JP2022105108A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2022105108A5 JP2022105108A5 JP2022073522A JP2022073522A JP2022105108A5 JP 2022105108 A5 JP2022105108 A5 JP 2022105108A5 JP 2022073522 A JP2022073522 A JP 2022073522A JP 2022073522 A JP2022073522 A JP 2022073522A JP 2022105108 A5 JP2022105108 A5 JP 2022105108A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- light chain
- variable region
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 6
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 229960002621 pembrolizumab Drugs 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 3
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 102000049823 human TIGIT Human genes 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 241000699802 Cricetulus griseus Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 241000235648 Pichia Species 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038912P | 2014-08-19 | 2014-08-19 | |
| US62/038,912 | 2014-08-19 | ||
| US201562126733P | 2015-03-02 | 2015-03-02 | |
| US62/126,733 | 2015-03-02 | ||
| JP2020101881A JP7066777B2 (ja) | 2014-08-19 | 2020-06-11 | 抗ｔｉｇｉｔ抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020101881A Division JP7066777B2 (ja) | 2014-08-19 | 2020-06-11 | 抗ｔｉｇｉｔ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022105108A JP2022105108A (ja) | 2022-07-12 |
| JP2022105108A5 true JP2022105108A5 (enExample) | 2022-11-10 |
| JP7487256B2 JP7487256B2 (ja) | 2024-05-20 |
Family
ID=53938463
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017509009A Active JP6920194B2 (ja) | 2014-08-19 | 2015-08-17 | 抗ｔｉｇｉｔ抗体 |
| JP2020101881A Active JP7066777B2 (ja) | 2014-08-19 | 2020-06-11 | 抗ｔｉｇｉｔ抗体 |
| JP2022073522A Active JP7487256B2 (ja) | 2014-08-19 | 2022-04-27 | 抗ｔｉｇｉｔ抗体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017509009A Active JP6920194B2 (ja) | 2014-08-19 | 2015-08-17 | 抗ｔｉｇｉｔ抗体 |
| JP2020101881A Active JP7066777B2 (ja) | 2014-08-19 | 2020-06-11 | 抗ｔｉｇｉｔ抗体 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US20160355589A1 (enExample) |
| EP (1) | EP3183267A1 (enExample) |
| JP (3) | JP6920194B2 (enExample) |
| KR (2) | KR102050082B1 (enExample) |
| CN (2) | CN107148430B (enExample) |
| AP (1) | AP2017009765A0 (enExample) |
| AU (3) | AU2015305754B2 (enExample) |
| CA (1) | CA2957722C (enExample) |
| CL (2) | CL2017000310A1 (enExample) |
| CO (1) | CO2017001561A2 (enExample) |
| CR (1) | CR20170060A (enExample) |
| DO (1) | DOP2017000046A (enExample) |
| EA (1) | EA036311B1 (enExample) |
| GE (1) | GEP20217331B (enExample) |
| GT (1) | GT201700033A (enExample) |
| IL (1) | IL250583B (enExample) |
| JO (2) | JO3664B1 (enExample) |
| MA (1) | MA40475A (enExample) |
| MD (1) | MD4733C1 (enExample) |
| MX (2) | MX389684B (enExample) |
| MY (2) | MY184288A (enExample) |
| NI (1) | NI201700019A (enExample) |
| PE (1) | PE20170289A1 (enExample) |
| PH (1) | PH12017500296A1 (enExample) |
| SG (1) | SG11201701161QA (enExample) |
| TN (1) | TN2017000024A1 (enExample) |
| TW (2) | TWI790593B (enExample) |
| UA (1) | UA122395C2 (enExample) |
| WO (1) | WO2016028656A1 (enExample) |
| ZA (1) | ZA201700955B (enExample) |
Families Citing this family (173)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| JP5770624B2 (ja) | 2008-04-09 | 2015-08-26 | ジェネンテック， インコーポレイテッド | 免疫関連疾患の治療のための新規組成物と方法 |
| PT3485903T (pt) | 2011-09-23 | 2023-02-17 | Mereo Biopharma 5 Inc | Agentes de ligação a vegf/dll4 e utilizações dos mesmos |
| CR20160319A (es) | 2013-12-12 | 2016-11-08 | Jiangsu Hengrui Medicine Co | Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| SG10201912986PA (en) | 2014-05-28 | 2020-02-27 | Agenus Inc | Anti-gitr antibodies and methods of use thereof |
| JO3664B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | أجسام مضادة لـ tigit |
| CN110256558B (zh) | 2014-12-23 | 2023-07-04 | 百时美施贵宝公司 | 针对tigit的抗体 |
| EP3978929A1 (en) | 2015-02-19 | 2022-04-06 | Compugen Ltd. | Pvrig polypeptides and methods of treatment |
| US10227408B2 (en) | 2015-02-19 | 2019-03-12 | Compugen Ltd. | Anti-PVRIG antibodies and methods of use |
| CN115109158A (zh) | 2015-05-07 | 2022-09-27 | 阿吉纳斯公司 | 抗ox40抗体及其使用方法 |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| CN115925931A (zh) | 2015-08-14 | 2023-04-07 | 默沙东公司 | 抗tigit抗体 |
| KR20220131277A (ko) | 2015-09-01 | 2022-09-27 | 아게누스 인코포레이티드 | 항-pd-1 항체 및 이를 이용하는 방법 |
| US10946095B2 (en) | 2015-09-02 | 2021-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to human T-cell immunoglobulin and ITIM domain (TIGIT) |
| AU2016326609B2 (en) | 2015-09-23 | 2023-03-09 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| JP7023233B2 (ja) | 2015-10-01 | 2022-02-21 | ポテンザ セラピューティックス インコーポレイテッド | 抗ｔｉｇｉｔ抗原結合タンパク質と、その使用方法 |
| CA3132021C (en) | 2015-11-18 | 2024-03-12 | Merck Sharp & Dohme Corp. | Pd1 and/or lag3 binders |
| IL299072A (en) | 2015-12-02 | 2023-02-01 | Memorial Sloan Kettering Cancer Center | Antibodies and methods of use thereof |
| TWI805127B (zh) * | 2016-03-04 | 2023-06-11 | 美商Ｊｎ生物科學有限責任公司 | 針對tigit之抗體 |
| CN109069638B (zh) | 2016-03-24 | 2022-03-29 | 璟尚生物制药公司 | 用于癌症治疗的三特异性抑制剂 |
| BR112018071153A2 (pt) * | 2016-04-15 | 2019-04-16 | Immunext, Inc. | anticorpos anti-vista humano e uso dos mesmos |
| KR20230091191A (ko) | 2016-05-27 | 2023-06-22 | 아게누스 인코포레이티드 | 항-tim-3 항체 및 이의 사용 방법 |
| WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| KR20230044038A (ko) | 2016-08-09 | 2023-03-31 | 키맵 리미티드 | 항-icos 항체 |
| DK3347379T5 (da) * | 2016-08-17 | 2020-06-15 | Compugen Ltd | Anti-tigit-antistoffer, anti-pvrig-antistoffer og kombinationer deraf |
| WO2018041120A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tigit |
| CN107815467B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| BR112019007369A2 (pt) | 2016-10-11 | 2019-07-16 | Agenus Inc | anticorpos anti-lag-3 e métodos de uso dos mesmos |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| EP3534933B1 (en) | 2016-11-04 | 2025-01-01 | Aximmune, Inc. | Beta-alethine in combination with immune modulators and uses thereof |
| WO2018089628A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
| US11230596B2 (en) * | 2016-11-30 | 2022-01-25 | Mereo Biopharma 5, Inc. | Methods for treatment of cancer comprising TIGIT-binding agents |
| WO2018102746A1 (en) * | 2016-12-02 | 2018-06-07 | Rigel Pharmaceuticals, Inc. | Antigen binding molecules to tigit |
| CA3046082A1 (en) | 2016-12-07 | 2018-06-14 | Agenus Inc. | Antibodies and methods of use thereof |
| US10232053B2 (en) | 2016-12-30 | 2019-03-19 | Trieza Therapeutics, Inc. | Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer |
| EP3565839A4 (en) | 2017-01-05 | 2021-04-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| EP3589657A1 (en) * | 2017-03-03 | 2020-01-08 | Rinat Neuroscience Corp. | Anti-gitr antibodies and methods of use thereof |
| JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
| US20200024351A1 (en) | 2017-04-03 | 2020-01-23 | Jounce Therapeutics, Inc. | Compositions and Methods for the Treatment of Cancer |
| JP7718815B2 (ja) | 2017-04-21 | 2025-08-05 | シルラゼン， インコーポレイテッド | 腫瘍溶解性ワクシニアウイルスおよびチェックポイント阻害剤の併用療法 |
| US11760777B2 (en) | 2017-04-26 | 2023-09-19 | Bristol-Myers Squibb Company | Methods of antibody production that minimize disulfide bond reduction |
| EP3618863B1 (en) | 2017-05-01 | 2023-07-26 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
| US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| US20200354453A1 (en) * | 2017-05-02 | 2020-11-12 | Merck Sharp & Dohme Corp. | Stable formulations of anti-tigit antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| MX2019014265A (es) | 2017-06-01 | 2020-08-03 | Compugen Ltd | Tratamientos conjuntos triples con anticuerpos. |
| WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
| BE1025333B1 (fr) * | 2017-07-27 | 2019-01-23 | Iteos Therapeutics S.A. | Anticorps anti-tigit |
| WO2019023504A1 (en) | 2017-07-27 | 2019-01-31 | Iteos Therapeutics Sa | ANTI-TIGIT ANTIBODIES |
| IL272227B2 (en) * | 2017-07-27 | 2025-09-01 | iTeos Belgium SA | Anti-tigit antibodies |
| TWI803523B (zh) * | 2017-09-29 | 2023-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｔｉｇｉｔ抗體、其抗原結合片段及醫藥用途 |
| GB201721338D0 (en) | 2017-12-19 | 2018-01-31 | Kymab Ltd | Anti-icos Antibodies |
| WO2019122882A1 (en) | 2017-12-19 | 2019-06-27 | Kymab Limited | Bispecific antibody for icos and pd-l1 |
| JP7369127B2 (ja) * | 2017-12-28 | 2023-10-25 | ナンジン レジェンド バイオテック カンパニー，リミテッド | Ｔｉｇｉｔに対する単一ドメイン抗体及びその変異体 |
| TWI816729B (zh) * | 2017-12-30 | 2023-10-01 | 英屬開曼群島商百濟神州有限公司 | 抗tigit抗體及其作為治療和診斷的用途 |
| US11708410B2 (en) | 2018-01-15 | 2023-07-25 | Nanjing Legend Biotech Co., Ltd. | Antibodies and variants thereof against TIGIT |
| US20210363243A1 (en) * | 2018-02-01 | 2021-11-25 | Merck Sharp & Dohme Corp. | Methods for treating cancer or infection using a combination of an anti-pd-1 antibody, an anti-lag3 antibody, and an anti-tigit antibody |
| WO2019154415A1 (en) * | 2018-02-06 | 2019-08-15 | I-Mab | Antibodies to t cell immunoreceptor with ig and itim domains (tigit) and uses thereof |
| MX2020008795A (es) * | 2018-02-28 | 2020-10-08 | Yuhan Corp | Anti cuerpos anti tigit y usos de los mismos. |
| CN120943884A (zh) | 2018-03-27 | 2025-11-14 | 百时美施贵宝公司 | 使用紫外线信号实时监测滴度 |
| US20190300610A1 (en) * | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Pte. Ltd. | Vista antigen-binding molecules |
| AR114789A1 (es) * | 2018-04-18 | 2020-10-14 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de los mismos |
| CN119823267A (zh) | 2018-05-09 | 2025-04-15 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 特异性针对人类连接蛋白4的抗体 |
| AU2019276578A1 (en) | 2018-06-01 | 2021-01-14 | Compugen Ltd | Anti-PVRIG/anti-TIGIT bispecific antibodies and methods of use |
| US11001635B2 (en) | 2018-06-29 | 2021-05-11 | Gensun Biopharma Inc. | Antitumor antagonists |
| CN112135626B (zh) * | 2018-07-25 | 2023-05-23 | 信达生物制药(苏州)有限公司 | 抗tigit抗体及其用途 |
| EP3841123A2 (en) | 2018-08-23 | 2021-06-30 | Seagen Inc. | Anti-tigit antibodies |
| CN110511912B (zh) * | 2018-08-30 | 2024-03-22 | 浙江煦顼技术有限公司 | 免疫细胞的功能调节 |
| JP7474769B2 (ja) | 2018-08-30 | 2024-04-25 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 一本鎖および多鎖キメラポリペプチドならびにその使用方法 |
| KR20250160211A (ko) | 2018-08-30 | 2025-11-11 | 이뮤니티바이오, 인크. | 다중-사슬 키메라 폴리펩타이드 및 이의 용도 |
| CN113365663B (zh) | 2018-08-30 | 2025-11-21 | 免疫生物公司 | 单链嵌合多肽和其用途 |
| AU2019375409A1 (en) * | 2018-11-05 | 2021-05-27 | Merck Sharp & Dohme Llc | Dosing regimen of anti-TIGIT antibody for treatment of cancer |
| KR20210089215A (ko) | 2018-11-07 | 2021-07-15 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항-pd-1 항체의 공동-제제 |
| CA3123338A1 (en) | 2018-12-21 | 2020-06-25 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
| EP3908609A1 (en) * | 2019-01-07 | 2021-11-17 | iTeos Belgium SA | Anti-tigit antibodies |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| US20220135619A1 (en) | 2019-02-24 | 2022-05-05 | Bristol-Myers Squibb Company | Methods of isolating a protein |
| WO2020185739A1 (en) | 2019-03-11 | 2020-09-17 | Jounce Therapeutics, Inc. | Anti-icos antibodies for the treatment of cancer |
| CN111744007B (zh) * | 2019-03-29 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 一种抗tigit抗体药物组合物及其用途 |
| CN111744013B (zh) * | 2019-03-29 | 2022-07-26 | 江苏恒瑞医药股份有限公司 | 抗tigit抗体联合pd-1抑制剂治疗疾病的方法和药物组合 |
| US20220220430A1 (en) | 2019-05-23 | 2022-07-14 | Bristol-Myers Squibb Company | Methods of monitoring cell culture media |
| TWI760751B (zh) | 2019-05-29 | 2022-04-11 | 美商美國禮來大藥廠 | Tigit及pd-1/tigit-結合分子 |
| CN113840840A (zh) * | 2019-06-13 | 2021-12-24 | 株式会社绿十字 | Tigit抗体及其用途 |
| US11738052B2 (en) | 2019-06-21 | 2023-08-29 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| EP3990116A1 (en) | 2019-06-28 | 2022-05-04 | Gensun Biopharma Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| KR20220042258A (ko) * | 2019-07-15 | 2022-04-04 | 상하이 준스 바이오사이언스 컴퍼니 리미티드 | 항 tigit 항체 및 그의 응용 |
| US20220251194A1 (en) * | 2019-07-30 | 2022-08-11 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3/tigit trispecific antibodies and anti-pd-1/lag3 bicpecific antibodies |
| CN112625130B (zh) * | 2019-09-24 | 2023-08-29 | 财团法人工业技术研究院 | 抗-tigit抗体及使用之方法 |
| BR112022005787A2 (pt) * | 2019-09-27 | 2022-06-21 | Glaxosmithkline Ip Dev Ltd | Proteínas de ligação a antígeno |
| US20220340660A1 (en) * | 2019-10-01 | 2022-10-27 | Merck Sharp & Dohme Corp. | Biomarkers for anti-tigit antibody treatment |
| AU2020378335A1 (en) * | 2019-11-05 | 2022-04-07 | Merck Patent Gmbh | Anti-TIGIT antibodies and uses thereof |
| JP2022554270A (ja) | 2019-11-05 | 2022-12-28 | ジョンス セラピューティクス， インコーポレイテッド | 抗ｐｄ－１抗体による癌を治療する方法 |
| TW202124452A (zh) * | 2019-11-14 | 2021-07-01 | 中國大陸商上海藥明生物技術有限公司 | 抗tigit的新型抗體 |
| WO2021113831A1 (en) | 2019-12-05 | 2021-06-10 | Compugen Ltd. | Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing |
| TW202136287A (zh) | 2019-12-17 | 2021-10-01 | 法商Ｏｓｅ免疫治療公司 | 包含il-7變體之雙官能分子 |
| US11396647B2 (en) | 2020-01-07 | 2022-07-26 | Board Of Regents, The University Of Texas System | Human methylthioadenosine/adenosine depleting enzyme variants for cancer therapy |
| KR20220140535A (ko) | 2020-02-11 | 2022-10-18 | 에이치씨더블유 바이올로직스, 인크. | 크로마토그래피 수지 및 이의 용도 |
| CA3169231A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of treating age-related and inflammatory diseases |
| WO2021163298A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| CN115003333A (zh) | 2020-03-13 | 2022-09-02 | 江苏恒瑞医药股份有限公司 | Pvrig结合蛋白及其医药用途 |
| WO2021216468A1 (en) * | 2020-04-19 | 2021-10-28 | Askgene Pharma Inc. | Human tigit specific single domain antibodies and methods of use |
| CN115427445A (zh) * | 2020-04-22 | 2022-12-02 | 彻莫马布有限公司 | 使用抗ccl24抗体的治疗方法 |
| CN113563470B (zh) | 2020-04-29 | 2023-02-10 | 广州昂科免疫生物技术有限公司 | 结合tigit抗原的抗体及其制备方法与应用 |
| JP7734693B2 (ja) | 2020-04-29 | 2025-09-05 | イミュニティーバイオ インコーポレイテッド | 抗ｃｄ２６タンパク質及びそれらの使用法 |
| WO2021224438A1 (en) | 2020-05-07 | 2021-11-11 | Institut Curie | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| CN114507284B (zh) * | 2020-05-09 | 2023-05-26 | 华博生物医药技术（上海）有限公司 | 抗tigit的抗体、其制备方法和应用 |
| CA3184756A1 (en) | 2020-06-01 | 2021-12-09 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| WO2021247003A1 (en) | 2020-06-01 | 2021-12-09 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| AU2021284273A1 (en) * | 2020-06-02 | 2022-12-15 | Arcus Biosciences, Inc. | Antibodies to TIGIT |
| WO2021257124A1 (en) | 2020-06-18 | 2021-12-23 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
| WO2021258337A1 (en) * | 2020-06-24 | 2021-12-30 | Huahui Health Ltd. | Human monoclonal antibodies against tigit for immune related diseases |
| CN111718415B (zh) * | 2020-07-03 | 2021-02-23 | 上海洛启生物医药技术有限公司 | 一种抗tigit纳米抗体及其应用 |
| TW202216778A (zh) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷 |
| EP4192883A4 (en) * | 2020-08-05 | 2024-12-04 | Crystal Bioscience Inc. | Anti-tigit antibody and methods of use thereof |
| WO2022044010A1 (en) | 2020-08-26 | 2022-03-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Anti-t-cell immunoglobulin and itim domain (tigit) antibodies for the treatment of fungal infections |
| EP4225770A1 (en) | 2020-10-05 | 2023-08-16 | Bristol-Myers Squibb Company | Methods for concentrating proteins |
| WO2022075474A1 (ja) * | 2020-10-09 | 2022-04-14 | 学校法人慶應義塾 | 免疫・炎症性疾患の治療薬 |
| IL302402A (en) | 2020-11-08 | 2023-06-01 | Seagen Inc | Combination therapy |
| US11028172B1 (en) * | 2020-11-10 | 2021-06-08 | Lepu Biopharma Co., Ltd. | Anti-TIGIT antibodies and uses thereof |
| WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
| WO2022111612A1 (zh) * | 2020-11-26 | 2022-06-02 | 信达生物制药(苏州)有限公司 | 包含抗tigit/pd-1双特异性抗体的制剂及其制备方法和用途 |
| US20240018248A1 (en) | 2020-12-02 | 2024-01-18 | Vib Vzw | An ltbr agonist in combination therapy against cancer |
| KR20220082776A (ko) * | 2020-12-10 | 2022-06-17 | 주식회사 유틸렉스 | 항-tigit 항체 및 이의 용도 |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| US11806507B2 (en) * | 2020-12-22 | 2023-11-07 | Regina E. HERZLINGER | Methods, systems, and apparatus for administering an antibody treatment via infusion |
| US12133966B2 (en) * | 2020-12-22 | 2024-11-05 | Regina E. HERZLINGER | Methods, systems, and apparatus for administering an antibody treatment via infusion |
| EP4267216A4 (en) * | 2020-12-22 | 2024-09-11 | Herzlinger, Regina E. | METHODS, SYSTEMS AND DEVICES FOR ADMINISTRATING TREATMENT WITH MONOCLONAL AND/OR POLYCLONAL ANTIBODIES VIA RAPID INFUSION |
| WO2022148781A1 (en) | 2021-01-05 | 2022-07-14 | Institut Curie | Combination of mcoln activators and immune checkpoint inhibitors |
| CN114762678B (zh) | 2021-01-14 | 2024-03-15 | 上海君实生物医药科技股份有限公司 | 抗tigit抗体药物组合物及其用途 |
| CN114989300A (zh) * | 2021-03-02 | 2022-09-02 | 百奥泰生物制药股份有限公司 | 抗tigit抗体在治疗肿瘤或癌症中的应用 |
| WO2022184067A1 (zh) * | 2021-03-02 | 2022-09-09 | 百奥泰生物制药股份有限公司 | 抗tigit抗体在联合用药中的应用 |
| WO2022204309A1 (en) * | 2021-03-24 | 2022-09-29 | Twist Bioscience Corporation | Variant nucleic acid libraries for tigit |
| EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
| CA3216170A1 (en) | 2021-04-09 | 2022-10-13 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
| IL307419A (en) | 2021-04-09 | 2023-12-01 | Ose Immunotherapeutics | A new scaffold for bifunctional molecules with improved properties |
| AR125753A1 (es) | 2021-05-04 | 2023-08-09 | Agenus Inc | Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos |
| BR112023023453A8 (pt) * | 2021-05-10 | 2024-02-15 | Medimabbio Inc | Anticorpo anti-tigit ou um fragmento de ligação ao antígeno deste, composições farmacêuticas e usos do referido anticorpo anti-tigit ou um fragmento de ligação ao antígeno deste |
| CN115368457A (zh) * | 2021-05-18 | 2022-11-22 | 苏州鑫康合生物医药科技有限公司 | 抗tigit抗体及其用途 |
| CN115466327B (zh) * | 2021-06-10 | 2025-07-08 | 北京天广实生物技术股份有限公司 | 结合tigit的抗体及其用途 |
| EP4377350A2 (en) | 2021-07-28 | 2024-06-05 | Genentech, Inc. | Methods and compositions for treating cancer |
| WO2023036340A1 (en) * | 2021-09-13 | 2023-03-16 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Protein complexes targeting il21 pathway |
| CA3231553A1 (en) | 2021-09-15 | 2023-03-23 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising anti-pvrig/tigit bispecific antibody |
| TW202328195A (zh) | 2021-09-15 | 2023-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合ｐｄ－１的蛋白及其醫藥用途 |
| CN115838424A (zh) * | 2021-09-22 | 2023-03-24 | 上海康岱生物医药技术股份有限公司 | 靶向tigit的单克隆抗体 |
| TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗ｔｉｇｉｔ抗體、抗ｃｄ３８抗體及ｐｄ—１軸結合拮抗劑治療血液癌症的方法 |
| WO2023108609A1 (en) * | 2021-12-17 | 2023-06-22 | Shanghai Nigene Biological Science And Technology Co., Ltd. | Tigit antibodies and uses thereof |
| CN114181310B (zh) * | 2022-02-14 | 2022-07-05 | 中山康方生物医药有限公司 | 抗tigit抗体、其药物组合物及用途 |
| AU2023228683B2 (en) | 2022-03-02 | 2025-12-04 | Immunitybio, Inc. | Method of treating pancreatic cancer |
| AU2023230110A1 (en) | 2022-03-08 | 2024-10-24 | Alentis Therapeutics Ag | Use of anti-claudin-1 antibodies to increase t cell availability |
| EP4490166A1 (en) | 2022-03-09 | 2025-01-15 | Bristol-Myers Squibb Company | Transient expression of therapeutic proteins |
| US20250297018A1 (en) | 2022-03-15 | 2025-09-25 | Compugen Ltd. | Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer |
| CA3255411A1 (en) | 2022-03-16 | 2025-03-04 | Daiichi Sankyo Company, Limited | COMBINATION OF MULTISPECIFIC MOLECULES AND AN IMMUNE CHECKPOINT INHIBITOR |
| JP2025516262A (ja) | 2022-05-02 | 2025-05-27 | アーカス バイオサイエンシズ インコーポレイティド | 抗ｔｉｇｉｔ抗体及びその使用 |
| KR20250022049A (ko) | 2022-06-07 | 2025-02-14 | 제넨테크, 인크. | 항-pd-l1 길항제 및 항-tigit 길항제 항체를 포함하는, 폐암 치료의 효율을 결정하는 방법 |
| KR102769147B1 (ko) * | 2022-06-10 | 2025-02-20 | 메디맵바이오 주식회사 | Tigit에 특이적으로 결합하는 항체 및 인터류킨-15를 포함하는 융합 단백질 및 이의 용도 |
| WO2023239228A1 (ko) * | 2022-06-10 | 2023-12-14 | 메디맵바이오 주식회사 | 항-tigit 항체, 인터류킨-15, 및 인터류킨-15 수용체 알파 스시 도메인을 포함하는 융합 단백질 및 이의 용도 |
| WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
| JP2025525886A (ja) | 2022-08-02 | 2025-08-07 | オーエスイー・イミュノセラピューティクス | Ｃｄ２８に対する多機能性分子 |
| WO2024085182A1 (ja) | 2022-10-18 | 2024-04-25 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | Ｔ細胞性腫瘍の治療剤 |
| WO2024191807A1 (en) | 2023-03-10 | 2024-09-19 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
| WO2024200823A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof |
| WO2024200820A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Method of synthesis of targeted lipid nanoparticle and uses thereof |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
| WO2025068452A1 (en) | 2023-09-29 | 2025-04-03 | Negio Therapeutics | Guanfacine derivatives and their use in treating cancer |
| WO2025068461A1 (en) | 2023-09-29 | 2025-04-03 | Negio Therapeutics | Guanfacine derivatives and their use in treating cancer |
| WO2025132831A1 (en) | 2023-12-19 | 2025-06-26 | Universite D'aix-Marseille | N-heteroaryl derivatives and uses thereof for treating cancer |
| KR102872375B1 (ko) * | 2024-01-24 | 2025-10-24 | 메디맵바이오 주식회사 | Tigit에 특이적으로 결합하는 항-tigit 항체, 상기 항체 및 인터루킨-10를 포함하는 융합 단백질 및 이들의 용도 |
| WO2025242836A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
Family Cites Families (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| DE3668186D1 (de) | 1985-04-01 | 1990-02-15 | Celltech Ltd | Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| CA2006596C (en) | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
| US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US6129914A (en) | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
| CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| ATE427968T1 (de) | 1992-08-21 | 2009-04-15 | Univ Bruxelles | Immunoglobuline ohne leichtkette |
| ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
| US5532210A (en) | 1994-06-08 | 1996-07-02 | E. I. Du Pont De Nemours And Company | High temperature superconductor dielectric slow wave structures for accelerators and traveling wave tubes |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| GB2339430A (en) | 1997-05-21 | 2000-01-26 | Biovation Ltd | Method for the production of non-immunogenic proteins |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| GB9818110D0 (en) | 1998-08-19 | 1998-10-14 | Weston Medical Ltd | Needleless injectors and other devices |
| US6096002A (en) | 1998-11-18 | 2000-08-01 | Bioject, Inc. | NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method |
| WO2000032634A1 (en) | 1998-12-01 | 2000-06-08 | Protein Design Labs, Inc. | Humanized antibodies to gamma-interferon |
| ES2694002T3 (es) | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
| US7368527B2 (en) | 1999-03-12 | 2008-05-06 | Human Genome Sciences, Inc. | HADDE71 polypeptides |
| WO2000058334A1 (en) | 1999-03-26 | 2000-10-05 | Human Genome Sciences, Inc. | 50 human secreted proteins |
| WO2000061739A1 (fr) | 1999-04-09 | 2000-10-19 | Kyowa Hakko Kogyo Co., Ltd. | Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle |
| US7504256B1 (en) | 1999-10-19 | 2009-03-17 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing polypeptide |
| US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
| ATE309385T1 (de) | 2000-06-28 | 2005-11-15 | Glycofi Inc | Verfahren für die herstellung modifizierter glykoproteine |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US6374470B1 (en) | 2000-10-06 | 2002-04-23 | Milliken & Company | Face plate for spun-like textured yarn |
| US7408041B2 (en) | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| CA2838062C (en) | 2001-08-03 | 2015-12-22 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| EP1575480A4 (en) | 2002-02-22 | 2008-08-06 | Genentech Inc | COMPOSITIONS AND METHODS FOR TREATING DISEASES RELATED TO THE IMMUNE SYSTEM |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| WO2003086310A2 (en) | 2002-04-12 | 2003-10-23 | Ramot At Tel Aviv University Ltd. | Prevention of brain inflammation as a result of induced autoimmune response |
| EP1575497A4 (en) | 2002-09-11 | 2010-11-03 | Genentech Inc | NEW COMPOSITION AND METHOD FOR TREATING PSORIASIS |
| AU2003270439B2 (en) | 2002-09-11 | 2009-09-24 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| SI2301965T1 (sl) | 2002-10-16 | 2015-07-31 | Purdue Pharma L.P. | Protitelesa, ki vežejo celično- povezan CA 125 / O722P in metode uporabe le-teh |
| US20090047213A1 (en) * | 2003-04-14 | 2009-02-19 | Young David S F | Cytotoxicity mediation of cells evidencing surface expression of CD59 |
| US7410483B2 (en) | 2003-05-23 | 2008-08-12 | Novare Surgical Systems, Inc. | Hand-actuated device for remote manipulation of a grasping tool |
| US7312320B2 (en) | 2003-12-10 | 2007-12-25 | Novimmune Sa | Neutralizing antibodies and methods of use thereof |
| ATE476993T1 (de) | 2004-06-07 | 2010-08-15 | Univ Ramot | Verfahren zur passiven immunisierung gegen eine durch amyloidaggregation gekennzeichnete krankheit oder erkrankung mit vermindertem nervenentzündungsrisiko |
| JP2008512353A (ja) | 2004-07-21 | 2008-04-24 | グライコフィ， インコーポレイテッド | 主にＧｌｃＮＡｃ２Ｍａｎ３ＧｌｃＮＡｃ２グリコフォームを含むイムノグロブリン |
| CN101023102B (zh) * | 2004-09-17 | 2013-05-29 | 霍夫曼-拉罗奇有限公司 | 抗-ox40l抗体 |
| EP2399932B1 (en) | 2005-05-12 | 2016-11-16 | ZymoGenetics, Inc. | Compositions and methods for modulating immune responses |
| ES2434470T3 (es) | 2005-07-08 | 2013-12-16 | Biogen Idec Ma Inc. | Anticuerpos SP35 y usos de éstos |
| CN101589059A (zh) * | 2006-10-20 | 2009-11-25 | 株式会社未来创药研究所 | 包含抗hb-egf抗体作为活性成分的药物组合物 |
| CL2007003291A1 (es) * | 2006-11-15 | 2008-07-04 | Medarex Inc | Anticuerpo monoclonal humano aislado que enlaza la proteina btla o fragmentos del mismo; acido nucleico que lo codifica; metodo de produccion; composicion e inmunoconjugado que los comprende; y metodo para inhibir el crecimiento de celulas de tumor e |
| NZ593450A (en) | 2007-02-02 | 2012-08-31 | Baylor Res Inst | Vaccines based on targeting antigen to dcir expressed on antigen-presenting cells |
| SI2426144T1 (sl) * | 2007-02-23 | 2019-02-28 | Merck Sharp & Dohme Corp. | Umetno proizvedena anti-IL23P19 antitelesa |
| PT2520590T (pt) | 2007-04-03 | 2018-11-14 | Amgen Res Munich Gmbh | Domínio de ligação específico de espécies cruzadas |
| AU2015202123B2 (en) | 2008-04-09 | 2017-06-15 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related diseases |
| JP5770624B2 (ja) | 2008-04-09 | 2015-08-26 | ジェネンテック， インコーポレイテッド | 免疫関連疾患の治療のための新規組成物と方法 |
| JP5769316B2 (ja) | 2009-08-06 | 2015-08-26 | イムナス・ファーマ株式会社 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
| EP2486052A4 (en) | 2009-10-09 | 2013-05-01 | Merck Sharp & Dohme | GENERATION, LABELING AND USE OF ANTI-HER3 ANTIBODIES |
| JP2013512866A (ja) | 2009-12-05 | 2013-04-18 | ルプレヒト−カールス−ウニヴェルジテート ハイデルベルク | アピコンプレクサＦｅｒｌｉｎ、Ｆｅｒｌｉｎ様タンパク質、及び他のＣ２ドメイン含有タンパク質に基づくマラリアワクチン |
| NZ602892A (en) | 2010-04-13 | 2014-08-29 | Celldex Therapeutics Inc | Antibodies that bind human cd27 and uses thereof |
| WO2011156356A1 (en) | 2010-06-09 | 2011-12-15 | Zymogenetics, Inc. | Dimeric vstm3 fusion proteins and related compositions and methods |
| PE20180042A1 (es) | 2010-08-23 | 2018-01-09 | Univ Texas | Anticuerpos anti-ox40 y metodos de uso de los mismos |
| UA112434C2 (uk) | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | Антигензв'язувальний білок, який специфічно зв'язується з всма |
| US9205144B2 (en) | 2011-06-03 | 2015-12-08 | Dana-Farber Cancer Institute, Inc. | Identification of conserved peptide blocks in homologous polypeptides |
| KR20130062168A (ko) | 2011-12-02 | 2013-06-12 | 고려대학교 산학협력단 | 재조합 형광 단백질 나노입자 |
| WO2013130905A1 (en) | 2012-02-29 | 2013-09-06 | Gilead Biologics, Inc. | Antibodies to matrix metalloproteinase 9 |
| WO2013148316A1 (en) | 2012-03-29 | 2013-10-03 | Biogen Idec Ma Inc. | Biomarkers for use in integrin therapy applications |
| WO2013151999A1 (en) | 2012-04-02 | 2013-10-10 | President And Fellows Of Harvard College | Cancer treatment and immune system regulation through fat10 pathway inhibition |
| KR20150018604A (ko) | 2012-06-06 | 2015-02-23 | 온코메드 파마슈티칼스, 인크. | 히포 경로를 조절하는 결합제 및 그의 용도 |
| SMT201900242T1 (it) | 2012-12-03 | 2019-05-10 | Bristol Myers Squibb Co | Incremento dell'attivita' anti-cancro di proteine di fuzione a fc immunomodulatrici |
| CA2892831A1 (en) * | 2012-12-04 | 2014-06-12 | Oncomed Pharmaceuticals, Inc. | Immunotherapy with binding agents |
| CN103073644B (zh) * | 2012-12-31 | 2014-03-12 | 中国科学技术大学 | 特异性抗小鼠tigit的单克隆抗体及其制备方法、鉴定及应用 |
| US20140314741A1 (en) | 2013-04-18 | 2014-10-23 | Developmen Center For Biotechnology | Human Antibody against Interleukin-20 and Treatment for Inflammatory Diseases |
| SG11201600310QA (en) * | 2013-07-16 | 2016-02-26 | Genentech Inc | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
| BR112016017402A2 (pt) | 2014-02-21 | 2017-10-17 | Medimmune Ltd | fusões anti-pcsk9~glp-1 e métodos para uso |
| SG10201811841UA (en) | 2014-07-16 | 2019-02-27 | Genentech Inc | Methods of treating cancer using tigit inhibitors and anti-cancer agents |
| JO3664B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | أجسام مضادة لـ tigit |
| KR20170072343A (ko) | 2014-11-06 | 2017-06-26 | 제넨테크, 인크. | Ox40 결합 효능제 및 tigit 억제제를 포함하는 병용 요법 |
| LT3221346T (lt) | 2014-11-21 | 2020-11-10 | Bristol-Myers Squibb Company | Antikūnai, apimantys modifikuotas sunkiosios grandinės pastoviąsias sritis |
| CN110256558B (zh) | 2014-12-23 | 2023-07-04 | 百时美施贵宝公司 | 针对tigit的抗体 |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| KR20230125094A (ko) | 2015-09-25 | 2023-08-28 | 제넨테크, 인크. | 항-tigit 항체 및 이의 이용 방법 |
-
2015
- 2015-08-17 JO JOP/2015/0195A patent/JO3664B1/ar active
- 2015-08-17 TW TW110113123A patent/TWI790593B/zh active
- 2015-08-17 PE PE2017000229A patent/PE20170289A1/es unknown
- 2015-08-17 CA CA2957722A patent/CA2957722C/en active Active
- 2015-08-17 AP AP2017009765A patent/AP2017009765A0/en unknown
- 2015-08-17 MY MYPI2017000221A patent/MY184288A/en unknown
- 2015-08-17 CR CR20170060A patent/CR20170060A/es unknown
- 2015-08-17 KR KR1020177007124A patent/KR102050082B1/ko active Active
- 2015-08-17 MX MX2017002229A patent/MX389684B/es unknown
- 2015-08-17 SG SG11201701161QA patent/SG11201701161QA/en unknown
- 2015-08-17 TN TN2017000024A patent/TN2017000024A1/en unknown
- 2015-08-17 IL IL250583A patent/IL250583B/en unknown
- 2015-08-17 TW TW104126739A patent/TWI724997B/zh active
- 2015-08-17 UA UAA201702456A patent/UA122395C2/uk unknown
- 2015-08-17 KR KR1020197034657A patent/KR102321168B1/ko active Active
- 2015-08-17 JP JP2017509009A patent/JP6920194B2/ja active Active
- 2015-08-17 MA MA040475A patent/MA40475A/fr unknown
- 2015-08-17 CN CN201580056517.5A patent/CN107148430B/zh active Active
- 2015-08-17 MY MYPI2020006588A patent/MY198017A/en unknown
- 2015-08-17 MD MDA20170032A patent/MD4733C1/ro active IP Right Grant
- 2015-08-17 GE GEAP201514450A patent/GEP20217331B/en unknown
- 2015-08-17 US US15/121,624 patent/US20160355589A1/en not_active Abandoned
- 2015-08-17 AU AU2015305754A patent/AU2015305754B2/en active Active
- 2015-08-17 CN CN202110901846.2A patent/CN113583131B/zh active Active
- 2015-08-17 EP EP15753872.9A patent/EP3183267A1/en active Pending
- 2015-08-17 WO PCT/US2015/045447 patent/WO2016028656A1/en not_active Ceased
- 2015-08-17 EA EA201790413A patent/EA036311B1/ru not_active IP Right Cessation
-
2017
- 2017-02-07 ZA ZA2017/00955A patent/ZA201700955B/en unknown
- 2017-02-07 CL CL2017000310A patent/CL2017000310A1/es unknown
- 2017-02-16 PH PH12017500296A patent/PH12017500296A1/en unknown
- 2017-02-17 NI NI201700019A patent/NI201700019A/es unknown
- 2017-02-17 CO CONC2017/0001561A patent/CO2017001561A2/es unknown
- 2017-02-17 MX MX2022001105A patent/MX2022001105A/es unknown
- 2017-02-17 DO DO2017000046A patent/DOP2017000046A/es unknown
- 2017-02-17 GT GT201700033A patent/GT201700033A/es unknown
- 2017-03-22 US US15/466,113 patent/US20170198042A1/en not_active Abandoned
- 2017-11-20 US US15/817,691 patent/US10618958B2/en active Active
-
2019
- 2019-01-22 AU AU2019200426A patent/AU2019200426B2/en active Active
- 2019-07-10 CL CL2019001926A patent/CL2019001926A1/es unknown
-
2020
- 2020-05-15 US US16/806,658 patent/US12102680B2/en active Active
- 2020-06-11 JP JP2020101881A patent/JP7066777B2/ja active Active
- 2020-08-05 JO JOP/2020/0192A patent/JOP20200192A1/ar unknown
-
2021
- 2021-04-19 AU AU2021202360A patent/AU2021202360B2/en active Active
-
2022
- 2022-04-27 JP JP2022073522A patent/JP7487256B2/ja active Active
-
2024
- 2024-08-05 US US18/794,138 patent/US20250064924A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022105108A5 (enExample) | ||
| JP7323513B2 (ja) | 抗４－１ｂｂ抗体とその作製及び使用方法 | |
| CN109206514B (zh) | Tslp单克隆抗体及其制备方法和应用 | |
| RU2013125459A (ru) | АНТИТЕЛА ПРОТИВ БЕЛКА РЕЦЕПТОРА c-Met | |
| RU2011116927A (ru) | Антитела против интерлейкина 17 (ил-17) человека и их применение | |
| CN115605511A (zh) | 抗tigit的抗体、其制备方法和应用 | |
| FI3561057T3 (fi) | Anti-cd3-vasta-aine ja vasta-ainetta sisältäviä molekyylejä | |
| RU2010119450A (ru) | Антитело против bst2 | |
| US12269886B2 (en) | Tetravalent bispecific antibody against PD-1 and PD-L1 | |
| AU2022332499A1 (en) | Fap/cd40 binding molecule and medicinal use thereof | |
| CA3196014A1 (en) | Specificity enchanced bispecific antibody (seba) | |
| RU2016117140A (ru) | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы | |
| CA2876796A1 (en) | Humanized antibodies to ca215 | |
| AU2024225804A1 (en) | Antibodies, antigen-binding fragments and methods of use | |
| US20220135686A1 (en) | Antibody that binds to human pd-l1 | |
| US20240067741A1 (en) | Anti-4-1bb antibodies and methods of making and using thereof | |
| US20240084026A1 (en) | Anti-4-1bb antibodies and methods of making and using thereof | |
| CN120040594B (zh) | 一种靶向flt3基因编辑通用型car-t细胞的制备方法和应用 | |
| JPWO2023078382A5 (enExample) | ||
| JPWO2022218380A5 (enExample) | ||
| CN102597004A (zh) | Cd151特异性嵌合抗体及其在癌症治疗中的用途 | |
| JPWO2023138551A5 (enExample) | ||
| JP2025529812A (ja) | 甲状腺刺激ホルモン受容体に結合する抗体及びその使用 | |
| CN120500500A (zh) | 一种抗gpr87的抗体及其制备方法和应用 | |
| CN119816523A (zh) | 抗Nectin-4抗体和包含其的多特异性抗体 |