JP4481011B2 - リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体 - Google Patents

リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体 Download PDF

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JP4481011B2
JP4481011B2 JP2003574195A JP2003574195A JP4481011B2 JP 4481011 B2 JP4481011 B2 JP 4481011B2 JP 2003574195 A JP2003574195 A JP 2003574195A JP 2003574195 A JP2003574195 A JP 2003574195A JP 4481011 B2 JP4481011 B2 JP 4481011B2
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alkylene
phenyl
aryl
phenoxy
mmol
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Expired - Lifetime
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Japanese (ja)
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JP2005525378A5 (enExample
JP2005525378A (ja
Inventor
アドナン エム． エム． ムジャリ、
ロバート シー． アンドリューズ、
ラメッシュ ゴパラスワミー、
アニサ ハリ、
クワシ アヴォア、
ガッサン カバジャ、
シャオ−チュアン グオ、
スパーナ グプタ、
デビッド アール． ジョーンズ、
シン チェン、
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vTv Therapeutics LLC
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vTvx Holdings I LLC
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
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  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003574195A 2002-03-05 2003-03-05 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体 Expired - Lifetime JP4481011B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36198302P 2002-03-05 2002-03-05
PCT/US2003/006749 WO2003075921A2 (en) 2002-03-05 2003-03-05 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage

Related Child Applications (1)

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JP2008271566A Division JP2009096806A (ja) 2002-03-05 2008-10-22 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体

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JP2005525378A JP2005525378A (ja) 2005-08-25
JP2005525378A5 JP2005525378A5 (enExample) 2007-12-06
JP4481011B2 true JP4481011B2 (ja) 2010-06-16

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JP2003574195A Expired - Lifetime JP4481011B2 (ja) 2002-03-05 2003-03-05 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体
JP2008271566A Pending JP2009096806A (ja) 2002-03-05 2008-10-22 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体

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JP2008271566A Pending JP2009096806A (ja) 2002-03-05 2008-10-22 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体

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US (5) US7361678B2 (enExample)
EP (2) EP1482931B1 (enExample)
JP (2) JP4481011B2 (enExample)
CN (3) CN100525763C (enExample)
AT (1) ATE529110T1 (enExample)
AU (2) AU2007202350B2 (enExample)
CA (1) CA2476594C (enExample)
DK (1) DK1482931T3 (enExample)
ES (1) ES2373875T3 (enExample)
WO (1) WO2003075921A2 (enExample)

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US20070213347A1 (en) 2007-09-13
WO2003075921A2 (en) 2003-09-18
US20120088778A1 (en) 2012-04-12
CN101597262A (zh) 2009-12-09
JP2005525378A (ja) 2005-08-25
US7714013B2 (en) 2010-05-11
CN101613321A (zh) 2009-12-30
AU2003217943A1 (en) 2003-09-22
EP1482931A2 (en) 2004-12-08
ES2373875T3 (es) 2012-02-09
CA2476594C (en) 2012-10-09
US20040082542A1 (en) 2004-04-29
JP2009096806A (ja) 2009-05-07
AU2009202814A1 (en) 2009-08-06
US20100256119A1 (en) 2010-10-07
US20070021386A1 (en) 2007-01-25
WO2003075921A3 (en) 2003-12-04
US7361678B2 (en) 2008-04-22
EP1482931B1 (en) 2011-10-19
CN100525763C (zh) 2009-08-12
EP2324830A1 (en) 2011-05-25
US7737285B2 (en) 2010-06-15
AU2007202350B2 (en) 2009-07-30
CN1633290A (zh) 2005-06-29
HK1069549A1 (en) 2005-05-27
ATE529110T1 (de) 2011-11-15
DK1482931T3 (da) 2011-12-19

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