RU2004130280A - Замещенные индазолы, обладающие притовораковой активностью - Google Patents

Замещенные индазолы, обладающие притовораковой активностью Download PDF

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Publication number
RU2004130280A
RU2004130280A RU2004130280/04A RU2004130280A RU2004130280A RU 2004130280 A RU2004130280 A RU 2004130280A RU 2004130280/04 A RU2004130280/04 A RU 2004130280/04A RU 2004130280 A RU2004130280 A RU 2004130280A RU 2004130280 A RU2004130280 A RU 2004130280A
Authority
RU
Russia
Prior art keywords
indazol
benzenesulfonamide
phenyl
methanesulfonylbenzenesulfonamide
substituted
Prior art date
Application number
RU2004130280/04A
Other languages
English (en)
Russian (ru)
Inventor
Доминик ДАМУР (FR)
Доминик Дамур
Жан-Кристоф КАРРИ (FR)
Жан-Кристоф Карри
Патрик НЕМЕСЕК (FR)
Патрик Немесек
Корин ТЕРРЬЕ (FR)
Корин ТЕРРЬЕ
Фредерико НАРДИ (FR)
Фредерико Нарди
Брюно ФИЛОШ (FR)
Брюно Филош
Мари-Пьер ШЕРРЬЕ (FR)
Мари-Пьер Шеррье
Даниель БЕЗАР (FR)
Даниель Безар
Original Assignee
Авентис Фарма С.А. (Fr)
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма С.А. (Fr), Авентис Фарма С.А. filed Critical Авентис Фарма С.А. (Fr)
Publication of RU2004130280A publication Critical patent/RU2004130280A/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
RU2004130280/04A 2002-03-11 2003-03-07 Замещенные индазолы, обладающие притовораковой активностью RU2004130280A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0202996 2002-03-11
FR0202996A FR2836914B1 (fr) 2002-03-11 2002-03-11 Indazoles substitues, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
RU2004130280A true RU2004130280A (ru) 2005-06-27

Family

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Family Applications (1)

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RU2004130280/04A RU2004130280A (ru) 2002-03-11 2003-03-07 Замещенные индазолы, обладающие притовораковой активностью

Country Status (29)

Country Link
US (2) US6858638B2 (cg-RX-API-DMAC7.html)
EP (1) EP1487803A1 (cg-RX-API-DMAC7.html)
JP (1) JP4643910B2 (cg-RX-API-DMAC7.html)
KR (1) KR20040091128A (cg-RX-API-DMAC7.html)
CN (1) CN100369899C (cg-RX-API-DMAC7.html)
AR (1) AR038914A1 (cg-RX-API-DMAC7.html)
AU (1) AU2003242808B2 (cg-RX-API-DMAC7.html)
BR (1) BR0308339A (cg-RX-API-DMAC7.html)
CA (1) CA2478540A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP045286A (cg-RX-API-DMAC7.html)
FR (1) FR2836914B1 (cg-RX-API-DMAC7.html)
GT (1) GT200300031A (cg-RX-API-DMAC7.html)
HN (1) HN2003000094A (cg-RX-API-DMAC7.html)
HR (1) HRP20040825A2 (cg-RX-API-DMAC7.html)
IL (2) IL163805A0 (cg-RX-API-DMAC7.html)
MA (1) MA27176A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA04008446A (cg-RX-API-DMAC7.html)
NO (1) NO20044261L (cg-RX-API-DMAC7.html)
OA (1) OA12784A (cg-RX-API-DMAC7.html)
PA (1) PA8566701A1 (cg-RX-API-DMAC7.html)
PE (1) PE20040071A1 (cg-RX-API-DMAC7.html)
PL (1) PL372389A1 (cg-RX-API-DMAC7.html)
RU (1) RU2004130280A (cg-RX-API-DMAC7.html)
SV (1) SV2003001493A (cg-RX-API-DMAC7.html)
TN (1) TNSN04175A1 (cg-RX-API-DMAC7.html)
TW (1) TW200303863A (cg-RX-API-DMAC7.html)
UY (1) UY27712A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003078402A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200406730B (cg-RX-API-DMAC7.html)

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WO2010138588A3 (en) * 2009-05-26 2011-04-07 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8017641B2 (en) 2003-03-03 2011-09-13 Array Biopharma Inc. P38 inhibitors and methods of use thereof
US8039639B2 (en) 2006-01-31 2011-10-18 Array Biopharma Inc. Kinase inhibitors and methods of use thereof
RU2452738C2 (ru) * 2006-11-22 2012-06-10 Плекссикон, Инк. Соединения, модулирующие активность c-fms и/или c-kit, и их применения
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8722657B2 (en) 2010-11-23 2014-05-13 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9345702B2 (en) 2010-11-23 2016-05-24 Abbvie Inc. Methods of treatment using selective Bcl-2 inhibitors
US10081628B2 (en) 2013-03-14 2018-09-25 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US10213433B2 (en) 2010-10-29 2019-02-26 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
US11369599B2 (en) 2010-10-29 2022-06-28 Abbvie Inc. Melt-extruded solid dispersions containing an apoptosis-inducing agent
US11897864B2 (en) 2009-05-26 2024-02-13 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases

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FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
GB0218625D0 (en) * 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
AU2003286711A1 (en) * 2002-10-25 2004-05-13 Vertex Pharmaceuticals Incorporated Indazolinone compositions useful as kinase inhibitors
WO2005014554A1 (en) * 2003-08-08 2005-02-17 Astex Therapeutics Limited 1h-indazole-3-carboxamide compounds as mapkap kinase modulators
FR2864084B1 (fr) * 2003-12-17 2006-02-10 Aventis Pharma Sa Nouveaux derives organophosphores des indazoles et leur utilisation comme medicaments
WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
GB0330042D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
WO2005105788A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
JP2008510734A (ja) 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
WO2006034804A1 (en) * 2004-09-29 2006-04-06 F.Hoffmann-La Roche Ag Indozolone derivatives as 11b-hsd1 inhibitors
JP2008516973A (ja) 2004-10-15 2008-05-22 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
SE0402762D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Indazole sulphonamide derivatives
WO2007023114A1 (en) * 2005-08-25 2007-03-01 F. Hoffmann-La Roche Ag P38 map kinase inhibitors and methods for using the same
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20100120717A1 (en) 2006-10-09 2010-05-13 Brown Jason W Kinase inhibitors
JP2010505961A (ja) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
EP2170834B1 (en) * 2007-07-16 2014-01-08 AbbVie Inc. Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
WO2011050245A1 (en) * 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
CN102247361B (zh) * 2010-05-20 2015-04-29 中国医学科学院药物研究所 5-硝基-1氢-吲唑-3-腈在制备药物中的应用
EP3215156B1 (en) 2014-11-03 2025-09-24 Iomet Pharma Ltd. Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
CN111278437A (zh) * 2017-07-21 2020-06-12 卡德门企业有限公司 Rho相关含卷曲螺旋蛋白激酶的抑制剂
WO2019046467A1 (en) 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey INDAZOLES THERAPEUTIC
JP2025504415A (ja) * 2022-01-12 2025-02-12 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する病態を治療するための化合物及び組成物
EP4488275A4 (en) 2022-03-04 2025-07-23 Shanghai Yingli Pharm Co Ltd COMPOUND CONTAINING A FIVE-MEMBERED HETEROAROMATIC RING STRUCTURE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
CN114605329B (zh) * 2022-03-28 2024-01-26 河南中医药大学 取代的吲唑甲酰胺或取代的氮杂吲唑甲酰胺类flt3抑制剂及其用途
EP4642764A2 (en) 2022-12-30 2025-11-05 Avicenna Biosciences, Inc. Azaindole rock inhibitors
WO2025117661A1 (en) * 2023-11-28 2025-06-05 Quantx Biosciences Us, Inc. Bicyclic heteroaryl compounds

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JPH061350B2 (ja) * 1985-07-26 1994-01-05 コニカ株式会社 ハロゲン化銀写真感光材料
NZ331941A (en) 1996-02-22 2000-04-28 Tularik Inc Pentafluorobenzenesulfonamides and analogs and use in regulation of LDL receptor synthesis
DE69724811T2 (de) * 1996-07-19 2004-04-08 Tularik, Inc., South San Francisco Pentafluorobenzensulfonamide und analoge
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6087368A (en) * 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
WO2000027627A1 (en) 1998-11-12 2000-05-18 Eli Lilly And Company Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
CO5170498A1 (es) * 1999-05-28 2002-06-27 Abbott Lab Biaril sulfonamidas son utiles como inhibidores de proliferacion celular
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
KR100423899B1 (ko) * 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
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JPWO2002100833A1 (ja) 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
EP1401831A1 (en) * 2001-07-03 2004-03-31 Chiron Corporation Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
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FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
FR2836915B1 (fr) 2002-03-11 2008-01-11 Aventis Pharma Sa Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518983B2 (en) 2003-03-03 2013-08-27 Array Biopharma Inc. P38 inhibitors and methods of use thereof
US8017641B2 (en) 2003-03-03 2011-09-13 Array Biopharma Inc. P38 inhibitors and methods of use thereof
US8039639B2 (en) 2006-01-31 2011-10-18 Array Biopharma Inc. Kinase inhibitors and methods of use thereof
US8044083B2 (en) 2006-01-31 2011-10-25 Array Biopharma Inc. Kinase inhibitors and methods of use thereof
RU2452738C2 (ru) * 2006-11-22 2012-06-10 Плекссикон, Инк. Соединения, модулирующие активность c-fms и/или c-kit, и их применения
US9045475B2 (en) 2009-05-26 2015-06-02 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8580794B2 (en) 2009-05-26 2013-11-12 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US11897864B2 (en) 2009-05-26 2024-02-13 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2010138588A3 (en) * 2009-05-26 2011-04-07 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9174982B2 (en) 2009-05-26 2015-11-03 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US10213433B2 (en) 2010-10-29 2019-02-26 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
US11369599B2 (en) 2010-10-29 2022-06-28 Abbvie Inc. Melt-extruded solid dispersions containing an apoptosis-inducing agent
US9238649B2 (en) 2010-11-23 2016-01-19 Abbvie Inc. Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
US9872861B2 (en) 2010-11-23 2018-01-23 Abbvie Inc. Methods of treatment using selective Bcl-2 inhibitors
US9840502B2 (en) 2010-11-23 2017-12-12 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
US10730873B2 (en) 2010-11-23 2020-08-04 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
US9345702B2 (en) 2010-11-23 2016-05-24 Abbvie Inc. Methods of treatment using selective Bcl-2 inhibitors
US8722657B2 (en) 2010-11-23 2014-05-13 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
US10081628B2 (en) 2013-03-14 2018-09-25 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Also Published As

Publication number Publication date
ZA200406730B (en) 2005-08-24
JP2005533004A (ja) 2005-11-04
TNSN04175A1 (fr) 2007-03-12
US20040106667A1 (en) 2004-06-03
US7473701B2 (en) 2009-01-06
MXPA04008446A (es) 2004-12-06
IL163805A0 (en) 2005-12-18
PA8566701A1 (es) 2003-12-10
UY27712A1 (es) 2003-09-30
GT200300031A (es) 2006-05-26
AU2003242808B2 (en) 2008-09-18
BR0308339A (pt) 2005-02-01
WO2003078402A1 (fr) 2003-09-25
FR2836914B1 (fr) 2008-03-14
SV2003001493A (es) 2003-07-10
FR2836914A1 (fr) 2003-09-12
JP4643910B2 (ja) 2011-03-02
US6858638B2 (en) 2005-02-22
ECSP045286A (es) 2004-10-26
MA27176A1 (fr) 2005-01-03
AU2003242808A1 (en) 2003-09-29
US20050059722A1 (en) 2005-03-17
TW200303863A (en) 2003-09-16
NO20044261L (no) 2004-11-25
HN2003000094A (es) 2003-12-15
PL372389A1 (en) 2005-07-25
AR038914A1 (es) 2005-02-02
HRP20040825A2 (en) 2005-06-30
CN100369899C (zh) 2008-02-20
PE20040071A1 (es) 2004-02-13
CN1642922A (zh) 2005-07-20
KR20040091128A (ko) 2004-10-27
OA12784A (fr) 2006-07-10
EP1487803A1 (fr) 2004-12-22
IL163805A (en) 2009-08-03
CA2478540A1 (fr) 2003-09-25

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Effective date: 20061013