JP4551761B2 - ケラチン由来の整形外科材料 - Google Patents
ケラチン由来の整形外科材料 Download PDFInfo
- Publication number
- JP4551761B2 JP4551761B2 JP2004510856A JP2004510856A JP4551761B2 JP 4551761 B2 JP4551761 B2 JP 4551761B2 JP 2004510856 A JP2004510856 A JP 2004510856A JP 2004510856 A JP2004510856 A JP 2004510856A JP 4551761 B2 JP4551761 B2 JP 4551761B2
- Authority
- JP
- Japan
- Prior art keywords
- keratin
- containing material
- bone
- sulfonated
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010076876 Keratins Proteins 0.000 title claims description 193
- 102000011782 Keratins Human genes 0.000 title claims description 193
- 239000000463 material Substances 0.000 title claims description 153
- 230000000399 orthopedic effect Effects 0.000 title description 14
- 210000000988 bone and bone Anatomy 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 49
- 239000000126 substance Substances 0.000 claims description 32
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 31
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 238000011282 treatment Methods 0.000 claims description 25
- 238000005406 washing Methods 0.000 claims description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- 239000011148 porous material Substances 0.000 claims description 18
- 102000012411 Intermediate Filament Proteins Human genes 0.000 claims description 15
- 108010061998 Intermediate Filament Proteins Proteins 0.000 claims description 15
- 238000007906 compression Methods 0.000 claims description 14
- 230000006835 compression Effects 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000003638 chemical reducing agent Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 230000003416 augmentation Effects 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims description 3
- 159000000007 calcium salts Chemical class 0.000 claims description 3
- 238000011161 development Methods 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000004132 cross linking Methods 0.000 claims 3
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- 238000011084 recovery Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 31
- 239000010408 film Substances 0.000 description 26
- 235000018102 proteins Nutrition 0.000 description 26
- 102000004169 proteins and genes Human genes 0.000 description 26
- 108090000623 proteins and genes Proteins 0.000 description 26
- 210000004027 cell Anatomy 0.000 description 23
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 18
- 239000000047 product Substances 0.000 description 14
- 210000001519 tissue Anatomy 0.000 description 13
- 230000008569 process Effects 0.000 description 12
- ZZTCCAPMZLDHFM-UHFFFAOYSA-N ammonium thioglycolate Chemical compound [NH4+].[O-]C(=O)CS ZZTCCAPMZLDHFM-UHFFFAOYSA-N 0.000 description 11
- 229940075861 ammonium thioglycolate Drugs 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 230000012010 growth Effects 0.000 description 10
- 125000000542 sulfonic acid group Chemical group 0.000 description 10
- 210000002268 wool Anatomy 0.000 description 10
- 210000002950 fibroblast Anatomy 0.000 description 9
- 239000003361 porogen Substances 0.000 description 9
- 210000000963 osteoblast Anatomy 0.000 description 8
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- 241001494479 Pecora Species 0.000 description 7
- 239000000835 fiber Substances 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- 239000008188 pellet Substances 0.000 description 7
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 239000012620 biological material Substances 0.000 description 6
- GEHJBWKLJVFKPS-UHFFFAOYSA-N bromochloroacetic acid Chemical compound OC(=O)C(Cl)Br GEHJBWKLJVFKPS-UHFFFAOYSA-N 0.000 description 6
- 229960003067 cystine Drugs 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000008439 repair process Effects 0.000 description 6
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 5
- 230000035876 healing Effects 0.000 description 5
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- 210000003963 intermediate filament Anatomy 0.000 description 5
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- 206010028980 Neoplasm Diseases 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 4
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 4
- 206010065687 Bone loss Diseases 0.000 description 3
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- 239000012567 medical material Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000010392 Bone Fractures Diseases 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- NOKPBJYHPHHWAN-REOHCLBHSA-N S-sulfo-L-cysteine Chemical compound OC(=O)[C@@H](N)CSS(O)(=O)=O NOKPBJYHPHHWAN-REOHCLBHSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
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- 238000005056 compaction Methods 0.000 description 2
- 230000030944 contact inhibition Effects 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
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- 239000012467 final product Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 210000000003 hoof Anatomy 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
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- 239000002198 insoluble material Substances 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
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- 230000002188 osteogenic effect Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- 230000009103 reabsorption Effects 0.000 description 2
- 238000003168 reconstitution method Methods 0.000 description 2
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- 239000000758 substrate Substances 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- FCWAUFMDOCOONS-QRPNPIFTSA-N 2-aminoacetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid Chemical compound NCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FCWAUFMDOCOONS-QRPNPIFTSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 101710200191 Feather keratin Proteins 0.000 description 1
- 101710145505 Fiber protein Proteins 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 208000007356 Fracture Dislocation Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
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- 101710172711 Structural protein Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
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- 150000001413 amino acids Chemical class 0.000 description 1
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- 108010049062 beta-Keratins Proteins 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000010256 bone deposition Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
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- 238000005266 casting Methods 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
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- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000078 claw Anatomy 0.000 description 1
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- 210000005088 multinucleated cell Anatomy 0.000 description 1
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- 239000007800 oxidant agent Substances 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
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- 238000011277 treatment modality Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000009790 vascular invasion Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ51945602 | 2002-06-10 | ||
| PCT/NZ2003/000116 WO2003103737A1 (en) | 2002-06-10 | 2003-06-10 | Orthopaedic materials derived from keratin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005536242A JP2005536242A (ja) | 2005-12-02 |
| JP2005536242A5 JP2005536242A5 (enExample) | 2006-04-20 |
| JP4551761B2 true JP4551761B2 (ja) | 2010-09-29 |
Family
ID=29728989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510856A Expired - Lifetime JP4551761B2 (ja) | 2002-06-10 | 2003-06-10 | ケラチン由来の整形外科材料 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7297342B2 (enExample) |
| EP (1) | EP1534353A4 (enExample) |
| JP (1) | JP4551761B2 (enExample) |
| CN (1) | CN100506294C (enExample) |
| AU (1) | AU2003238745B2 (enExample) |
| BR (1) | BR0311723A (enExample) |
| CA (1) | CA2488721A1 (enExample) |
| MX (1) | MXPA04012434A (enExample) |
| NZ (1) | NZ550755A (enExample) |
| WO (1) | WO2003103737A1 (enExample) |
| ZA (1) | ZA200409777B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1997408A (zh) | 2003-12-19 | 2007-07-11 | 凯瑞泰克有限公司 | 包含角蛋白的伤口护理产品 |
| US7579317B2 (en) | 2005-03-11 | 2009-08-25 | Keratec, Ltd. | Nutraceutical composition comprising soluble keratin or derivative thereof |
| US8920827B2 (en) * | 2005-10-21 | 2014-12-30 | Wake Forest University Health Sciences | Keratin bioceramic compositions |
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2003
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- 2003-06-10 CN CNB038193280A patent/CN100506294C/zh not_active Expired - Lifetime
- 2003-06-10 MX MXPA04012434A patent/MXPA04012434A/es active IP Right Grant
- 2003-06-10 CA CA002488721A patent/CA2488721A1/en not_active Abandoned
- 2003-06-10 US US10/517,378 patent/US7297342B2/en not_active Expired - Lifetime
- 2003-06-10 NZ NZ550755A patent/NZ550755A/en not_active IP Right Cessation
- 2003-06-10 AU AU2003238745A patent/AU2003238745B2/en not_active Ceased
- 2003-06-10 JP JP2004510856A patent/JP4551761B2/ja not_active Expired - Lifetime
- 2003-06-10 EP EP03733659A patent/EP1534353A4/en not_active Withdrawn
- 2003-06-10 BR BR0311723-5A patent/BR0311723A/pt not_active Application Discontinuation
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2004
- 2004-12-02 ZA ZA200409777A patent/ZA200409777B/en unknown
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| MXPA04012434A (es) | 2005-10-19 |
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| WO2003103737A1 (en) | 2003-12-18 |
| AU2003238745B2 (en) | 2008-12-11 |
| US7892572B2 (en) | 2011-02-22 |
| US20080039951A1 (en) | 2008-02-14 |
| JP2005536242A (ja) | 2005-12-02 |
| CN1674946A (zh) | 2005-09-28 |
| EP1534353A1 (en) | 2005-06-01 |
| BR0311723A (pt) | 2005-03-01 |
| CN100506294C (zh) | 2009-07-01 |
| US20050232963A1 (en) | 2005-10-20 |
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