JP2022121532A5 - - Google Patents

Info

Publication number

JP2022121532A5

JP2022121532A5 JP2022101327A JP2022101327A JP2022121532A5 JP 2022121532 A5 JP2022121532 A5 JP 2022121532A5 JP 2022101327 A JP2022101327 A JP 2022101327A JP 2022101327 A JP2022101327 A JP 2022101327A JP 2022121532 A5 JP2022121532 A5 JP 2022121532A5

Authority

JP

Japan

Prior art keywords

particles

paclitaxel

composition

docetaxel

pharmaceutically acceptable

Prior art date

2022-06-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 22
• 239000002245 particle Substances 0.000 claims 18
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 15
• 229930012538 Paclitaxel Natural products 0.000 claims 14
• 229960001592 paclitaxel Drugs 0.000 claims 14
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 14
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 11
• 229960003668 docetaxel Drugs 0.000 claims 11
• 150000003839 salts Chemical class 0.000 claims 10
• 229940123237 Taxane Drugs 0.000 claims 9
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 9
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
• OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 229960001573 cabazitaxel Drugs 0.000 claims 2
• BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• JQIPMLOMQMJUPJ-UHFFFAOYSA-N Brevifoliol Natural products CC(=O)OC1C2(C)C(OC(=O)C)CC(O)C(=C)C2CC2C(C(C)(C)O)C(O)C(C)=C2C1OC(=O)C1=CC=CC=C1 JQIPMLOMQMJUPJ-UHFFFAOYSA-N 0.000 claims 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
• 229930195725 Mannitol Natural products 0.000 claims 1
• FRJSECSOXKQMOD-HQRMLTQVSA-N Taxa-4(5),11(12)-diene Chemical compound C1C[C@]2(C)CCC=C(C)[C@H]2C[C@@H]2CCC(C)=C1C2(C)C FRJSECSOXKQMOD-HQRMLTQVSA-N 0.000 claims 1
• VWGCDYGRSUJYGJ-GPOPEEISSA-N [(2s,4r,5r,5as,6s,8s,9ar,10as)-5,6-diacetyloxy-2,8-dihydroxy-10a-(2-hydroxypropan-2-yl)-3,5a-dimethyl-9-methylidene-2,4,5,6,7,8,9a,10-octahydro-1h-benzo[g]azulen-4-yl] benzoate Chemical compound O([C@@H]1C2=C(C)[C@@H](O)C[C@]2(C[C@@H]2C(=C)[C@@H](O)C[C@@H]([C@]2([C@H]1OC(C)=O)C)OC(=O)C)C(C)(C)O)C(=O)C1=CC=CC=C1 VWGCDYGRSUJYGJ-GPOPEEISSA-N 0.000 claims 1
• 239000008365 aqueous carrier Substances 0.000 claims 1
• 229930014667 baccatin III Natural products 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 150000005690 diesters Chemical class 0.000 claims 1
• 125000005456 glyceride group Chemical group 0.000 claims 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
• 239000004615 ingredient Substances 0.000 claims 1
• 239000000594 mannitol Substances 0.000 claims 1
• 235000010355 mannitol Nutrition 0.000 claims 1
• 229920000609 methyl cellulose Polymers 0.000 claims 1
• 239000001923 methylcellulose Substances 0.000 claims 1
• 235000010981 methylcellulose Nutrition 0.000 claims 1
• 239000008389 polyethoxylated castor oil Substances 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 229920000136 polysorbate Polymers 0.000 claims 1
• 229950008882 polysorbate Drugs 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1
• -1 taxkinin A Chemical compound 0.000 claims 1
• 150000003626 triacylglycerols Chemical class 0.000 claims 1