetate Substances 0.000 claims description 5
- 229960005147 calcium acetate Drugs 0.000 claims description 5
- 235000011092 calcium acetate Nutrition 0.000 claims description 5
- 229960002079 calcium pantothenate Drugs 0.000 claims description 5
- 239000004330 calcium propionate Substances 0.000 claims description 5
- 235000010331 calcium propionate Nutrition 0.000 claims description 5
- 159000000007 calcium salts Chemical class 0.000 claims description 5
- 229940042585 tocopherol acetate Drugs 0.000 claims description 5
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 4
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 claims description 4
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 claims description 4
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 claims description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 4
- 239000000419 plant extract Substances 0.000 claims description 4
- 229950009883 tocopheryl nicotinate Drugs 0.000 claims description 4
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims description 3
- 239000002967 calcium-L-ascorbate Substances 0.000 claims description 3
- 235000005937 calcium-L-ascorbate Nutrition 0.000 claims description 3
- CLWAXFZCVYJLLM-UHFFFAOYSA-N 1-chlorohexadecane Chemical compound CCCCCCCCCCCCCCCCCl CLWAXFZCVYJLLM-UHFFFAOYSA-N 0.000 claims description 2
- 239000002563 ionic surfactant Substances 0.000 claims description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 23
- 238000001179 sorption measurement Methods 0.000 description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 235000014113 dietary fatty acids Nutrition 0.000 description 13
- 239000000194 fatty acid Substances 0.000 description 13
- 229930195729 fatty acid Natural products 0.000 description 13
- 239000004615 ingredient Substances 0.000 description 13
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 12
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 12
- 235000002639 sodium chloride Nutrition 0.000 description 12
- 239000000796 flavoring agent Substances 0.000 description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 235000019634 flavors Nutrition 0.000 description 10
- 239000003002 pH adjusting agent Substances 0.000 description 10
- 239000008213 purified water Substances 0.000 description 10
- 239000000551 dentifrice Substances 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 7
- 125000002252 acyl group Chemical group 0.000 description 7
- 125000005907 alkyl ester group Chemical group 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 229940085605 saccharin sodium Drugs 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- ODHCTXKNWHHXJC-VKHMYHEASA-M 5-oxo-L-prolinate Chemical compound [O-]C(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-M 0.000 description 6
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- 125000002091 cationic group Chemical group 0.000 description 5
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Description
項1.
グルコン酸カルシウム、乳酸カルシウム、塩化カルシウム、酢酸カルシウム、L−アスコルビン酸カルシウム、パントテン酸カルシウム、プロピオン酸カルシウム、硝酸カルシウム及び炭酸カルシウムからなる群より選択される少なくとも1種であるカルシウム塩と、塩化セチルピリジニウム、油溶性成分および非イオン性界面活性剤を含有し、さらに油溶性成分に対する非イオン性界面活性剤の配合比率が0.57〜3.5であり、かつ油溶性成分(A)と非イオン性界面活性剤(B)の配合量の差(A)−(B)が、−0.25〜0.15であることを特徴とする透明な液体口腔用組成物。
項2.
油溶性成分が、油溶性薬効成分および/または香料からなることを特徴とする項1に記載の透明な液体口腔用組成物。
項3.
油溶性成分を0.1〜0.5質量%含有することを特徴とする項2に記載の透明な液体口腔用組成物。
項4.
油溶性薬効成分が、トリクロサン、酢酸トコフェロール、β−グリチルレチン酸、p−ヒドロキシ安息香酸エステル、イソプロピルメチルフェノール、ニコチン酸トコフェロール及び油溶性植物抽出物からなる群より選択される少なくとも1種であることを特徴とする項2又は3の何れかに記載の透明な液体口腔用組成物。
項5.
塩化セチルピリジニウムを0.01〜1.0質量%含有することを特徴とする項1〜4の何れかに記載の透明な液体口腔用組成物。
項6.
非イオン性界面活性剤が、ポリオキシエチレン硬化ヒマシ油であることを特徴とする項1〜5の何れかに記載の透明な液体口腔用組成物。
項7.
エチルアルコ-ルの配合量が1質量%未満であることを特徴とする項1〜6の何れかに記載の透明な液体口腔用組成物。
また本発明はエチルアルコールを配合しないことを特徴とする液体口腔用組成物をも提供するものである。
<塩化セチルピリジニウムの歯牙表面への吸着試験>
歯牙のエナメル質のモデルとしてヒドロキシアパタイト粉末(BIO−RAD Lab. Hydroxyapatite Bio−Gel HTP Gel)(以下、HAと略す。)を、人の唾液中に37℃、24時間浸漬したものを使用した。唾液中に浸漬することにより、HA表面に唾液ムコ蛋白質などを吸着させ、唾液に濡れた実際の歯牙エナメル質の状態に近似させた。この唾液処理済みHAに表1に示す各試料をそれぞれ添加して37℃にて、15分間振とうさせた。その後、蒸留水ですすぎ、最終的にHAに吸着した塩化セチルピリジニウムを液体クロマトグラフィーを用いて定量し、油溶性成分に対する非イオン界面活性剤の配合比率の影響を検討した。また、その判断基準としては、以下の通りとした。ここで、塩化セチルピリジニウムの吸着量の単位はμg/HA50mgである。
◎:塩化セチルピリジニウムの吸着量が60以上
○:塩化セチルピリジニウムの吸着量が40以上60未満
×:塩化セチルピリジニウムの吸着量が40未満
上記の通り、表1に示す各試料について調製をした後、目視により液体製剤としての透明性を調べた。その判断基準は以下の通りとした。なお、表1及び表2に示す各成分の数値は質量%を示す。
◎:無色透明である
○:やや透明である
×:白濁している
成分 配合量
塩化セチルピリジニウム 0.05
グルコン酸カルシウム 1.0
香料(A) 0.2
パラオキシ安息香酸メチル(A) 0.1
トリクロサン(A) 0.05
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.2
グリセリン 10.0
プロピレングリコール 5.0
サッカリンナトリウム 0.01
N−ココイル−L−アルギニンエチルエステル
・ピロリドンカルボン酸塩 0.01
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は0.57。A-B値は0.15。
成分 配合量
塩化セチルピリジニウム 0.05
グルコン酸カルシウム 1.5
l−メントール(A) 0.1
酢酸トコフェロール(A) 0.05
パラオキシ安息香酸メチル(A) 0.2
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.3
グリセリン 10.0
マルチトール 0.5
プロピレングリコール 5.0
N−ココイル−L−アルギニンエチルエステル
・ピロリドンカルボン酸塩 0.01
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は0.85。A-B値は0.05。
成分 配合量
塩化セチルピリジニウム 0.05
グルコン酸カルシウム 1.5
l−メントール(A) 0.15
イソプロピルメチルフェノール(A) 0.05
パラオキシ安息香酸メチル(A) 0.1
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.25
グリセリン 13.0
キシリトール 1.0
ヒドロキシエチルセルロース 0.2
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は0.83。A-B値は0.05。
成分 配合量
塩化セチルピリジニウム 0.3
グルコン酸カルシウム 1.5
l−メントール(A) 0.05
パラオキシ安息香酸メチル(A) 0.15
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.15
グリセリン 10.0
還元パラチノース 1.0
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は0.75。A-B値は0.05。
成分 配合量
塩化セチルピリジニウム 0.05
グルコン酸カルシウム 1.5
l−メントール(A) 0.05
パラオキシ安息香酸メチル(A) 0.05
ポリオキシエチレン(40)硬化ヒマシ油(B) 0.3
グリセリン 10.0
プロピレングリコール 5.0
サッカリンナトリウム 0.01
N−ココイル−L−アルギニンエチルエステル
・ピロリドンカルボン酸塩 0.01
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は3。A-B値は−0.2。
成分 配合量
塩化セチルピリジニウム 0.05
乳酸カルシウム 1.0
l−メントール(A) 0.05
酢酸トコフェロール(A) 0.01
パラオキシ安息香酸メチル(A) 0.05
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.15
グリセリン 10.0
1,3ブチレングリコール 2.0
還元パラチノース 1.0
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は1.36。A-B値は−0.04。
成分 配合量
塩化セチルピリジニウム 0.05
乳酸カルシウム 1.0
l−メントール(A) 0.05
パラオキシ安息香酸メチル(A) 0.05
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.35
グリセリン 10.0
プロピレングリコール 5.0
サッカリンナトリウム 0.01
N−ココイル−L−アルギニンエチルエステル
・ピロリドンカルボン酸塩 0.01
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は3.5。A-B値は−0.25。
成分 配合量
塩化セチルピリジニウム 0.05
塩化カルシウム 0.5
l−メントール(A) 0.15
トリクロサン(A) 0.05
パラオキシ安息香酸メチル(A) 0.05
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.4
グリセリン 10.0
1,3ブチレングリコール 3.0
サッカリンナトリウム 0.01
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は1.6。A-B値は−0.15。
成分 配合量
塩化セチルピリジニウム 0.05
パントテン酸カルシウム 1.0
香料(A) 0.15
ニコチン酸トコフェロール(A) 0.05
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.3
グリセリン 10.0
サッカリンナトリウム 0.01
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は1.5。A-B値は−0.1。
成分 配合量
塩化セチルピリジニウム 0.05
プロピオン酸カルシウム 0.5
油溶性カンゾウ(A) 0.01
l−メントール(A) 0.1
パラオキシ安息香酸メチル(A) 0.1
ポリオキシエチレン(60)硬化ヒマシ油(B) 0.3
グリセリン 10.0
サッカリンナトリウム 0.01
pH調整剤 適量
精製水 残部
合計 100.0
B/A値は1.42。A-B値は−0.09。
Claims (7)
- グルコン酸カルシウム、乳酸カルシウム、塩化カルシウム、酢酸カルシウム、L−アスコルビン酸カルシウム、パントテン酸カルシウム、プロピオン酸カルシウム、硝酸カルシウム及び炭酸カルシウムからなる群より選択される少なくとも1種であるカルシウム塩と、塩化セチルピリジニウム、油溶性成分および非イオン性界面活性剤を含有し、さらに油溶性成分に対する非イオン性界面活性剤の配合比率が0.57〜3.5であり、かつ油溶性成分(A)と非イオン性界面活性剤(B)の配合量の差(A)−(B)が、−0.25〜0.15であることを特徴とする透明な液体口腔用組成物。
- 油溶性成分が、油溶性薬効成分および/または香料からなることを特徴とする請求項1に記載の透明な液体口腔用組成物。
- 油溶性成分を0.1〜0.5質量%含有することを特徴とする請求項2に記載の透明な液体口腔用組成物。
- 油溶性薬効成分が、トリクロサン、酢酸トコフェロール、β−グリチルレチン酸、p−ヒドロキシ安息香酸エステル、イソプロピルメチルフェノール、ニコチン酸トコフェロール及び油溶性植物抽出物からなる群より選択される少なくとも1種であることを特徴とする請求項2又は3の何れかに記載の透明な液体口腔用組成物。
- 塩化セチルピリジニウムを0.01〜1.0質量%含有することを特徴とする請求項1〜4の何れかに記載の透明な液体口腔用組成物。
- 非イオン性界面活性剤が、ポリオキシエチレン硬化ヒマシ油であることを特徴とする請求項1〜5の何れかに記載の透明な液体口腔用組成物。
- エチルアルコ-ルの配合量が1質量%未満であることを特徴とする請求項1〜6の何れかに記載の透明な液体口腔用組成物。
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