JP4435325B2 - 置換三環式化合物およびそれを含有する組成物 - Google Patents

置換三環式化合物およびそれを含有する組成物 Download PDF

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Publication number
JP4435325B2
JP4435325B2 JP10965699A JP10965699A JP4435325B2 JP 4435325 B2 JP4435325 B2 JP 4435325B2 JP 10965699 A JP10965699 A JP 10965699A JP 10965699 A JP10965699 A JP 10965699A JP 4435325 B2 JP4435325 B2 JP 4435325B2
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JP
Japan
Prior art keywords
mmol
alkyl
phenyl
benzyl
oxo
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Expired - Fee Related
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JP10965699A
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English (en)
Japanese (ja)
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JPH11322745A5 (https=
JPH11322745A (ja
Inventor
ニコラス・ジェイムズ・バック
ジョリー・アン・バスティアン
ダグラス・ウェイド・ベイト
マイケル・ディーン・キニック
マイケル・ジョン・マルティネリ
エドワード・デイビッド・ミヘリッチ
ジョン・マイケル・モリン・ジュニア
ダニエル・ジョン・サル
ジェイソン・スコット・ソーヤー
エドワード・シー・アール・スミス
テュリオ・スアレス
チウピン・ワン
トーマス・マイケル・ウィルソン
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of JPH11322745A publication Critical patent/JPH11322745A/ja
Publication of JPH11322745A5 publication Critical patent/JPH11322745A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP10965699A 1998-04-17 1999-04-16 置換三環式化合物およびそれを含有する組成物 Expired - Fee Related JP4435325B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6216598A 1998-04-17 1998-04-17
US09/062165 1998-04-17

Publications (3)

Publication Number Publication Date
JPH11322745A JPH11322745A (ja) 1999-11-24
JPH11322745A5 JPH11322745A5 (https=) 2007-04-05
JP4435325B2 true JP4435325B2 (ja) 2010-03-17

Family

ID=22040624

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10965699A Expired - Fee Related JP4435325B2 (ja) 1998-04-17 1999-04-16 置換三環式化合物およびそれを含有する組成物

Country Status (27)

Country Link
EP (2) EP0950661B1 (https=)
JP (1) JP4435325B2 (https=)
KR (1) KR19990083234A (https=)
CN (1) CN1235968A (https=)
AR (1) AR018185A1 (https=)
AT (2) ATE254128T1 (https=)
AU (1) AU757454B2 (https=)
BR (1) BR9901275A (https=)
CA (1) CA2269256A1 (https=)
CO (1) CO5080728A1 (https=)
CZ (1) CZ137199A3 (https=)
DE (2) DE69912670T2 (https=)
EA (1) EA003129B1 (https=)
ES (2) ES2213668T3 (https=)
HU (1) HUP9901219A1 (https=)
ID (1) ID23219A (https=)
IL (1) IL129484A0 (https=)
NO (1) NO991823L (https=)
NZ (1) NZ335252A (https=)
PE (1) PE20000472A1 (https=)
PL (1) PL332564A1 (https=)
SG (1) SG106035A1 (https=)
SV (1) SV1999000052A (https=)
TR (1) TR199900842A2 (https=)
TW (1) TW555760B (https=)
YU (1) YU19099A (https=)
ZA (1) ZA992773B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2301586A1 (en) * 1997-08-28 1999-03-04 William Louis Macias Method for treatment of non-rheumatoid arthritis
WO2001074817A1 (en) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Hydrazide derivatives
EP1303262A2 (en) * 2000-07-14 2003-04-23 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
WO2002050029A2 (en) * 2000-12-18 2002-06-27 Eli Lilly And Company Tetracyclic derivatives as spla2 inhibitors
CA2441077A1 (en) 2001-03-28 2002-10-10 Eli Lilly And Company Substituted carbazoles as inhibitors of spla2
US7160909B2 (en) 2001-08-09 2007-01-09 Eli Lilly And Company Cyclopenta[b]indole derivatives as sPLA2 inhibitors
US7109231B2 (en) 2001-08-09 2006-09-19 Eli Lilly And Company Cyclohept[b]indole derivatives
US6992100B2 (en) 2001-12-06 2006-01-31 Eli Lilly And Company sPLA2 inhibitors
WO2006050007A2 (en) 2004-11-01 2006-05-11 Wyeth Substituted indolizines and derivatives as cns agents
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
DK2697223T3 (en) * 2011-04-14 2016-09-05 Actelion Pharmaceuticals Ltd 7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor
SI2825541T1 (sl) 2012-03-16 2016-10-28 Vitae Pharmaceuticals, Inc. Modulatorji jetrnega receptorja X
ES2607113T3 (es) 2012-03-16 2017-03-29 Vitae Pharmaceuticals, Inc. Moduladores de los receptores X del hígado

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
BR9508298A (pt) * 1994-07-21 1998-11-03 Shionogi & Co Inibidores de indolizina de spla2
EP0779271B1 (en) * 1995-12-13 2001-08-01 Eli Lilly And Company Naphthyl acetamides as sPLA2 inhibitors
CA2269203A1 (en) * 1996-10-30 1998-05-07 Nicholas James Bach Substituted tricyclics
EP1007056A1 (en) * 1997-09-26 2000-06-14 Eli Lilly And Company Method for the treatment of cystic fibrosis
WO1999025340A1 (en) * 1997-11-14 1999-05-27 Eli Lilly And Company Treatment for alzheimer's disease

Also Published As

Publication number Publication date
EP1156050A2 (en) 2001-11-21
BR9901275A (pt) 2000-05-02
AR018185A1 (es) 2001-10-31
SG106035A1 (en) 2004-09-30
DE69914951T2 (de) 2004-12-23
TR199900842A2 (xx) 2000-09-21
ZA992773B (en) 2002-07-16
EP1156050A3 (en) 2001-11-28
SV1999000052A (es) 2000-03-14
KR19990083234A (ko) 1999-11-25
ATE259818T1 (de) 2004-03-15
AU2381899A (en) 1999-10-28
NZ335252A (en) 2000-11-24
CO5080728A1 (es) 2001-09-25
ID23219A (id) 2000-03-30
CZ137199A3 (cs) 1999-11-17
YU19099A (sh) 2001-09-28
DE69914951D1 (de) 2004-03-25
DE69912670D1 (de) 2003-12-18
ES2210979T3 (es) 2004-07-01
CN1235968A (zh) 1999-11-24
EA199900304A3 (ru) 2000-04-24
EA199900304A2 (ru) 1999-10-28
EP1156050B1 (en) 2004-02-18
TW555760B (en) 2003-10-01
PL332564A1 (en) 1999-10-25
PE20000472A1 (es) 2000-06-02
ATE254128T1 (de) 2003-11-15
IL129484A0 (en) 2000-02-29
ES2213668T3 (es) 2004-09-01
NO991823L (no) 1999-10-18
AU757454B2 (en) 2003-02-20
HU9901219D0 (en) 1999-06-28
DE69912670T2 (de) 2004-08-12
JPH11322745A (ja) 1999-11-24
CA2269256A1 (en) 1999-10-17
HUP9901219A1 (hu) 2000-08-28
EA003129B1 (ru) 2003-02-27
NO991823D0 (no) 1999-04-16
EP0950661B1 (en) 2003-11-12
EP0950661A1 (en) 1999-10-20

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