AU2003238745B2 - Orthopaedic materials derived from keratin - Google Patents
Orthopaedic materials derived from keratin Download PDFInfo
- Publication number
- AU2003238745B2 AU2003238745B2 AU2003238745A AU2003238745A AU2003238745B2 AU 2003238745 B2 AU2003238745 B2 AU 2003238745B2 AU 2003238745 A AU2003238745 A AU 2003238745A AU 2003238745 A AU2003238745 A AU 2003238745A AU 2003238745 B2 AU2003238745 B2 AU 2003238745B2
- Authority
- AU
- Australia
- Prior art keywords
- keratin
- sulfonated
- sulfonated keratin
- bone
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000011782 Keratins Human genes 0.000 title claims description 240
- 108010076876 Keratins Proteins 0.000 title claims description 240
- 239000000463 material Substances 0.000 title claims description 177
- 210000000988 bone and bone Anatomy 0.000 claims description 75
- 238000000034 method Methods 0.000 claims description 60
- 239000000126 substance Substances 0.000 claims description 43
- 238000011282 treatment Methods 0.000 claims description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 30
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 30
- 102000004169 proteins and genes Human genes 0.000 claims description 28
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- 102000012411 Intermediate Filament Proteins Human genes 0.000 claims description 25
- 108010061998 Intermediate Filament Proteins Proteins 0.000 claims description 25
- 238000007906 compression Methods 0.000 claims description 25
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- ZZTCCAPMZLDHFM-UHFFFAOYSA-N ammonium thioglycolate Chemical compound [NH4+].[O-]C(=O)CS ZZTCCAPMZLDHFM-UHFFFAOYSA-N 0.000 claims description 24
- 238000005406 washing Methods 0.000 claims description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims description 20
- 239000012567 medical material Substances 0.000 claims description 19
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- 150000001875 compounds Chemical class 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims description 12
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- GEHJBWKLJVFKPS-UHFFFAOYSA-N bromochloroacetic acid Chemical compound OC(=O)C(Cl)Br GEHJBWKLJVFKPS-UHFFFAOYSA-N 0.000 description 12
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- XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 4
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 4
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- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
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- 239000004793 Polystyrene Substances 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- NOKPBJYHPHHWAN-REOHCLBHSA-N S-sulfo-L-cysteine Chemical compound OC(=O)[C@@H](N)CSS(O)(=O)=O NOKPBJYHPHHWAN-REOHCLBHSA-N 0.000 description 2
- 206010061363 Skeletal injury Diseases 0.000 description 2
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- 235000018417 cysteine Nutrition 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
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- 230000008733 trauma Effects 0.000 description 2
- 101710200191 Feather keratin Proteins 0.000 description 1
- 208000007356 Fracture Dislocation Diseases 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ51945602 | 2002-06-10 | ||
| NZ519456 | 2002-06-10 | ||
| PCT/NZ2003/000116 WO2003103737A1 (en) | 2002-06-10 | 2003-06-10 | Orthopaedic materials derived from keratin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003238745A1 AU2003238745A1 (en) | 2003-12-22 |
| AU2003238745B2 true AU2003238745B2 (en) | 2008-12-11 |
Family
ID=29728989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003238745A Ceased AU2003238745B2 (en) | 2002-06-10 | 2003-06-10 | Orthopaedic materials derived from keratin |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7297342B2 (enExample) |
| EP (1) | EP1534353A4 (enExample) |
| JP (1) | JP4551761B2 (enExample) |
| CN (1) | CN100506294C (enExample) |
| AU (1) | AU2003238745B2 (enExample) |
| BR (1) | BR0311723A (enExample) |
| CA (1) | CA2488721A1 (enExample) |
| MX (1) | MXPA04012434A (enExample) |
| NZ (1) | NZ550755A (enExample) |
| WO (1) | WO2003103737A1 (enExample) |
| ZA (1) | ZA200409777B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1997408A (zh) | 2003-12-19 | 2007-07-11 | 凯瑞泰克有限公司 | 包含角蛋白的伤口护理产品 |
| US7579317B2 (en) | 2005-03-11 | 2009-08-25 | Keratec, Ltd. | Nutraceutical composition comprising soluble keratin or derivative thereof |
| US8920827B2 (en) * | 2005-10-21 | 2014-12-30 | Wake Forest University Health Sciences | Keratin bioceramic compositions |
| US20070207097A1 (en) * | 2006-02-21 | 2007-09-06 | Kelly Robert J | Treating hair or nails with internal wool lipids |
| CA2665253A1 (en) * | 2006-10-02 | 2008-04-10 | Coloplast A/S | Cross-linking of foams of s-sulfonated keratin |
| DK2099400T3 (da) | 2006-12-06 | 2014-10-20 | Weber Jeffrey A | Knoglehulrumsfyldstof og fremgangsmåde til fremstilling deraf |
| WO2008073376A2 (en) * | 2006-12-11 | 2008-06-19 | Keratec, Ltd. | Porous keratin construct and method of making the same |
| DE102008053114B4 (de) * | 2008-10-26 | 2011-05-05 | Technische Universität Braunschweig | Pharmazeutischer Keratinschwamm |
| JP2012526845A (ja) * | 2009-05-13 | 2012-11-01 | ケラプラスト テクノロジーズ， リミテッド | バイオポリマー材料 |
| CA2818166C (en) | 2010-11-17 | 2019-04-30 | Wake Forest University Health Sciences | Keratin compositions for treatment of bone deficiency or injury |
| EP3412683B1 (en) | 2011-08-17 | 2022-02-09 | KeraNetics, Inc. | Methods for extracting keratin proteins |
| EP2744480B8 (en) | 2011-08-17 | 2019-06-26 | Keratin Biosciences, Inc. | Low protein percentage gelling compositions |
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- 2003-06-10 MX MXPA04012434A patent/MXPA04012434A/es active IP Right Grant
- 2003-06-10 CA CA002488721A patent/CA2488721A1/en not_active Abandoned
- 2003-06-10 US US10/517,378 patent/US7297342B2/en not_active Expired - Lifetime
- 2003-06-10 NZ NZ550755A patent/NZ550755A/en not_active IP Right Cessation
- 2003-06-10 AU AU2003238745A patent/AU2003238745B2/en not_active Ceased
- 2003-06-10 JP JP2004510856A patent/JP4551761B2/ja not_active Expired - Lifetime
- 2003-06-10 EP EP03733659A patent/EP1534353A4/en not_active Withdrawn
- 2003-06-10 BR BR0311723-5A patent/BR0311723A/pt not_active Application Discontinuation
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2004
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| WO1999026570A1 (en) * | 1997-11-26 | 1999-06-03 | Keraplast Technologies, Ltd. | Method of cross-linking keratin-based films, sheets, and bulk materials |
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| US7297342B2 (en) | 2007-11-20 |
| NZ550755A (en) | 2009-06-26 |
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| MXPA04012434A (es) | 2005-10-19 |
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| CA2488721A1 (en) | 2003-12-18 |
| WO2003103737A1 (en) | 2003-12-18 |
| JP4551761B2 (ja) | 2010-09-29 |
| US7892572B2 (en) | 2011-02-22 |
| US20080039951A1 (en) | 2008-02-14 |
| JP2005536242A (ja) | 2005-12-02 |
| CN1674946A (zh) | 2005-09-28 |
| EP1534353A1 (en) | 2005-06-01 |
| BR0311723A (pt) | 2005-03-01 |
| CN100506294C (zh) | 2009-07-01 |
| US20050232963A1 (en) | 2005-10-20 |
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