UA101943C2 - Биарилзамещенные гетероциклические ингибиторы lta4h для лечения воспаления - Google Patents

Биарилзамещенные гетероциклические ингибиторы lta4h для лечения воспаления

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Publication number
UA101943C2
UA101943C2 UAA200804989A UAA200804989A UA101943C2 UA 101943 C2 UA101943 C2 UA 101943C2 UA A200804989 A UAA200804989 A UA A200804989A UA A200804989 A UAA200804989 A UA A200804989A UA 101943 C2 UA101943 C2 UA 101943C2
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UA
Ukraine
Prior art keywords
heading
lta4h
substituted heterocycle
normal
treating inflammation
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Application number
UAA200804989A
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English (en)
Ukrainian (uk)
Inventor
Джасбир Сингх
Винсент Санданаяка
Марк Гарни
Пен Юй
Луис Беделл
Бьерн Мамат
Лей Чжао
Рама К. Мишра
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Декод Дженетикс Ехф
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Application filed by Декод Дженетикс Ехф filed Critical Декод Дженетикс Ехф
Publication of UA101943C2 publication Critical patent/UA101943C2/ru

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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Hydrogenated Pyridines (AREA)
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Abstract

Представленное изобретение касается биарилзамещенных гетероциклических ингибиторов LTA4H(лейкотриен-А4-гидролазы) формулы,пригодных для лечения, а также предотвращения и профилактики воспалительных заболеваний и расстройств.
UAA200804989A 2005-09-21 2006-06-23 Биарилзамещенные гетероциклические ингибиторы lta4h для лечения воспаления UA101943C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71901605P 2005-09-21 2005-09-21
PCT/US2006/024393 WO2007040682A1 (en) 2005-09-21 2006-06-23 Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation

Publications (1)

Publication Number Publication Date
UA101943C2 true UA101943C2 (ru) 2013-05-27

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UAA200804989A UA101943C2 (ru) 2005-09-21 2006-06-23 Биарилзамещенные гетероциклические ингибиторы lta4h для лечения воспаления

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US (3) US20070078263A1 (ru)
EP (1) EP1926708B1 (ru)
JP (1) JP5133889B2 (ru)
KR (1) KR101328306B1 (ru)
CN (1) CN101312948B (ru)
AU (1) AU2006297798B2 (ru)
BR (1) BRPI0616187A2 (ru)
CA (1) CA2623348A1 (ru)
EA (1) EA017618B1 (ru)
IL (1) IL190372A0 (ru)
NO (1) NO20081829L (ru)
NZ (1) NZ566788A (ru)
SG (1) SG166769A1 (ru)
UA (1) UA101943C2 (ru)
WO (2) WO2007040681A1 (ru)

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WO2008019302A1 (en) * 2006-08-04 2008-02-14 Decode Genetics Ehf Pyrazolylphenyl and pyrrolylphenyl inhibitors of lta4h for treating inflammation
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WO2010045633A2 (en) * 2008-10-17 2010-04-22 National Jewish Health Measurement and analysis of leukotrienes
CN102459251B (zh) * 2009-05-14 2015-05-20 詹森药业有限公司 作为白三烯a4水解酶的调节剂的具有两个稠合双环杂芳基部分的化合物
WO2011011598A1 (en) 2009-07-24 2011-01-27 Decode Genetics Ehf Process for preparing 4- { (s) -2- (4-(4-chlorophenoxy) phenoxymethyl) pyrrolidin-1-yl) } butyric acid and salts thereof
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EP2600864B1 (en) * 2010-08-04 2019-01-09 University Of Virginia Patent Foundation Compositions and methods for treating inflammatory diseases
PL2686310T3 (pl) 2011-03-14 2018-06-29 Boehringer Ingelheim International Gmbh Benzodioksanowe inhibitory wytwarzania leukotrienu
WO2013012844A1 (en) * 2011-07-19 2013-01-24 Boehringer Ingelheim International Gmbh Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
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