BR0316080A - Remédio para bexiga superativa compreendendo derivado de ácido acético anildo como o ingrediente ativo - Google Patents
Remédio para bexiga superativa compreendendo derivado de ácido acético anildo como o ingrediente ativoInfo
- Publication number
- BR0316080A BR0316080A BR0316080-7A BR0316080A BR0316080A BR 0316080 A BR0316080 A BR 0316080A BR 0316080 A BR0316080 A BR 0316080A BR 0316080 A BR0316080 A BR 0316080A
- Authority
- BR
- Brazil
- Prior art keywords
- bladder
- remedy
- active ingredient
- acetic acid
- acid derivative
- Prior art date
Links
- 206010020853 Hypertonic bladder Diseases 0.000 title abstract 3
- 208000009722 Overactive Urinary Bladder Diseases 0.000 title abstract 3
- 208000020629 overactive bladder Diseases 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 150000001242 acetic acid derivatives Chemical class 0.000 title 1
- -1 2-Aminothiazol-4-yl Chemical group 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 230000008602 contraction Effects 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000005259 measurement Methods 0.000 abstract 2
- 230000001020 rhythmical effect Effects 0.000 abstract 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 230000027939 micturition Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000011552 rat model Methods 0.000 abstract 1
- 230000004648 relaxation of smooth muscle Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002323792 | 2002-11-07 | ||
| PCT/JP2003/014065 WO2004041276A1 (ja) | 2002-11-07 | 2003-11-04 | 酢酸アニリド誘導体を有効成分とする過活動膀胱治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0316080A true BR0316080A (pt) | 2005-09-27 |
Family
ID=32310425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0316080-7A BR0316080A (pt) | 2002-11-07 | 2003-11-04 | Remédio para bexiga superativa compreendendo derivado de ácido acético anildo como o ingrediente ativo |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US7750029B2 (enExample) |
| EP (1) | EP1559427B1 (enExample) |
| JP (1) | JP3815496B2 (enExample) |
| KR (1) | KR100967070B1 (enExample) |
| CN (1) | CN100406011C (enExample) |
| AT (1) | ATE500827T1 (enExample) |
| AU (1) | AU2003284700B2 (enExample) |
| BE (1) | BE2013C040I2 (enExample) |
| BR (1) | BR0316080A (enExample) |
| CA (1) | CA2503570C (enExample) |
| CY (2) | CY1111399T1 (enExample) |
| DE (1) | DE60336334D1 (enExample) |
| DK (1) | DK1559427T3 (enExample) |
| ES (1) | ES2360353T3 (enExample) |
| FR (1) | FR13C0032I2 (enExample) |
| HU (1) | HUS1300027I1 (enExample) |
| IL (1) | IL168121A (enExample) |
| LU (1) | LU92218I2 (enExample) |
| MX (1) | MXPA05004925A (enExample) |
| NL (1) | NL300599I2 (enExample) |
| NO (2) | NO334948B1 (enExample) |
| NZ (1) | NZ539577A (enExample) |
| PL (1) | PL211687B1 (enExample) |
| PT (1) | PT1559427E (enExample) |
| RU (1) | RU2321401C2 (enExample) |
| SI (1) | SI1559427T1 (enExample) |
| WO (1) | WO2004041276A1 (enExample) |
| ZA (1) | ZA200503510B (enExample) |
Families Citing this family (51)
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|---|---|---|---|---|
| DE10351271A1 (de) * | 2003-10-31 | 2005-06-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Zusammensetzung zur Behandlung der Stressinkontinenz und/oder Mischinkontinenz |
| SI2216021T1 (sl) * | 2007-11-02 | 2013-01-31 | Astellas Pharma Inc. | Farmacevtski sestavek za zdravljenje prekomerno aktivnega sečnega mehurja |
| EP2223690A4 (en) * | 2007-12-21 | 2011-02-23 | Astellas Pharma Inc | PHARMACEUTICAL COMPOSITION FOR THE REDUCTION OF LOWER HARNESS SYMPTOMS |
| PE20091825A1 (es) * | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| TWI478712B (zh) * | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| WO2010053068A1 (ja) * | 2008-11-07 | 2010-05-14 | 大日本住友製薬株式会社 | 新規で有用な下部尿路症状治療剤 |
| WO2010147830A2 (en) * | 2009-06-15 | 2010-12-23 | Auspex Pharmaceuticals, Inc. | Aminothiazole modulators of beta-3-adrenoreceptor |
| JP5849946B2 (ja) * | 2010-03-29 | 2016-02-03 | アステラス製薬株式会社 | 放出制御医薬組成物 |
| ES2665467T3 (es) | 2010-03-29 | 2018-04-25 | Astellas Pharma Inc. | Composición farmacéutica de liberación modificada |
| US9655885B2 (en) | 2011-05-18 | 2017-05-23 | Dr. Reddy's Laboratories Ltd. | Amorphous mirabegron and processes for crystal forms of mirabegron |
| IN2013CN09704A (enExample) | 2011-05-18 | 2015-07-03 | Reddys Lab Ltd Dr | |
| EP2832730A4 (en) | 2012-03-30 | 2015-09-09 | Astellas Pharma Inc | MIRABEGRAPHIC PHARMACEUTICAL COMPOSITION |
| TW201424772A (zh) | 2012-08-31 | 2014-07-01 | Astellas Pharma Inc | 經口投與用醫藥組成物 |
| WO2014132270A2 (en) * | 2013-02-27 | 2014-09-04 | Msn Laboratories Limited | Process for the preparation of 2-(2-aminothiazol-4-yl)-n-[4-(2-{[(2r)-2-hydroxy-2-phenyl ethyl]amino}ethyl)phenyl]acetamide monohydrochloride, its intermediates and polymorph thereof |
| CN103193730A (zh) * | 2013-04-17 | 2013-07-10 | 苏州永健生物医药有限公司 | 一种米拉贝隆的合成方法 |
| CN103193658A (zh) * | 2013-04-18 | 2013-07-10 | 苏州永健生物医药有限公司 | 一种（r）-2-对硝基苯乙胺基-1-苯乙醇及其盐的合成方法 |
| CN103232368B (zh) * | 2013-04-18 | 2015-08-12 | 苏州永健生物医药有限公司 | 一种(r)-4-硝基苯乙基-(2-羟基-2-苯乙基)-氨基甲酸叔丁酯的合成方法 |
| CN103232352B (zh) * | 2013-05-11 | 2015-12-23 | 苏州永健生物医药有限公司 | (r)-4-(2-(2-羟基-2-苯乙胺基)乙基)苯胺基甲酸叔丁基酯 |
| CN105579057A (zh) * | 2013-07-23 | 2016-05-11 | 阿勒根公司 | 包含与β-3-肾上腺素能受体激动剂组合的去氨加压素的方法和组合物 |
| ITMI20131653A1 (it) * | 2013-10-07 | 2015-04-08 | Dipharma Francis Srl | Forme cristalline di un agonista adrenergico |
| RU2550968C1 (ru) * | 2013-11-29 | 2015-05-20 | Федеральное государственное бюджетное учреждение "Научный центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации | Комплексный способ лечения пациенток с хроническими рецидивирующими циститами и рефрактерным гиперактивным мочевым пузырем |
| WO2015155664A1 (en) * | 2014-04-08 | 2015-10-15 | Suven Life Sciences Limited | An improved process for the preparation of 2-(2-aminothiazol-4-yl)-n-[4-(2-[[(2r)-2-hydroxy-2- phenylethyl]amino]-ethyl)phenyl]acetamide |
| WO2015162536A1 (en) * | 2014-04-22 | 2015-10-29 | Calyx Chemicals And Pharmaceuticals Ltd. | Novel process for preparation of mirabegron and it's intermediate |
| CN104016943A (zh) * | 2014-05-23 | 2014-09-03 | 苏州凯瑞医药科技有限公司 | 一种米拉贝隆的合成方法 |
| CN104016877B (zh) * | 2014-06-13 | 2017-02-15 | 南京海融制药有限公司 | 一种苯基乙酰胺类化合物及在制备米拉贝隆中的应用 |
| CN104230840A (zh) * | 2014-09-05 | 2014-12-24 | 安徽联创药物化学有限公司 | 米拉贝隆的合成方法 |
| CA2967390A1 (en) | 2014-11-20 | 2016-05-26 | Allergan, Inc. | Methods and compositions comprising desmopressin in combination with an alpha-adrenergic receptor antagonist |
| CN104496841B (zh) * | 2014-11-26 | 2017-01-25 | 南京工业大学 | 一种米拉贝隆中间体的合成方法 |
| CN104744292A (zh) * | 2015-03-11 | 2015-07-01 | 南京工业大学 | (r)-2-((4-硝基苯乙基)氨基)-2-氧代-1-苯乙基乙酸酯或其衍生物的制备方法 |
| JP2018090490A (ja) | 2015-03-31 | 2018-06-14 | アステラス製薬株式会社 | ミラベグロン含有医薬組成物 |
| JP6618736B2 (ja) | 2015-09-01 | 2019-12-11 | 沢井製薬株式会社 | ミラベグロン含有錠剤、ミラベグロン含有製剤の製造方法及びミラベグロン含有造粒物の製造方法 |
| CN106278909B (zh) * | 2016-08-12 | 2022-07-15 | 浙江华海药业股份有限公司 | 一种米拉贝隆中间体的后处理方法 |
| EP3360866B1 (en) | 2017-02-14 | 2019-01-02 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Mirabegron prodrugs |
| KR102051132B1 (ko) * | 2017-03-17 | 2019-12-02 | 주식회사 종근당 | 미라베그론 또는 이의 염을 포함하는 방출조절용 약제학적 조성물 |
| KR101868438B1 (ko) | 2017-04-13 | 2018-06-20 | (주) 성운파마코피아 | 아미드 유도체의 제조방법 |
| EP3636256B1 (en) | 2017-05-31 | 2024-07-03 | SBI Pharmaceuticals Co., Ltd. | Prophylactic or therapeutic agent for hyperactive bladder |
| KR20250099259A (ko) | 2017-06-06 | 2025-07-01 | 유로반트 사이언시즈 게엠베하 | 과민성 방광의 치료를 위한 비베그론의 용도 |
| KR102398639B1 (ko) | 2017-06-20 | 2022-05-17 | (주) 성운파마코피아 | 아미드 유도체의 염 및 그 제조방법 |
| KR101937713B1 (ko) | 2017-07-14 | 2019-01-14 | 주식회사 대웅제약 | 약제학적 제제 및 그 제조방법 |
| WO2019013583A2 (ko) | 2017-07-14 | 2019-01-17 | 주식회사 대웅제약 | 약제학적 제제 및 그 제조방법 |
| TW202038963A (zh) | 2018-12-05 | 2020-11-01 | 瑞士商優洛凡特科學公司 | 維貝隆（ｖｉｂｅｇｒｏｎ）於治療患有良性前列腺增生之男性中膀胱過動症症狀之用途 |
| KR20200117091A (ko) | 2019-04-02 | 2020-10-14 | 제이투에이치바이오텍 (주) | 미라베그론 전구체 약물 화합물 및 이의 과민성 방광 질환의 치료 또는 개선을 위한 의약 용도 |
| EP3722285B1 (en) | 2020-04-08 | 2022-03-30 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Process for preparing mirabegron enacarbil |
| CN113816864B (zh) * | 2020-06-18 | 2024-03-29 | 南京正大天晴制药有限公司 | 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法 |
| KR20220081033A (ko) | 2020-12-08 | 2022-06-15 | 주식회사 한서켐 | 미라베그론 α형 결정의 제조방법 |
| EP4338729A1 (en) | 2022-09-19 | 2024-03-20 | Sanovel Ilac Sanayi Ve Ticaret A.S. | A tablet comprising mirabegron |
| EP4410279A1 (en) | 2023-01-25 | 2024-08-07 | Sanovel Ilac Sanayi Ve Ticaret A.S. | A film tablet comprising mirabegron |
| KR20240171516A (ko) | 2023-05-30 | 2024-12-09 | 주식회사 디앤아이바이오 | 미라베그론 서방정 |
| US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
| TR2024008630A1 (tr) | 2024-07-04 | 2026-01-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Mi̇rabegron i̇çeren modi̇fi̇ye salimli bi̇r tablet bi̇leşi̇mi̇ |
| WO2026064392A1 (en) | 2024-09-17 | 2026-03-26 | Flavostar Llc | Fixed dose combination of flavoxate and beta-3 adrenergic receptor agonists, and formulations and manufacturing processes thereof |
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| JPH07119189B2 (ja) | 1989-09-28 | 1995-12-20 | 北陸製薬株式会社 | 光学活性なベンジルアルコール誘導体及びその用途 |
| GB9107827D0 (en) | 1991-04-12 | 1991-05-29 | Fujisawa Pharmaceutical Co | New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| IL104567A (en) | 1992-02-03 | 1997-03-18 | Fujisawa Pharmaceutical Co | Ethanolamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| JPH06293664A (ja) | 1993-04-05 | 1994-10-21 | Fujisawa Pharmaceut Co Ltd | β３−アドレナリン作動薬の新規医薬用途 |
| AU6581294A (en) | 1993-04-26 | 1994-11-21 | Fujisawa Pharmaceutical Co., Ltd. | Ethanolamine derivatives useful for the treatment of gastrointestinal disorders |
| JPH07228543A (ja) | 1994-02-16 | 1995-08-29 | Fujisawa Pharmaceut Co Ltd | β３−アドレナリン作動薬の新規医薬用途 |
| CZ126598A3 (cs) | 1995-10-26 | 1998-09-16 | Mitsubishi-Tokyo Pharmaceuticals, Inc. | Fenylethanolaminové sloučeniny, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
| EP0932401A1 (en) * | 1996-07-01 | 1999-08-04 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate |
| CA2263659A1 (en) | 1996-08-19 | 1998-02-26 | Kissei Pharmaceutical Co., Ltd. | Preventive/remedy for frequent urination and urinary incontinence |
| CA2302496C (en) * | 1997-08-28 | 2009-12-08 | Mount Cook Biosciences, Inc. | Urinary incontinence therapy |
| KR100506568B1 (ko) | 1997-10-17 | 2006-04-21 | 아스텔라스세이야쿠 가부시키가이샤 | 아미드유도체및이의염,및이를포함하는약제학적제제 |
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| ATE275126T1 (de) * | 1998-04-14 | 2004-09-15 | Kissei Pharmaceutical | 2-methylpropionsäure-derivate und sie enthaltende medizinische zubereitungen |
| MY126489A (en) | 1998-07-08 | 2006-10-31 | Kissei Pharmaceutical | Phenoxyacetic acid derivatives and medicinal compositions containing the same |
| CA2362586A1 (en) * | 1999-02-12 | 2000-08-17 | Genset S.A. | Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism |
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| AUPQ585000A0 (en) * | 2000-02-28 | 2000-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
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-
2003
- 2003-11-04 CA CA2503570A patent/CA2503570C/en not_active Expired - Lifetime
- 2003-11-04 MX MXPA05004925A patent/MXPA05004925A/es active IP Right Grant
- 2003-11-04 US US10/534,290 patent/US7750029B2/en not_active Ceased
- 2003-11-04 US US13/542,308 patent/USRE44872E1/en not_active Expired - Lifetime
- 2003-11-04 AT AT03770134T patent/ATE500827T1/de active
- 2003-11-04 ES ES03770134T patent/ES2360353T3/es not_active Expired - Lifetime
- 2003-11-04 EP EP03770134A patent/EP1559427B1/en not_active Expired - Lifetime
- 2003-11-04 JP JP2004549600A patent/JP3815496B2/ja not_active Expired - Lifetime
- 2003-11-04 CN CNB2003801028894A patent/CN100406011C/zh not_active Ceased
- 2003-11-04 DE DE60336334T patent/DE60336334D1/de not_active Expired - Lifetime
- 2003-11-04 SI SI200331996T patent/SI1559427T1/sl unknown
- 2003-11-04 KR KR1020057008158A patent/KR100967070B1/ko not_active Ceased
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- 2003-11-04 DK DK03770134.9T patent/DK1559427T3/da active
- 2003-11-04 RU RU2005117367/15A patent/RU2321401C2/ru active
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- 2003-11-04 US US10/534,290 patent/US20060115540A1/en active Granted
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2005
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2008
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2011
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2013
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- 2013-06-19 FR FR13C0032C patent/FR13C0032I2/fr active Active
- 2013-06-19 CY CY2013023C patent/CY2013023I2/el unknown
- 2013-06-19 HU HUS1300027C patent/HUS1300027I1/hu unknown
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