NO20044261L - Indazoler substituerte med en anticanceros aktivitet - Google Patents

Indazoler substituerte med en anticanceros aktivitet

Info

Publication number
NO20044261L
NO20044261L NO20044261A NO20044261A NO20044261L NO 20044261 L NO20044261 L NO 20044261L NO 20044261 A NO20044261 A NO 20044261A NO 20044261 A NO20044261 A NO 20044261A NO 20044261 L NO20044261 L NO 20044261L
Authority
NO
Norway
Prior art keywords
activity
anticancer drug
indazoles
substituted
indazoles substituted
Prior art date
Application number
NO20044261A
Other languages
English (en)
Norwegian (no)
Inventor
Corinne Terrier
Bruno Filoche
Jean-Christophe Carry
Patrick Nemecek
Mariepierre Cherrier
Domenique Damour
Frederico Nardi
Daniel Bezard
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO20044261L publication Critical patent/NO20044261L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
NO20044261A 2002-03-11 2004-10-07 Indazoler substituerte med en anticanceros aktivitet NO20044261L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0202996A FR2836914B1 (fr) 2002-03-11 2002-03-11 Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
PCT/FR2003/000751 WO2003078402A1 (fr) 2002-03-11 2003-03-07 Indazoles substitues avec une activite anticancereuse

Publications (1)

Publication Number Publication Date
NO20044261L true NO20044261L (no) 2004-11-25

Family

ID=27763684

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044261A NO20044261L (no) 2002-03-11 2004-10-07 Indazoler substituerte med en anticanceros aktivitet

Country Status (29)

Country Link
US (2) US6858638B2 (cg-RX-API-DMAC7.html)
EP (1) EP1487803A1 (cg-RX-API-DMAC7.html)
JP (1) JP4643910B2 (cg-RX-API-DMAC7.html)
KR (1) KR20040091128A (cg-RX-API-DMAC7.html)
CN (1) CN100369899C (cg-RX-API-DMAC7.html)
AR (1) AR038914A1 (cg-RX-API-DMAC7.html)
AU (1) AU2003242808B2 (cg-RX-API-DMAC7.html)
BR (1) BR0308339A (cg-RX-API-DMAC7.html)
CA (1) CA2478540A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP045286A (cg-RX-API-DMAC7.html)
FR (1) FR2836914B1 (cg-RX-API-DMAC7.html)
GT (1) GT200300031A (cg-RX-API-DMAC7.html)
HN (1) HN2003000094A (cg-RX-API-DMAC7.html)
HR (1) HRP20040825A2 (cg-RX-API-DMAC7.html)
IL (2) IL163805A0 (cg-RX-API-DMAC7.html)
MA (1) MA27176A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA04008446A (cg-RX-API-DMAC7.html)
NO (1) NO20044261L (cg-RX-API-DMAC7.html)
OA (1) OA12784A (cg-RX-API-DMAC7.html)
PA (1) PA8566701A1 (cg-RX-API-DMAC7.html)
PE (1) PE20040071A1 (cg-RX-API-DMAC7.html)
PL (1) PL372389A1 (cg-RX-API-DMAC7.html)
RU (1) RU2004130280A (cg-RX-API-DMAC7.html)
SV (1) SV2003001493A (cg-RX-API-DMAC7.html)
TN (1) TNSN04175A1 (cg-RX-API-DMAC7.html)
TW (1) TW200303863A (cg-RX-API-DMAC7.html)
UY (1) UY27712A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003078402A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200406730B (cg-RX-API-DMAC7.html)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
GB0218625D0 (en) * 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
AU2003286711A1 (en) * 2002-10-25 2004-05-13 Vertex Pharmaceuticals Incorporated Indazolinone compositions useful as kinase inhibitors
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
WO2005014554A1 (en) * 2003-08-08 2005-02-17 Astex Therapeutics Limited 1h-indazole-3-carboxamide compounds as mapkap kinase modulators
FR2864084B1 (fr) * 2003-12-17 2006-02-10 Aventis Pharma Sa Nouveaux derives organophosphores des indazoles et leur utilisation comme medicaments
WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
GB0330042D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
WO2005105788A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
JP2008510734A (ja) 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
WO2006034804A1 (en) * 2004-09-29 2006-04-06 F.Hoffmann-La Roche Ag Indozolone derivatives as 11b-hsd1 inhibitors
JP2008516973A (ja) 2004-10-15 2008-05-22 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
SE0402762D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Indazole sulphonamide derivatives
WO2007023114A1 (en) * 2005-08-25 2007-03-01 F. Hoffmann-La Roche Ag P38 map kinase inhibitors and methods for using the same
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
NZ570846A (en) 2006-01-31 2011-08-26 Array Biopharma Inc Kinase inhibitors and methods of use thereof
US20100120717A1 (en) 2006-10-09 2010-05-13 Brown Jason W Kinase inhibitors
JP2010505961A (ja) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
EP2170834B1 (en) * 2007-07-16 2014-01-08 AbbVie Inc. Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
MX339469B (es) * 2009-05-26 2016-05-27 Abbvie Bahamas Ltd Agentes inductores de apotosis para el tratamiento de cancer y enfermedades inmunes y autoinmunes.
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2011050245A1 (en) * 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
CN102247361B (zh) * 2010-05-20 2015-04-29 中国医学科学院药物研究所 5-硝基-1氢-吲唑-3-腈在制备药物中的应用
SG10201801794WA (en) 2010-10-29 2018-04-27 Abbvie Inc Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
NZ610151A (en) 2010-11-23 2015-06-26 Abbvie Inc Salts and crystalline forms of an apoptosis-inducing agent
PH12013501006A1 (en) 2010-11-23 2022-03-30 Abbvie Ireland Unlimited Co Methods of treatment using selective bcl-2 inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP3215156B1 (en) 2014-11-03 2025-09-24 Iomet Pharma Ltd. Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
CN111278437A (zh) * 2017-07-21 2020-06-12 卡德门企业有限公司 Rho相关含卷曲螺旋蛋白激酶的抑制剂
WO2019046467A1 (en) 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey INDAZOLES THERAPEUTIC
JP2025504415A (ja) * 2022-01-12 2025-02-12 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する病態を治療するための化合物及び組成物
EP4488275A4 (en) 2022-03-04 2025-07-23 Shanghai Yingli Pharm Co Ltd COMPOUND CONTAINING A FIVE-MEMBERED HETEROAROMATIC RING STRUCTURE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
CN114605329B (zh) * 2022-03-28 2024-01-26 河南中医药大学 取代的吲唑甲酰胺或取代的氮杂吲唑甲酰胺类flt3抑制剂及其用途
EP4642764A2 (en) 2022-12-30 2025-11-05 Avicenna Biosciences, Inc. Azaindole rock inhibitors
WO2025117661A1 (en) * 2023-11-28 2025-06-05 Quantx Biosciences Us, Inc. Bicyclic heteroaryl compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS514505Y2 (cg-RX-API-DMAC7.html) 1971-02-13 1976-02-07
JPH061350B2 (ja) * 1985-07-26 1994-01-05 コニカ株式会社 ハロゲン化銀写真感光材料
NZ331941A (en) 1996-02-22 2000-04-28 Tularik Inc Pentafluorobenzenesulfonamides and analogs and use in regulation of LDL receptor synthesis
DE69724811T2 (de) * 1996-07-19 2004-04-08 Tularik, Inc., South San Francisco Pentafluorobenzensulfonamide und analoge
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6087368A (en) * 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
WO2000027627A1 (en) 1998-11-12 2000-05-18 Eli Lilly And Company Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
CO5170498A1 (es) * 1999-05-28 2002-06-27 Abbott Lab Biaril sulfonamidas son utiles como inhibidores de proliferacion celular
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
KR100423899B1 (ko) * 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
KR20040007497A (ko) 2001-04-16 2004-01-24 에자이 가부시키가이샤 신규 1ｈ-인다졸 화합물
JPWO2002100833A1 (ja) 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
EP1401831A1 (en) * 2001-07-03 2004-03-31 Chiron Corporation Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
US7101884B2 (en) 2001-09-14 2006-09-05 Merck & Co., Inc. Tyrosine kinase inhibitors
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
FR2836915B1 (fr) 2002-03-11 2008-01-11 Aventis Pharma Sa Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
ZA200406730B (en) 2005-08-24
JP2005533004A (ja) 2005-11-04
TNSN04175A1 (fr) 2007-03-12
US20040106667A1 (en) 2004-06-03
US7473701B2 (en) 2009-01-06
MXPA04008446A (es) 2004-12-06
IL163805A0 (en) 2005-12-18
PA8566701A1 (es) 2003-12-10
UY27712A1 (es) 2003-09-30
GT200300031A (es) 2006-05-26
AU2003242808B2 (en) 2008-09-18
BR0308339A (pt) 2005-02-01
WO2003078402A1 (fr) 2003-09-25
FR2836914B1 (fr) 2008-03-14
SV2003001493A (es) 2003-07-10
FR2836914A1 (fr) 2003-09-12
JP4643910B2 (ja) 2011-03-02
US6858638B2 (en) 2005-02-22
ECSP045286A (es) 2004-10-26
MA27176A1 (fr) 2005-01-03
AU2003242808A1 (en) 2003-09-29
US20050059722A1 (en) 2005-03-17
TW200303863A (en) 2003-09-16
HN2003000094A (es) 2003-12-15
PL372389A1 (en) 2005-07-25
AR038914A1 (es) 2005-02-02
HRP20040825A2 (en) 2005-06-30
CN100369899C (zh) 2008-02-20
PE20040071A1 (es) 2004-02-13
CN1642922A (zh) 2005-07-20
KR20040091128A (ko) 2004-10-27
OA12784A (fr) 2006-07-10
EP1487803A1 (fr) 2004-12-22
IL163805A (en) 2009-08-03
CA2478540A1 (fr) 2003-09-25
RU2004130280A (ru) 2005-06-27

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