JP6013751B2 - 歯垢形成防止用液体口腔用組成物 - Google Patents
歯垢形成防止用液体口腔用組成物 Download PDFInfo
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- JP6013751B2 JP6013751B2 JP2012078022A JP2012078022A JP6013751B2 JP 6013751 B2 JP6013751 B2 JP 6013751B2 JP 2012078022 A JP2012078022 A JP 2012078022A JP 2012078022 A JP2012078022 A JP 2012078022A JP 6013751 B2 JP6013751 B2 JP 6013751B2
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Landscapes
- Cosmetics (AREA)
Description
(a)塩化セチルピリジニウム、
(b)ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、エチレンオキシドの平均付加モル数が5〜20であるポリエチレングリコール脂肪酸エステル、エチレンオキシドの平均付加モル数が5〜25であるポリオキシエチレンステロール、およびアルキル基の平均炭素数が12〜14であり、且つ、グリセリル基の平均付加モル数が6〜10であるポリグリセリン脂肪酸エステルよりなる群から選択される少なくとも1種以上のノニオン界面活性剤を0.01〜1.0質量%、
(c)油溶性薬効成分、油溶性香料、油溶性アルコール類、およびp−ヒドロキシ安息香酸エステルよりなる群から選択される少なくとも1種以上の油溶性成分を0.001〜1.0質量%
本発明では、任意のポリオキシエチレンソルビタン脂肪酸エステルを使用することができる。特に、これを単独で使用する場合は、アルキル基の平均炭素数、およびEOの平均付加モル数が適切に制御されたものを用いることが良く、これにより、液体製剤としての外観性状に優れており、且つ、塩化セチルピリジニウムの吸着量を一層促進させることができる。好ましくは、アルキル基の平均炭素数が10〜18であり、且つ、EOの平均付加モル数が10〜20を有するものであり、より好ましくは、アルキル基の平均炭素数が16〜18であり、且つ、EOの平均付加モル数が18〜20を有するものである。後記する実施例に示すように、EOの平均付加モル数が10未満のものは、外観性状が低下し、一方、EOの平均付加モル数が20超のものは、塩化セチルピリジニウムの吸着量が低下した。
本発明では、任意のポリオキシエチレングリセリン脂肪酸エステルを使用することができる。特に、良好な外観性状を維持しつつ、塩化セチルピリジニウムの吸着量を一層促進させたい場合には、アルキル基の平均炭素数、およびEOの平均付加モル数が適切に制御されたものを用いることが良く、好ましくは、アルキル基の平均炭素数が16〜20であり、且つ、EOの平均付加モル数が10〜20を有するものである。
本発明では、EOの平均付加モル数が上記範囲のポリエチレングリコール脂肪酸エステルを用いる。後記する実施例に示すように、EOの平均付加モル数が20を超えるものは、塩化セチルピリジニウムの吸着量が低下した。また、EOの平均付加モル数が5未満のものは、外観性状の低下が懸念される。更に、アルキル基の平均炭素数が適切に制御されたものを用いることが良く、これにより、塩化セチルピリジニウムの吸着量が一層促進されるようになる。好ましくは、アルキル基の平均炭素数が10〜14であり、且つ、EOの平均付加モル数が5〜15を有するものである。
本発明では、EOの平均付加モル数が上記範囲のポリオキシエチレンステロールを用いる。後記する実施例に示すように、EOの平均付加モル数が25を超えるものは、塩化セチルピリジニウムの吸着量が低下した。また、EOの平均付加モル数が5未満のものは、外観性状の低下が懸念される。EOの平均付加モル数は、少ない方が良く、好ましくは、5〜15である。
本発明では、アルキル基の平均炭素数、およびグリセリル基の平均付加モル数が上記範囲のポリグリセリン脂肪酸エステルを用いる。後記する実施例に示すように、アルキル基の平均炭素数が本発明の上限を超えるものや、グリセリル基の平均付加モル数が本発明の下限を下回るものは、外観性状が低下した。また、アルキル基の平均炭素数が本発明の下限を下回るものや、グリセリル基の平均付加モル数が本発明者の上限を超えるものは、塩化セチルピリジニウムの吸着効果の低下が懸念される。
本実施例では、本発明における(b)ノニオン界面活性剤の添加効果を調べるため、上記(b)成分の種類のみを変化させた各種液体口腔用組成物を調製した。上記組成物は、以下のようにして調製した。なお、上記組成物のpHは、おおむね、6.0〜6.2の範囲であった。
調製直後の組成物の外観を目視で観察し、下記判断基準に従い、液体製剤としての透明性を評価した。
○:無色透明
×:白濁または分離
歯牙エナメル質のモデルとして、ヒドロキシアパタイト粉末[米国BIO−RAD Lab.社製のHydroxyapatite Bio−Gel(登録商標)HTP Gel)(以下、「HA」と略する。)50mgを、紫外線で滅菌したヒト唾液2mL中に37℃で15時間浸漬したものを用意し、ペリクル(唾液タンパク質)を上記HA表面に形成させた。その後、遠心処理(3000rpmで10分間)し、上清を除去した。
(総合評価)
◎:外観性状が○で、且つ、CPCの吸着量が900μg以上
○:外観性状が○で、且つ、CPCの吸着量が800μg以上、900μg未満
×:外観性状が×;または外観性状が○で、且つ、CPCの吸着量が800μg未満
成分 配合量
塩化セチルピリジニウム 0.05
ポリオキシエチレン(60)硬化ヒマシ油 0.2
モノステアリン酸ポリエチレングリコール(10EO)0.1
β−グリチルレチン酸 0.02
パラオキシ安息香酸メチル 0.1
1−オクタノール 0.1
グリセリン 10.0
プロピレングリコール 3.0
サッカリンナトリウム 0.01
pH調整剤(クエン酸、クエン酸ナトリウム) 適量
精製水 残部
合計 100.0
成分 配合量
塩化セチルピリジニウム 0.01
モノミリスチン酸デカグリセリル 0.3
チモール 0.02
油溶性香料(スペアミント油) 0.1
グリセリン 9.0
プロピレングリコール 3.0
サッカリンナトリウム 0.01
N−ココイル−L−アルギニンエチルエステル
・ピロリドンカルボン酸塩 0.05
pH調整剤(クエン酸、クエン酸ナトリウム) 適量
精製水 残部
合計 100.0
成分 配合量
塩化セチルピリジニウム 0.05
モノステアリン酸ポリオキシエチレン(6)
ソルビタン 0.01
ポリオキシエチレン(40)硬化ヒマシ油 0.2
油溶性薬効成分(トリクロサン) 0.02
油溶性香料(ペパーミント油) 0.1
グリセリン 10.0
1,3−ブチレングリコール 5.0
サッカリンナトリウム 0.01
pH調整剤(リン酸ニ水素ナトリウム、
リン酸一水素ナトリウム) 適量
精製水 残部
合計 100.0
成分 配合量
塩化セチルピリジニウム 1.0
ポリオキシエチレン(40)硬化ヒマシ油 0.8
ポリオキシエチレン(5)フィトステロール 0.01
油溶性香料(スペアミント油) 0.5
グリセリン 10.0
エタノール 40.0
サッカリンナトリウム 0.2
pH調整剤(クエン酸、クエン酸ナトリウム) 適量
精製水 残部
合計 100.0
成分 配合量
塩化セチルピリジニウム 0.2
ヤシ油脂肪酸
ポリオキシエチレン(20)ソルビタン 0.2
油溶性薬効成分(ヒノキチオール) 0.01
油溶性香料(ペパーミント油) 0.1
グリセリン 10.0
エタノール 5.0
サッカリンナトリウム 0.01
pH調整剤(クエン酸、クエン酸ナトリウム) 適量
精製水 残部
合計 100.0
成分 配合量
塩化セチルピリジニウム 0.05
モノステアリン酸ポリエチレングリコール(20EO) 0.1
ポリオキシエチレン(60)硬化ヒマシ油 0.2
油溶性香料(l−メントール) 0.1
パラオキシ安息香酸メチル 0.1
グリセリン 10.0
プロピレングリコール 3.0
サッカリンナトリウム 0.01
pH調整剤(リン酸ニ水素ナトリウム、
リン酸一水素ナトリウム) 適量
精製水 残部
合計 100.0
成分 配合量
塩化セチルピリジニウム 0.05
ラウリン酸ポリオキシエチレン(12)グリセリル 0.1
モノステアリン酸ポリオキシエチレン(5)グリセリル 0.1
ポリオキシエチレン(60)硬化ヒマシ油 0.2
油溶性香料(l−メントール) 0.1
油溶性薬効成分(酢酸dl−α−トコフェロール) 0.05
グリセリン 10.0
ヘキシレングリコール 3.0
サッカリンナトリウム 0.01
pH調整剤(クエン酸、クエン酸ナトリウム) 適量
精製水 残部
合計 100.0
成分 配合量
塩化セチルピリジニウム 0.5
モノステアリン酸ポリオキシエチレン(5)
グリセリル 0.2
ポリオキシエチレン(60)硬化ヒマシ油 0.5
塩酸クロルヘキシジン 0.001
グリセリン 20.0
プロピレングリコール 3.0
ヒドロキシエチルセルロース 1.0
フッ化ナトリウム 0.2
油溶性香料(メントン) 0.1
クエン酸、クエン酸ナトリウム 適量
精製水 残部
合計 100.0
成分 配合量
塩化セチルピリジニウム 0.05
ポリオキシエチレン(40)硬化ヒマシ油 0.5
モノミリスチン酸ヘキサグリセリル 0.3
油溶性薬効成分(酢酸dl−α−トコフェロール) 0.5
l−メントール 0.2
油溶性香料(ペパーミント油) 0.3
エタノール 35.0
グリセリン 10.0
サッカリンナトリウム 0.1
pH調整剤(クエン酸、クエン酸ナトリウム) 適量
精製水 残部
合計 100.0
Claims (3)
- 下記の(a)、(b)および(c)を含有することを特徴とする、塩化セチルピリジニウムの歯牙表面への吸着能、および外観性状に優れた歯垢形成防止用液体口腔用組成物。
(a)塩化セチルピリジニウム、
(b)下記成分からなるノニオン界面活性剤を0.01〜0.2質量%
(b−1)エチレンオキシドの平均付加モル数が10〜20であるラウリン酸ポリオキシエチレンソルビタン;
(b−2)アルキル基の平均炭素数が16〜20であり、且つ、エチレンオキシドの平均付加モル数が10〜20であるポリオキシエチレングリセリン脂肪酸エステル;
(b−4)エチレンオキシドの平均付加モル数が5〜25であるポリオキシエチレンステロール;および
(b−5)アルキル基の平均炭素数が12〜14であり、且つ、グリセリル基の平均付加モル数が6〜10であるポリグリセリン脂肪酸エステルよりなる群から選択される少なくとも1種以上、
(c)油溶性薬効成分、油溶性香料、油溶性アルコール類、およびp−ヒドロキシ安息香酸エステルよりなる群から選択される少なくとも1種以上の油溶性成分を0.001〜1.0質量% - 前記(b−4)は、エチレンオキシドの平均付加モル数が5〜15であるポリオキシエチレンステロールである請求項1に記載の液体口腔用組成物。
- 前記(a)塩化セチルピリジニウムを0.01〜1.0質量%含有する請求項1または2に記載の液体口腔用組成物。
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