JP2023529211A - Ｚｂｔｂ３２阻害剤及びその使用 - Google Patents

Ｚｂｔｂ３２阻害剤及びその使用 Download PDF

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JP2023529211A
JP2023529211A JP2022575951A JP2022575951A JP2023529211A JP 2023529211 A JP2023529211 A JP 2023529211A JP 2022575951 A JP2022575951 A JP 2022575951A JP 2022575951 A JP2022575951 A JP 2022575951A JP 2023529211 A JP2023529211 A JP 2023529211A
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cell
zbtb32
inhibitor
cancer
gene
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JP2023529211A5 (enExample
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シルバ，マリア エステベス
ガン，イェ
シュー，ユーフェイ
オーランド，エレナ
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ノバルティス アーゲー
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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JP2022575951A 2020-06-11 2021-06-11 Ｚｂｔｂ３２阻害剤及びその使用 Pending JP2023529211A (ja)

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Application Number Priority Date Filing Date Title
US202063037826P 2020-06-11 2020-06-11
US63/037,826 2020-06-11
PCT/US2021/037048 WO2021252920A1 (en) 2020-06-11 2021-06-11 Zbtb32 inhibitors and uses thereof

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JP2023529211A true JP2023529211A (ja) 2023-07-07
JP2023529211A5 JP2023529211A5 (enExample) 2024-06-19

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US (1) US20230332104A1 (enExample)
EP (1) EP4165169A1 (enExample)
JP (1) JP2023529211A (enExample)
KR (1) KR20230024967A (enExample)
CN (1) CN116096862A (enExample)
AU (1) AU2021288224A1 (enExample)
CA (1) CA3185455A1 (enExample)
IL (1) IL298473A (enExample)
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EP3097117B1 (en) 2014-01-21 2023-10-04 Novartis Ag Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
AU2015292744C1 (en) 2014-07-21 2021-01-21 Novartis Ag Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
PL3280729T3 (pl) 2015-04-08 2022-08-22 Novartis Ag Terapie cd20, terapie cd22 i terapie skojarzone komórką eksprymującą chimeryczny receptor antygenowy (car) cd19
US10829735B2 (en) 2015-07-21 2020-11-10 The Trustees Of The University Of Pennsylvania Methods for improving the efficacy and expansion of immune cells
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
JP7467117B2 (ja) 2016-10-07 2024-04-15 ノバルティス アーゲー 癌の治療のためのキメラ抗原受容体
SG11202003415XA (en) 2017-10-18 2020-05-28 Novartis Ag Compositions and methods for selective protein degradation
IL279367B2 (en) 2018-06-13 2026-05-01 Novartis Ag BCMA chimeric antigen receptors and their uses
SI3844267T1 (sl) 2018-08-31 2025-10-30 Novartis Ag Postopki izdelave celic, ki izražajo receptorje himernega antigena
JP7805928B2 (ja) 2019-11-26 2026-01-26 ノバルティス アーゲー Ｃｄ１９及びｃｄ２２キメラ抗原受容体及びその使用
WO2021108661A2 (en) 2019-11-26 2021-06-03 Novartis Ag Chimeric antigen receptors and uses thereof
WO2023150518A1 (en) * 2022-02-01 2023-08-10 Sana Biotechnology, Inc. Cd3-targeted lentiviral vectors and uses thereof
WO2024173766A1 (en) * 2023-02-17 2024-08-22 Differentiated Therapeutics, Inc. Cyclin dependent kinase degraders and methods of use thereof
WO2025097146A1 (en) * 2023-11-02 2025-05-08 Roswell Park Cancer Institute Corporation Methods for characterizing and treating multiple myeloma
TW202617764A (zh) * 2024-08-28 2026-05-01 美商埃蘭迪爾實驗室有限公司 Ｔｌ１ａ抗體及其用途

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