JP4632262B2 - サンプルの処理 - Google Patents

サンプルの処理 Download PDF

Info

Publication number
JP4632262B2
JP4632262B2 JP2006508686A JP2006508686A JP4632262B2 JP 4632262 B2 JP4632262 B2 JP 4632262B2 JP 2006508686 A JP2006508686 A JP 2006508686A JP 2006508686 A JP2006508686 A JP 2006508686A JP 4632262 B2 JP4632262 B2 JP 4632262B2
Authority
JP
Japan
Prior art keywords
tubule
segment
reagent
sample
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2006508686A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006518221A (ja
JP2006518221A5 (https=
Inventor
スーチー チェン，
ベルトラン レミエウックス，
チィウ ウォン，
ケビン， アール． コプティンスキ，
リンジュン チェン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IQuum Inc
Original Assignee
IQuum Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IQuum Inc filed Critical IQuum Inc
Publication of JP2006518221A publication Critical patent/JP2006518221A/ja
Publication of JP2006518221A5 publication Critical patent/JP2006518221A5/ja
Application granted granted Critical
Publication of JP4632262B2 publication Critical patent/JP4632262B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/55—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being contained in a flexible bag submitted to periodical deformation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Flexible containers without fluid transport within
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hydrology & Water Resources (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2006508686A 2003-02-05 2004-02-05 サンプルの処理 Expired - Lifetime JP4632262B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44530403P 2003-02-05 2003-02-05
PCT/US2004/003541 WO2004080597A2 (en) 2003-02-05 2004-02-05 Sample processing tubule

Publications (3)

Publication Number Publication Date
JP2006518221A JP2006518221A (ja) 2006-08-10
JP2006518221A5 JP2006518221A5 (https=) 2010-07-29
JP4632262B2 true JP4632262B2 (ja) 2011-02-16

Family

ID=32990611

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006508686A Expired - Lifetime JP4632262B2 (ja) 2003-02-05 2004-02-05 サンプルの処理

Country Status (8)

Country Link
US (4) US7718421B2 (https=)
EP (2) EP1603674B1 (https=)
JP (1) JP4632262B2 (https=)
CN (1) CN1767897B (https=)
AU (1) AU2004220626B2 (https=)
CA (1) CA2515075C (https=)
ES (2) ES2566509T3 (https=)
WO (1) WO2004080597A2 (https=)

Families Citing this family (246)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
AU2002341644B2 (en) * 2001-09-11 2008-02-28 Iquum, Inc. Sample vessels
GB0128350D0 (en) 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
EP1603674B1 (en) * 2003-02-05 2016-01-06 Iquum, Inc. Sample processing
CA2526409A1 (en) * 2003-05-19 2004-12-02 Brandeis University Nucleic acid processing methods, kits and devices
US20040267181A1 (en) * 2003-06-26 2004-12-30 Asd Swab sample collection and recovery device
US7947450B2 (en) 2003-07-10 2011-05-24 Universite Libre De Bruxelles Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed
US7700276B2 (en) * 2003-07-10 2010-04-20 Universite Libre De Bruxelles Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed
EP3718635A1 (en) 2003-07-31 2020-10-07 Handylab, Inc. Processing particle-containing samples
US7337907B2 (en) * 2003-08-01 2008-03-04 Polyzen, Inc. Press-flat centrifuge tube and specimen collection assembly comprising same
US8426126B2 (en) * 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
ES2553097T3 (es) * 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP4429069B2 (ja) * 2004-05-06 2010-03-10 三洋電機株式会社 微生物の検出装置および方法
US7785535B2 (en) * 2004-06-07 2010-08-31 Iquum, Inc. Sample multiprocessing
US20060188892A1 (en) * 2005-02-18 2006-08-24 Ambion, Inc. Enzymatic digestion of tissue
US7745204B1 (en) 2005-04-29 2010-06-29 Georgia Tech Research Corporation Automation of biological sample aliquoting
ES2373686T3 (es) * 2005-06-23 2012-02-07 Biocartis Sa Cartucho, sistema y procedimiento para diagnósticos médicos automatizados.
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
DE102005054924B4 (de) * 2005-11-17 2012-06-14 Siemens Ag Vorrichtung und Verfahren zum Extrahieren einer Abstrichprobe
KR101157174B1 (ko) * 2005-11-24 2012-06-20 삼성전자주식회사 세포 또는 바이러스의 신속한 파괴 방법 및 장치
JP5063616B2 (ja) 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
US20080003564A1 (en) * 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
JP5069871B2 (ja) * 2006-05-30 2012-11-07 シスメックス株式会社 新規な癌細胞検出試料調製用キット及びそれを用いた癌細胞検出用キット
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
CN101479603B (zh) * 2006-06-02 2012-11-21 卢米尼克斯股份有限公司 包括使用磁粒子和应用磁场的用于执行一种或多种分析物的测量系统和方法
EP2049261B1 (en) 2006-07-28 2018-07-04 Diagnostics for the Real World, Ltd Device, system and method for processing a sample
US20080069732A1 (en) * 2006-09-20 2008-03-20 Robert Yi Diagnostic test system
EP2140026B1 (en) 2006-11-03 2019-08-14 Siemens Healthcare Diagnostics Inc. Random access method for polymerase chain reaction testing
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
JP4884180B2 (ja) * 2006-11-21 2012-02-29 東京エレクトロン株式会社 基板処理装置および基板処理方法
EP1938756A1 (en) * 2006-12-29 2008-07-02 Qiagen GmbH Method and materials for triggered release of a biological sample
JP2008167722A (ja) * 2007-01-15 2008-07-24 Konica Minolta Medical & Graphic Inc 磁性支持体上での加熱による核酸単離方法
GB2445738A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Microfluidic device
GB2445739A (en) 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
EP1970711A1 (en) * 2007-03-16 2008-09-17 Radiometer Medical ApS Reagent cup device
WO2008116182A1 (en) * 2007-03-21 2008-09-25 Ibis Biosciences, Inc. Reagents for nucleic acid purification
US20090042241A1 (en) 2007-04-06 2009-02-12 California Institute Of Technology Microfluidic device
CA2754884C (en) 2007-06-21 2013-04-30 Gen-Probe Incorporated Methods of concentrating an analyte
TW200916587A (en) * 2007-06-29 2009-04-16 Toppan Printing Co Ltd Genetic diagnosis device, gene-reaction device, and incubator
CN101779113A (zh) * 2007-07-12 2010-07-14 史密斯探测公司 样本制备设备
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
JP4999588B2 (ja) * 2007-07-24 2012-08-15 キヤノン株式会社 容器装置、これを備えたｄｎａ検査装置およびその貫通方法
WO2009024773A1 (en) 2007-08-17 2009-02-26 Diagnostics For The Real World, Ltd Device, system and method for processing a sample
FR2921490B1 (fr) * 2007-09-21 2010-09-10 Metagenex Procede et dispositif pour recueillir du materiel cellulaire de cellules isolees sur filtre
US8460528B2 (en) * 2007-10-17 2013-06-11 Advanced Liquid Logic Inc. Reagent storage and reconstitution for a droplet actuator
US9631244B2 (en) 2007-10-17 2017-04-25 Advanced Liquid Logic, Inc. Reagent storage on a droplet actuator
US20090104076A1 (en) * 2007-10-19 2009-04-23 Los Alamos National Security Llc Sample preparation cartridge and system
US8187808B2 (en) * 2008-02-29 2012-05-29 Northwestern University Barriers for facilitating biological reactions
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
GB0814570D0 (en) 2008-08-08 2008-09-17 Diagnostics For The Real World Isolation of nucleic acid
JP5470391B2 (ja) * 2008-09-08 2014-04-16 オゲノ ゲーエムベーハー 試料材料の濃縮用の生検器具
ATE547522T1 (de) * 2008-12-23 2012-03-15 Qiagen Gmbh Verfahren und vorrichtung zur durchführung einer nukleinsäurepräparation und/oder amplifikation
WO2010076013A1 (de) * 2008-12-30 2010-07-08 Qiagen Gmbh Verfahren zum nachweis methicillin-resistenter staphylococcus aureus (mrsa)-stämme
BRPI0918693A2 (pt) 2008-12-31 2016-07-26 3M Innovative Properties Co dispositivos para amostragem e métodos para concentração de microorganismos
EP2379226B1 (en) 2008-12-31 2016-04-20 3M Innovative Properties Company Live bioload detection using microparticles
US8368882B2 (en) * 2009-01-30 2013-02-05 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
WO2010124325A1 (en) * 2009-04-27 2010-11-04 Axxin Pty Ltd A capillary flow test assembly
US8236254B2 (en) * 2009-05-14 2012-08-07 Abbott Diabetes Care Inc. Cap-linked test strip carrier for vial augmentation
JP2012529268A (ja) 2009-06-05 2012-11-22 インテジェンクス，インコーポレイテッド ユニバーサルサンプル調製システムおよび統合解析システムの使用方法
US20110146418A1 (en) * 2009-10-02 2011-06-23 Brevnov Maxim G Sample Preparation Devices and Methods
JP5907880B2 (ja) 2009-11-13 2016-04-26 ベックマン コールター， インコーポレイテッド クラスタリングを用いて生物学的持続状態の存在を検出するためのシステムおよび方法
JP5972174B2 (ja) 2009-12-30 2016-08-17 スリーエム イノベイティブ プロパティズ カンパニー 微小粒子を用いた生きた生物負荷の検出法
LT2521780T (lt) * 2010-01-07 2018-02-12 Bigtec Private Limited Neklerūgščių išskyrimo būdas ir rinkinys
KR20160088958A (ko) 2010-02-23 2016-07-26 루미넥스 코포레이션 일체화된 샘플 제조, 반응 및 검출을 위한 장치 및 방법
GB201005885D0 (en) * 2010-04-08 2010-05-26 Avacta Ltd Apparatus and method
US20130109030A1 (en) * 2010-07-05 2013-05-02 Koninklijke Philips Electronics N.V. Examination system with sample incubation
US20130112622A1 (en) * 2010-07-14 2013-05-09 Qiagen Gmbh New liquid processing device
EP2593768B1 (en) * 2010-07-14 2024-06-19 Qiagen GmbH New storage, collection or isolation device
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
AU2011293832B2 (en) 2010-08-26 2014-07-17 Spot Bioscience, Llc Biological fluid sampling and storage apparatus for remote use
KR101420094B1 (ko) 2010-10-27 2014-07-17 (주)바이오니아 다양한 생체시료분석을 위한 전자동실시간정량증폭장비, 다양한 생체시료분석을 위한 자동정제 및 반응준비 장치, 전자동 핵산정제 및 실시간 정량 유전자증폭 방법, 전자동 핵산정제방법, 실시간정량ｐｃｒ을 이용한 병원균의 전자동 생균수검사방법, 정량면역ｐｃｒ을 이용한 전자동 항원농도획득방법 및 타겟항원에 라벨링된 부착용 타겟핵산의 정제방법
IT1403618B1 (it) * 2011-01-05 2013-10-31 Copan Italia Spa Procedimento per realizzare un dispositivo per il prelievo ed il trasferimento di campioni per biologia molecolare
US20120241391A1 (en) * 2011-03-25 2012-09-27 Receptors Llc Filtration article with microbial removal, micro-biocidal, or static growth capability
JP6088487B2 (ja) 2011-04-15 2017-03-01 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法
CN104023834B (zh) 2011-05-04 2016-09-28 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
CN106442039B (zh) 2011-06-19 2020-08-07 阿博根公司 用于样品采集的装置、溶液和方法
WO2013016510A1 (en) * 2011-07-27 2013-01-31 Baylor College Of Medicine Process for preparing biological samples
RU2622432C2 (ru) 2011-09-30 2017-06-15 Бектон, Дикинсон Энд Компани Унифицированная полоска для реактивов
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US20130092690A1 (en) * 2011-10-18 2013-04-18 Reflex Medical Corp. Seal cap with pre-filled agent for a specimen container
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
SG11201402821VA (en) * 2011-12-07 2014-06-27 Cytovera Inc Method and device for sample processing
JP5807542B2 (ja) 2011-12-22 2015-11-10 株式会社島津製作所 対象成分を操作するためのチップデバイス及びそれを用いた方法
ES2665252T3 (es) 2011-12-30 2018-04-25 Abbott Molecular Inc. Purificación de ácido nucleico de microorganismos a partir de muestras del hospedador
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
AU2013203281A1 (en) 2012-02-03 2013-08-22 Axxin Pty Ltd Nucleic acid amplification and detection apparatus and method
USD679410S1 (en) * 2012-02-03 2013-04-02 Respirio Pty Ltd Sampling and testing device
BR112014032911A2 (pt) 2012-06-28 2017-06-27 Fluoresentric Inc dispositivo indicador químico
EP2879581B1 (en) * 2012-08-02 2017-12-06 Siemens Healthcare Diagnostics Inc. Biological liquid collection vessels
US9347056B2 (en) 2012-10-26 2016-05-24 Seiko Epson Corporation Nucleic acid extraction device, and nucleic acid extraction method, nucleic acid extraction kit, and nucleic acid extraction apparatus, each using the same
CN103849548A (zh) 2012-12-03 2014-06-11 三星电子株式会社 用于扩增核酸的试剂容器及其制备方法、存储试剂的方法和用于核酸分析的微流体系统
EP2932268A4 (en) 2012-12-17 2016-10-19 Leukodx Ltd SYSTEMS AND METHOD FOR RECOGNIZING A BIOLOGICAL CONDITION
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US9272277B2 (en) * 2013-02-15 2016-03-01 Honeywell International Inc. Capillary groove for isobaric waste entry
JP2014176304A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp 核酸増幅反応用カートリッジ
CN105992648B (zh) * 2013-05-31 2019-04-26 彼克斯赛尔医疗科技有限公司 用于制备含有用于分析的细胞的样品流体的盒
JP2015073513A (ja) * 2013-10-11 2015-04-20 セイコーエプソン株式会社 核酸抽出用デバイス、核酸抽出用キット、及び核酸抽出用装置
JP2015084657A (ja) * 2013-10-28 2015-05-07 セイコーエプソン株式会社 核酸抽出用デバイス
CN105873681B (zh) 2013-11-18 2019-10-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US10746683B2 (en) 2013-12-12 2020-08-18 Altratech Limited Capacitive sensor and method of use
CN105980558B (zh) 2013-12-12 2021-08-24 阿尔查技术有限公司 样品制备方法和设备
EP3083056B1 (en) 2013-12-20 2023-04-05 Spot Bioscience, LLC Whole blood separation sampling apparatus
JP2015159786A (ja) * 2014-02-28 2015-09-07 セイコーエプソン株式会社 標的物質の精製装置及び精製方法
US9462815B2 (en) * 2014-03-20 2016-10-11 Rex Adams Flavor dispensing systems
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
US10610552B2 (en) * 2016-04-05 2020-04-07 Nch Corporation Nutrient rich germinant composition and spore incubation method
EP3149151B1 (en) * 2014-05-30 2021-08-04 Pressure Biosciences, Inc. Sample preparation devices and methods
US10316347B2 (en) 2014-06-26 2019-06-11 Ecolab Usa Inc. Endospore detection using hydrophobic collection material
US9145581B1 (en) * 2014-10-17 2015-09-29 Daniel Lai Rapid nucleic acid extraction method and apparatus
US10690627B2 (en) 2014-10-22 2020-06-23 IntegenX, Inc. Systems and methods for sample preparation, processing and analysis
EP3218698B1 (en) 2014-11-14 2020-05-13 Axxin Pty Ltd Biological sample collection and storage assembly
US9464969B2 (en) 2014-11-20 2016-10-11 Monolythix, Inc. Monoliths
WO2016117701A1 (ja) * 2015-01-22 2016-07-28 Ｎｅｃソリューションイノベータ株式会社 ターゲット分析用具およびターゲット分析方法
EP4286516A3 (en) 2015-02-24 2024-03-06 10X Genomics, Inc. Partition processing methods and systems
ES2925909T3 (es) 2015-06-05 2022-10-20 Orion Genomics Llc Dispositivo de recogida de muestras
US11260386B2 (en) * 2015-06-05 2022-03-01 The Emerther Company Component of a device, a device, and a method for purifying and testing biomolecules from biological samples
CN107771285A (zh) 2015-06-08 2018-03-06 阿奎尔诊断有限公司 方法
EP4060344A1 (en) 2015-06-08 2022-09-21 Arquer Diagnostics Limited Methods and kits
CN105188010A (zh) * 2015-06-30 2015-12-23 瓮安县创新电子厂 耳机喇叭pc板安装杆
EP3325156A4 (en) 2015-07-17 2019-01-16 Axxin Pty Ltd DIAGNOSTIC TEST ASSEMBLY, APPARATUS, METHOD
CN209155878U (zh) * 2015-08-10 2019-07-26 生命科技公司 样本载体和利用其的系统
WO2017031369A1 (en) * 2015-08-18 2017-02-23 Monolythix, Inc. Sample concentration devices
US10570439B2 (en) 2015-08-18 2020-02-25 Monolythix, Inc. Sample concentration devices
WO2017040994A1 (en) * 2015-09-02 2017-03-09 Polymer Technology Systems, Inc. Systems and methods for controlling excessive fluid flow in a cassette designed to receive a fluid sample
KR101810942B1 (ko) * 2015-09-04 2018-01-25 (주)나노엔텍 샘플 전처리 시스템 및 그 제어방법
CN113122535A (zh) * 2015-09-10 2021-07-16 株式会社钟化 从含有核酸的样品中分离核酸的方法及用于该方法的样品处理试剂
CN105349530B (zh) * 2015-12-11 2018-02-27 杭州优思达生物技术有限公司 一种核酸检测方法及检测管
US10391498B2 (en) * 2015-12-11 2019-08-27 Spartan Bioscience Inc. Systems and methods for nucleic acid amplification
CN105483219B (zh) * 2015-12-11 2019-01-15 杭州优思达生物技术有限公司 结核分枝杆菌复合群核酸检测方法及试剂盒
EP3402595A4 (en) * 2016-01-11 2019-10-02 Fluoresentric, Inc. SYSTEMS, DEVICES AND METHOD FOR INLINE SAMPLE PREPARATION
US10569939B1 (en) 2016-03-21 2020-02-25 United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Axially sealing plug
US9933445B1 (en) 2016-05-16 2018-04-03 Hound Labs, Inc. System and method for target substance identification
US10774393B2 (en) * 2016-05-20 2020-09-15 Roche Molecular Systems, Inc. Cell surface marker depletion in a sample processing device
CN105886387B (zh) * 2016-05-30 2018-08-07 北京安洁优科技有限公司 诊断试剂的一管化包装方法及一管化包装诊断试剂瓶
CN106222236A (zh) * 2016-07-27 2016-12-14 郑州点石生物技术有限公司 血液中微生物检测试剂及其制备方法
US20180051273A1 (en) * 2016-08-17 2018-02-22 Syracuse University System and method for dna extraction
CN106318859B (zh) * 2016-08-22 2018-08-31 中国人民解放军南京军区南京总医院 一种密闭连续菌液配置装置
US11478791B2 (en) 2016-09-12 2022-10-25 Delta Electronics Int'l (Singapore) Pte Ltd Flow control and processing cartridge
US11376581B2 (en) 2016-09-12 2022-07-05 Delta Electronics Int'l (Singapore) Pte Ltd Flow control and processing cartridge
US10590469B2 (en) * 2016-09-15 2020-03-17 Roche Molecular Svstems, Inc. Methods for performing multiplexed real-time PCR in a self-contained nucleic acid analysis pouch
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
CN110461473B (zh) * 2016-11-16 2021-11-05 奎多公司 全血分离的装置
US11231347B2 (en) * 2016-11-29 2022-01-25 S2 Genomics, Inc. Method and apparatus for processing tissue samples
AU2017368329B2 (en) 2016-12-01 2023-11-02 Novel Microdevices, Inc. Automated point-of-care devices for complex sample processing and methods of use thereof
JP6858540B2 (ja) 2016-12-08 2021-04-14 株式会社ミズホメディー 核酸増幅反応用デバイス
TWI611171B (zh) 2016-12-14 2018-01-11 財團法人工業技術研究院 生物樣品處理裝置
CN110494386B (zh) * 2016-12-22 2021-06-04 巴斯夫欧洲公司 具有探针的容器联接和打开装置
GB201703383D0 (en) 2017-03-02 2017-04-19 Gargle Tech Ltd Testing for particulates
EP3600669A4 (en) * 2017-03-24 2020-12-23 Universal Biosensors, Pty. Ltd. DEVICES AND METHODS FOR PRE-TREATMENT OF SAMPLE
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
US10906035B2 (en) * 2017-05-30 2021-02-02 Roche Molecular Systems, Inc. Modified sample processing device
US11602750B2 (en) * 2017-05-30 2023-03-14 Roche Molecular Systems, Inc. Customizable sample processing device
CN107091923B (zh) * 2017-06-02 2018-01-30 成都普利泰生物科技有限公司 一种毛细管化学发光检测装置及其检测方法
CN107151700B (zh) * 2017-06-08 2023-11-07 杭州遂真生物技术有限公司 一种基因检测方法及基因检测试剂盒和基因检测设备
CN111108216B (zh) 2017-09-20 2024-02-23 阿尔查技术有限公司 诊断装置和系统
EP3460077B1 (en) 2017-09-20 2020-06-17 Altratech Limited Diagnostic device and system
GB201715399D0 (en) * 2017-09-22 2017-11-08 Ge Healthcare Bio Sciences Ab Valve unit for a chromatography apparatus
EP3688465B1 (en) 2017-09-27 2025-11-12 Axxin Pty Ltd Diagnostic test system and method
CA3080871C (en) 2017-10-31 2024-05-28 F. Hoffmann-La Roche Ag Improved magnetic beads comprising a liquid-glass coating and uses thereof in nucleic acid capture or purification
EP3727805B1 (en) 2017-12-19 2023-09-13 F. Hoffmann-La Roche AG Sealing press and method of making a frangible seal in a sample processing device
WO2019169347A1 (en) 2018-03-02 2019-09-06 10X Genomics, Inc. Systems and apparatus for holding plates
WO2019181400A1 (ja) * 2018-03-22 2019-09-26 富士フイルム株式会社 被検体の処理方法および被検体処理用容器
CN108753591B (zh) * 2018-05-30 2022-03-22 天津达伟医疗科技有限公司 一种一体式肛检增菌取样管、方法以及用途
US11618876B2 (en) 2018-06-01 2023-04-04 S2 Genomics, Inc. Method and apparatus for processing tissue samples
CN108949499A (zh) * 2018-06-12 2018-12-07 广州和实生物技术有限公司 一种旋转式试剂提取扩增装置
CN108949498B (zh) * 2018-06-12 2024-01-30 广州和实生物技术有限公司 一种全封闭一体化试剂提取扩增装置
GB201813334D0 (en) * 2018-08-15 2018-09-26 Wang Tiesheng Nanocomposite materials and methods of manufacture thereof
EP4205851A3 (en) 2018-09-05 2023-10-04 Hero Scientific Ltd Testing for particulates
US11712692B2 (en) 2018-11-20 2023-08-01 Spectrum Solutions L.L.C. Sample collection system including sealing cap and valve
CN113286547B (zh) * 2018-12-02 2025-01-17 聚合物技术系统公司 包括预混合设备的用于分析物测试的集成耗材的系统和方法
KR102041333B1 (ko) * 2018-12-24 2019-11-06 주식회사 덴오믹스 세포 용해 조성물 및 이를 이용한 핵산의 추출 방법
US20200245899A1 (en) 2019-01-31 2020-08-06 Hound Labs, Inc. Mechanical Breath Collection Device
US11977086B2 (en) 2019-03-21 2024-05-07 Hound Labs, Inc. Biomarker detection from breath samples
CN110373309A (zh) * 2019-06-12 2019-10-25 广州知芯科技有限公司 一种核酸提取扩增系统及分子检测装置
US11701094B2 (en) 2019-06-20 2023-07-18 Spectrum Solutions L.L.C. Sample collection system including valve and plug assemblies
CN112138729B (zh) * 2019-06-26 2025-03-18 京东方科技集团股份有限公司 采样结构、密封结构以及检测组件
WO2021046504A1 (en) * 2019-09-06 2021-03-11 Teleflex Medical Incorporated Infection detection systems and methods including a sample processor having integrated sample filter and meter
CN110596066A (zh) * 2019-09-28 2019-12-20 佛山克情日用品有限公司 一种餐具洁净程度检测设备
US11857981B2 (en) 2019-12-23 2024-01-02 10X Genomics, Inc. Magnetic separator for an automated single cell sequencing system
CN110964842B (zh) * 2019-12-31 2023-11-03 广州金域医学检验集团股份有限公司 一种检测结核分枝杆菌核酸的样本处理试剂、试剂盒及结核分枝杆菌的核酸扩增方法
US12449336B2 (en) 2020-03-11 2025-10-21 Hero Scientific Ltd. Testing devices
US11701668B1 (en) 2020-05-08 2023-07-18 10X Genomics, Inc. Methods and devices for magnetic separation
US11933731B1 (en) 2020-05-13 2024-03-19 Hound Labs, Inc. Systems and methods using Surface-Enhanced Raman Spectroscopy for detecting tetrahydrocannabinol
US11946038B1 (en) 2020-05-29 2024-04-02 10X Genomics, Inc. Methods and systems including flow and magnetic modules
US12263482B1 (en) 2020-06-03 2025-04-01 10X Genomics, Inc. Methods and devices for magnetic separation in a flow path
JP7830359B2 (ja) * 2020-07-14 2026-03-16 イルミナ インコーポレイテッド マイクロアレイ、ハイブリダイゼーション封止部、及び関連する方法
CN115279498A (zh) * 2020-07-17 2022-11-01 深圳华大智造科技股份有限公司 生化反应装置及其应用
US20220042117A1 (en) 2020-08-06 2022-02-10 Roche Molecular Systems, Inc. COMPOSITIONS AND METHODS FOR THE SIMULTANEOUS DETECTION OF INFLUENZA A, INFLUENZA B, AND SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)
EP4217504A4 (en) * 2020-09-25 2024-12-25 Charm Sciences, Inc. SYSTEMS AND METHODS FOR SAMPLE PREPARATION AND DETECTION
CN114381360A (zh) * 2020-10-22 2022-04-22 佳能医疗系统株式会社 核酸检测系统及其应用
TWI750907B (zh) * 2020-11-19 2021-12-21 廣普生物科技股份有限公司 微量管組件及微量管操作系統
WO2022113112A1 (en) * 2020-11-27 2022-06-02 Reliance Industries Limited Device for rna extraction for sars-cov-2 detection
EP4165385B1 (en) 2021-01-06 2024-04-17 Hero Scientific Ltd Filtration sampling devices
US12392769B1 (en) 2021-01-12 2025-08-19 Hound Labs, Inc. Ambient contamination in breath analyte detection and measurement
CN112899151A (zh) * 2021-02-01 2021-06-04 青岛迪诺瓦基因科技有限公司 一种流动液体变温装置及其使用方法
CN112575090B (zh) * 2021-02-05 2022-05-20 济南千麦医学检验有限公司 一种检测brca基因突变的pcr反应试剂盒
CN113243938B (zh) * 2021-05-13 2022-05-17 高美龄 一种柱塞阀式过滤的医用吸嘴头
US20220387004A1 (en) * 2021-05-24 2022-12-08 Graphene-Dx, Inc. Device for collection of biological samples
JP7756180B2 (ja) * 2021-07-02 2025-10-17 クレガナ・アンリミテッド・カンパニー 使い捨て貫流診断用デバイスおよびその構築方法
EP4363109A1 (en) * 2021-07-02 2024-05-08 Creganna Unlimited Company Disposable flow through diagnostic device and method of construction thereof
CN113528333B (zh) * 2021-07-20 2022-03-08 北京擎科生物科技有限公司 核酸合成反应装置及核酸合成方法
CN113604346B (zh) * 2021-09-02 2023-11-17 浙江仅一医疗科技有限公司 装有试剂的检测装置和利用检测装置检测核酸使用方法
CN113846014A (zh) * 2021-10-29 2021-12-28 青岛全诊生物技术有限公司 核酸提取和扩增装置
CN114045216B (zh) * 2022-01-11 2022-04-15 至美时代生物智能科技(北京)有限公司 一种空气采样瓶、空气采样系统及空气采样方法
WO2023138793A1 (de) * 2022-01-21 2023-07-27 Procomcure Biotech Gmbh Vorrichtung zur aufnahme von proben
CN115078606B (zh) * 2022-06-14 2023-06-06 浙江工商大学 一种基于脂质组学鉴定虾糜制品品种的方法
CN115099206B (zh) * 2022-08-23 2022-12-06 佰墨思(成都)数字技术有限公司 一种生物制药生产全周期过程动态表单生成方法及系统
JP2025533607A (ja) * 2022-09-30 2025-10-07 北京▲華▼▲視▼▲諾▼▲維▼医▲療▼科技有限公司 涙液サンプル溶出液、希釈液及びその製造方法並びに涙液採取・処理装置
CN119968230A (zh) * 2022-10-05 2025-05-09 宏布雷彻康系统工程公司 容器、混合装置和用于使用混合装置的方法
WO2024137351A1 (en) 2022-12-19 2024-06-27 Anchorline Biolabs, Inc. Capillary partitioning microfluidics
KR102708532B1 (ko) * 2023-04-12 2024-09-23 주식회사 리바이오 혈구분리 장치
WO2025036740A1 (en) * 2023-08-14 2025-02-20 F. Hoffmann-La Roche Ag Devices and applications of coupled nucleic acid amplification tests and crispr systems
CN117025379B (zh) * 2023-10-09 2023-12-15 迪飞医学科技(南京)有限公司 一种rapid恒温扩增核酸检测装置以及检测方法
CN118272221B (zh) * 2024-05-23 2024-08-16 浙江正合谷生物科技有限公司 一种水产检测用套式pcr扩增装置以及检测方法
GB2643864A (en) * 2024-08-19 2026-03-11 Protondx Ltd Apparatus for maintaining separation of liquids, and method of using the same to process a sample
CN119144431B (zh) * 2024-09-11 2025-06-20 中国科学院过程工程研究所 基于柔性结构和推拉结构的核酸一体化检测装置
CN119464030A (zh) * 2025-01-15 2025-02-18 广州市刑事科学技术研究所 一种脱落细胞粘取采样装置

Family Cites Families (163)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895475A (en) * 1956-12-03 1959-07-21 Everett L Cole Container for collecting, storing and dispensing biological fluids
US3036894A (en) * 1958-10-22 1962-05-29 Jasper A Forestiere Method of using testing containers
US3260413A (en) * 1964-08-31 1966-07-12 Scientific Industries Automatic chemical analyzer
USRE29725E (en) * 1966-04-26 1978-08-08 E. I. Du Pont De Nemours And Company Analytical test pack and process for analysis
US3697227A (en) 1966-05-13 1972-10-10 Westinghouse Electric Corp Chemical constituent sampler
BE702970A (https=) 1966-09-08 1968-02-23
FR1513306A (fr) 1966-09-08 1968-02-16 Automatisme Cie Gle Perfectionnements aux installations d'analyses
US3441205A (en) 1966-10-10 1969-04-29 Marvin Kendall Young Jr Method for separating sediment from supernatant fluid
US3607097A (en) 1967-08-09 1971-09-21 Philips Corp Analyzer for liquid samples
US3579303A (en) * 1968-03-06 1971-05-18 Donald E Pickering System for handling specimens and other substances in medicine and physical sciences
FR2035058A1 (https=) 1969-03-19 1970-12-18 American Optical Corp
US3736933A (en) 1970-12-02 1973-06-05 B Szabo Burstable seamed hypodermic applicators
CA983358A (en) * 1971-09-08 1976-02-10 Kenneth D. Bagshawe Performance of chemical or biological reactions
US3819158A (en) * 1972-08-17 1974-06-25 Lever Brothers Ltd Devices for blending materials
US3918913A (en) 1974-12-02 1975-11-11 Lilly Co Eli Sampler-injector for liquid chromatography
US4038030A (en) * 1975-04-10 1977-07-26 American Hospital Supply Corporation Profile analysis pack and method
US4065263A (en) 1976-04-02 1977-12-27 Woodbridge Iii Richard G Analytical test strip apparatus
US4073693A (en) * 1976-06-08 1978-02-14 American Home Products Corporation Apparatus and method for conducting a plurality of biological tests
US4166457A (en) 1976-08-16 1979-09-04 University Of Utah Research Institute Fluid self-sealing bioelectrode
DE2753865A1 (de) 1977-12-02 1979-06-07 Ultrakust Geraetebau Verfahren und vorrichtung zum handhaben von milchproben
DE2804881C3 (de) * 1978-02-04 1980-08-07 Fa. Carl Zeiss, 7920 Heidenheim Gerät zur automatischen Analyse von flüssigen Proben
US4187861A (en) 1978-02-21 1980-02-12 Heffernan Bart T Blood sample handling apparatus and method
IT1119828B (it) * 1978-08-15 1986-03-10 Lucas Industries Ltd Cavo nastriforme
US4266559A (en) 1979-04-02 1981-05-12 American Hospital Supply Corporation Blood sampler
US4596271A (en) * 1980-10-02 1986-06-24 Brundage Robert W Fluid pressure device
US4329698A (en) * 1980-12-19 1982-05-11 International Business Machines Corporation Disposable cartridge for ink drop printer
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
JPS5818167A (ja) 1981-07-24 1983-02-02 Fuji Photo Film Co Ltd 分析フイルム及びこれを用いる分析方法
US4446232A (en) * 1981-10-13 1984-05-01 Liotta Lance A Enzyme immunoassay with two-zoned device having bound antigens
US5073484A (en) 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US4483920A (en) 1982-05-17 1984-11-20 Hahnemann University Immobilization of message RNA directly from cells onto filter material
US4427580A (en) 1982-09-01 1984-01-24 Cornell Research Foundation, Inc. Method for separation and recovery of proteins and nucleic acids from nucleoproteins using water destructuring salts
US4752449A (en) * 1982-10-15 1988-06-21 Hemotec, Inc. Apparatus for coagulation detection by gas flow or plunger sensing techniques
US4608275A (en) * 1983-07-01 1986-08-26 Macdermid, Incorporated Oxidizing accelerator
EP0139373A1 (en) 1983-08-26 1985-05-02 The Regents Of The University Of California Multiple immunoassay system
JPS61247965A (ja) * 1985-04-25 1986-11-05 Susumu Kogyo Kk 酵素免疫測定法
US4695430A (en) 1985-10-31 1987-09-22 Bio/Data Corporation Analytical apparatus
FR2590673B1 (fr) 1985-11-05 1988-09-16 Bally Philippe Dispositif de test autonome miniaturise a usage unique
JPS62226057A (ja) * 1986-03-28 1987-10-05 Minoru Tomita 全血用赤血球の凝集率測定方法及びその装置
US5057438A (en) 1986-09-24 1991-10-15 Agency Of Industrial Science And Technology Electrophoretic antigen-antibody determination with laminate of multiple membranes
US5714380A (en) * 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US4846005A (en) * 1986-12-12 1989-07-11 Baxter International Inc. Set with attachable sample cell
US4820297A (en) * 1986-12-12 1989-04-11 Baxter International Inc. Fluid delivery system with integrally formed sample cell
US4900321A (en) * 1986-12-12 1990-02-13 Baxter International Inc. Set with integrally formed sample cell
AT391213B (de) * 1987-05-12 1990-09-10 Avl Verbrennungskraft Messtech Einrichtung zur wahlweisen beschickung eines analysengeraetes
US5178832A (en) * 1987-09-28 1993-01-12 The Texas A&M University System Selective immobilization and detection of mycotoxins in solution
US4874691A (en) 1987-10-16 1989-10-17 Quadra Logic Technologies Inc. Membrane-supported immunoassays
DE3737604A1 (de) * 1987-11-05 1989-05-24 Biotechnolog Forschung Gmbh Geraet zur fliess-injektions-analyse
CA1339723C (en) 1988-01-19 1998-03-17 Philip Mcmahon Immunoassay with multiple test spots
US5137804A (en) * 1988-05-10 1992-08-11 E. I. Du Pont De Nemours And Company Assay device and immunoassay
US5019348A (en) * 1988-05-26 1991-05-28 Beckman Instruments, Inc. Automated chemical conversion unit in a peptide/protein sequenator
US5061445A (en) 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
US5354440A (en) * 1988-11-29 1994-10-11 Isco, Inc. Capillary electrophoresis technique
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
CA1338505C (en) * 1989-02-03 1996-08-06 John Bruce Findlay Containment cuvette for pcr and method of use
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
CA1328359C (en) * 1989-03-27 1994-04-12 Michael D. Mintz Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5120662A (en) * 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5504007A (en) * 1989-05-19 1996-04-02 Becton, Dickinson And Company Rapid thermal cycle apparatus
CA1329698C (en) 1989-06-12 1994-05-24 Mark Joseph Devaney, Jr. Temperature control device
US5089233A (en) * 1989-06-12 1992-02-18 Eastman Kodak Company Processing apparatus for a chemical reaction pack
GB8917963D0 (en) * 1989-08-05 1989-09-20 Scras Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples
US5185127A (en) * 1989-09-21 1993-02-09 Becton, Dickinson And Company Test device including flow control means
CA2031108A1 (en) 1989-12-26 1991-06-27 Thomas William Glanville Chemical reaction pack and method of using same
US5098660A (en) * 1990-01-08 1992-03-24 Eastman Kodak Company Transfer apparatus for chemical reaction pack
US5143084A (en) 1990-05-24 1992-09-01 Spacelabs, Inc. Disposable cartridge for sampling and analyzing body fluids
US5455175A (en) 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5187084A (en) * 1990-06-22 1993-02-16 The Dow Chemical Company Automatic air temperature cycler and method of use in polymerose chain reaction
DE59103769D1 (de) * 1990-08-16 1995-01-19 Draegerwerk Ag Kolorimetrische Nachweisvorrichtung mit einem Reagenzvorratsbehälter.
DE4029004C1 (https=) * 1990-09-13 1992-04-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De
US5066463A (en) * 1990-10-01 1991-11-19 Chang Maw Guay Multiple-purpose fecal examination apparatus
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
KR100231383B1 (ko) * 1990-12-31 1999-11-15 랜들 엘. 다이어몬드 Rna 레플리카제의 dna-의존성 rna 폴리머라제 활성을 이용한 핵산 증폭
US5709668A (en) * 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
FR2672231A1 (fr) 1991-02-01 1992-08-07 Eibet Appareil d'execution automatique repetee d'un cycle thermique, notamment pour l'amplification du nombre d'une sequence definie d'acide nucleique.
US5270183A (en) 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
EP0504772A3 (en) 1991-03-18 1993-01-27 Paradigm Biotechnologies Partnership Analytical apparatus
US5258314A (en) 1991-03-18 1993-11-02 Paradigm Biotechnologies Partnership Microprocessor-based biomedical monitoring apparatus and method
DE4202850A1 (de) * 1992-01-31 1993-08-05 Boehringer Mannheim Gmbh Analysenelement fuer immunoassays
US5422271A (en) * 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
WO1994020831A1 (en) 1993-03-08 1994-09-15 Norman Wainwright Aligned fiber diagnostic chromatography
SE9301495D0 (sv) * 1993-04-30 1993-04-30 Kabi Pharmacia Ab A device for metering and administrering a liquid preparation
WO1994026414A1 (en) * 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
SE9302121D0 (sv) 1993-06-18 1993-06-18 Kabi Pharmacia Ab Apparatus for controlled delivery of liquids
US5491067A (en) * 1993-07-15 1996-02-13 Ortho Diagnostic Systems Inc. Agglutination reaction and separation vessel
EP0636413B1 (en) 1993-07-28 2001-11-14 PE Corporation (NY) Nucleic acid amplification reaction apparatus and method
IL106662A (en) * 1993-08-11 1996-10-31 Yissum Res Dev Co Install a flow cell to monitor blood or any single cell suspension under flow
CA2130013C (en) * 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
US5374395A (en) 1993-10-14 1994-12-20 Amoco Corporation Diagnostics instrument
JP3346064B2 (ja) * 1993-12-28 2002-11-18 セイコーエプソン株式会社 インクジェットカートリッジ
US5567617A (en) 1994-01-06 1996-10-22 Johnson & Johnson Clinical Diagnostics, Inc. Apparatus for heating a fluid-carrying compartment of reaction cuvette
AU1527095A (en) 1994-01-11 1995-08-01 Abbott Laboratories Apparatus and method for thermal cycling nucleic acid assays
US6143263A (en) 1994-04-29 2000-11-07 The Babcock & Wilcox Company Method and system for SO2 and SO3 control by dry sorbent/reagent injection and wet scrubbing
US5508197A (en) * 1994-07-25 1996-04-16 The Regents, University Of California High-speed thermal cycling system and method of use
US5705628A (en) 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
US5658413A (en) * 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
CA2203504A1 (en) 1994-10-24 1996-05-02 James A. Williams Vaccine and antitoxin for treatment and prevention of c. difficile disease
JPH08196299A (ja) * 1995-01-26 1996-08-06 Tosoh Corp サーマルサイクリング反応装置及びこれに用いる反応容器
US5780222A (en) * 1995-04-10 1998-07-14 Alpha Therapeutic Corporation Method of PCR testing of pooled blood samples
US5591573A (en) * 1995-04-10 1997-01-07 Alpha Therapeutic Corporation Method and system for testing blood samples
GB2303799B (en) 1995-07-29 1999-03-10 Siemens Plc Improvements in or relating to aqueous sample testing apparatus
GB2303916B (en) 1995-07-29 1999-03-03 Siemens Plc Improvements in or relating to aqueous sample testing apparatus
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US5847734A (en) 1995-12-04 1998-12-08 Pawlowski, Jr.; Norman E. Air purge system for an ink-jet printer
US6068751A (en) 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US5830657A (en) * 1996-05-01 1998-11-03 Visible Genetics Inc. Method for single-tube sequencing of nucleic acid polymers
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
ES2115521B1 (es) 1996-02-26 1999-02-16 Grifols Grupo Sa Dispositivo para la realizacion de reacciones eritrocitarias.
FR2746001B1 (fr) * 1996-03-12 1998-06-12 Ensemble de chirurgie orthopedique pour prothese de hanche a col amovible
CA2252571A1 (en) 1996-05-01 1997-11-06 Visible Genetics Inc. Method and apparatus for thermal cycling and for automated sample preparation with thermal cycling
US5913232A (en) 1996-05-20 1999-06-15 Sendx Medical, Inc. reference solution container for blood gas/electrolyte measuring system
EP1033411B1 (en) * 1996-06-04 2006-02-22 University of Utah Research Foundation Fluorescent donor-acceptor pair
US5985651A (en) 1996-06-17 1999-11-16 The Board Of Trustees Of The Leland Stanford Junior University Thermocycling apparatus and method
GB9618595D0 (en) 1996-09-06 1996-10-16 Central Research Lab Ltd Reaction cell
US6210036B1 (en) * 1996-09-06 2001-04-03 Gerald P. Eberle Connector thermal sensor
GB9621357D0 (en) 1996-10-12 1996-12-04 Central Research Lab Ltd Heating apparatus
DE19646116A1 (de) * 1996-11-08 1998-05-14 Eppendorf Geraetebau Netheler Temperierblock mit Aufnahmen
US5811296A (en) 1996-12-20 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Blocked compartments in a PCR reaction vessel
US6180698B1 (en) * 1997-02-28 2001-01-30 Candescent Technologies Corporation Polycarbonate-containing liquid chemical formulation and method for making polycarbonate film
JP3428426B2 (ja) * 1997-03-26 2003-07-22 株式会社日立製作所 検体分析システム
WO1998043740A2 (en) 1997-03-28 1998-10-08 The Perkin-Elmer Corporation Improvements in thermal cycler for pcr
US6186982B1 (en) * 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
WO1998050147A1 (en) 1997-05-09 1998-11-12 The Regents Of The University Of California Peltier-assisted microfabricated reaction chambers for thermal cycling
US6194160B1 (en) * 1998-03-19 2001-02-27 Immunetics, Inc. Systems and methods for rapid blot screening
US5866366A (en) * 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
US6300138B1 (en) 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US6426230B1 (en) 1997-08-01 2002-07-30 Qualigen, Inc. Disposable diagnostic device and method
US6066296A (en) * 1997-09-23 2000-05-23 Array Medical, Inc. Sample addition, reagent application, and testing chamber
US5942432A (en) * 1997-10-07 1999-08-24 The Perkin-Elmer Corporation Apparatus for a fluid impingement thermal cycler
US6111096A (en) * 1997-10-31 2000-08-29 Bbi Bioseq, Inc. Nucleic acid isolation and purification
WO1999025475A1 (de) * 1997-11-19 1999-05-27 Peter Miethe Vorrichtung zur sequentiellen ausgabe von fliessfähigen reagenzien
EP1034040A2 (en) 1997-11-25 2000-09-13 Mosaic Technologies Devices and methods for detecting target molecules in biological samples
EP1039942B1 (en) * 1997-12-16 2004-10-13 Meridian Medical Technologies, Inc. Automatic injector for administrating a medicament
DK1179585T3 (da) * 1997-12-24 2008-11-10 Cepheid Indretning og fremgangsmåde til lysis
US6413874B1 (en) * 1997-12-26 2002-07-02 Canon Kabushiki Kaisha Method and apparatus for etching a semiconductor article and method of preparing a semiconductor article by using the same
US6300308B1 (en) 1997-12-31 2001-10-09 Board Of Regents, The University Of Texas System Methods and compositions for inducing autoimmunity in the treatment of cancers
ATE278471T1 (de) 1998-05-04 2004-10-15 Hoffmann La Roche Thermozyklierapparat mit einem automatisch positionierbaren deckel
US6534262B1 (en) 1998-05-14 2003-03-18 Whitehead Institute For Biomedical Research Solid phase technique for selectively isolating nucleic acids
US6780617B2 (en) * 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
AU4957699A (en) 1998-06-24 2000-01-10 Chen & Chen, Llc Fluid sample testing system
WO1999067647A1 (en) 1998-06-24 1999-12-29 Chen & Chen, Llc Multi-layer testing column
GB9814506D0 (en) 1998-07-03 1998-09-02 Stanley Christopher J Optical sensor for insitu measurement of analytes
GB9819897D0 (en) * 1998-09-11 1998-11-04 Seward Limited Devices for blending materials
CA2347125A1 (en) 1998-10-16 2000-04-27 Larry S. Millstein Methods of making patterned arrays of analyte-binding molecules
EP1000661A1 (en) 1998-10-29 2000-05-17 Hans-Knöll-Institut für Naturstoff-Forschung e.v. Ultrathin-walled multiwell plate for heat block thermocycling
US6159727A (en) 1999-06-04 2000-12-12 Clontech Laboratories, Inc. Hybridization chamber
US6250166B1 (en) * 1999-06-04 2001-06-26 General Electric Company Simulated dovetail testing
WO2001007892A1 (en) 1999-07-27 2001-02-01 Esperion Therapeutics, Inc. Method and device for measurement of cholesterol efflux
US6719715B2 (en) 1999-09-16 2004-04-13 Vasogen Ireland Limited Apparatus and process for conditioning organic fluid
US6471069B2 (en) 1999-12-03 2002-10-29 Becton Dickinson And Company Device for separating components of a fluid sample
IL134035A0 (en) * 2000-01-13 2001-04-30 Ronen Daniel A device, system and method for remote push-publishing of content onto display screens of mobile devices including a screen saver application
US6440072B1 (en) * 2000-03-30 2002-08-27 Acuson Corporation Medical diagnostic ultrasound imaging system and method for transferring ultrasound examination data to a portable computing device
WO2002078847A1 (en) * 2001-03-28 2002-10-10 Hitachi, Ltd. Instrument and method for recovering nucleic acid
CA2450343C (en) 2001-07-16 2013-12-17 Idaho Technology, Inc. Thermal cycling system and method of use
DK1451322T3 (da) * 2001-11-05 2010-02-01 Zymogenetics Inc Il-21-antagonister
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
EP1583950B1 (en) * 2002-12-26 2017-04-05 Meso Scale Technologies, LLC. Assay cartridges and methods of using the same
EP1603674B1 (en) 2003-02-05 2016-01-06 Iquum, Inc. Sample processing
US7785535B2 (en) 2004-06-07 2010-08-31 Iquum, Inc. Sample multiprocessing
US20080003564A1 (en) * 2006-02-14 2008-01-03 Iquum, Inc. Sample processing

Also Published As

Publication number Publication date
US7718421B2 (en) 2010-05-18
US20170283790A1 (en) 2017-10-05
EP2574400A1 (en) 2013-04-03
AU2004220626B2 (en) 2010-07-29
AU2004220626A1 (en) 2004-09-23
CN1767897A (zh) 2006-05-03
US20040161788A1 (en) 2004-08-19
JP2006518221A (ja) 2006-08-10
CN1767897B (zh) 2011-03-02
ES2604352T3 (es) 2017-03-06
WO2004080597A3 (en) 2005-03-31
US20100218621A1 (en) 2010-09-02
US8936933B2 (en) 2015-01-20
EP2574400B1 (en) 2016-09-28
US20150105300A1 (en) 2015-04-16
CA2515075A1 (en) 2004-09-23
EP1603674B1 (en) 2016-01-06
EP1603674A2 (en) 2005-12-14
US9708599B2 (en) 2017-07-18
WO2004080597A2 (en) 2004-09-23
CA2515075C (en) 2012-10-02
US10443050B2 (en) 2019-10-15
ES2566509T3 (es) 2016-04-13

Similar Documents

Publication Publication Date Title
JP4632262B2 (ja) サンプルの処理
US20080003564A1 (en) Sample processing
CN101432698B (zh) 处理样品的方法
JP7126445B2 (ja) 扱いにくい試料タイプのための試料調製
JP5254949B2 (ja) 一体型の核酸アッセイ
KR101786506B1 (ko) 핵산 정제
US10471408B2 (en) Microspotting device
JP2024500169A (ja) 大ストークスシフト蛍光色素を使用して多重化リアルタイムｐｃｒを行うための方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070205

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070205

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091201

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100301

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100308

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100330

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100406

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100601

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20100601

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100622

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100916

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20101012

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20101110

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

Ref document number: 4632262

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131126

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term