JP4643910B2 - 抗癌活性を有する置換インダゾール - Google Patents

抗癌活性を有する置換インダゾール Download PDF

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Publication number
JP4643910B2
JP4643910B2 JP2003576408A JP2003576408A JP4643910B2 JP 4643910 B2 JP4643910 B2 JP 4643910B2 JP 2003576408 A JP2003576408 A JP 2003576408A JP 2003576408 A JP2003576408 A JP 2003576408A JP 4643910 B2 JP4643910 B2 JP 4643910B2
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JP
Japan
Prior art keywords
indazol
benzenesulfonamide
phenyl
aryl
methanesulfonylbenzenesulfonamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2003576408A
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English (en)
Japanese (ja)
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JP2005533004A (ja
JP2005533004A5 (cg-RX-API-DMAC7.html
Inventor
ドミニク・ダムール
ジャン−クリストフ・カリ
パトリック・ネメセク
コリン・テリエ
フレデリコ・ナルディ
ブリュノ・フィロシュ
マリ−ピエール・シェリエ
ダニエル・ベザール
Original Assignee
アベンティス・ファーマ・ソシエテ・アノニム
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Publication of JP2005533004A5 publication Critical patent/JP2005533004A5/ja
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Publication of JP4643910B2 publication Critical patent/JP4643910B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
JP2003576408A 2002-03-11 2003-03-07 抗癌活性を有する置換インダゾール Expired - Fee Related JP4643910B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0202996A FR2836914B1 (fr) 2002-03-11 2002-03-11 Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
PCT/FR2003/000751 WO2003078402A1 (fr) 2002-03-11 2003-03-07 Indazoles substitues avec une activite anticancereuse

Publications (3)

Publication Number Publication Date
JP2005533004A JP2005533004A (ja) 2005-11-04
JP2005533004A5 JP2005533004A5 (cg-RX-API-DMAC7.html) 2006-04-20
JP4643910B2 true JP4643910B2 (ja) 2011-03-02

Family

ID=27763684

Family Applications (1)

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JP2003576408A Expired - Fee Related JP4643910B2 (ja) 2002-03-11 2003-03-07 抗癌活性を有する置換インダゾール

Country Status (29)

Country Link
US (2) US6858638B2 (cg-RX-API-DMAC7.html)
EP (1) EP1487803A1 (cg-RX-API-DMAC7.html)
JP (1) JP4643910B2 (cg-RX-API-DMAC7.html)
KR (1) KR20040091128A (cg-RX-API-DMAC7.html)
CN (1) CN100369899C (cg-RX-API-DMAC7.html)
AR (1) AR038914A1 (cg-RX-API-DMAC7.html)
AU (1) AU2003242808B2 (cg-RX-API-DMAC7.html)
BR (1) BR0308339A (cg-RX-API-DMAC7.html)
CA (1) CA2478540A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP045286A (cg-RX-API-DMAC7.html)
FR (1) FR2836914B1 (cg-RX-API-DMAC7.html)
GT (1) GT200300031A (cg-RX-API-DMAC7.html)
HN (1) HN2003000094A (cg-RX-API-DMAC7.html)
HR (1) HRP20040825A2 (cg-RX-API-DMAC7.html)
IL (2) IL163805A0 (cg-RX-API-DMAC7.html)
MA (1) MA27176A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA04008446A (cg-RX-API-DMAC7.html)
NO (1) NO20044261L (cg-RX-API-DMAC7.html)
OA (1) OA12784A (cg-RX-API-DMAC7.html)
PA (1) PA8566701A1 (cg-RX-API-DMAC7.html)
PE (1) PE20040071A1 (cg-RX-API-DMAC7.html)
PL (1) PL372389A1 (cg-RX-API-DMAC7.html)
RU (1) RU2004130280A (cg-RX-API-DMAC7.html)
SV (1) SV2003001493A (cg-RX-API-DMAC7.html)
TN (1) TNSN04175A1 (cg-RX-API-DMAC7.html)
TW (1) TW200303863A (cg-RX-API-DMAC7.html)
UY (1) UY27712A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003078402A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200406730B (cg-RX-API-DMAC7.html)

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WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
GB0330042D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
WO2005105788A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
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WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
EP2170834B1 (en) * 2007-07-16 2014-01-08 AbbVie Inc. Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
MX339469B (es) * 2009-05-26 2016-05-27 Abbvie Bahamas Ltd Agentes inductores de apotosis para el tratamiento de cancer y enfermedades inmunes y autoinmunes.
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2011050245A1 (en) * 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
CN102247361B (zh) * 2010-05-20 2015-04-29 中国医学科学院药物研究所 5-硝基-1氢-吲唑-3-腈在制备药物中的应用
SG10201801794WA (en) 2010-10-29 2018-04-27 Abbvie Inc Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
NZ610151A (en) 2010-11-23 2015-06-26 Abbvie Inc Salts and crystalline forms of an apoptosis-inducing agent
PH12013501006A1 (en) 2010-11-23 2022-03-30 Abbvie Ireland Unlimited Co Methods of treatment using selective bcl-2 inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP3215156B1 (en) 2014-11-03 2025-09-24 Iomet Pharma Ltd. Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
CN111278437A (zh) * 2017-07-21 2020-06-12 卡德门企业有限公司 Rho相关含卷曲螺旋蛋白激酶的抑制剂
WO2019046467A1 (en) 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey INDAZOLES THERAPEUTIC
JP2025504415A (ja) * 2022-01-12 2025-02-12 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する病態を治療するための化合物及び組成物
EP4488275A4 (en) 2022-03-04 2025-07-23 Shanghai Yingli Pharm Co Ltd COMPOUND CONTAINING A FIVE-MEMBERED HETEROAROMATIC RING STRUCTURE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
CN114605329B (zh) * 2022-03-28 2024-01-26 河南中医药大学 取代的吲唑甲酰胺或取代的氮杂吲唑甲酰胺类flt3抑制剂及其用途
EP4642764A2 (en) 2022-12-30 2025-11-05 Avicenna Biosciences, Inc. Azaindole rock inhibitors
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Also Published As

Publication number Publication date
ZA200406730B (en) 2005-08-24
JP2005533004A (ja) 2005-11-04
TNSN04175A1 (fr) 2007-03-12
US20040106667A1 (en) 2004-06-03
US7473701B2 (en) 2009-01-06
MXPA04008446A (es) 2004-12-06
IL163805A0 (en) 2005-12-18
PA8566701A1 (es) 2003-12-10
UY27712A1 (es) 2003-09-30
GT200300031A (es) 2006-05-26
AU2003242808B2 (en) 2008-09-18
BR0308339A (pt) 2005-02-01
WO2003078402A1 (fr) 2003-09-25
FR2836914B1 (fr) 2008-03-14
SV2003001493A (es) 2003-07-10
FR2836914A1 (fr) 2003-09-12
US6858638B2 (en) 2005-02-22
ECSP045286A (es) 2004-10-26
MA27176A1 (fr) 2005-01-03
AU2003242808A1 (en) 2003-09-29
US20050059722A1 (en) 2005-03-17
TW200303863A (en) 2003-09-16
NO20044261L (no) 2004-11-25
HN2003000094A (es) 2003-12-15
PL372389A1 (en) 2005-07-25
AR038914A1 (es) 2005-02-02
HRP20040825A2 (en) 2005-06-30
CN100369899C (zh) 2008-02-20
PE20040071A1 (es) 2004-02-13
CN1642922A (zh) 2005-07-20
KR20040091128A (ko) 2004-10-27
OA12784A (fr) 2006-07-10
EP1487803A1 (fr) 2004-12-22
IL163805A (en) 2009-08-03
CA2478540A1 (fr) 2003-09-25
RU2004130280A (ru) 2005-06-27

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