JP2004527505A5 - - Google Patents
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- Publication number
- JP2004527505A5 JP2004527505A5 JP2002571029A JP2002571029A JP2004527505A5 JP 2004527505 A5 JP2004527505 A5 JP 2004527505A5 JP 2002571029 A JP2002571029 A JP 2002571029A JP 2002571029 A JP2002571029 A JP 2002571029A JP 2004527505 A5 JP2004527505 A5 JP 2004527505A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- liquid
- polymer
- microparticles
- acid labile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 15
- 239000007788 liquid Substances 0.000 claims 14
- 239000011859 microparticle Substances 0.000 claims 13
- 239000002253 acid Substances 0.000 claims 9
- 239000000362 adenosine triphosphatase inhibitor Substances 0.000 claims 9
- 159000000011 group IA salts Chemical class 0.000 claims 9
- 229940121819 ATPase inhibitor Drugs 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 7
- 239000010419 fine particle Substances 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000003507 refrigerant Substances 0.000 claims 3
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000002702 enteric coating Substances 0.000 claims 2
- 238000009505 enteric coating Methods 0.000 claims 2
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 claims 2
- 229960004770 esomeprazole Drugs 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 210000004211 gastric acid Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229960000381 omeprazole Drugs 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 229920003176 water-insoluble polymer Polymers 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 1
- 229910052786 argon Inorganic materials 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002183 duodenal effect Effects 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229920005615 natural polymer Polymers 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 208000000689 peptic esophagitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 238000000859 sublimation Methods 0.000 claims 1
- 230000008022 sublimation Effects 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100823A SE0100823D0 (sv) | 2001-03-09 | 2001-03-09 | Method I to obtain microparticles |
| PCT/SE2002/000399 WO2002072070A1 (en) | 2001-03-09 | 2002-03-06 | Method to obtain microparticles containing a h+, k+-atp-ase inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527505A JP2004527505A (ja) | 2004-09-09 |
| JP2004527505A5 true JP2004527505A5 (https=) | 2005-12-22 |
Family
ID=20283294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571029A Pending JP2004527505A (ja) | 2001-03-09 | 2002-03-06 | Ｈ＋，ｋ＋−ａｔｐアーゼ阻害剤を含む微粒子の製造方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040131689A1 (https=) |
| EP (1) | EP1370242A1 (https=) |
| JP (1) | JP2004527505A (https=) |
| CN (1) | CN1507344A (https=) |
| AU (1) | AU2002235100B8 (https=) |
| CA (1) | CA2440158A1 (https=) |
| NZ (1) | NZ527996A (https=) |
| SE (1) | SE0100823D0 (https=) |
| WO (1) | WO2002072070A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060159756A1 (en) * | 1999-09-10 | 2006-07-20 | Brita Sjoblom | Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor |
| US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| SE0100824D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method III to obtain microparticles |
| SE0100822D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method II to obtain microparticles |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| JP2005504090A (ja) | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| FR2845915B1 (fr) * | 2002-10-21 | 2006-06-23 | Negma Gild | Utilisation du tenatoprazole pour le traitement du reflux gastro-oesophagien |
| US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CA2531564C (en) * | 2003-07-18 | 2016-01-19 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
| WO2005072702A2 (en) * | 2004-01-20 | 2005-08-11 | Alkermes Controlled Therapeutics, Inc. | Method for milling frozen microparticles |
| DE102005001162A1 (de) * | 2005-01-10 | 2006-07-20 | Haemosys Gmbh | Adsorptionssystem zur Entfernung von Viren und viralen Bestandteilen aus Flüssigkeiten, insbesondere aus Blut und Blutplasma |
| WO2007056205A2 (en) * | 2005-11-04 | 2007-05-18 | Eastman Chemical Company | Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents |
| WO2007122478A2 (en) * | 2006-04-20 | 2007-11-01 | Themis Laboratories Private Limited | Multiple unit compositions |
| GB0707612D0 (en) | 2007-04-19 | 2007-05-30 | Stratosphere Pharma Ab | Cores and microcapsules suitable for parenteral administration as well as process for their manufacture |
| EP2044929A1 (en) * | 2007-10-04 | 2009-04-08 | Laboratorios del Dr. Esteve S.A. | Oral fast distintegrating tablets |
| CN102512382B (zh) * | 2011-12-23 | 2013-09-04 | 天津市汉康医药生物技术有限公司 | 供注射用埃索美拉唑钠药物组合物 |
| DE102019133243A1 (de) * | 2019-12-05 | 2021-06-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Verfahren zur Herstellung sprühgefriergetrockneter Partikel und entsprechend hergestellte Partikel |
| JP2023151957A (ja) * | 2022-04-01 | 2023-10-16 | 理研ビタミン株式会社 | 薬物含有粒子の製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932943A (en) * | 1970-08-14 | 1976-01-20 | E. I. Du Pont De Nemours And Company | Method of preparation of lyophilized biological products |
| US3721725A (en) * | 1970-08-14 | 1973-03-20 | Du Pont | Process for preparing powder blends |
| US4526734A (en) * | 1981-03-05 | 1985-07-02 | Ibigawa Electric Industry Co., Ltd. | Process for the production of silicon carbide sintered bodies |
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US5017383A (en) * | 1989-08-22 | 1991-05-21 | Taisho Pharmaceutical Co., Ltd. | Method of producing fine coated pharmaceutical preparation |
| US5102983A (en) * | 1990-04-02 | 1992-04-07 | United States Surgical Corporation | Process for preparing foamed, bioabsorbable polymer particles |
| DE4201179A1 (de) * | 1992-01-17 | 1993-07-22 | Alfatec Pharma Gmbh | Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung |
| EE03305B1 (et) * | 1994-07-08 | 2000-12-15 | Astra Aktiebolag | Paljuosaline tableteeritud annusvorm I |
| GB2329124B (en) * | 1997-09-12 | 2002-05-08 | Hiran Asoka Malinga Ratwatte | Method of forming dose units of active agents |
| CA2376202C (en) * | 1999-06-07 | 2008-11-18 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel preparation and administration form comprising an acid-labile active compound |
| SE9903236D0 (sv) * | 1999-09-10 | 1999-09-10 | Astra Ab | Method to obtain microparticles |
| SE0100824D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method III to obtain microparticles |
| SE0100822D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method II to obtain microparticles |
-
2001
- 2001-03-09 SE SE0100823A patent/SE0100823D0/xx unknown
-
2002
- 2002-03-06 JP JP2002571029A patent/JP2004527505A/ja active Pending
- 2002-03-06 US US10/469,888 patent/US20040131689A1/en not_active Abandoned
- 2002-03-06 AU AU2002235100A patent/AU2002235100B8/en not_active Ceased
- 2002-03-06 CA CA002440158A patent/CA2440158A1/en not_active Abandoned
- 2002-03-06 CN CNA028096088A patent/CN1507344A/zh active Pending
- 2002-03-06 NZ NZ527996A patent/NZ527996A/en unknown
- 2002-03-06 EP EP02701871A patent/EP1370242A1/en not_active Withdrawn
- 2002-03-06 WO PCT/SE2002/000399 patent/WO2002072070A1/en not_active Ceased
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