JP4283474B2 - ヒト化抗−ＥｒｂＢ２抗体及び抗−ＥｒｂＢ２抗体を用いた治療 - Google Patents

ヒト化抗−ＥｒｂＢ２抗体及び抗−ＥｒｂＢ２抗体を用いた治療 Download PDF

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Publication number
JP4283474B2
JP4283474B2 JP2001505952A JP2001505952A JP4283474B2 JP 4283474 B2 JP4283474 B2 JP 4283474B2 JP 2001505952 A JP2001505952 A JP 2001505952A JP 2001505952 A JP2001505952 A JP 2001505952A JP 4283474 B2 JP4283474 B2 JP 4283474B2
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antibody
erbb2
cells
antibodies
cancer
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Expired - Lifetime
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Japanese (ja)
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JP2003503366A5 (Direct
JP2003503366A (ja
Inventor
アダムス，カメリア，ダブリュ．
プレスタ，レオナード，ジー．
スリューコースキー，マーク
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
JP2001505952A 1999-06-25 2000-06-23 ヒト化抗−ＥｒｂＢ２抗体及び抗−ＥｒｂＢ２抗体を用いた治療 Expired - Lifetime JP4283474B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14131699P 1999-06-25 1999-06-25
US60/141,316 1999-06-25
PCT/US2000/017366 WO2001000245A2 (en) 1999-06-25 2000-06-23 HUMANIZED ANTI-ErbB2 ANTIBODIES AND TREATMENT WITH ANTI-ErbB2 ANTIBODIES

Related Child Applications (1)

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JP2008333670A Division JP2009142280A (ja) 1999-06-25 2008-12-26 ヒト化抗−ＥｒｂＢ２抗体及び抗−ＥｒｂＢ２抗体を用いた治療

Publications (3)

Publication Number Publication Date
JP2003503366A JP2003503366A (ja) 2003-01-28
JP2003503366A5 JP2003503366A5 (Direct) 2008-06-05
JP4283474B2 true JP4283474B2 (ja) 2009-06-24

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JP2001505952A Expired - Lifetime JP4283474B2 (ja) 1999-06-25 2000-06-23 ヒト化抗−ＥｒｂＢ２抗体及び抗−ＥｒｂＢ２抗体を用いた治療
JP2008333670A Withdrawn JP2009142280A (ja) 1999-06-25 2008-12-26 ヒト化抗−ＥｒｂＢ２抗体及び抗−ＥｒｂＢ２抗体を用いた治療

Family Applications After (1)

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JP2008333670A Withdrawn JP2009142280A (ja) 1999-06-25 2008-12-26 ヒト化抗−ＥｒｂＢ２抗体及び抗−ＥｒｂＢ２抗体を用いた治療

Country Status (32)

Country Link
EP (2) EP2112167A3 (Direct)
JP (2) JP4283474B2 (Direct)
KR (2) KR100850389B1 (Direct)
CN (4) CN100340575C (Direct)
AR (1) AR024464A1 (Direct)
AT (2) ATE437655T1 (Direct)
AU (2) AU784045B2 (Direct)
BE (1) BE2013C020I2 (Direct)
BR (2) BRPI0012198B8 (Direct)
CA (2) CA2727172A1 (Direct)
CH (1) CH694589A5 (Direct)
CY (2) CY1109525T1 (Direct)
CZ (1) CZ299702B6 (Direct)
DE (2) DE60042648D1 (Direct)
DK (1) DK1189641T5 (Direct)
ES (1) ES2329437T3 (Direct)
FR (1) FR13C0016I2 (Direct)
GB (1) GB2368796B (Direct)
GE (1) GEP20104998B (Direct)
HU (1) HU226742B1 (Direct)
IL (3) IL146954A0 (Direct)
LU (1) LU92164I2 (Direct)
MX (1) MXPA01013458A (Direct)
NO (3) NO328377B1 (Direct)
NZ (2) NZ516830A (Direct)
PL (2) PL203326B1 (Direct)
PT (1) PT1189641E (Direct)
RU (2) RU2270029C2 (Direct)
SI (3) SI1189641T1 (Direct)
TR (1) TR200103756T2 (Direct)
WO (1) WO2001000245A2 (Direct)
ZA (2) ZA200109786B (Direct)

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