JP4177455B2 - 逆キメラおよびハイブリッドオリゴヌクレオチド - Google Patents
逆キメラおよびハイブリッドオリゴヌクレオチド Download PDFInfo
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- JP4177455B2 JP4177455B2 JP50953597A JP50953597A JP4177455B2 JP 4177455 B2 JP4177455 B2 JP 4177455B2 JP 50953597 A JP50953597 A JP 50953597A JP 50953597 A JP50953597 A JP 50953597A JP 4177455 B2 JP4177455 B2 JP 4177455B2
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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| US08/516,454 US5652356A (en) | 1995-08-17 | 1995-08-17 | Inverted chimeric and hybrid oligonucleotides |
| US08/516,454 | 1995-08-17 | ||
| PCT/US1996/013371 WO1997006662A2 (en) | 1995-08-17 | 1996-08-16 | Inverted chimeric and hybrid oligonucleotides |
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| JPH11512088A JPH11512088A (ja) | 1999-10-19 |
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| DE69433036T2 (de) | 1993-09-03 | 2004-05-27 | Isis Pharmaceuticals, Inc., Carlsbad | Aminoderivatisierte nukleoside und oligonukleoside |
| US6420549B1 (en) | 1995-06-06 | 2002-07-16 | Isis Pharmaceuticals, Inc. | Oligonucleotide analogs having modified dimers |
| US9096636B2 (en) * | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
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| DE69628864D1 (de) | 2003-07-31 |
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| WO1997006662A2 (en) | 1997-02-27 |
| PT1019428E (pt) | 2003-10-31 |
| DE69628864T2 (de) | 2004-05-06 |
| ES2315442T3 (es) | 2009-04-01 |
| AU6953896A (en) | 1997-03-12 |
| DK1019428T3 (da) | 2003-09-22 |
| CA2229811C (en) | 2012-01-03 |
| ATE243706T1 (de) | 2003-07-15 |
| EP1019428A2 (en) | 2000-07-19 |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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| EXPY | Cancellation because of completion of term |