NL300599I2 - - Google Patents
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- Publication number
- NL300599I2 NL300599I2 NL300599C NL300599C NL300599I2 NL 300599 I2 NL300599 I2 NL 300599I2 NL 300599 C NL300599 C NL 300599C NL 300599 C NL300599 C NL 300599C NL 300599 I2 NL300599 I2 NL 300599I2
- Authority
- NL
- Netherlands
- Prior art keywords
- bladder
- rat
- urination
- rhythmic
- measurement test
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002323792 | 2002-11-07 | ||
PCT/JP2003/014065 WO2004041276A1 (ja) | 2002-11-07 | 2003-11-04 | 酢酸アニリド誘導体を有効成分とする過活動膀胱治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
NL300599I2 true NL300599I2 (nl) | 2017-01-03 |
Family
ID=32310425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL300599C NL300599I2 (nl) | 2002-11-07 | 2013-06-20 |
Country Status (28)
Country | Link |
---|---|
US (5) | USRE44872E1 (nl) |
EP (1) | EP1559427B1 (nl) |
JP (1) | JP3815496B2 (nl) |
KR (1) | KR100967070B1 (nl) |
CN (1) | CN100406011C (nl) |
AT (1) | ATE500827T1 (nl) |
AU (1) | AU2003284700B2 (nl) |
BE (1) | BE2013C040I2 (nl) |
BR (1) | BR0316080A (nl) |
CA (1) | CA2503570C (nl) |
CY (2) | CY1111399T1 (nl) |
DE (1) | DE60336334D1 (nl) |
DK (1) | DK1559427T3 (nl) |
ES (1) | ES2360353T3 (nl) |
FR (1) | FR13C0032I2 (nl) |
HU (1) | HUS1300027I1 (nl) |
IL (1) | IL168121A (nl) |
LU (1) | LU92218I2 (nl) |
MX (1) | MXPA05004925A (nl) |
NL (1) | NL300599I2 (nl) |
NO (2) | NO334948B1 (nl) |
NZ (1) | NZ539577A (nl) |
PL (1) | PL211687B1 (nl) |
PT (1) | PT1559427E (nl) |
RU (1) | RU2321401C2 (nl) |
SI (1) | SI1559427T1 (nl) |
WO (1) | WO2004041276A1 (nl) |
ZA (1) | ZA200503510B (nl) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10351271A1 (de) * | 2003-10-31 | 2005-06-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Zusammensetzung zur Behandlung der Stressinkontinenz und/oder Mischinkontinenz |
PT2216021E (pt) | 2007-11-02 | 2012-11-06 | Astellas Pharma Inc | Composição farmacêutica para tratar uma bexiga hiperactiva |
EP2223690A4 (en) * | 2007-12-21 | 2011-02-23 | Astellas Pharma Inc | PHARMACEUTICAL COMPOSITION USED TO MITIGATE SYMPTOMS OF THE INFINITE URINARY TRACT |
PE20091825A1 (es) * | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
WO2010053068A1 (ja) * | 2008-11-07 | 2010-05-14 | 大日本住友製薬株式会社 | 新規で有用な下部尿路症状治療剤 |
US8586760B2 (en) | 2009-06-15 | 2013-11-19 | Auspex Pharmaceuticals, Inc. | Aminothiazole modulators of beta-3-adrenoreceptor |
JP5849946B2 (ja) * | 2010-03-29 | 2016-02-03 | アステラス製薬株式会社 | 放出制御医薬組成物 |
EP2554168B1 (en) | 2010-03-29 | 2018-01-24 | Astellas Pharma Inc. | Controlled release pharmaceutical composition |
US9655885B2 (en) | 2011-05-18 | 2017-05-23 | Dr. Reddy's Laboratories Ltd. | Amorphous mirabegron and processes for crystal forms of mirabegron |
IN2013CN09704A (nl) * | 2011-05-18 | 2015-07-03 | Reddys Lab Ltd Dr | |
WO2013147134A1 (ja) | 2012-03-30 | 2013-10-03 | アステラス製薬株式会社 | ミラベグロン含有医薬組成物 |
EP2891493A4 (en) | 2012-08-31 | 2016-05-18 | Astellas Pharma Inc | MEDICAL COMPOSITION ADMINISTERED ORALLY |
WO2014132270A2 (en) * | 2013-02-27 | 2014-09-04 | Msn Laboratories Limited | Process for the preparation of 2-(2-aminothiazol-4-yl)-n-[4-(2-{[(2r)-2-hydroxy-2-phenyl ethyl]amino}ethyl)phenyl]acetamide monohydrochloride, its intermediates and polymorph thereof |
CN103193730A (zh) * | 2013-04-17 | 2013-07-10 | 苏州永健生物医药有限公司 | 一种米拉贝隆的合成方法 |
CN103232368B (zh) * | 2013-04-18 | 2015-08-12 | 苏州永健生物医药有限公司 | 一种(r)-4-硝基苯乙基-(2-羟基-2-苯乙基)-氨基甲酸叔丁酯的合成方法 |
CN103193658A (zh) * | 2013-04-18 | 2013-07-10 | 苏州永健生物医药有限公司 | 一种(r)-2-对硝基苯乙胺基-1-苯乙醇及其盐的合成方法 |
CN103232352B (zh) * | 2013-05-11 | 2015-12-23 | 苏州永健生物医药有限公司 | (r)-4-(2-(2-羟基-2-苯乙胺基)乙基)苯胺基甲酸叔丁基酯 |
US9814753B2 (en) * | 2013-07-23 | 2017-11-14 | Serenity Pharmaceuticals Llc | Methods and compositions comprising desmopressin in combination with a beta-3-adrenergic receptor agonist |
ITMI20131653A1 (it) * | 2013-10-07 | 2015-04-08 | Dipharma Francis Srl | Forme cristalline di un agonista adrenergico |
RU2550968C1 (ru) * | 2013-11-29 | 2015-05-20 | Федеральное государственное бюджетное учреждение "Научный центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации | Комплексный способ лечения пациенток с хроническими рецидивирующими циститами и рефрактерным гиперактивным мочевым пузырем |
WO2015155664A1 (en) * | 2014-04-08 | 2015-10-15 | Suven Life Sciences Limited | An improved process for the preparation of 2-(2-aminothiazol-4-yl)-n-[4-(2-[[(2r)-2-hydroxy-2- phenylethyl]amino]-ethyl)phenyl]acetamide |
WO2015162536A1 (en) * | 2014-04-22 | 2015-10-29 | Calyx Chemicals And Pharmaceuticals Ltd. | Novel process for preparation of mirabegron and it's intermediate |
CN104016943A (zh) * | 2014-05-23 | 2014-09-03 | 苏州凯瑞医药科技有限公司 | 一种米拉贝隆的合成方法 |
CN104016877B (zh) * | 2014-06-13 | 2017-02-15 | 南京海融制药有限公司 | 一种苯基乙酰胺类化合物及在制备米拉贝隆中的应用 |
CN104230840A (zh) * | 2014-09-05 | 2014-12-24 | 安徽联创药物化学有限公司 | 米拉贝隆的合成方法 |
CN106999538A (zh) | 2014-11-20 | 2017-08-01 | 阿勒根公司 | 包含去氨加压素与α‑肾上腺素能受体拮抗剂组合的方法和组合物 |
CN104496841B (zh) * | 2014-11-26 | 2017-01-25 | 南京工业大学 | 一种米拉贝隆中间体的合成方法 |
CN104744292A (zh) * | 2015-03-11 | 2015-07-01 | 南京工业大学 | (r)-2-((4-硝基苯乙基)氨基)-2-氧代-1-苯乙基乙酸酯或其衍生物的制备方法 |
JP2018090490A (ja) | 2015-03-31 | 2018-06-14 | アステラス製薬株式会社 | ミラベグロン含有医薬組成物 |
JP6618736B2 (ja) | 2015-09-01 | 2019-12-11 | 沢井製薬株式会社 | ミラベグロン含有錠剤、ミラベグロン含有製剤の製造方法及びミラベグロン含有造粒物の製造方法 |
CN106278909B (zh) * | 2016-08-12 | 2022-07-15 | 浙江华海药业股份有限公司 | 一种米拉贝隆中间体的后处理方法 |
ES2717534T3 (es) | 2017-02-14 | 2019-06-21 | Tiefenbacher Alfred E Gmbh & Co Kg | Profármacos de Mirabegron |
KR102051132B1 (ko) * | 2017-03-17 | 2019-12-02 | 주식회사 종근당 | 미라베그론 또는 이의 염을 포함하는 방출조절용 약제학적 조성물 |
KR101868438B1 (ko) | 2017-04-13 | 2018-06-20 | (주) 성운파마코피아 | 아미드 유도체의 제조방법 |
JP7113434B2 (ja) | 2017-05-31 | 2022-08-05 | Sbiファーマ株式会社 | 過活動膀胱の予防剤または治療剤 |
KR102398639B1 (ko) | 2017-06-20 | 2022-05-17 | (주) 성운파마코피아 | 아미드 유도체의 염 및 그 제조방법 |
WO2019013583A2 (ko) | 2017-07-14 | 2019-01-17 | 주식회사 대웅제약 | 약제학적 제제 및 그 제조방법 |
KR101937713B1 (ko) | 2017-07-14 | 2019-01-14 | 주식회사 대웅제약 | 약제학적 제제 및 그 제조방법 |
KR20200117091A (ko) | 2019-04-02 | 2020-10-14 | 제이투에이치바이오텍 (주) | 미라베그론 전구체 약물 화합물 및 이의 과민성 방광 질환의 치료 또는 개선을 위한 의약 용도 |
EP3722285B1 (en) | 2020-04-08 | 2022-03-30 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Process for preparing mirabegron enacarbil |
CN113816864B (zh) * | 2020-06-18 | 2024-03-29 | 南京正大天晴制药有限公司 | 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法 |
KR20220081033A (ko) | 2020-12-08 | 2022-06-15 | 주식회사 한서켐 | 미라베그론 α형 결정의 제조방법 |
EP4338729A1 (en) | 2022-09-19 | 2024-03-20 | Sanovel Ilac Sanayi Ve Ticaret A.S. | A tablet comprising mirabegron |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07119189B2 (ja) | 1989-09-28 | 1995-12-20 | 北陸製薬株式会社 | 光学活性なベンジルアルコール誘導体及びその用途 |
GB9107827D0 (en) | 1991-04-12 | 1991-05-29 | Fujisawa Pharmaceutical Co | New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
IL104567A (en) | 1992-02-03 | 1997-03-18 | Fujisawa Pharmaceutical Co | Ethanolamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
JPH06293664A (ja) | 1993-04-05 | 1994-10-21 | Fujisawa Pharmaceut Co Ltd | β3−アドレナリン作動薬の新規医薬用途 |
AU6581294A (en) | 1993-04-26 | 1994-11-21 | Fujisawa Pharmaceutical Co., Ltd. | Ethanolamine derivatives useful for the treatment of gastrointestinal disorders |
JPH07228543A (ja) | 1994-02-16 | 1995-08-29 | Fujisawa Pharmaceut Co Ltd | β3−アドレナリン作動薬の新規医薬用途 |
WO1997015549A1 (fr) | 1995-10-26 | 1997-05-01 | Tokyo Tanabe Company Limited | COMPOSES DE PHENYLETHANOLAMINE UTILES EN TANT QUE β3 AGONISTES, LEURS PROCEDE ET INTERMEDIAIRES DE PRODUCTION |
EP0932401A1 (en) | 1996-07-01 | 1999-08-04 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate |
AU731391B2 (en) | 1996-08-19 | 2001-03-29 | Kissei Pharmaceutical Co. Ltd. | Drug for the prevention or treatment of pollakiuria and urinary incontinence |
JP2001513551A (ja) * | 1997-08-28 | 2001-09-04 | アフェロン コーポレイション | 尿失禁の治療 |
US6346532B1 (en) | 1997-10-17 | 2002-02-12 | Yamanouchi Pharmaceutical Co., Ltd. | Amide derivatives or salts thereof |
EP1043308B1 (en) * | 1997-12-18 | 2003-09-24 | Kissei Pharmaceutical Co., Ltd. | Phenylaminoalkylcarboxylic acid derivatives and medicinal compositions containing the same |
ES2228028T3 (es) | 1998-04-14 | 2005-04-01 | Kissei Pharmaceutical Co., Ltd. | Derivados de acido 2-metilpropionico y composiciones medicinales que los contienen. |
MY126489A (en) | 1998-07-08 | 2006-10-31 | Kissei Pharmaceutical | Phenoxyacetic acid derivatives and medicinal compositions containing the same |
EP1218536A2 (en) * | 1999-02-12 | 2002-07-03 | Genset | Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism |
GB2356197A (en) * | 1999-10-12 | 2001-05-16 | Merck & Co Inc | Amide derivatives as beta 3 agonists |
JP2001114736A (ja) * | 1999-10-19 | 2001-04-24 | Kissei Pharmaceut Co Ltd | 2−アミノプロパノール誘導体 |
US20030018061A1 (en) | 2000-01-28 | 2003-01-23 | Kohei Ogawa | Novel remedies with the use of beta 3 agonist |
AUPQ585000A0 (en) * | 2000-02-28 | 2000-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
AUPQ841300A0 (en) | 2000-06-27 | 2000-07-20 | Fujisawa Pharmaceutical Co., Ltd. | New aminoalcohol derivatives |
AR035605A1 (es) * | 2000-12-11 | 2004-06-16 | Bayer Corp | Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores |
US7342117B2 (en) | 2001-10-30 | 2008-03-11 | Astellas Pharma Inc. | α-form or β-form crystal of acetanilide derivative |
CA2646729A1 (en) * | 2005-03-21 | 2006-09-28 | Dov Pharmaceutical, Inc. | Methods and compositions for the treatment of urinary incontinence |
-
2003
- 2003-11-04 ES ES03770134T patent/ES2360353T3/es not_active Expired - Lifetime
- 2003-11-04 PL PL376771A patent/PL211687B1/pl unknown
- 2003-11-04 KR KR1020057008158A patent/KR100967070B1/ko active IP Right Review Request
- 2003-11-04 SI SI200331996T patent/SI1559427T1/sl unknown
- 2003-11-04 BR BR0316080-7A patent/BR0316080A/pt not_active Application Discontinuation
- 2003-11-04 AT AT03770134T patent/ATE500827T1/de active
- 2003-11-04 CA CA2503570A patent/CA2503570C/en not_active Expired - Lifetime
- 2003-11-04 US US13/542,308 patent/USRE44872E1/en not_active Expired - Lifetime
- 2003-11-04 WO PCT/JP2003/014065 patent/WO2004041276A1/ja active Application Filing
- 2003-11-04 MX MXPA05004925A patent/MXPA05004925A/es active IP Right Grant
- 2003-11-04 US US10/534,290 patent/US20060115540A1/en active Granted
- 2003-11-04 RU RU2005117367/15A patent/RU2321401C2/ru active
- 2003-11-04 AU AU2003284700A patent/AU2003284700B2/en not_active Expired
- 2003-11-04 EP EP03770134A patent/EP1559427B1/en not_active Expired - Lifetime
- 2003-11-04 CN CNB2003801028894A patent/CN100406011C/zh not_active Expired - Lifetime
- 2003-11-04 US US10/534,290 patent/US7750029B2/en not_active Ceased
- 2003-11-04 ZA ZA200503510A patent/ZA200503510B/en unknown
- 2003-11-04 NZ NZ539577A patent/NZ539577A/en not_active IP Right Cessation
- 2003-11-04 DE DE60336334T patent/DE60336334D1/de not_active Expired - Lifetime
- 2003-11-04 JP JP2004549600A patent/JP3815496B2/ja not_active Expired - Lifetime
- 2003-11-04 PT PT03770134T patent/PT1559427E/pt unknown
- 2003-11-04 DK DK03770134.9T patent/DK1559427T3/da active
-
2005
- 2005-04-19 IL IL168121A patent/IL168121A/en active IP Right Grant
- 2005-06-06 NO NO20052691A patent/NO334948B1/no not_active IP Right Cessation
-
2008
- 2008-12-12 US US12/333,357 patent/US20090093529A1/en not_active Abandoned
-
2011
- 2011-04-18 CY CY20111100395T patent/CY1111399T1/el unknown
- 2011-05-27 US US13/117,638 patent/US8835474B2/en not_active Expired - Lifetime
-
2013
- 2013-06-17 LU LU92218C patent/LU92218I2/fr unknown
- 2013-06-19 HU HUS1300027C patent/HUS1300027I1/hu unknown
- 2013-06-19 FR FR13C0032C patent/FR13C0032I2/fr active Active
- 2013-06-19 CY CY2013023C patent/CY2013023I1/el unknown
- 2013-06-20 NL NL300599C patent/NL300599I2/nl unknown
- 2013-06-20 BE BE2013C040C patent/BE2013C040I2/fr unknown
-
2015
- 2015-01-19 NO NO2015001C patent/NO2015001I2/no unknown
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