JP4272537B2 - Ｙ型分鎖親水性ポリマー誘導体、それらの調製方法、前記誘導体および薬剤分子の結合生成物、ならびに前記結合生成物を含む医薬組成物 - Google Patents

Ｙ型分鎖親水性ポリマー誘導体、それらの調製方法、前記誘導体および薬剤分子の結合生成物、ならびに前記結合生成物を含む医薬組成物 Download PDF

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JP4272537B2
JP4272537B2 JP2003574704A JP2003574704A JP4272537B2 JP 4272537 B2 JP4272537 B2 JP 4272537B2 JP 2003574704 A JP2003574704 A JP 2003574704A JP 2003574704 A JP2003574704 A JP 2003574704A JP 4272537 B2 JP4272537 B2 JP 4272537B2
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世山 ▲稽▼
▲徳▼▲權▼ 朱
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北京鍵▲凱▼科技有限公司
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Materials For Medical Uses (AREA)
JP2003574704A 2002-03-13 2003-03-12 Ｙ型分鎖親水性ポリマー誘導体、それらの調製方法、前記誘導体および薬剤分子の結合生成物、ならびに前記結合生成物を含む医薬組成物 Expired - Fee Related JP4272537B2 (ja)

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Application Number Priority Date Filing Date Title
CN0200147 2002-03-13
PCT/CN2003/000179 WO2003076490A1 (en) 2002-03-13 2003-03-12 Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound

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JP2005520006A JP2005520006A (ja) 2005-07-07
JP2005520006A5 JP2005520006A5 (cg-RX-API-DMAC7.html) 2008-04-24
JP4272537B2 true JP4272537B2 (ja) 2009-06-03

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US (3) US8003089B2 (cg-RX-API-DMAC7.html)
EP (1) EP1496076B1 (cg-RX-API-DMAC7.html)
JP (1) JP4272537B2 (cg-RX-API-DMAC7.html)
CN (1) CN1243779C (cg-RX-API-DMAC7.html)
AT (1) ATE368066T1 (cg-RX-API-DMAC7.html)
AU (1) AU2003221291A1 (cg-RX-API-DMAC7.html)
DE (1) DE60315145T2 (cg-RX-API-DMAC7.html)
ES (1) ES2291620T3 (cg-RX-API-DMAC7.html)
WO (1) WO2003076490A1 (cg-RX-API-DMAC7.html)

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CN104109235B (zh) * 2014-05-30 2017-07-18 厦门赛诺邦格生物科技股份有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN106146325B (zh) * 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
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CN108530637B (zh) * 2017-03-05 2021-03-30 厦门赛诺邦格生物科技股份有限公司 一种单一功能化支化聚乙二醇的制备方法
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CN108530642B (zh) * 2017-11-24 2021-01-15 四川大学 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法
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DE60315145T2 (de) 2008-04-30
EP1496076A1 (en) 2005-01-12
DE60315145D1 (de) 2007-09-06
CN1243779C (zh) 2006-03-01
JP2005520006A (ja) 2005-07-07
ATE368066T1 (de) 2007-08-15
WO2003076490A1 (en) 2003-09-18
ES2291620T3 (es) 2008-03-01
US8003089B2 (en) 2011-08-23
US20050180946A1 (en) 2005-08-18
EP1496076A4 (en) 2006-06-21
US20100221213A1 (en) 2010-09-02
AU2003221291A1 (en) 2003-09-22
EP1496076B1 (en) 2007-07-25
CN1556828A (zh) 2004-12-22
US20110243892A1 (en) 2011-10-06
WO2003076490A8 (en) 2004-10-28

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