JP2848958B2 - 水溶性カンプトテシン類似体、方法および手段 - Google Patents

水溶性カンプトテシン類似体、方法および手段

Info

Publication number
JP2848958B2
JP2848958B2 JP3516992A JP51699291A JP2848958B2 JP 2848958 B2 JP2848958 B2 JP 2848958B2 JP 3516992 A JP3516992 A JP 3516992A JP 51699291 A JP51699291 A JP 51699291A JP 2848958 B2 JP2848958 B2 JP 2848958B2
Authority
JP
Japan
Prior art keywords
compound
camptothecin
group
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP3516992A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06501476A (ja
Inventor
フォートゥナック，ジョゼフ・マリアン
ウッド，ジェフリー・リー
マストロコーラ，アントニエッタ・ローズ
メリンジャー，マーク
バーク，パトリック・リー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUMISUKURAIN BIICHAMU CORP
Original Assignee
SUMISUKURAIN BIICHAMU CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SUMISUKURAIN BIICHAMU CORP filed Critical SUMISUKURAIN BIICHAMU CORP
Publication of JPH06501476A publication Critical patent/JPH06501476A/ja
Application granted granted Critical
Publication of JP2848958B2 publication Critical patent/JP2848958B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
JP3516992A 1990-09-28 1991-09-23 水溶性カンプトテシン類似体、方法および手段 Expired - Lifetime JP2848958B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28
US589,643 1990-09-28

Publications (2)

Publication Number Publication Date
JPH06501476A JPH06501476A (ja) 1994-02-17
JP2848958B2 true JP2848958B2 (ja) 1999-01-20

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3516992A Expired - Lifetime JP2848958B2 (ja) 1990-09-28 1991-09-23 水溶性カンプトテシン類似体、方法および手段

Country Status (24)

Country Link
US (1) US5734056A (enExample)
EP (1) EP0547165B1 (enExample)
JP (1) JP2848958B2 (enExample)
CN (1) CN1033509C (enExample)
AT (1) ATE186461T1 (enExample)
AU (1) AU664830B2 (enExample)
CA (1) CA2090967C (enExample)
CZ (1) CZ51593A3 (enExample)
DE (1) DE69131775T2 (enExample)
DK (1) DK0547165T3 (enExample)
ES (1) ES2137932T3 (enExample)
FI (1) FI931384A7 (enExample)
GR (1) GR3031823T3 (enExample)
HU (1) HUT70024A (enExample)
IE (1) IE913402A1 (enExample)
IL (1) IL99571A (enExample)
NO (1) NO931153D0 (enExample)
NZ (1) NZ239947A (enExample)
PT (1) PT99109B (enExample)
SI (1) SI9111599A (enExample)
SK (1) SK283693B6 (enExample)
WO (1) WO1992005785A1 (enExample)
YU (1) YU159991A (enExample)
ZA (1) ZA917748B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009145282A1 (ja) 2008-05-29 2009-12-03 メルシャン株式会社 カンプトテシン誘導体の製造方法

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US5447936A (en) * 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
KR960029336A (ko) 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
JPH08333370A (ja) * 1995-06-08 1996-12-17 Kyorin Pharmaceut Co Ltd 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法
AU7732996A (en) * 1995-11-22 1997-06-11 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2004055020A1 (en) * 2002-12-16 2004-07-01 Council Of Scientific And Industrial Research Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones
DE60316849T2 (de) * 2003-03-31 2008-07-17 Council Of Scientific And Industrial Research Verfahren zur herstellung von topotecan aus 10-hydroxy-4-(s) camtothecin
JP5270091B2 (ja) 2003-05-12 2013-08-21 サイノファーム シンガポール ピーティーイー リミテッド ７−アルキル−１０−ヒドロキシ−２０（ｓ）−カンプトテシンを調製するためのプロセス
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ298934B6 (cs) * 2003-08-26 2008-03-12 Pliva- Lachema A.S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
TWI333492B (en) * 2003-11-12 2010-11-21 Smithkline Beecham Cork Ltd Crystalline topotecan hydrochloride product and preparation thereof
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
JP2008509211A (ja) * 2004-08-09 2008-03-27 シルパ・メディケア・リミテッド 塩酸イリノテカン三水和物の改良された製造方法
KR100848919B1 (ko) * 2004-11-05 2008-07-29 주식회사 삼양사 10-히드록시캄토테신 화합물의 극성 비수성 용매에 대한용해도를 증가시키기 위한 약제학적 제형
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
CN101242822B (zh) * 2005-07-18 2011-08-24 彼帕科学公司 治疗卵巢癌的药物
KR20080068052A (ko) * 2005-10-10 2008-07-22 씨아이피엘에이 엘티디. 신규의 결정형
US7547785B2 (en) 2005-12-26 2009-06-16 Dr. Reddy's Laboratories Limited Process for preparing topotecan
WO2007127839A2 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
AR060635A1 (es) 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
CA2655257A1 (en) * 2006-06-12 2008-12-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
JP2010502731A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤による脂肪酸合成の阻害、及びその治療方法
AU2007292387A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Treatment of cancer
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US7977483B2 (en) 2007-04-11 2011-07-12 Scinopharm Taiwan, Ltd. Process for making topotecan
JP2011500684A (ja) * 2007-10-19 2011-01-06 バイパー サイエンシズ，インコーポレイティド ベンゾピロン系ｐａｒｐ阻害剤を用いる癌の処置方法および組成物
AU2008315048A1 (en) 2007-10-23 2009-04-30 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
NZ586123A (en) * 2007-11-12 2012-12-21 Bipar Sciences Inc Treatment of ovarian cancer with 4-iodo-3-nitrobenzamide in combination with topoisomerase inhibitors
KR20100102609A (ko) * 2007-11-12 2010-09-24 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 유방암을 치료하는 방법
ITMI20072268A1 (it) 2007-12-04 2009-06-05 Antibioticos Spa Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione
EP2224804A4 (en) * 2007-12-07 2011-06-01 Bipar Sciences Inc TREATMENT OF CANCER WITH COMBINATIONS OF TOPOÎSOMERASE INHIBITORS AND PARP INHIBITORS
CN101450949B (zh) * 2007-12-07 2011-10-05 上海龙翔生物医药开发有限公司 一种10-羟基喜树碱的化学半合成工艺
EP2401281A4 (en) 2009-02-25 2012-08-15 Msd Kk PYRIMIDINPYRIMIDOINDAZOLDERIVAT
WO2010101734A1 (en) 2009-03-06 2010-09-10 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
EP2654754B1 (en) 2010-12-17 2016-12-21 Novartis AG Combination for treating osteosarcoma, rhabdomyosarcoma and neuroblastoma
EP2672969A4 (en) 2011-02-01 2014-07-16 Glaxosmithkline Intellectual Property Ltd COMBINATION
CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (en) * 2013-12-03 2015-06-10 Synbias Pharma AG Method for the synthesis of irinotecan
WO2017155834A1 (en) * 2016-03-08 2017-09-14 Cheng Lab & Company, Llc Herbal formulation to raise the human body's ph level from one that is acidic to one that is more alkaline
WO2021173773A1 (en) 2020-02-25 2021-09-02 Mediboston, Inc. Camptothecin derivatives and conjugates thereof
WO2023220641A2 (en) 2022-05-11 2023-11-16 Juno Therapeutics, Inc. Methods and uses related to t cell therapy and production of same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50151861A (enExample) * 1974-05-18 1975-12-06
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPH01186893A (ja) * 1987-12-01 1989-07-26 Smithkline Beckman Corp 水溶性カンプトテシン類似体

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US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS5946284A (ja) * 1982-09-10 1984-03-15 Yakult Honsha Co Ltd １１−ニトロカンプトテシン誘導体およびその製造法
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds

Patent Citations (3)

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JPS50151861A (enExample) * 1974-05-18 1975-12-06
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPH01186893A (ja) * 1987-12-01 1989-07-26 Smithkline Beckman Corp 水溶性カンプトテシン類似体

Non-Patent Citations (5)

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Title
Ｊｏｕｒｎａｌ ｏｆ Ｍｏｄｉｃｉｎａｌ ｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．２９，Ｎｏ．８，ｐ．１５５３〜１５５５（１９８６）
化学大辞典編集委員会編「化学大辞典３」（昭３８−９−１５）共立出版「再結晶」の項
化学大辞典編集委員会編「化学大辞典３」（昭３８−９−１５）共立出版「酸化剤」の項
小方芳郎 編著「有機化合物の酸化と還元」（昭３８−１１−１）、南江堂 ｐ．５５０〜５５１
小方芳郎 編著「有機化合物の酸化と還元」（昭３８−１１−１）南江堂ｐ．３４２〜３４９

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009145282A1 (ja) 2008-05-29 2009-12-03 メルシャン株式会社 カンプトテシン誘導体の製造方法
KR20110010767A (ko) 2008-05-29 2011-02-07 메루샹가부시키가이샤 캠토테신 유도체의 제조 방법
US8299251B2 (en) 2008-05-29 2012-10-30 Sichuan Xieli Pharmaceutical Co., Ltd. Method for producing camptothecin derivatives

Also Published As

Publication number Publication date
HU9300878D0 (en) 1993-06-28
FI931384L (fi) 1993-03-26
YU159991A (sh) 1994-06-10
DE69131775T2 (de) 2000-04-20
US5734056A (en) 1998-03-31
SK25993A3 (en) 1993-07-07
JPH06501476A (ja) 1994-02-17
CZ51593A3 (en) 1994-01-19
NO931153L (no) 1993-03-26
EP0547165B1 (en) 1999-11-10
AU664830B2 (en) 1995-12-07
HUT70024A (en) 1995-09-28
IL99571A (en) 2000-08-31
NZ239947A (en) 1994-07-26
PT99109B (pt) 1999-02-26
CN1062731A (zh) 1992-07-15
FI931384A0 (fi) 1993-03-26
CA2090967A1 (en) 1992-03-29
GR3031823T3 (en) 2000-02-29
DE69131775D1 (de) 1999-12-16
SK283693B6 (sk) 2003-12-02
ZA917748B (en) 1992-09-30
ES2137932T3 (es) 2000-01-01
CA2090967C (en) 2007-02-06
EP0547165A1 (en) 1993-06-23
AU8739991A (en) 1992-04-28
ATE186461T1 (de) 1999-11-15
FI931384A7 (fi) 1993-03-26
SI9111599A (sl) 1998-02-28
IE913402A1 (en) 1992-04-08
EP0547165A4 (enExample) 1994-03-30
PT99109A (pt) 1992-08-31
WO1992005785A1 (en) 1992-04-16
DK0547165T3 (da) 2000-03-27
CN1033509C (zh) 1996-12-11
HK1012283A1 (en) 1999-07-30
IL99571A0 (en) 1992-08-18
NO931153D0 (no) 1993-03-26

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