JP3815496B2 - 酢酸アニリド誘導体を有効成分とする過活動膀胱治療剤 - Google Patents

酢酸アニリド誘導体を有効成分とする過活動膀胱治療剤 Download PDF

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JP3815496B2
JP3815496B2 JP2004549600A JP2004549600A JP3815496B2 JP 3815496 B2 JP3815496 B2 JP 3815496B2 JP 2004549600 A JP2004549600 A JP 2004549600A JP 2004549600 A JP2004549600 A JP 2004549600A JP 3815496 B2 JP3815496 B2 JP 3815496B2
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bladder
therapeutic agent
overactive bladder
active ingredient
test
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Expired - Lifetime
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Japanese (ja)
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JPWO2004041276A1 (ja
Inventor
俊行 高須
修一 佐藤
政志 鵜飼
龍也 丸山
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Astellas Pharma Inc
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Astellas Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2004549600A 2002-11-07 2003-11-04 酢酸アニリド誘導体を有効成分とする過活動膀胱治療剤 Expired - Lifetime JP3815496B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002323792 2002-11-07
JP2002323792 2002-11-07
PCT/JP2003/014065 WO2004041276A1 (ja) 2002-11-07 2003-11-04 酢酸アニリド誘導体を有効成分とする過活動膀胱治療剤

Publications (2)

Publication Number Publication Date
JPWO2004041276A1 JPWO2004041276A1 (ja) 2006-03-02
JP3815496B2 true JP3815496B2 (ja) 2006-08-30

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JP2004549600A Expired - Lifetime JP3815496B2 (ja) 2002-11-07 2003-11-04 酢酸アニリド誘導体を有効成分とする過活動膀胱治療剤

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US (5) US7750029B2 (enExample)
EP (1) EP1559427B1 (enExample)
JP (1) JP3815496B2 (enExample)
KR (1) KR100967070B1 (enExample)
CN (1) CN100406011C (enExample)
AT (1) ATE500827T1 (enExample)
AU (1) AU2003284700B2 (enExample)
BE (1) BE2013C040I2 (enExample)
BR (1) BR0316080A (enExample)
CA (1) CA2503570C (enExample)
CY (2) CY1111399T1 (enExample)
DE (1) DE60336334D1 (enExample)
DK (1) DK1559427T3 (enExample)
ES (1) ES2360353T3 (enExample)
FR (1) FR13C0032I2 (enExample)
HU (1) HUS1300027I1 (enExample)
IL (1) IL168121A (enExample)
LU (1) LU92218I2 (enExample)
MX (1) MXPA05004925A (enExample)
NL (1) NL300599I2 (enExample)
NO (2) NO334948B1 (enExample)
NZ (1) NZ539577A (enExample)
PL (1) PL211687B1 (enExample)
PT (1) PT1559427E (enExample)
RU (1) RU2321401C2 (enExample)
SI (1) SI1559427T1 (enExample)
WO (1) WO2004041276A1 (enExample)
ZA (1) ZA200503510B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10842780B2 (en) 2008-09-30 2020-11-24 Astellas Pharma Inc. Pharmaceutical composition for modified release
US11707451B2 (en) 2010-03-29 2023-07-25 Astellas Pharma Inc. Pharmaceutical composition for modified release
US12097189B1 (en) 2024-02-09 2024-09-24 Astellas Pharma Inc. Pharmaceutical composition for modified release

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DE10351271A1 (de) * 2003-10-31 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung zur Behandlung der Stressinkontinenz und/oder Mischinkontinenz
PT2216021E (pt) 2007-11-02 2012-11-06 Astellas Pharma Inc Composição farmacêutica para tratar uma bexiga hiperactiva
CA2709727A1 (en) * 2007-12-21 2009-07-02 Astellas Pharma Inc. Pharmaceutical composition for improving lower urinary tract symptoms
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WO2015162536A1 (en) * 2014-04-22 2015-10-29 Calyx Chemicals And Pharmaceuticals Ltd. Novel process for preparation of mirabegron and it's intermediate
CN104016943A (zh) * 2014-05-23 2014-09-03 苏州凯瑞医药科技有限公司 一种米拉贝隆的合成方法
CN104016877B (zh) * 2014-06-13 2017-02-15 南京海融制药有限公司 一种苯基乙酰胺类化合物及在制备米拉贝隆中的应用
CN104230840A (zh) * 2014-09-05 2014-12-24 安徽联创药物化学有限公司 米拉贝隆的合成方法
JP2017535567A (ja) 2014-11-20 2017-11-30 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ アルファ−アドレナリン受容体拮抗薬と組み合わせたデスモプレシンを含む方法及び組成物
CN104496841B (zh) * 2014-11-26 2017-01-25 南京工业大学 一种米拉贝隆中间体的合成方法
CN104744292A (zh) * 2015-03-11 2015-07-01 南京工业大学 (r)-2-((4-硝基苯乙基)氨基)-2-氧代-1-苯乙基乙酸酯或其衍生物的制备方法
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CN106278909B (zh) * 2016-08-12 2022-07-15 浙江华海药业股份有限公司 一种米拉贝隆中间体的后处理方法
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10842780B2 (en) 2008-09-30 2020-11-24 Astellas Pharma Inc. Pharmaceutical composition for modified release
US12059409B1 (en) 2008-09-30 2024-08-13 Astellas Pharma Inc. Pharmaceutical composition for modified release
US11707451B2 (en) 2010-03-29 2023-07-25 Astellas Pharma Inc. Pharmaceutical composition for modified release
US12097189B1 (en) 2024-02-09 2024-09-24 Astellas Pharma Inc. Pharmaceutical composition for modified release

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NZ539577A (en) 2007-06-29
NO20052691L (no) 2005-07-15
CA2503570C (en) 2011-04-19
ATE500827T1 (de) 2011-03-15
EP1559427A4 (en) 2007-05-30
US8835474B2 (en) 2014-09-16
BR0316080A (pt) 2005-09-27
PL376771A1 (pl) 2006-01-09
CY2013023I2 (el) 2015-10-07
PL211687B1 (pl) 2012-06-29
MXPA05004925A (es) 2005-08-18
US7750029B2 (en) 2010-07-06
US20060115540A1 (en) 2006-06-01
IL168121A (en) 2011-12-29
CN100406011C (zh) 2008-07-30
ES2360353T3 (es) 2011-06-03
US20090093529A1 (en) 2009-04-09
RU2005117367A (ru) 2006-01-20
BE2013C040I2 (enExample) 2023-03-07
RU2321401C2 (ru) 2008-04-10
KR100967070B1 (ko) 2010-07-01
AU2003284700A1 (en) 2004-06-07
USRE44872E1 (en) 2014-04-29
CY2013023I1 (el) 2015-10-07
FR13C0032I1 (enExample) 2013-08-09
LU92218I9 (enExample) 2019-01-17
NO334948B1 (no) 2014-08-04
NO20052691D0 (no) 2005-06-06
AU2003284700B2 (en) 2009-05-28
CA2503570A1 (en) 2004-05-21
KR20050072809A (ko) 2005-07-12
FR13C0032I2 (fr) 2014-03-07
EP1559427A1 (en) 2005-08-03
DE60336334D1 (de) 2011-04-21
NO2015001I2 (no) 2015-01-26
CN1711085A (zh) 2005-12-21
JPWO2004041276A1 (ja) 2006-03-02
SI1559427T1 (sl) 2011-06-30
WO2004041276A1 (ja) 2004-05-21
PT1559427E (pt) 2011-05-27
EP1559427B1 (en) 2011-03-09
CY1111399T1 (el) 2015-08-05
ZA200503510B (en) 2006-12-27
US20110230530A1 (en) 2011-09-22
NL300599I2 (enExample) 2017-01-03
HUS1300027I1 (hu) 2016-08-29
NO2015001I1 (no) 2015-01-19
LU92218I2 (fr) 2014-01-07
DK1559427T3 (da) 2011-04-26

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