JP2022515197A - がんを治療するためのｆｇｆｒ阻害剤としての７－（（３，５－ジメトキシフェニル）アミノ）キノキサリン誘導体 - Google Patents

がんを治療するためのｆｇｆｒ阻害剤としての７－（（３，５－ジメトキシフェニル）アミノ）キノキサリン誘導体 Download PDF

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JP2022515197A
JP2022515197A JP2021536037A JP2021536037A JP2022515197A JP 2022515197 A JP2022515197 A JP 2022515197A JP 2021536037 A JP2021536037 A JP 2021536037A JP 2021536037 A JP2021536037 A JP 2021536037A JP 2022515197 A JP2022515197 A JP 2022515197A
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fgfr
cancer
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kinase
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ブレイク，ジェイムズ
レン，リィ
エイ モレノ，デイビッド
エム ウォールズ，シェイン
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アレイ バイオファーマ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2021536037A 2018-12-19 2019-12-16 がんを治療するためのｆｇｆｒ阻害剤としての７－（（３，５－ジメトキシフェニル）アミノ）キノキサリン誘導体 Ceased JP2022515197A (ja)

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US201862781977P 2018-12-19 2018-12-19
US62/781,977 2018-12-19
PCT/US2019/066478 WO2020131674A1 (en) 2018-12-19 2019-12-16 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer

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JP2022515197A true JP2022515197A (ja) 2022-02-17
JP2022515197A5 JP2022515197A5 (https=) 2022-12-20
JPWO2020131674A5 JPWO2020131674A5 (https=) 2022-12-20

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EP (1) EP3898615A1 (https=)
JP (1) JP2022515197A (https=)
CN (1) CN113474337A (https=)
WO (1) WO2020131674A1 (https=)

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WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021153703A1 (ja) * 2020-01-31 2021-08-05 国立大学法人京都大学 軟骨形成異常症の治療
TW202304459A (zh) 2021-04-12 2023-02-01 美商英塞特公司 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
EP4352059A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2022261159A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2023175185A1 (en) 2022-03-17 2023-09-21 Forx Therapeutics Ag 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer
JP2025537185A (ja) * 2022-11-10 2025-11-14 アジレント・テクノロジーズ・インク 生細胞を分析するための機器および方法
CN116159142B (zh) * 2023-03-23 2026-02-17 上海市光华中西医结合医院(上海市光华医院) 一组fgfr抑制剂在制备治疗类风湿性关节炎药物中的应用
WO2025046148A1 (en) 2023-09-01 2025-03-06 Forx Therapeutics Ag Novel parg inhibitors
CN120860030B (zh) * 2025-09-29 2026-01-27 四川大学华西医院 Fgfr抑制剂在制备治疗颅咽管瘤的药物中的用途

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JP2014534212A (ja) * 2011-10-28 2014-12-18 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ Ｆｇｆｒキナーゼ阻害を介した抗癌ベンゾピラジン
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