JP2022506586A - 腫瘍浸潤リンパ球の産生のためのプロセスおよび免疫療法におけるその使用 - Google Patents
腫瘍浸潤リンパ球の産生のためのプロセスおよび免疫療法におけるその使用 Download PDFInfo
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- JP2022506586A JP2022506586A JP2021524021A JP2021524021A JP2022506586A JP 2022506586 A JP2022506586 A JP 2022506586A JP 2021524021 A JP2021524021 A JP 2021524021A JP 2021524021 A JP2021524021 A JP 2021524021A JP 2022506586 A JP2022506586 A JP 2022506586A
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/98—Xeno-free medium and culture conditions
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1121—Dendritic cells
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
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- Peptides Or Proteins (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025001727A JP2025081294A (ja) | 2018-11-05 | 2025-01-06 | 腫瘍浸潤リンパ球の産生のためのプロセスおよび免疫療法におけるその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862755954P | 2018-11-05 | 2018-11-05 | |
| US62/755,954 | 2018-11-05 | ||
| US201962903585P | 2019-09-20 | 2019-09-20 | |
| US62/903,585 | 2019-09-20 | ||
| PCT/US2019/059718 WO2020096988A2 (en) | 2018-11-05 | 2019-11-04 | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025001727A Division JP2025081294A (ja) | 2018-11-05 | 2025-01-06 | 腫瘍浸潤リンパ球の産生のためのプロセスおよび免疫療法におけるその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022506586A true JP2022506586A (ja) | 2022-01-17 |
| JP2022506586A5 JP2022506586A5 (enExample) | 2022-11-14 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524021A Pending JP2022506586A (ja) | 2018-11-05 | 2019-11-04 | 腫瘍浸潤リンパ球の産生のためのプロセスおよび免疫療法におけるその使用 |
| JP2025001727A Pending JP2025081294A (ja) | 2018-11-05 | 2025-01-06 | 腫瘍浸潤リンパ球の産生のためのプロセスおよび免疫療法におけるその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025001727A Pending JP2025081294A (ja) | 2018-11-05 | 2025-01-06 | 腫瘍浸潤リンパ球の産生のためのプロセスおよび免疫療法におけるその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US12453697B2 (enExample) |
| EP (1) | EP3877513B1 (enExample) |
| JP (2) | JP2022506586A (enExample) |
| CN (1) | CN113272421B (enExample) |
| AU (1) | AU2019374761B2 (enExample) |
| BR (1) | BR112021008573A2 (enExample) |
| CA (1) | CA3118624A1 (enExample) |
| CL (1) | CL2021001178A1 (enExample) |
| CO (1) | CO2021007362A2 (enExample) |
| CR (1) | CR20210295A (enExample) |
| ES (1) | ES3036072T3 (enExample) |
| IL (1) | IL282919A (enExample) |
| JO (1) | JOP20210094A1 (enExample) |
| MX (1) | MX2021005216A (enExample) |
| MY (1) | MY210603A (enExample) |
| PE (1) | PE20211292A1 (enExample) |
| PH (1) | PH12021551033A1 (enExample) |
| SG (1) | SG11202104615VA (enExample) |
| TW (1) | TW202039830A (enExample) |
| WO (1) | WO2020096988A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025047660A1 (ja) * | 2023-08-31 | 2025-03-06 | 国立大学法人筑波大学 | 腫瘍性濾胞制御性t細胞及び腫瘍性濾胞殺細胞性t細胞を定量する方法、腫瘍性濾胞制御性t細胞及び腫瘍性濾胞殺細胞性t細胞をスクリーニングする方法、治療用組成物、及びキット |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| WO2019210131A1 (en) * | 2018-04-27 | 2019-10-31 | Iovance Biotherapeutics, Inc. | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| WO2020232029A1 (en) * | 2019-05-13 | 2020-11-19 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| BR112022011795A2 (pt) | 2019-12-20 | 2022-08-30 | Instil Bio Uk Ltd | Métodos para preparar e isolar uma população terapêutica de linfócitos e para tratar câncer em um indivíduo, população terapêutica de linfócitos, bolsa criopreservada, recipiente flexível, e, sistema para extração de linfócitos |
| CA3158133A1 (en) | 2020-04-28 | 2021-11-04 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| CA3176826A1 (en) * | 2020-05-04 | 2021-11-11 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| JP2023546359A (ja) | 2020-10-06 | 2023-11-02 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍浸潤リンパ球療法によるnsclc患者の治療 |
| EP4239059A4 (en) * | 2020-11-19 | 2024-05-15 | Suzhou Grit Biotechnology Co., Ltd. | METHOD FOR CULTIVATION OF TUMOR INFILTRATING LYMPHOCYTES AND USE THEREOF |
| EP4259164A1 (en) | 2020-12-11 | 2023-10-18 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors |
| AU2021401302A1 (en) | 2020-12-17 | 2023-07-06 | Iovance Biotherapeutics, Inc. | Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors |
| EP4262827A1 (en) | 2020-12-17 | 2023-10-25 | Iovance Biotherapeutics, Inc. | Treatment of cancers with tumor infiltrating lymphocytes |
| JP2024501845A (ja) | 2020-12-31 | 2024-01-16 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍浸潤リンパ球の自動化された産生のためのデバイス及びプロセス |
| CN114686430A (zh) * | 2020-12-31 | 2022-07-01 | 上海赛比曼生物科技有限公司 | 一种制备til的方法 |
| WO2022165260A1 (en) * | 2021-01-29 | 2022-08-04 | Iovance Biotherapeutics, Inc. | Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy |
| CA3207359A1 (en) | 2021-02-05 | 2022-08-11 | Cecile Chartier-Courtaud | Adjuvant therapy for cancer |
| EP4301138A2 (en) | 2021-03-05 | 2024-01-10 | Iovance Biotherapeutics, Inc. | Tumor storage and cell culture compositions |
| US20240191191A1 (en) | 2021-03-19 | 2024-06-13 | Iovance Biotherapeutics, Inc. | Methods for infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils |
| JP2024512029A (ja) | 2021-03-25 | 2024-03-18 | アイオバンス バイオセラピューティクス,インコーポレイテッド | T細胞共培養効力アッセイのための方法及び組成物、ならびに細胞療法製品との使用 |
| JP2024519029A (ja) | 2021-05-17 | 2024-05-08 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Pd-1遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用 |
| JP2024527961A (ja) | 2021-07-28 | 2024-07-26 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Kras阻害剤と併用した腫瘍浸潤リンパ球療法によるがん患者の治療 |
| WO2023039488A1 (en) | 2021-09-09 | 2023-03-16 | Iovance Biotherapeutics, Inc. | Processes for generating til products using pd-1 talen knockdown |
| US20250000903A1 (en) | 2021-09-24 | 2025-01-02 | Iovance Biotherapeutics, Inc. | Expansion processes and agents for tumor infiltrating lymphocytes |
| WO2023077015A2 (en) | 2021-10-27 | 2023-05-04 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| CA3237410A1 (en) | 2021-11-10 | 2023-05-19 | Friedrich Graf Finck VON FINCKENSTEIN | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
| CN118525084A (zh) * | 2022-01-19 | 2024-08-20 | 苏州沙砾生物科技有限公司 | 肿瘤浸润淋巴细胞在疾病治疗中的用途 |
| CA3243416A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | TUMOR INFILTRATION LYMPHOCYTES MODIFIED TO EXPRESS PAYLOADS |
| JP2025512401A (ja) | 2022-04-15 | 2025-04-17 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 特定のサイトカインの組み合わせ及び/またはAKTi処理を使用したTIL拡張プロセス |
| WO2024011114A1 (en) | 2022-07-06 | 2024-01-11 | Iovance Biotherapeutics, Inc. | Devices and processes for automated production of tumor infiltrating lymphocytes |
| EP4612277A1 (en) | 2022-11-04 | 2025-09-10 | Iovance Biotherapeutics, Inc. | Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection |
| CN117448270B (zh) * | 2023-12-22 | 2024-07-26 | 上海元戊医学技术有限公司 | 一种高效诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法 |
| CN117683121B (zh) * | 2024-01-30 | 2024-04-16 | 北京百普赛斯生物科技股份有限公司 | 抗水痘-带状疱疹病毒抗体及其应用 |
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| WO2018081473A1 (en) * | 2016-10-26 | 2018-05-03 | Iovance Biotherapeutics, Inc. | Restimulation of cryopreserved tumor infiltrating lymphocytes |
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| WO2018081473A1 (en) * | 2016-10-26 | 2018-05-03 | Iovance Biotherapeutics, Inc. | Restimulation of cryopreserved tumor infiltrating lymphocytes |
| WO2018081789A1 (en) * | 2016-10-31 | 2018-05-03 | Iovance Biotherapeutics, Inc. | Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion |
| WO2018182817A1 (en) * | 2017-03-29 | 2018-10-04 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025047660A1 (ja) * | 2023-08-31 | 2025-03-06 | 国立大学法人筑波大学 | 腫瘍性濾胞制御性t細胞及び腫瘍性濾胞殺細胞性t細胞を定量する方法、腫瘍性濾胞制御性t細胞及び腫瘍性濾胞殺細胞性t細胞をスクリーニングする方法、治療用組成物、及びキット |
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| EP3877513C0 (en) | 2025-05-07 |
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| US12226522B2 (en) | 2025-02-18 |
| MY210603A (en) | 2025-10-01 |
| PE20211292A1 (es) | 2021-07-20 |
| AU2019374761B2 (en) | 2026-02-19 |
| SG11202104615VA (en) | 2021-06-29 |
| IL282919A (en) | 2021-06-30 |
| CA3118624A1 (en) | 2020-05-14 |
| EP3877513A2 (en) | 2021-09-15 |
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| US20220090018A1 (en) | 2022-03-24 |
| BR112021008573A2 (pt) | 2021-10-26 |
| CO2021007362A2 (es) | 2021-08-30 |
| US20240240146A1 (en) | 2024-07-18 |
| JOP20210094A1 (ar) | 2023-01-30 |
| CN113272421A (zh) | 2021-08-17 |
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