AU2007202350B2 - Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE - Google Patents

Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE Download PDF

Info

Publication number
AU2007202350B2
AU2007202350B2 AU2007202350A AU2007202350A AU2007202350B2 AU 2007202350 B2 AU2007202350 B2 AU 2007202350B2 AU 2007202350 A AU2007202350 A AU 2007202350A AU 2007202350 A AU2007202350 A AU 2007202350A AU 2007202350 B2 AU2007202350 B2 AU 2007202350B2
Authority
AU
Australia
Prior art keywords
phenyl
alkylene
aryl
butyl
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007202350A
Other languages
English (en)
Other versions
AU2007202350A1 (en
Inventor
Robert C. Andrews
Kwasi Avor
Xin Chen
Ramesh Gopalaswamy
Xiao-Chuan Guo
Suparna Gupta
Anitha Hari
David R. Jones
Adnan M. M. Mjalli
Ghassan Qabaja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
vTv Therapeutics LLC
Original Assignee
vTv Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2003217943A external-priority patent/AU2003217943B2/en
Application filed by vTv Therapeutics LLC filed Critical vTv Therapeutics LLC
Priority to AU2007202350A priority Critical patent/AU2007202350B2/en
Publication of AU2007202350A1 publication Critical patent/AU2007202350A1/en
Priority to AU2009202814A priority patent/AU2009202814B2/en
Application granted granted Critical
Publication of AU2007202350B2 publication Critical patent/AU2007202350B2/en
Assigned to TRANSTECH PHARMA, LLC reassignment TRANSTECH PHARMA, LLC Request for Assignment Assignors: TRANSTECH PHARMA, INC.
Assigned to VTV THERAPEUTICS LLC reassignment VTV THERAPEUTICS LLC Request to Amend Deed and Register Assignors: TRANSTECH PHARMA, LLC
Assigned to VTV THERAPEUTICS LLC reassignment VTV THERAPEUTICS LLC Request for Assignment Assignors: VTV THERAPEUTICS LLC
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2007202350A 2002-03-05 2007-05-24 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE Ceased AU2007202350B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2007202350A AU2007202350B2 (en) 2002-03-05 2007-05-24 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE
AU2009202814A AU2009202814B2 (en) 2002-03-05 2009-07-13 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36198302P 2002-03-05 2002-03-05
US60/361,983 2002-03-05
PCT/US2003/006749 WO2003075921A2 (en) 2002-03-05 2003-03-05 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage
AU2003217943A AU2003217943B2 (en) 2002-03-05 2003-03-05 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE
AU2007202350A AU2007202350B2 (en) 2002-03-05 2007-05-24 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2003217943A Division AU2003217943B2 (en) 2002-03-05 2003-03-05 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2009202814A Division AU2009202814B2 (en) 2002-03-05 2009-07-13 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage

Publications (2)

Publication Number Publication Date
AU2007202350A1 AU2007202350A1 (en) 2007-06-14
AU2007202350B2 true AU2007202350B2 (en) 2009-07-30

Family

ID=27805104

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2007202350A Ceased AU2007202350B2 (en) 2002-03-05 2007-05-24 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE
AU2009202814A Ceased AU2009202814B2 (en) 2002-03-05 2009-07-13 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2009202814A Ceased AU2009202814B2 (en) 2002-03-05 2009-07-13 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage

Country Status (10)

Country Link
US (5) US7361678B2 (enExample)
EP (2) EP2324830A1 (enExample)
JP (2) JP4481011B2 (enExample)
CN (3) CN100525763C (enExample)
AT (1) ATE529110T1 (enExample)
AU (2) AU2007202350B2 (enExample)
CA (1) CA2476594C (enExample)
DK (1) DK1482931T3 (enExample)
ES (1) ES2373875T3 (enExample)
WO (1) WO2003075921A2 (enExample)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
JP2004523565A (ja) * 2001-03-05 2004-08-05 トランス　テック　ファーマ，インコーポレイテッド 治療因子としてのベンゾイミダゾール誘導体
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
ES2610611T3 (es) 2002-01-18 2017-04-28 Astellas Pharma Inc. Derivado de 2-acilaminotiazol o sal del mismo
ATE529110T1 (de) * 2002-03-05 2011-11-15 Transtech Pharma Inc Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
CA2514363A1 (en) * 2003-02-12 2004-08-26 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
EP1635823A1 (en) * 2003-05-20 2006-03-22 TransTech Pharma Inc. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
AU2004272607B2 (en) 2003-09-11 2008-11-06 Cornerstone Therapeutics Inc. Monoclonal antibodies against HMGB1
AU2005214349B2 (en) * 2004-02-12 2011-11-03 Transtech Pharma, Inc. Substituted azole derivatives, compositions, and methods of use
US20070197619A1 (en) * 2004-03-08 2007-08-23 Robert Zelle Ion Channel Modulators
US20080242716A1 (en) * 2004-03-08 2008-10-02 Robert Zelle Ion Channel Modulators
JP4607950B2 (ja) * 2004-03-18 2011-01-05 トランス テック ファーマ，インコーポレイテッド 蛍光偏光アッセイ
CA2560417C (en) 2004-04-03 2011-04-19 Astrazeneca Ab 1,2-diarylimidazole-4-carboxamide derivatives
US7470521B2 (en) * 2004-07-20 2008-12-30 Critical Therapeutics, Inc. RAGE protein derivatives
BRPI0514013A (pt) * 2004-08-03 2008-05-27 Transtech Pharma Inc proteìnas de fusão do rage e métodos de uso
EP2457901A1 (en) * 2005-03-14 2012-05-30 High Point Pharmaceuticals, LLC Benzazole derivatives, compositions, and methods of use as B-secretase inhibitors
US20070087406A1 (en) * 2005-05-04 2007-04-19 Pei Jin Isoforms of receptor for advanced glycation end products (RAGE) and methods of identifying and using same
AU2006261845C1 (en) 2005-06-27 2013-05-16 Exelixis Patent Company Llc Imidazole based LXR modulators
WO2007008942A2 (en) * 2005-07-11 2007-01-18 Aerie Pharmaceuticals, Inc. Phenylamino-acetic acid [1-(pyridin-4-yl)-methylidene]-hydrazide derivatives and related compounds as modulators of g protein-coupled receptor kinases for the treatment of eye diseases
US7470787B2 (en) * 2005-07-11 2008-12-30 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
US20070078263A1 (en) * 2005-09-21 2007-04-05 Decode Chemistry, Inc. Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation
ATE533485T1 (de) 2005-10-31 2011-12-15 Merck Sharp & Dohme Cetp-inhibitoren
EP1991544B1 (en) * 2006-01-30 2018-08-15 vTv Therapeutics LLC Substituted imidazole derivatives and their use as ptpase inhibitors
MX2008010187A (es) 2006-02-10 2008-10-31 Summit Corp Plc Tratamiento de distrofia muscular de duchenne.
FR2900404B1 (fr) * 2006-04-27 2008-07-18 Sod Conseils Rech Applic Nouveaux derives d'imidazoles, leur preparation et leur utilisation en tant que medicament
EP2038274A2 (en) * 2006-06-23 2009-03-25 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CN101511796B (zh) 2006-09-05 2012-05-09 协和发酵麒麟株式会社 咪唑衍生物
EP2526948A1 (en) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO kinase inhibitors
WO2008083124A1 (en) 2006-12-28 2008-07-10 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
JP2010523559A (ja) * 2007-04-05 2010-07-15 トランス テック ファーマ，インコーポレイテッド ［３−（４−｛２−ブチル−１−［４−（４−クロロ−フェノキシ）−フェニル］−１ｈ−イミダゾール−４−イル｝−フェノキシ）−プロピル］−ジエチルアミンの結晶形態
WO2008153957A1 (en) * 2007-06-07 2008-12-18 The Trustees Of Columbia University In The City Of New York Uses of rage antagonists for treating obesity and related diseases
SI2170396T1 (sl) * 2007-08-03 2017-04-26 Summit (Oxford) Limited Kombinacije zdravil za zdravljenje duchennove mišične distrofije
GB0715937D0 (en) * 2007-08-15 2007-09-26 Vastox Plc Method of treatment og duchenne muscular dystrophy
US8138168B1 (en) 2007-09-26 2012-03-20 Takeda Pharmaceutical Company Limited Renin inhibitors
JP5620821B2 (ja) * 2007-12-13 2014-11-05 シエナ ビオテク ソシエタ ペル アチオニＳｉｅｎａ Ｂｉｏｔｅｃｈ Ｓ．Ｐ．Ａ． ヘッジホッグ経路拮抗薬およびその治療用途
US8455514B2 (en) * 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
EP2240159A2 (en) * 2008-02-05 2010-10-20 Actavis Group PTC EHF Alendronate formulations, method of making and method of use thereof
JP2011511078A (ja) * 2008-02-06 2011-04-07 レアド トヘラペウトイクス，インコーポレーテッド ポリ（ａｄｐリボース）ポリメラーゼ（ｐａｒｐ）のベンズオキサゾールカルボキサミド阻害剤
CN101990433B (zh) 2008-02-07 2014-11-05 马萨诸塞眼科耳科诊所 提高Atoh1表达的化合物
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8436025B2 (en) * 2008-09-19 2013-05-07 CompleGen Partners, Inc. Compounds and methods for PKC theta inhibition
CN102177151A (zh) * 2008-10-09 2011-09-07 弗·哈夫曼-拉罗切有限公司 β-淀粉样蛋白的调节剂
WO2010050445A1 (ja) * 2008-10-27 2010-05-06 武田薬品工業株式会社 二環性化合物
WO2010103306A1 (en) * 2009-03-10 2010-09-16 Astrazeneca Uk Limited Benzimidazole derivatives and their use as antivaral agents
EP2424533A4 (en) 2009-04-27 2012-10-17 High Point Pharmaceuticals Llc SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE AS-SECRETASE INHIBITORS
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
TWI517850B (zh) 2009-09-30 2016-01-21 Ｖｔｖ治療有限責任公司 經取代之咪唑衍生物及其使用方法
JP5894540B2 (ja) * 2010-02-18 2016-03-30 ブイティーブイ・セラピューティクス・エルエルシー フェニル−ヘテロアリール誘導体とその使用の方法
EP2549874A4 (en) 2010-03-23 2013-10-02 High Point Pharmaceuticals Llc SUBSTITUTED IMIDAZOLE [1,2-B] PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS
WO2013074820A1 (en) 2011-11-16 2013-05-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Immunogenic tumor associated stromal cell antigen peptides and methods of their use
KR101415174B1 (ko) * 2012-04-26 2014-07-04 (주) 메디프론디비티 신규한 벤조옥사졸계 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 ｒａｇｅ 수용체 관련 질환의 예방 또는 치료용 약학적 조성물
JP6566868B2 (ja) * 2012-10-05 2019-08-28 ブイティーブイ・セラピューティクス・エルエルシー 軽度および中等度アルツハイマー病の処置
US9717710B2 (en) 2012-10-05 2017-08-01 Vtv Therapeutics Llc Treatment of mild and moderate Alzheimer's disease
CN110396085B (zh) 2013-03-15 2024-11-15 爱尔康公司 联合治疗
WO2015050984A1 (en) 2013-10-01 2015-04-09 New York University Amino, amido, and heterocyclic compounds as modulators of rage activity and uses thereof
US10040767B2 (en) * 2014-05-15 2018-08-07 Peloton Therapeutics, Inc. Benzimidazole derivatives and uses thereof
JP6580074B2 (ja) * 2014-05-23 2019-09-25 アクティブ バイオテック エイビー Ｓ１００阻害薬として有用な新規化合物
EP3015459A1 (en) * 2014-10-30 2016-05-04 Sanofi Benzylhydroxyde derivatives, preparation thereof and therapeutic use thereof
EP3307781B8 (en) 2015-06-10 2020-12-02 The Broad Institute, Inc. Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia
WO2017086941A1 (en) 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
WO2017151376A1 (en) * 2016-03-01 2017-09-08 Vtv Therapeutics Llc Piperidine derivative and methods of use thereof
EP3445170A4 (en) 2016-04-18 2019-11-20 New York University Quinoline compounds as modulators of rage activity and uses thereof
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
CN109896986B (zh) * 2017-12-07 2022-03-15 中国医学科学院药物研究所 木脂素类天然产物4-o-甲基三白草醇的结构简化物，其制法和其药物组合物与用途
WO2019190822A1 (en) 2018-03-28 2019-10-03 Vtv Therapeutics Llc Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine
WO2019190823A1 (en) 2018-03-28 2019-10-03 Vtv Therapeutics Llc Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
EP3864008A1 (en) 2018-10-10 2021-08-18 vTv Therapeutics LLC Metabolites of [3-(4-{2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lh-imidazol-4-yl } -phen ox y)-prop yl] -diethyl-amine
WO2020086388A1 (en) 2018-10-22 2020-04-30 Vtv Therapeutics Llc Glucokinase activator compositions for the treatment of cognitive impairment
WO2021026185A1 (en) * 2019-08-08 2021-02-11 New York University Indole compounds as modulators of rage activity and uses thereof
KR102532692B1 (ko) * 2021-03-15 2023-05-16 (주)피알지에스앤텍 신경섬유종증 2형 증후군 예방 또는 치료용 조성물
CN115594642B (zh) * 2021-06-28 2024-12-27 广西医科大学 阿齐瑞格三氮唑衍生物及其抗乳腺癌用途
EP4558141A4 (en) * 2022-07-20 2025-08-06 Hadasit Medical Res Services&Development Ltd COMBINATION FOR THE TREATMENT OF RETINAL DISEASE
KR102896914B1 (ko) * 2022-12-27 2025-12-09 (주)피알지에스앤텍 신규 화합물 제조방법
US11648235B1 (en) * 2022-12-30 2023-05-16 Cantex Pharmaceuticals, Inc. Treatment of glioblastoma
WO2024184479A1 (en) 2023-03-08 2024-09-12 Institut National de la Santé et de la Recherche Médicale Methods for the treatment of food allergy
CN116785311A (zh) * 2023-07-17 2023-09-22 华中科技大学同济医学院附属梨园医院 Rage基因表达拮抗剂的应用及包含该拮抗剂的药物
WO2025146850A1 (ko) * 2024-01-05 2025-07-10 (주)피알지에스앤텍 신규 화합물 제조방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586806A1 (de) * 1992-07-13 1994-03-16 Hoechst Aktiengesellschaft Verwendung von 2-(N-(2-Aminoethyl)amino)-essigsäure-derivaten zur Behandlung von Erkrankungen, die durch die nichtenzymatische Glykosylierung bedingt sind
US5358960A (en) * 1984-03-19 1994-10-25 The Rockefeller University Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US552317A (en) * 1895-12-31 Cigar-mold
US361983A (en) 1887-04-26 Edwin f
NL7017486A (enExample) * 1969-12-15 1971-06-17
US3708598A (en) * 1970-07-10 1973-01-02 Sandoz Ag Substituted 2,4-(omega-aminoalkoxy)phenyl imidazoles as cholesterol reducing agents
US4024271A (en) * 1971-03-09 1977-05-17 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
IL55573A0 (en) 1977-10-03 1978-12-17 Erba Carlo Spa Substituted n-(ss-alkoxy-ethyl)-n-(4-phenoxybenzyl)-dichloroacetamides and process for their preparation
US4356108A (en) * 1979-12-20 1982-10-26 The Mead Corporation Encapsulation process
US4265874A (en) * 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4356106A (en) * 1980-05-09 1982-10-26 United Kingdom Atomic Energy Authority Cerium compounds
US5202424A (en) * 1984-03-19 1993-04-13 The Rockefeller University Mesangial cell-derived receptors for advanced glycosylation endproducts and uses thereof
US5585344A (en) * 1984-03-19 1996-12-17 The Rockefeller University Liver-derived receptors for advanced glycosylation endproducts and uses thereof
US4873313A (en) * 1985-01-18 1989-10-10 Beckman Research Institute Of City Of Hope Specific hybridoma cell line and monocolonal antibodies produced from such specific hybridoma cell line and method of using such monoclonal antibodies to detect carcinoembryonic antigens
US4963539A (en) * 1987-09-10 1990-10-16 E. R. Squibb & Sons, Inc. Phosphonate and phosphonamide endopeptidase inhibitors
US4963422A (en) * 1987-10-28 1990-10-16 National Starch And Chemical Investment Holding Corporation Ethylene vinyl acetate alkyl acrylate compositions for flocking adhesives
DE3815234A1 (de) * 1988-05-05 1989-11-16 Sueddeutsche Kalkstickstoff Beschleuniger fuer cyanamid enthaltende epoxidhaerter
EP0352581A3 (de) * 1988-07-28 1990-07-04 F. Hoffmann-La Roche Ag Aethylendiaminmonoamid-Derivate
US5318984A (en) * 1988-12-05 1994-06-07 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
US5166214A (en) * 1988-12-05 1992-11-24 Du Pont Merck Pharmaceutical Company Use of imidazoles for the treatment of atherosclerosis
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
US5192785A (en) * 1989-09-03 1993-03-09 A. H. Robins Company, Incorporated Sulfamates as antiglaucoma agents
DE4015535A1 (de) * 1990-05-15 1991-11-21 Basf Ag Verfahren zur herstellung von n-substituierten imidazolen
US5192789A (en) 1991-01-18 1993-03-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds
US5500463A (en) * 1991-03-11 1996-03-19 Nippon Paint Co., Ltd. Aqueous resin composition and method for forming coating film on can body
MX9205392A (es) 1991-10-29 1993-04-01 Du Pont Triazolcarbozamidas herbicidas y procedimiento para su obtencion.
CA2085844A1 (en) * 1991-12-27 1993-06-28 Nobuyuki Hamanaka Fused benzeneoxyacetic acid derivatives
JPH0656665A (ja) 1992-08-03 1994-03-01 Nippon Chemiphar Co Ltd イミダゾール誘導体を含有する胃溶性抗潰瘍剤
JPH0680656A (ja) 1992-09-03 1994-03-22 Mitsui Petrochem Ind Ltd 光学活性エポキシドの製造方法
JPH07304748A (ja) 1993-06-29 1995-11-21 Nissan Chem Ind Ltd アルドキシム誘導体および農園芸用殺菌剤
JPH0770083A (ja) 1993-07-05 1995-03-14 Nippon Chemiphar Co Ltd イミダゾール誘導体を有効成分とする血圧降下剤
US5523317A (en) * 1993-07-05 1996-06-04 Nippon Chemiphar Co., Ltd. Method of reducing blood pressure
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
ES2170104T3 (es) 1993-10-01 2002-08-01 Merrell Pharma Inc Inhibidores de la produccion de proteinas de beta-amiloide.
EP0754042A4 (en) * 1994-03-29 2004-06-23 Merck & Co Inc TREATING ATHEROSCLEROSIS WITH IMIDAZOLES BLOCKING THE ANGIOTENSIN II RECEPTOR
GB9406573D0 (en) * 1994-03-31 1994-05-25 Merck Sharp & Dohme Medicaments
GB9409150D0 (en) 1994-05-09 1994-06-29 Black James Foundation Cck and gastrin receptor ligands
US5597845A (en) 1994-06-20 1997-01-28 Merrell Pharmaceuticals Inc. Substituted alkyldiamine derivatives
US5939526A (en) * 1995-03-21 1999-08-17 Ludwig Institute For Cancer Research Isolated RAGE-1 derived peptides which complex with HLA-B7 molecules and uses thereof
AU700693B2 (en) 1995-04-13 1999-01-14 Aventis Pharmaceuticals Inc. Novel substituted piperazine derivatives having tachykinin receptor antagonists activity
JP3849157B2 (ja) 1995-08-01 2006-11-22 東ソー株式会社 ２−イミダゾリン類の製造法
US6228858B1 (en) 1995-09-12 2001-05-08 University Of Kansas Medical Center Advanced glycation end-product intermediaries and post-amadori inhibition
US5843904A (en) 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
AU1832797A (en) 1996-01-26 1997-08-20 Trustees Of Columbia University In The City Of New York, The A polypeptide from lung extract which binds amyloid-beta peptide
US6673927B2 (en) * 1996-02-16 2004-01-06 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Farnesyl transferase inhibitors
US5864018A (en) * 1996-04-16 1999-01-26 Schering Aktiengesellschaft Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor
AU2696097A (en) 1996-04-16 1997-11-07 Schering Aktiengesellschaft Advanced glycosylation end-product receptor peptides and uses therefor
US5688653A (en) * 1996-06-27 1997-11-18 The Picower Institute For Medical Research 3-alkylamino-2-hydroxy-4-hydroxymethyl-2-cyclopenten-1-one advanced glycosylation endproducts and methods of use therefor
US6416733B1 (en) * 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
US6555651B2 (en) 1997-10-09 2003-04-29 The Trustees Of Columbia University In The City Of New York Ligand binding site of rage and uses thereof
US6790443B2 (en) 1996-11-22 2004-09-14 The Trustees Of Columbia University In The City Of New York Method for treating symptoms of diabetes
US7258857B2 (en) * 1996-11-22 2007-08-21 The Trustees Of Columbia University In The City Of New York Rage-related methods for treating inflammation
US6201002B1 (en) * 1997-01-10 2001-03-13 Merck & Co., Inc. Method for reducing mortality with an angiotensin II antagonist
US5962535A (en) * 1997-01-17 1999-10-05 Takeda Chemical Industries, Ltd. Composition for alzheimer's disease
US6004958A (en) 1997-02-05 1999-12-21 Fox Chase Cancer Center Compounds and methods for therapeutic intervention in preventing diabetic complications and procedures for assessing a diabetic's risk of developing complications and determining the efficacy of therapeutic intervention
US6100098A (en) * 1997-02-18 2000-08-08 Mcgill University Anti-AGE IgG and uses thereof for the diagnosis of severe disease
CN1252793A (zh) * 1997-02-18 2000-05-10 美国家用产品公司 4－氨基烷氧基－1h－苯并咪唑衍生物、它们的制备方法以及它们作为多巴胺自身受体(d2)激动剂的用途
PL335401A1 (en) 1997-02-27 2000-04-25 American Cyanamid Co N-hydroxy-2-(alkyl, aryl or heteroaryl sulphanyl, sulphinyn of sulphonyl)-3-substituted alkyl, aryl or heteroaryl amides as inhibotors of intercellular substance metaloproteinases
US6197791B1 (en) * 1997-02-27 2001-03-06 American Cyanamid Company N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US5817823A (en) * 1997-04-17 1998-10-06 Sepracor Inc. Method for synthesizing 2-substituted imidazoles
US7101838B2 (en) * 1997-08-05 2006-09-05 The Trustees Of Columbia University In The City Of New York Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts
FR2767527B1 (fr) * 1997-08-25 1999-11-12 Pf Medicament Derives de piperazines indoliques, utiles comme medicaments et procede de preparation
EP1017682A4 (en) * 1997-09-26 2000-11-08 Merck & Co Inc NEW ANGIOGENESIS INHIBITORS
HUP9902721A2 (hu) * 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
FR2773800B1 (fr) * 1998-01-20 2000-02-18 Synthelabo Derives de benzimidazole, leur procede de preparation et leur application en therapeutique
WO1999043210A1 (en) * 1998-02-25 1999-09-02 Merck & Co., Inc. Method for decreasing qt dispersion or inhibiting the progression of qt dispersion with an angiotensin ii receptor antagonist
EP1066247B1 (en) 1998-03-31 2006-11-22 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
US6465422B1 (en) 1998-04-17 2002-10-15 The Trustees Of Columbia University In The City Of New York Method for inhibiting tumor invasion or spreading in a subject
FR2780404B1 (fr) * 1998-06-26 2001-04-13 Adir Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU1199600A (en) * 1998-10-02 2000-04-26 Board Of Trustees Of The University Of Illinois, The Estrogen receptor ligands
US6753150B2 (en) 1998-10-05 2004-06-22 The Trustees Of Columbia University In The City Of New York Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage
EP1121454B1 (en) 1998-10-06 2007-11-14 The Trustees of Columbia University in the City of New York Extracellular novel rage binding protein (en-rage) and uses thereof
CO5210925A1 (es) * 1998-11-17 2002-10-30 Novartis Ag Derivados de diamino nitroguanidina tetrasustituidos
EP1140941B1 (en) * 1998-12-23 2004-10-20 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor xa inhibitors
DE19859809A1 (de) 1998-12-23 2000-06-29 Henkel Kgaa Mittel zum Färben von keratinhaltigen Fasern
EP1210087A2 (en) * 1999-04-29 2002-06-05 City of Hope Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (age's)
IT1313601B1 (it) * 1999-08-05 2002-09-09 Isagro Ricerca Srl Fenilpirazoli ad attivita' erbicida
CA2389773A1 (en) * 1999-11-05 2001-05-10 Robert Glen Activators of soluble guanylate cyclase
US6613801B2 (en) * 2000-05-30 2003-09-02 Transtech Pharma, Inc. Method for the synthesis of compounds of formula I and their uses thereof
AU2001266505A1 (en) * 2000-06-28 2002-01-08 Astrazeneca Ab Substituted quinazoline derivatives and their use as inhibitors
CA2410391A1 (en) * 2000-06-28 2002-11-28 Ssp Co., Ltd. Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts
US6541639B2 (en) * 2000-07-26 2003-04-01 Bristol-Myers Squibb Pharma Company Efficient ligand-mediated Ullmann coupling of anilines and azoles
US6825164B1 (en) 2000-08-14 2004-11-30 The Trustees Of Columbia University In The City Of New York Method to increase cerebral blood flow in amyloid angiopathy
WO2002032877A2 (en) * 2000-10-16 2002-04-25 Chugai Seiyaku Kabushiki Kaisha Process for preparation of n-substituted 2-sulfanylimidazoles
US6441064B1 (en) * 2000-11-01 2002-08-27 Air Products And Chemicals, Inc. Imidazole-phosphoric acid salts as accelerators for dicyandiamide in one-component epoxy compositions
CN1494425B (zh) * 2001-03-05 2011-12-07 特兰斯泰克制药公司 用作治疗剂的羧酰胺衍生物
JP2004523565A (ja) * 2001-03-05 2004-08-05 トランス　テック　ファーマ，インコーポレイテッド 治療因子としてのベンゾイミダゾール誘導体
JP2003012690A (ja) 2001-07-03 2003-01-15 Mitsui Chemicals Inc 置換イミダゾール誘導体又は置換ベンズイミダゾール誘導体を用いたヌクレオチドの製造法
JP2003040888A (ja) 2001-07-30 2003-02-13 Sankyo Co Ltd イミダゾール誘導体
FR2829765A1 (fr) 2001-09-14 2003-03-21 Lipha Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique
EP1458385A4 (en) 2001-12-19 2005-12-21 Merck & Co Inc METABOTROPIC GLUTAMATE RECEPTOR 5-HETEROARYL-SUBSTITUTED IMIDAZOLE MODULATORS
ATE529110T1 (de) * 2002-03-05 2011-11-15 Transtech Pharma Inc Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
US7026312B2 (en) 2002-03-14 2006-04-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
AU2003216579A1 (en) 2002-04-12 2003-10-27 Pfizer Inc. Imidazole compounds as anti-inflammatory and analgesic agents
JP2003313172A (ja) 2002-04-23 2003-11-06 Tosoh Corp Ｎ−置換イミダゾール化合物の製造方法
JP4529342B2 (ja) 2002-04-23 2010-08-25 東ソー株式会社 環状アミジニウム有機酸塩の製造方法
US7077873B2 (en) 2002-09-10 2006-07-18 L'Oréal, SA Composition for the dyeing of human keratinous fibres comprising a monocationic monoazo dye
AU2003280373A1 (en) 2002-10-15 2004-05-04 Novartis Ag Method of administering bisphosphonates
AU2003302106A1 (en) 2002-11-21 2004-06-15 Vicore Pharma Ab New tricyclic angiotensin ii agonists
JP2004221557A (ja) 2002-12-25 2004-08-05 Sanyo Chem Ind Ltd 電解液
CA2516830A1 (en) * 2003-02-24 2004-09-10 Autocell Laboratories, Inc. System and method for channel selection in a wireless network
EP1613615A2 (en) 2003-04-03 2006-01-11 Merck & Co., Inc. 4-ring imidazole derivatives as modulators of metabotropic glutamate receptor-5
EP1635823A1 (en) 2003-05-20 2006-03-22 TransTech Pharma Inc. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
MXPA06002214A (es) 2003-08-26 2006-04-27 Ecole Polytech Liquidos ionicos basados en sales de imidazolio que incorporan una funcionalidad de nitrilo.
DE102004050176A1 (de) * 2004-09-20 2006-03-23 Universität Duisburg-Essen Optoelektronisches Bauelement und Verfahren zum Steuern von Tunnelelektronenströmen durch Photonen
CA2484381C (en) * 2004-10-08 2013-03-19 Anne Marie Sedgwick Supporting device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358960A (en) * 1984-03-19 1994-10-25 The Rockefeller University Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles
EP0586806A1 (de) * 1992-07-13 1994-03-16 Hoechst Aktiengesellschaft Verwendung von 2-(N-(2-Aminoethyl)amino)-essigsäure-derivaten zur Behandlung von Erkrankungen, die durch die nichtenzymatische Glykosylierung bedingt sind

Also Published As

Publication number Publication date
EP1482931A2 (en) 2004-12-08
JP2009096806A (ja) 2009-05-07
JP4481011B2 (ja) 2010-06-16
EP2324830A1 (en) 2011-05-25
WO2003075921A3 (en) 2003-12-04
DK1482931T3 (da) 2011-12-19
WO2003075921A2 (en) 2003-09-18
US7714013B2 (en) 2010-05-11
CA2476594C (en) 2012-10-09
CA2476594A1 (en) 2003-09-18
HK1069549A1 (en) 2005-05-27
ATE529110T1 (de) 2011-11-15
US20070213347A1 (en) 2007-09-13
AU2009202814A1 (en) 2009-08-06
ES2373875T3 (es) 2012-02-09
JP2005525378A (ja) 2005-08-25
US20100256119A1 (en) 2010-10-07
AU2007202350A1 (en) 2007-06-14
CN100525763C (zh) 2009-08-12
US7737285B2 (en) 2010-06-15
US20070021386A1 (en) 2007-01-25
EP1482931B1 (en) 2011-10-19
CN101597262A (zh) 2009-12-09
CN1633290A (zh) 2005-06-29
US7361678B2 (en) 2008-04-22
AU2009202814B2 (en) 2011-07-14
AU2003217943A1 (en) 2003-09-22
US20040082542A1 (en) 2004-04-29
US20120088778A1 (en) 2012-04-12
CN101613321A (zh) 2009-12-30

Similar Documents

Publication Publication Date Title
AU2007202350B2 (en) Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE
US7728026B2 (en) 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
CA2440042C (en) Carboxamide derivatives as therapeutic agents
US5017573A (en) Indazole-3-carboxylic acid derivatives
EP0399732A1 (en) Benzimidazole derivatives
US20030139450A1 (en) Substituted benzimidazole antiviral agents
AU2002245591A1 (en) Carboxamide derivatives as therapeutic agents
US6617347B1 (en) Selective β3 adrenergic agonists
US5352687A (en) Substituted phenylacetamides
CZ297792A3 (en) Cyclically substituted derivatives of imidazolyl-propenoic acid
DE4132631A1 (de) Imidazolyl-propensaeurederivate
AU2003217943B2 (en) Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with RAGE
SK66793A3 (en) Imidazolyl substituted derivatives of phenylpropane and cinnamon acid
AU2011226965A1 (en) Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage
HK1138578A (en) Mono and bicyclic azole derivatives that inhibit the interaction of ligands with rage
HK1138275A (en) Mono and bicyclic azole derivatives that inhibit the interaction of ligands with rage
HK1069549B (en) Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage
SK14393A3 (en) Sulfonylbenzene substituted derivatives of imidazolylpropene acid
AU2007203289B2 (en) Carboxamide derivatives as therapeutic agents

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: TRANSTECH PHARMA, LLC

Free format text: FORMER OWNER WAS: TRANSTECH PHARMA, INC.

PC Assignment registered

Owner name: VTV THERAPEUTICS LLC

Free format text: FORMER OWNER WAS: VTV THERAPEUTICS LLC

MK14 Patent ceased section 143(a) (annual fees not paid) or expired