JP4632262B2 - サンプルの処理 - Google Patents

サンプルの処理 Download PDF

Info

Publication number
JP4632262B2
JP4632262B2 JP2006508686A JP2006508686A JP4632262B2 JP 4632262 B2 JP4632262 B2 JP 4632262B2 JP 2006508686 A JP2006508686 A JP 2006508686A JP 2006508686 A JP2006508686 A JP 2006508686A JP 4632262 B2 JP4632262 B2 JP 4632262B2
Authority
JP
Japan
Prior art keywords
tubule
segment
reagent
sample
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2006508686A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006518221A5 (https=
JP2006518221A (ja
Inventor
スーチー チェン，
ベルトラン レミエウックス，
チィウ ウォン，
ケビン， アール． コプティンスキ，
リンジュン チェン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IQuum Inc
Original Assignee
IQuum Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IQuum Inc filed Critical IQuum Inc
Publication of JP2006518221A publication Critical patent/JP2006518221A/ja
Publication of JP2006518221A5 publication Critical patent/JP2006518221A5/ja
Application granted granted Critical
Publication of JP4632262B2 publication Critical patent/JP4632262B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/55—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being contained in a flexible bag submitted to periodical deformation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Flexible containers without fluid transport within
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Clinical Laboratory Science (AREA)
  • Hydrology & Water Resources (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2006508686A 2003-02-05 2004-02-05 サンプルの処理 Expired - Lifetime JP4632262B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44530403P 2003-02-05 2003-02-05
PCT/US2004/003541 WO2004080597A2 (en) 2003-02-05 2004-02-05 Sample processing tubule

Publications (3)

Publication Number Publication Date
JP2006518221A JP2006518221A (ja) 2006-08-10
JP2006518221A5 JP2006518221A5 (https=) 2010-07-29
JP4632262B2 true JP4632262B2 (ja) 2011-02-16

Family

ID=32990611

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006508686A Expired - Lifetime JP4632262B2 (ja) 2003-02-05 2004-02-05 サンプルの処理

Country Status (8)

Country Link
US (4) US7718421B2 (https=)
EP (2) EP1603674B1 (https=)
JP (1) JP4632262B2 (https=)
CN (1) CN1767897B (https=)
AU (1) AU2004220626B2 (https=)
CA (1) CA2515075C (https=)
ES (2) ES2604352T3 (https=)
WO (1) WO2004080597A2 (https=)

Families Citing this family (246)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
CA2460192C (en) * 2001-09-11 2011-04-19 Iquum, Inc. Sample vessels
GB0128350D0 (en) 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
CA2515075C (en) 2003-02-05 2012-10-02 Iquum, Inc. Sample processing
DE602004030785D1 (de) * 2003-05-19 2011-02-10 Univ Brandeis Verfahren, kits und vorrichtungen zur prozessierung von nukleinsäuren
US20040267181A1 (en) * 2003-06-26 2004-12-30 Asd Swab sample collection and recovery device
JP4472634B2 (ja) * 2003-07-10 2010-06-02 ユニヴェルシテ リブル ドゥ ブリュッセル 生物学的試料を試剤でパルスし、こうしてパルスされた試料を安定化するための装置、キット及び方法
US7947450B2 (en) 2003-07-10 2011-05-24 Universite Libre De Bruxelles Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
US7337907B2 (en) * 2003-08-01 2008-03-04 Polyzen, Inc. Press-flat centrifuge tube and specimen collection assembly comprising same
US8426126B2 (en) 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
ES2572382T3 (es) * 2004-05-03 2016-05-31 Handylab Inc Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP4429069B2 (ja) * 2004-05-06 2010-03-10 三洋電機株式会社 微生物の検出装置および方法
JP2008505346A (ja) * 2004-06-07 2008-02-21 アイキューム， インク． サンプルマルチ処理
US20060188892A1 (en) * 2005-02-18 2006-08-24 Ambion, Inc. Enzymatic digestion of tissue
US7745204B1 (en) 2005-04-29 2010-06-29 Georgia Tech Research Corporation Automation of biological sample aliquoting
ES2689172T3 (es) * 2005-06-23 2018-11-08 Biocartis Nv Cartucho modular, sistema y procedimiento para diagnóstico médico automatizado
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
DE102005054924B4 (de) 2005-11-17 2012-06-14 Siemens Ag Vorrichtung und Verfahren zum Extrahieren einer Abstrichprobe
KR101157174B1 (ko) * 2005-11-24 2012-06-20 삼성전자주식회사 세포 또는 바이러스의 신속한 파괴 방법 및 장치
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc MICROFLUIDIC DEVICES
US20080003564A1 (en) * 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
JP5069871B2 (ja) * 2006-05-30 2012-11-07 シスメックス株式会社 新規な癌細胞検出試料調製用キット及びそれを用いた癌細胞検出用キット
CN101479603B (zh) * 2006-06-02 2012-11-21 卢米尼克斯股份有限公司 包括使用磁粒子和应用磁场的用于执行一种或多种分析物的测量系统和方法
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
ES2688281T3 (es) 2006-07-28 2018-10-31 Diagnostics For The Real World, Ltd Dispositivo, sistema y método para procesar una muestra
US20080069732A1 (en) * 2006-09-20 2008-03-20 Robert Yi Diagnostic test system
US8895267B2 (en) * 2006-11-03 2014-11-25 Siemens Healthcare Diagnostics Inc. Random access system and method for polymerase chain reaction testing
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
JP4884180B2 (ja) * 2006-11-21 2012-02-29 東京エレクトロン株式会社 基板処理装置および基板処理方法
EP1938756A1 (en) * 2006-12-29 2008-07-02 Qiagen GmbH Method and materials for triggered release of a biological sample
JP2008167722A (ja) * 2007-01-15 2008-07-24 Konica Minolta Medical & Graphic Inc 磁性支持体上での加熱による核酸単離方法
GB2445738A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Microfluidic device
GB2445739A (en) 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
EP1970711A1 (en) * 2007-03-16 2008-09-17 Radiometer Medical ApS Reagent cup device
US20100190240A1 (en) * 2007-03-21 2010-07-29 Ibis Biosciences, Inc. Reagents for nucleic acid purification
US20090042241A1 (en) 2007-04-06 2009-02-12 California Institute Of Technology Microfluidic device
US9458451B2 (en) 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
US8828712B2 (en) * 2007-06-29 2014-09-09 Toppan Printing Co., Ltd. Genetic detection and determination apparatus and method, gene reactor, and incubator
EP2167932B1 (en) * 2007-07-12 2013-06-19 Smiths Detection Inc. Sample preparation apparatus
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
JP4999588B2 (ja) * 2007-07-24 2012-08-15 キヤノン株式会社 容器装置、これを備えたｄｎａ検査装置およびその貫通方法
GB2456079B (en) 2007-08-17 2010-07-14 Diagnostics For The Real World Device, system and method for processing a sample
FR2921490B1 (fr) * 2007-09-21 2010-09-10 Metagenex Procede et dispositif pour recueillir du materiel cellulaire de cellules isolees sur filtre
WO2009052095A1 (en) * 2007-10-17 2009-04-23 Advanced Liquid Logic, Inc. Reagent storage and reconstitution for a droplet actuator
US20090104076A1 (en) * 2007-10-19 2009-04-23 Los Alamos National Security Llc Sample preparation cartridge and system
CN102027367B (zh) * 2008-02-29 2016-03-23 西北大学 促进生物反应的屏障
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
GB0814570D0 (en) 2008-08-08 2008-09-17 Diagnostics For The Real World Isolation of nucleic acid
US9943292B2 (en) * 2008-09-08 2018-04-17 Ogeno Gmbh Biopsy instrument for enriching sample material
EP2206780B1 (de) * 2008-12-23 2012-02-29 Qiagen GmbH Verfahren und Vorrichtung zur Durchführung einer Nukleinsäurepräparation und/oder Amplifikation
EP2373813B1 (de) * 2008-12-30 2012-10-31 Qiagen Hamburg GmbH Verfahren zum nachweis methicillin-resistenter staphylococcus aureus (mrsa)-stämme
EP2379697A2 (en) 2008-12-31 2011-10-26 3M Innovative Properties Company Sampling devices and methods for concentrating microorganisms
EP2379226B1 (en) 2008-12-31 2016-04-20 3M Innovative Properties Company Live bioload detection using microparticles
EP2391452B1 (en) * 2009-01-30 2015-06-17 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
EP2425246A4 (en) * 2009-04-27 2012-10-17 Axxin Pty Ltd CAPILLARY FLOW TEST ASSEMBLY
US8236254B2 (en) * 2009-05-14 2012-08-07 Abbott Diabetes Care Inc. Cap-linked test strip carrier for vial augmentation
EP3586945A3 (en) 2009-06-05 2020-03-04 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
US20110146418A1 (en) * 2009-10-02 2011-06-23 Brevnov Maxim G Sample Preparation Devices and Methods
JP5907880B2 (ja) 2009-11-13 2016-04-26 ベックマン コールター， インコーポレイテッド クラスタリングを用いて生物学的持続状態の存在を検出するためのシステムおよび方法
EP2519355B1 (en) 2009-12-30 2017-01-25 3M Innovative Properties Company Live bioload detection using microparticles
LT2521780T (lt) * 2010-01-07 2018-02-12 Bigtec Private Limited Neklerūgščių išskyrimo būdas ir rinkinys
AU2011220873B2 (en) * 2010-02-23 2014-07-10 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
GB201005885D0 (en) * 2010-04-08 2010-05-26 Avacta Ltd Apparatus and method
US20130109030A1 (en) * 2010-07-05 2013-05-02 Koninklijke Philips Electronics N.V. Examination system with sample incubation
JP2013537621A (ja) * 2010-07-14 2013-10-03 キアゲン ゲーエムベーハー 新規の液体プロセシングデバイス
EP2593768B1 (en) * 2010-07-14 2024-06-19 Qiagen GmbH New storage, collection or isolation device
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
EP2608828B1 (en) 2010-08-26 2016-09-14 Spot on Sciences, Inc. Biological fluid sampling and storage apparatus
KR101420094B1 (ko) 2010-10-27 2014-07-17 (주)바이오니아 다양한 생체시료분석을 위한 전자동실시간정량증폭장비, 다양한 생체시료분석을 위한 자동정제 및 반응준비 장치, 전자동 핵산정제 및 실시간 정량 유전자증폭 방법, 전자동 핵산정제방법, 실시간정량ｐｃｒ을 이용한 병원균의 전자동 생균수검사방법, 정량면역ｐｃｒ을 이용한 전자동 항원농도획득방법 및 타겟항원에 라벨링된 부착용 타겟핵산의 정제방법
IT1403618B1 (it) * 2011-01-05 2013-10-31 Copan Italia Spa Procedimento per realizzare un dispositivo per il prelievo ed il trasferimento di campioni per biologia molecolare
WO2012135034A1 (en) * 2011-03-25 2012-10-04 Receptors Llc Fiber with microbial removal, micro-biocidal, or static growth capability
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
CN104023834B (zh) 2011-05-04 2016-09-28 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
WO2012177656A2 (en) 2011-06-19 2012-12-27 Abogen, Inc. Devices, solutions and methods for sample collection
CA2840949A1 (en) 2011-07-06 2013-01-10 Advanced Liquid Logic Inc Reagent storage on a droplet actuator
US20140162941A1 (en) * 2011-07-27 2014-06-12 Baylor College Of Medicine Process for preparing biological samples
ES2645966T3 (es) 2011-09-30 2017-12-11 Becton, Dickinson And Company Tira reactiva unificada
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US20130092690A1 (en) * 2011-10-18 2013-04-18 Reflex Medical Corp. Seal cap with pre-filled agent for a specimen container
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
EP2788008A4 (en) * 2011-12-07 2015-08-26 Cytovera Inc PROCESS AND DEVICE FOR SAMPLE PROCESSING
JP5807542B2 (ja) 2011-12-22 2015-11-10 株式会社島津製作所 対象成分を操作するためのチップデバイス及びそれを用いた方法
WO2013101741A1 (en) 2011-12-30 2013-07-04 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US10428375B2 (en) 2012-02-03 2019-10-01 Axxin Pty Ltd Nucleic acid amplification and detection apparatus and method
USD679410S1 (en) * 2012-02-03 2013-04-02 Respirio Pty Ltd Sampling and testing device
MX350425B (es) 2012-06-28 2017-09-05 Fluoresentric Inc Dispositivo de indicador quimico.
EP2879581B1 (en) * 2012-08-02 2017-12-06 Siemens Healthcare Diagnostics Inc. Biological liquid collection vessels
US9347056B2 (en) * 2012-10-26 2016-05-24 Seiko Epson Corporation Nucleic acid extraction device, and nucleic acid extraction method, nucleic acid extraction kit, and nucleic acid extraction apparatus, each using the same
CN103849548A (zh) 2012-12-03 2014-06-11 三星电子株式会社 用于扩增核酸的试剂容器及其制备方法、存储试剂的方法和用于核酸分析的微流体系统
JP6349327B2 (ja) 2012-12-17 2018-06-27 レウコドゥックス，リミテッド 化学的状態を判定するためのシステムおよび方法
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
US9272277B2 (en) * 2013-02-15 2016-03-01 Honeywell International Inc. Capillary groove for isobaric waste entry
JP2014176304A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応用カートリッジ
US10335786B2 (en) 2013-05-31 2019-07-02 Pixcell Medical Technologies Ltd. Cartridge for preparing a sample fluid containing cells for analysis
JP2015073513A (ja) * 2013-10-11 2015-04-20 セイコーエプソン株式会社 核酸抽出用デバイス、核酸抽出用キット、及び核酸抽出用装置
JP2015084657A (ja) * 2013-10-28 2015-05-07 セイコーエプソン株式会社 核酸抽出用デバイス
CN114471756B (zh) 2013-11-18 2024-04-16 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US10160966B2 (en) 2013-12-12 2018-12-25 Altratech Limited Sample preparation method and apparatus
EP3375892B1 (en) 2013-12-12 2020-07-01 Altratech Limited Capacitive sensor
ES2949108T3 (es) 2013-12-20 2023-09-25 Spot Bioscience Llc Aparato de muestreo para la separación de sangre completa
JP2015159786A (ja) * 2014-02-28 2015-09-07 セイコーエプソン株式会社 標的物質の精製装置及び精製方法
US9462815B2 (en) * 2014-03-20 2016-10-11 Rex Adams Flavor dispensing systems
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
WO2015184360A1 (en) * 2014-05-30 2015-12-03 Pressure Biosciences, Inc. Sample preparation devices and methods
US10316347B2 (en) 2014-06-26 2019-06-11 Ecolab Usa Inc. Endospore detection using hydrophobic collection material
US9145581B1 (en) * 2014-10-17 2015-09-29 Daniel Lai Rapid nucleic acid extraction method and apparatus
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
WO2016074046A1 (en) 2014-11-14 2016-05-19 Axxin Pty Ltd Biological sample collection and storage assembly
US9464969B2 (en) 2014-11-20 2016-10-11 Monolythix, Inc. Monoliths
EP3249404B1 (en) * 2015-01-22 2019-10-02 NEC Solution Innovators, Ltd. Target analysis apparatus and target analysis method
EP3262407B1 (en) * 2015-02-24 2023-08-30 10X Genomics, Inc. Partition processing methods and systems
US11260386B2 (en) * 2015-06-05 2022-03-01 The Emerther Company Component of a device, a device, and a method for purifying and testing biomolecules from biological samples
MY196441A (en) * 2015-06-05 2023-04-11 Orion Genomics Llc Sample Collection Device
JP6854246B2 (ja) 2015-06-08 2021-04-07 アーケア ダイアグノスティクス リミテッド 尿サンプルの分析方法
EP3304084B1 (en) 2015-06-08 2022-03-23 Arquer Diagnostics Limited Methods and kits
CN105188010A (zh) * 2015-06-30 2015-12-23 瓮安县创新电子厂 耳机喇叭pc板安装杆
WO2017011862A1 (en) 2015-07-17 2017-01-26 Axxin Pty Ltd Diagnostic test assembly, apparatus, method
CN209155878U (zh) 2015-08-10 2019-07-26 生命科技公司 样本载体和利用其的系统
US10570439B2 (en) 2015-08-18 2020-02-25 Monolythix, Inc. Sample concentration devices
WO2017031369A1 (en) * 2015-08-18 2017-02-23 Monolythix, Inc. Sample concentration devices
EP3344392B1 (en) * 2015-09-02 2021-06-23 Polymer Technology Systems, Inc. Systems and methods for controlling excessive fluid flow in a cassette designed to receive a fluid sample
KR101810942B1 (ko) * 2015-09-04 2018-01-25 (주)나노엔텍 샘플 전처리 시스템 및 그 제어방법
CN113122535A (zh) * 2015-09-10 2021-07-16 株式会社钟化 从含有核酸的样品中分离核酸的方法及用于该方法的样品处理试剂
CN105349530B (zh) * 2015-12-11 2018-02-27 杭州优思达生物技术有限公司 一种核酸检测方法及检测管
CN108350407B (zh) * 2015-12-11 2022-07-08 杰诺玛迪克斯公司 用于核酸扩增的管密封系统和方法
CN105483219B (zh) * 2015-12-11 2019-01-15 杭州优思达生物技术有限公司 结核分枝杆菌复合群核酸检测方法及试剂盒
EP3402595A4 (en) * 2016-01-11 2019-10-02 Fluoresentric, Inc. SYSTEMS, DEVICES AND METHOD FOR INLINE SAMPLE PREPARATION
US10569939B1 (en) 2016-03-21 2020-02-25 United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Axially sealing plug
CA3019732A1 (en) * 2016-04-05 2017-10-12 Nch Corporation Nutrient rich germinant composition and spore incubation method
US9933445B1 (en) 2016-05-16 2018-04-03 Hound Labs, Inc. System and method for target substance identification
US10774393B2 (en) * 2016-05-20 2020-09-15 Roche Molecular Systems, Inc. Cell surface marker depletion in a sample processing device
CN105886387B (zh) * 2016-05-30 2018-08-07 北京安洁优科技有限公司 诊断试剂的一管化包装方法及一管化包装诊断试剂瓶
CN106222236A (zh) * 2016-07-27 2016-12-14 郑州点石生物技术有限公司 血液中微生物检测试剂及其制备方法
US20180051273A1 (en) * 2016-08-17 2018-02-22 Syracuse University System and method for dna extraction
CN106318859B (zh) * 2016-08-22 2018-08-31 中国人民解放军南京军区南京总医院 一种密闭连续菌液配置装置
US11478791B2 (en) 2016-09-12 2022-10-25 Delta Electronics Int'l (Singapore) Pte Ltd Flow control and processing cartridge
US11376581B2 (en) 2016-09-12 2022-07-05 Delta Electronics Int'l (Singapore) Pte Ltd Flow control and processing cartridge
US10590469B2 (en) * 2016-09-15 2020-03-17 Roche Molecular Svstems, Inc. Methods for performing multiplexed real-time PCR in a self-contained nucleic acid analysis pouch
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
EP3541515A1 (en) * 2016-11-16 2019-09-25 Quidel Corporation Device for whole blood separation
US11231347B2 (en) * 2016-11-29 2022-01-25 S2 Genomics, Inc. Method and apparatus for processing tissue samples
CN115786089A (zh) 2016-12-01 2023-03-14 新型微装置有限责任公司 用于复杂样品处理的自动化现场测试装置及其使用方法
JP6858540B2 (ja) 2016-12-08 2021-04-14 株式会社ミズホメディー 核酸増幅反応用デバイス
TWI611171B (zh) 2016-12-14 2018-01-11 財團法人工業技術研究院 生物樣品處理裝置
ES2967940T3 (es) * 2016-12-22 2024-05-06 Basf Se Dispositivo de acoplamiento y apertura de recipientes con sonda
GB201703383D0 (en) 2017-03-02 2017-04-19 Gargle Tech Ltd Testing for particulates
CN110678265A (zh) * 2017-03-24 2020-01-10 通用生物传感器有限公司 样品预处理装置和方法
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
US10906035B2 (en) * 2017-05-30 2021-02-02 Roche Molecular Systems, Inc. Modified sample processing device
US11602750B2 (en) 2017-05-30 2023-03-14 Roche Molecular Systems, Inc. Customizable sample processing device
CN107091923B (zh) * 2017-06-02 2018-01-30 成都普利泰生物科技有限公司 一种毛细管化学发光检测装置及其检测方法
CN107151700B (zh) * 2017-06-08 2023-11-07 杭州遂真生物技术有限公司 一种基因检测方法及基因检测试剂盒和基因检测设备
EP3460077B1 (en) 2017-09-20 2020-06-17 Altratech Limited Diagnostic device and system
CN111108216B (zh) 2017-09-20 2024-02-23 阿尔查技术有限公司 诊断装置和系统
GB201715399D0 (en) * 2017-09-22 2017-11-08 Ge Healthcare Bio Sciences Ab Valve unit for a chromatography apparatus
CA3076836A1 (en) 2017-09-27 2019-04-04 Axxin Pty Ltd Diagnostic test system and method
WO2019086517A1 (en) 2017-10-31 2019-05-09 Roche Diagnostics Gmbh Improved magnetic particles and uses thereof
EP3727805B1 (en) * 2017-12-19 2023-09-13 F. Hoffmann-La Roche AG Sealing press and method of making a frangible seal in a sample processing device
WO2019169347A1 (en) 2018-03-02 2019-09-06 10X Genomics, Inc. Systems and apparatus for holding plates
WO2019181400A1 (ja) * 2018-03-22 2019-09-26 富士フイルム株式会社 被検体の処理方法および被検体処理用容器
CN108753591B (zh) * 2018-05-30 2022-03-22 天津达伟医疗科技有限公司 一种一体式肛检增菌取样管、方法以及用途
EP3803324A4 (en) 2018-06-01 2023-02-22 S2 Genomics, Inc. Method and apparatus for processing tissue samples
CN108949499A (zh) * 2018-06-12 2018-12-07 广州和实生物技术有限公司 一种旋转式试剂提取扩增装置
CN108949498B (zh) * 2018-06-12 2024-01-30 广州和实生物技术有限公司 一种全封闭一体化试剂提取扩增装置
GB201813334D0 (en) * 2018-08-15 2018-09-26 Wang Tiesheng Nanocomposite materials and methods of manufacture thereof
EP3846939B1 (en) 2018-09-05 2023-05-03 Hero Scientific Ltd Testing for particulates
US11712692B2 (en) 2018-11-20 2023-08-01 Spectrum Solutions L.L.C. Sample collection system including sealing cap and valve
WO2020117710A1 (en) * 2018-12-02 2020-06-11 Polymer Technology Systems, Inc. Systems and methods for an integrated consumable for analyte testing, including a premix apparatus
KR102041333B1 (ko) * 2018-12-24 2019-11-06 주식회사 덴오믹스 세포 용해 조성물 및 이를 이용한 핵산의 추출 방법
US20200245898A1 (en) 2019-01-31 2020-08-06 Hound Labs, Inc. Single-use Microfluidic Cartridge for Detection of Target Chemical Presence in Human Breath
US11977086B2 (en) 2019-03-21 2024-05-07 Hound Labs, Inc. Biomarker detection from breath samples
CN110373309A (zh) * 2019-06-12 2019-10-25 广州知芯科技有限公司 一种核酸提取扩增系统及分子检测装置
US11701094B2 (en) 2019-06-20 2023-07-18 Spectrum Solutions L.L.C. Sample collection system including valve and plug assemblies
CN112138729B (zh) * 2019-06-26 2025-03-18 京东方科技集团股份有限公司 采样结构、密封结构以及检测组件
WO2021046504A1 (en) * 2019-09-06 2021-03-11 Teleflex Medical Incorporated Infection detection systems and methods including a sample processor having integrated sample filter and meter
CN110596066A (zh) * 2019-09-28 2019-12-20 佛山克情日用品有限公司 一种餐具洁净程度检测设备
US11857981B2 (en) 2019-12-23 2024-01-02 10X Genomics, Inc. Magnetic separator for an automated single cell sequencing system
CN110964842B (zh) * 2019-12-31 2023-11-03 广州金域医学检验集团股份有限公司 一种检测结核分枝杆菌核酸的样本处理试剂、试剂盒及结核分枝杆菌的核酸扩增方法
EP4118412A1 (en) 2020-03-11 2023-01-18 Hero Scientific Ltd Testing devices
US11701668B1 (en) 2020-05-08 2023-07-18 10X Genomics, Inc. Methods and devices for magnetic separation
US11933731B1 (en) 2020-05-13 2024-03-19 Hound Labs, Inc. Systems and methods using Surface-Enhanced Raman Spectroscopy for detecting tetrahydrocannabinol
US11946038B1 (en) 2020-05-29 2024-04-02 10X Genomics, Inc. Methods and systems including flow and magnetic modules
US12263482B1 (en) 2020-06-03 2025-04-01 10X Genomics, Inc. Methods and devices for magnetic separation in a flow path
CA3182824A1 (en) * 2020-07-14 2022-01-20 Adam GAUSTAD Microarrays, hybridization seals, and related methods
CN115279498A (zh) * 2020-07-17 2022-11-01 深圳华大智造科技股份有限公司 生化反应装置及其应用
JP2023536962A (ja) 2020-08-06 2023-08-30 エフ． ホフマン－ラ ロシュ アーゲー 重症急性呼吸器症候群コロナウイルス２（ｓａｒｓ－２）、インフルエンザａ及びインフルエンザｂの検出のための組成物及び方法
EP4217504A4 (en) * 2020-09-25 2024-12-25 Charm Sciences, Inc. SYSTEMS AND METHODS FOR SAMPLE PREPARATION AND DETECTION
CN114381360A (zh) * 2020-10-22 2022-04-22 佳能医疗系统株式会社 核酸检测系统及其应用
TWI750907B (zh) * 2020-11-19 2021-12-21 廣普生物科技股份有限公司 微量管組件及微量管操作系統
WO2022113112A1 (en) * 2020-11-27 2022-06-02 Reliance Industries Limited Device for rna extraction for sars-cov-2 detection
CA3202405A1 (en) 2021-01-06 2022-07-14 Zvi Feldman Filtration sampling devices
US12392769B1 (en) 2021-01-12 2025-08-19 Hound Labs, Inc. Ambient contamination in breath analyte detection and measurement
CN112899151A (zh) * 2021-02-01 2021-06-04 青岛迪诺瓦基因科技有限公司 一种流动液体变温装置及其使用方法
CN112575090B (zh) * 2021-02-05 2022-05-20 济南千麦医学检验有限公司 一种检测brca基因突变的pcr反应试剂盒
CN113243938B (zh) * 2021-05-13 2022-05-17 高美龄 一种柱塞阀式过滤的医用吸嘴头
US20220387004A1 (en) * 2021-05-24 2022-12-08 Graphene-Dx, Inc. Device for collection of biological samples
EP4363109A1 (en) * 2021-07-02 2024-05-08 Creganna Unlimited Company Disposable flow through diagnostic device and method of construction thereof
JP7756180B2 (ja) * 2021-07-02 2025-10-17 クレガナ・アンリミテッド・カンパニー 使い捨て貫流診断用デバイスおよびその構築方法
CN113528333B (zh) * 2021-07-20 2022-03-08 北京擎科生物科技有限公司 核酸合成反应装置及核酸合成方法
CN113604346B (zh) * 2021-09-02 2023-11-17 浙江仅一医疗科技有限公司 装有试剂的检测装置和利用检测装置检测核酸使用方法
CN113846014A (zh) * 2021-10-29 2021-12-28 青岛全诊生物技术有限公司 核酸提取和扩增装置
CN114045216B (zh) * 2022-01-11 2022-04-15 至美时代生物智能科技(北京)有限公司 一种空气采样瓶、空气采样系统及空气采样方法
EP4466103A1 (de) * 2022-01-21 2024-11-27 Procomcure Biotech GmbH Vorrichtung zur aufnahme von proben
CN115078606B (zh) * 2022-06-14 2023-06-06 浙江工商大学 一种基于脂质组学鉴定虾糜制品品种的方法
CN115099206B (zh) * 2022-08-23 2022-12-06 佰墨思(成都)数字技术有限公司 一种生物制药生产全周期过程动态表单生成方法及系统
EP4579209A4 (en) * 2022-09-30 2026-03-11 Beijing Sightnovo Medical Tech Co Ltd TEAR SAMPLE ELUENT, DILUTANT AND ITS PREPARATION METHOD, AND APPARATUS FOR COLLECTING AND PROCESSING TEAR
JP2025532126A (ja) * 2022-10-05 2025-09-29 ホンブレヒティコン システムズ エンジニアリング アクチェンゲゼルシャフト 容器、混合装置、及び混合装置を使用するための方法
US20240198336A1 (en) 2022-12-19 2024-06-20 Anchorline Biolabs, Inc. Capillary partitioning microfluidics
KR102708532B1 (ko) * 2023-04-12 2024-09-23 주식회사 리바이오 혈구분리 장치
WO2025036740A1 (en) * 2023-08-14 2025-02-20 F. Hoffmann-La Roche Ag Devices and applications of coupled nucleic acid amplification tests and crispr systems
CN117025379B (zh) * 2023-10-09 2023-12-15 迪飞医学科技(南京)有限公司 一种rapid恒温扩增核酸检测装置以及检测方法
CN118272221B (zh) * 2024-05-23 2024-08-16 浙江正合谷生物科技有限公司 一种水产检测用套式pcr扩增装置以及检测方法
GB2643864A (en) * 2024-08-19 2026-03-11 Protondx Ltd Apparatus for maintaining separation of liquids, and method of using the same to process a sample
CN119144431B (zh) * 2024-09-11 2025-06-20 中国科学院过程工程研究所 基于柔性结构和推拉结构的核酸一体化检测装置
CN119464030A (zh) * 2025-01-15 2025-02-18 广州市刑事科学技术研究所 一种脱落细胞粘取采样装置

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895475A (en) 1956-12-03 1959-07-21 Everett L Cole Container for collecting, storing and dispensing biological fluids
US3036894A (en) 1958-10-22 1962-05-29 Jasper A Forestiere Method of using testing containers
US3260413A (en) 1964-08-31 1966-07-12 Scientific Industries Automatic chemical analyzer
USRE29725E (en) 1966-04-26 1978-08-08 E. I. Du Pont De Nemours And Company Analytical test pack and process for analysis
US3697227A (en) 1966-05-13 1972-10-10 Westinghouse Electric Corp Chemical constituent sampler
FR1513306A (fr) 1966-09-08 1968-02-16 Automatisme Cie Gle Perfectionnements aux installations d'analyses
BE702970A (https=) 1966-09-08 1968-02-23
US3441205A (en) 1966-10-10 1969-04-29 Marvin Kendall Young Jr Method for separating sediment from supernatant fluid
US3607097A (en) 1967-08-09 1971-09-21 Philips Corp Analyzer for liquid samples
US3579303A (en) 1968-03-06 1971-05-18 Donald E Pickering System for handling specimens and other substances in medicine and physical sciences
FR2035058A1 (https=) 1969-03-19 1970-12-18 American Optical Corp
US3736933A (en) 1970-12-02 1973-06-05 B Szabo Burstable seamed hypodermic applicators
CA983358A (en) 1971-09-08 1976-02-10 Kenneth D. Bagshawe Performance of chemical or biological reactions
US3819158A (en) 1972-08-17 1974-06-25 Lever Brothers Ltd Devices for blending materials
US3918913A (en) 1974-12-02 1975-11-11 Lilly Co Eli Sampler-injector for liquid chromatography
US4038030A (en) 1975-04-10 1977-07-26 American Hospital Supply Corporation Profile analysis pack and method
US4065263A (en) 1976-04-02 1977-12-27 Woodbridge Iii Richard G Analytical test strip apparatus
US4073693A (en) * 1976-06-08 1978-02-14 American Home Products Corporation Apparatus and method for conducting a plurality of biological tests
US4166457A (en) 1976-08-16 1979-09-04 University Of Utah Research Institute Fluid self-sealing bioelectrode
DE2753865A1 (de) 1977-12-02 1979-06-07 Ultrakust Geraetebau Verfahren und vorrichtung zum handhaben von milchproben
DE2804881C3 (de) 1978-02-04 1980-08-07 Fa. Carl Zeiss, 7920 Heidenheim Gerät zur automatischen Analyse von flüssigen Proben
US4187861A (en) 1978-02-21 1980-02-12 Heffernan Bart T Blood sample handling apparatus and method
US4381208A (en) 1978-08-15 1983-04-26 Lucas Industries Limited Method of making a ribbon cable
US4266559A (en) 1979-04-02 1981-05-12 American Hospital Supply Corporation Blood sampler
US4596271A (en) 1980-10-02 1986-06-24 Brundage Robert W Fluid pressure device
US4329698A (en) 1980-12-19 1982-05-11 International Business Machines Corporation Disposable cartridge for ink drop printer
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
JPS5818167A (ja) 1981-07-24 1983-02-02 Fuji Photo Film Co Ltd 分析フイルム及びこれを用いる分析方法
US4446232A (en) 1981-10-13 1984-05-01 Liotta Lance A Enzyme immunoassay with two-zoned device having bound antigens
US5073484A (en) 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US4483920A (en) 1982-05-17 1984-11-20 Hahnemann University Immobilization of message RNA directly from cells onto filter material
US4427580A (en) 1982-09-01 1984-01-24 Cornell Research Foundation, Inc. Method for separation and recovery of proteins and nucleic acids from nucleoproteins using water destructuring salts
US4752449A (en) 1982-10-15 1988-06-21 Hemotec, Inc. Apparatus for coagulation detection by gas flow or plunger sensing techniques
US4608275A (en) 1983-07-01 1986-08-26 Macdermid, Incorporated Oxidizing accelerator
EP0139373A1 (en) 1983-08-26 1985-05-02 The Regents Of The University Of California Multiple immunoassay system
JPS61247965A (ja) 1985-04-25 1986-11-05 Susumu Kogyo Kk 酵素免疫測定法
US4695430A (en) 1985-10-31 1987-09-22 Bio/Data Corporation Analytical apparatus
FR2590673B1 (fr) 1985-11-05 1988-09-16 Bally Philippe Dispositif de test autonome miniaturise a usage unique
JPS62226057A (ja) 1986-03-28 1987-10-05 Minoru Tomita 全血用赤血球の凝集率測定方法及びその装置
US5057438A (en) 1986-09-24 1991-10-15 Agency Of Industrial Science And Technology Electrophoretic antigen-antibody determination with laminate of multiple membranes
US5714380A (en) * 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US4820297A (en) 1986-12-12 1989-04-11 Baxter International Inc. Fluid delivery system with integrally formed sample cell
US4846005A (en) 1986-12-12 1989-07-11 Baxter International Inc. Set with attachable sample cell
US4900321A (en) 1986-12-12 1990-02-13 Baxter International Inc. Set with integrally formed sample cell
AT391213B (de) 1987-05-12 1990-09-10 Avl Verbrennungskraft Messtech Einrichtung zur wahlweisen beschickung eines analysengeraetes
US5178832A (en) 1987-09-28 1993-01-12 The Texas A&M University System Selective immobilization and detection of mycotoxins in solution
US4874691A (en) 1987-10-16 1989-10-17 Quadra Logic Technologies Inc. Membrane-supported immunoassays
DE3737604A1 (de) 1987-11-05 1989-05-24 Biotechnolog Forschung Gmbh Geraet zur fliess-injektions-analyse
CA1339723C (en) 1988-01-19 1998-03-17 Philip Mcmahon Immunoassay with multiple test spots
US5137804A (en) 1988-05-10 1992-08-11 E. I. Du Pont De Nemours And Company Assay device and immunoassay
US5019348A (en) 1988-05-26 1991-05-28 Beckman Instruments, Inc. Automated chemical conversion unit in a peptide/protein sequenator
US5061445A (en) 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
US5354440A (en) 1988-11-29 1994-10-11 Isco, Inc. Capillary electrophoresis technique
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
CA1338505C (en) * 1989-02-03 1996-08-06 John Bruce Findlay Containment cuvette for pcr and method of use
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
CA1328359C (en) * 1989-03-27 1994-04-12 Michael D. Mintz Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5120662A (en) 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5504007A (en) 1989-05-19 1996-04-02 Becton, Dickinson And Company Rapid thermal cycle apparatus
CA1329698C (en) 1989-06-12 1994-05-24 Mark Joseph Devaney, Jr. Temperature control device
US5089233A (en) 1989-06-12 1992-02-18 Eastman Kodak Company Processing apparatus for a chemical reaction pack
GB8917963D0 (en) 1989-08-05 1989-09-20 Scras Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples
US5185127A (en) 1989-09-21 1993-02-09 Becton, Dickinson And Company Test device including flow control means
CA2031108A1 (en) * 1989-12-26 1991-06-27 Thomas William Glanville Chemical reaction pack and method of using same
US5098660A (en) 1990-01-08 1992-03-24 Eastman Kodak Company Transfer apparatus for chemical reaction pack
US5143084A (en) 1990-05-24 1992-09-01 Spacelabs, Inc. Disposable cartridge for sampling and analyzing body fluids
US5455175A (en) 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5187084A (en) 1990-06-22 1993-02-16 The Dow Chemical Company Automatic air temperature cycler and method of use in polymerose chain reaction
EP0471940B1 (de) * 1990-08-16 1994-12-07 Drägerwerk Aktiengesellschaft Kolorimetrische Nachweisvorrichtung mit einem Reagenzvorratsbehälter
DE4029004C1 (https=) 1990-09-13 1992-04-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De
US5066463A (en) * 1990-10-01 1991-11-19 Chang Maw Guay Multiple-purpose fecal examination apparatus
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
ATE159763T1 (de) * 1990-12-31 1997-11-15 Promega Corp Nuklein-säure amplifikation mit dns abhängigen rns polymerasen aktivität von rns-replikasen
US5709668A (en) 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
FR2672231A1 (fr) 1991-02-01 1992-08-07 Eibet Appareil d'execution automatique repetee d'un cycle thermique, notamment pour l'amplification du nombre d'une sequence definie d'acide nucleique.
US5270183A (en) 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
US5258314A (en) 1991-03-18 1993-11-02 Paradigm Biotechnologies Partnership Microprocessor-based biomedical monitoring apparatus and method
EP0504772A3 (en) 1991-03-18 1993-01-27 Paradigm Biotechnologies Partnership Analytical apparatus
DE4202850A1 (de) 1992-01-31 1993-08-05 Boehringer Mannheim Gmbh Analysenelement fuer immunoassays
US5422271A (en) * 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
US5876918A (en) 1993-03-08 1999-03-02 Hydros, Inc. Aligned fiber diagnostic chromatography with positive and negative controls
SE9301495D0 (sv) 1993-04-30 1993-04-30 Kabi Pharmacia Ab A device for metering and administrering a liquid preparation
WO1994026414A1 (en) * 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
SE9302121D0 (sv) 1993-06-18 1993-06-18 Kabi Pharmacia Ab Apparatus for controlled delivery of liquids
US5491067A (en) 1993-07-15 1996-02-13 Ortho Diagnostic Systems Inc. Agglutination reaction and separation vessel
DE69429038T2 (de) 1993-07-28 2002-03-21 Pe Corporation (Ny), Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
IL106662A (en) 1993-08-11 1996-10-31 Yissum Res Dev Co Install a flow cell to monitor blood or any single cell suspension under flow
CA2130013C (en) 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
US5374395A (en) 1993-10-14 1994-12-20 Amoco Corporation Diagnostics instrument
JP3346064B2 (ja) 1993-12-28 2002-11-18 セイコーエプソン株式会社 インクジェットカートリッジ
ATE193465T1 (de) 1994-01-06 2000-06-15 Johnson & Johnson Clin Diag Vorrichtung zum erwärmen einer flüssigkeitsführenden kammer von einer reaktionscuvette
ES2120174T3 (es) 1994-01-11 1998-10-16 Abbott Lab Aparato y procedimiento de ciclado termico de dosificados de acidos nucleicos.
US6143263A (en) 1994-04-29 2000-11-07 The Babcock & Wilcox Company Method and system for SO2 and SO3 control by dry sorbent/reagent injection and wet scrubbing
US5508197A (en) 1994-07-25 1996-04-16 The Regents, University Of California High-speed thermal cycling system and method of use
US5705628A (en) 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
US5658413A (en) 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
NZ295998A (en) 1994-10-24 1999-10-28 Ophidian Pharm Inc Neutralizing antitoxins against clostridium difficile and clostidium botulinum toxins
JPH08196299A (ja) 1995-01-26 1996-08-06 Tosoh Corp サーマルサイクリング反応装置及びこれに用いる反応容器
US5780222A (en) 1995-04-10 1998-07-14 Alpha Therapeutic Corporation Method of PCR testing of pooled blood samples
US5591573A (en) 1995-04-10 1997-01-07 Alpha Therapeutic Corporation Method and system for testing blood samples
GB2303916B (en) 1995-07-29 1999-03-03 Siemens Plc Improvements in or relating to aqueous sample testing apparatus
GB2303799B (en) 1995-07-29 1999-03-10 Siemens Plc Improvements in or relating to aqueous sample testing apparatus
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US5847734A (en) 1995-12-04 1998-12-08 Pawlowski, Jr.; Norman E. Air purge system for an ink-jet printer
US6068751A (en) 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US5830657A (en) 1996-05-01 1998-11-03 Visible Genetics Inc. Method for single-tube sequencing of nucleic acid polymers
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
ES2115521B1 (es) 1996-02-26 1999-02-16 Grifols Grupo Sa Dispositivo para la realizacion de reacciones eritrocitarias.
FR2746001B1 (fr) 1996-03-12 1998-06-12 Ensemble de chirurgie orthopedique pour prothese de hanche a col amovible
EP1015116A1 (en) 1996-05-01 2000-07-05 Visible Genetics Inc. Method and apparatus for thermal cycling and for automated sample preparation with thermal cycling
US5913232A (en) 1996-05-20 1999-06-15 Sendx Medical, Inc. reference solution container for blood gas/electrolyte measuring system
JP4540754B2 (ja) 1996-06-04 2010-09-08 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｐｃｒ中のハイブリダイゼーションのモニタリング
US5985651A (en) 1996-06-17 1999-11-16 The Board Of Trustees Of The Leland Stanford Junior University Thermocycling apparatus and method
GB9618595D0 (en) 1996-09-06 1996-10-16 Central Research Lab Ltd Reaction cell
US6210036B1 (en) 1996-09-06 2001-04-03 Gerald P. Eberle Connector thermal sensor
GB9621357D0 (en) 1996-10-12 1996-12-04 Central Research Lab Ltd Heating apparatus
DE19646116A1 (de) 1996-11-08 1998-05-14 Eppendorf Geraetebau Netheler Temperierblock mit Aufnahmen
US5811296A (en) 1996-12-20 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Blocked compartments in a PCR reaction vessel
US6180698B1 (en) 1997-02-28 2001-01-30 Candescent Technologies Corporation Polycarbonate-containing liquid chemical formulation and method for making polycarbonate film
JP3428426B2 (ja) 1997-03-26 2003-07-22 株式会社日立製作所 検体分析システム
EP2156892B1 (en) 1997-03-28 2013-05-08 Applera Corporation Thermal cycler for PCR
US6186982B1 (en) 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
AU7477398A (en) 1997-05-09 1998-11-27 Regents Of The University Of California, The Peltier-assisted microfabricated reaction chambers for thermal cycling
US6194160B1 (en) 1998-03-19 2001-02-27 Immunetics, Inc. Systems and methods for rapid blot screening
US5866366A (en) 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
US6300138B1 (en) 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US6426230B1 (en) 1997-08-01 2002-07-30 Qualigen, Inc. Disposable diagnostic device and method
US6066296A (en) 1997-09-23 2000-05-23 Array Medical, Inc. Sample addition, reagent application, and testing chamber
US5942432A (en) 1997-10-07 1999-08-24 The Perkin-Elmer Corporation Apparatus for a fluid impingement thermal cycler
US6111096A (en) 1997-10-31 2000-08-29 Bbi Bioseq, Inc. Nucleic acid isolation and purification
ATE216637T1 (de) * 1997-11-19 2002-05-15 Biognosis Gmbh Vorrichtung zur sequentiellen ausgabe von fliessfähigen reagenzien
US6251660B1 (en) * 1997-11-25 2001-06-26 Mosaic Technologies, Inc. Devices and methods for detecting target molecules in biological samples
WO1999030759A2 (en) 1997-12-16 1999-06-24 Meridian Medical Technologies, Inc. Automatic injector for administrating a medicament
EP1179585B1 (en) 1997-12-24 2008-07-09 Cepheid Device and method for lysis
US6413874B1 (en) * 1997-12-26 2002-07-02 Canon Kabushiki Kaisha Method and apparatus for etching a semiconductor article and method of preparing a semiconductor article by using the same
US6300308B1 (en) 1997-12-31 2001-10-09 Board Of Regents, The University Of Texas System Methods and compositions for inducing autoimmunity in the treatment of cancers
EP0955097B1 (en) 1998-05-04 2004-10-06 F. Hoffmann-La Roche Ag Thermal cycler having an automatically positionable cover
WO1999058664A1 (en) 1998-05-14 1999-11-18 Whitehead Institute For Biomedical Research Solid phase technique for selectively isolating nucleic acids
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
AU4827999A (en) 1998-06-24 2000-01-10 Chen & Chen, Llc Multi-layer testing column
JP4321738B2 (ja) 1998-06-24 2009-08-26 チェン アンド チェン エルエルシー 液体試料試験システム
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
GB9814506D0 (en) 1998-07-03 1998-09-02 Stanley Christopher J Optical sensor for insitu measurement of analytes
GB9819897D0 (en) 1998-09-11 1998-11-04 Seward Limited Devices for blending materials
WO2000023803A1 (en) 1998-10-16 2000-04-27 Millstein Larry S Methods of making patterned arrays of analyte-binding molecules
EP1000661A1 (en) 1998-10-29 2000-05-17 Hans-Knöll-Institut für Naturstoff-Forschung e.v. Ultrathin-walled multiwell plate for heat block thermocycling
US6250166B1 (en) 1999-06-04 2001-06-26 General Electric Company Simulated dovetail testing
US6159727A (en) 1999-06-04 2000-12-12 Clontech Laboratories, Inc. Hybridization chamber
WO2001007892A1 (en) 1999-07-27 2001-02-01 Esperion Therapeutics, Inc. Method and device for measurement of cholesterol efflux
US6719715B2 (en) 1999-09-16 2004-04-13 Vasogen Ireland Limited Apparatus and process for conditioning organic fluid
US6471069B2 (en) 1999-12-03 2002-10-29 Becton Dickinson And Company Device for separating components of a fluid sample
IL134035A0 (en) * 2000-01-13 2001-04-30 Ronen Daniel A device, system and method for remote push-publishing of content onto display screens of mobile devices including a screen saver application
US6440072B1 (en) 2000-03-30 2002-08-27 Acuson Corporation Medical diagnostic ultrasound imaging system and method for transferring ultrasound examination data to a portable computing device
WO2002078847A1 (en) * 2001-03-28 2002-10-10 Hitachi, Ltd. Instrument and method for recovering nucleic acid
EP1415113B1 (en) 2001-07-16 2011-08-31 Idaho Technology, Inc. Thermal cycling system and method of use
ES2334338T3 (es) * 2001-11-05 2010-03-09 Zymogenetics, Inc. Antagonistas de il-21.
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
CA2772050C (en) * 2002-12-26 2016-09-06 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
CA2515075C (en) 2003-02-05 2012-10-02 Iquum, Inc. Sample processing
JP2008505346A (ja) 2004-06-07 2008-02-21 アイキューム， インク． サンプルマルチ処理
US20080003564A1 (en) 2006-02-14 2008-01-03 Iquum, Inc. Sample processing

Also Published As

Publication number Publication date
CN1767897B (zh) 2011-03-02
US20040161788A1 (en) 2004-08-19
WO2004080597A3 (en) 2005-03-31
EP1603674A2 (en) 2005-12-14
US20100218621A1 (en) 2010-09-02
US7718421B2 (en) 2010-05-18
US10443050B2 (en) 2019-10-15
US8936933B2 (en) 2015-01-20
EP2574400B1 (en) 2016-09-28
EP2574400A1 (en) 2013-04-03
AU2004220626B2 (en) 2010-07-29
CN1767897A (zh) 2006-05-03
CA2515075C (en) 2012-10-02
AU2004220626A1 (en) 2004-09-23
US9708599B2 (en) 2017-07-18
CA2515075A1 (en) 2004-09-23
JP2006518221A (ja) 2006-08-10
US20170283790A1 (en) 2017-10-05
EP1603674B1 (en) 2016-01-06
US20150105300A1 (en) 2015-04-16
ES2566509T3 (es) 2016-04-13
ES2604352T3 (es) 2017-03-06
WO2004080597A2 (en) 2004-09-23

Similar Documents

Publication Publication Date Title
JP4632262B2 (ja) サンプルの処理
US20080003564A1 (en) Sample processing
CN101432698B (zh) 处理样品的方法
JP7126445B2 (ja) 扱いにくい試料タイプのための試料調製
JP5254949B2 (ja) 一体型の核酸アッセイ
KR101786506B1 (ko) 핵산 정제
US10471408B2 (en) Microspotting device
JP2024500169A (ja) 大ストークスシフト蛍光色素を使用して多重化リアルタイムｐｃｒを行うための方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070205

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070205

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091201

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100301

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100308

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100330

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100406

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100601

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20100601

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100622

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100916

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20101012

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20101110

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

Ref document number: 4632262

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131126

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term