CN115605511A - 抗tigit的抗体、其制备方法和应用 - Google Patents
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract
提供了一种分离的抗原结合蛋白，该抗原结合蛋白包含重链可变区VH中的至少一个CDR，该VH包含SEQ ID NO:55所示的氨基酸序列。还提供了抗TIGIT的抗体、其制备方法和应用。该抗原结合蛋白能够特异性结合TIGIT抗原，阻断TIGIT与其配体的结合，并且能够用于制备预防或治疗TIGIT相关的疾病的药物。
Description
PCT国内申请，说明书已公开。
Claims (67)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010387630.4A CN111995681B (zh) | 2020-05-09 | 2020-05-09 | 抗tigit的抗体、其制备方法和应用 |
| CN2020103876304 | 2020-05-09 | ||
| PCT/CN2021/092043 WO2021227940A1 (zh) | 2020-05-09 | 2021-05-07 | 抗tigit的抗体、其制备方法和应用 |
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| CN115605511A true CN115605511A (zh) | 2023-01-13 |
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| CN202210181241.5A Active CN114507284B (zh) | 2020-05-09 | 2020-05-09 | 抗tigit的抗体、其制备方法和应用 |
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| CN202210181241.5A Active CN114507284B (zh) | 2020-05-09 | 2020-05-09 | 抗tigit的抗体、其制备方法和应用 |
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| CN111995681B (zh) * | 2020-05-09 | 2022-03-08 | 华博生物医药技术（上海）有限公司 | 抗tigit的抗体、其制备方法和应用 |
| TW202216778A (zh) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷 |
| CN113150156B (zh) * | 2021-04-22 | 2022-06-07 | 浙江博锐生物制药有限公司 | 抗tigit抗体及其用途 |
| AU2022320667A1 (en) * | 2021-07-30 | 2024-03-14 | Shandong Simcere Biopharmaceutical Co., Ltd. | Anti-pvrig/anti-tigit bispecific antibody and application |
| CN114106182B (zh) * | 2022-01-26 | 2022-05-17 | 中山康方生物医药有限公司 | 抗tigit的抗体及其用途 |
| CN115043910B (zh) * | 2022-03-25 | 2023-04-07 | 湖南中晟全肽生化有限公司 | 抑制tigit与cd155结合的多肽及其应用 |
| WO2023212662A2 (en) * | 2022-04-28 | 2023-11-02 | Oregon Health & Science University | Compositions and methods for modulating antigen binding activity |
| WO2024083074A1 (en) * | 2022-10-17 | 2024-04-25 | Beigene, Ltd. | Formulations containing anti-tigit antibody and methods of use thereof |
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|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
| AU757961B2 (en) * | 1998-09-30 | 2003-03-13 | Sankyo Company Limited | Anti-Fas antibodies |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| AR093788A1 (es) * | 2012-12-04 | 2015-06-24 | Oncomed Pharm Inc | Inmunoterapia con agentes de enlace |
| PT3021869T (pt) | 2013-07-16 | 2020-09-10 | Hoffmann La Roche | Métodos de tratamento do cancro com antagonistas da ligação ao eixo pd-1 e inibidores do tigit |
| MX2017002229A (es) * | 2014-08-19 | 2017-05-09 | Merck Sharp & Dohme | Anticuerpos anti tigit. |
| JP6180663B2 (ja) * | 2014-12-23 | 2017-08-16 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｔｉｇｉｔに対する抗体 |
| RU2732591C2 (ru) * | 2015-09-25 | 2020-09-21 | Дженентек, Инк. | Анти-tigit антитела и способы применения |
| JP2018535655A (ja) * | 2015-09-29 | 2018-12-06 | アムジエン・インコーポレーテツド | Ａｓｇｒ阻害剤 |
| KR102460525B1 (ko) * | 2016-08-26 | 2022-11-01 | 베이진 엘티디 | 항-tim-3 항체 및 그의 용도 |
| BR112019022698A2 (pt) * | 2017-05-02 | 2020-05-19 | Merck Sharp & Dohme | formulações estáveis de anticorpos anti-tigit isolados e em combinação com anticorpos do receptor de morte programada 1 (pd-1) e métodos de uso das mesmas |
| EP3630180A1 (en) * | 2017-06-01 | 2020-04-08 | Compugen Ltd. | Triple combination antibody therapies |
| CN110003332B (zh) * | 2018-01-05 | 2021-05-11 | 上海原能细胞医学技术有限公司 | Cd137抗体及其应用 |
| TW201932489A (zh) * | 2018-01-15 | 2019-08-16 | 大陸商南京傳奇生物科技有限公司 | 針對ｔｉｇｉｔ之抗體及其變異體 |
| US10973853B2 (en) * | 2018-02-06 | 2021-04-13 | I-Mab Biopharma Us Limited | Antibodies to T cell immunoreceptor with IG and ITIM domains (TIGIT) and uses thereof |
| CN110790839B (zh) * | 2018-08-03 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 抗pd-1抗体、其抗原结合片段及医药用途 |
| CN109384846B (zh) * | 2018-09-25 | 2020-03-03 | 合肥瑞达免疫药物研究所有限公司 | 能够结合tigit的抗体或其抗原结合片段及用途 |
| CN110922486B (zh) * | 2020-02-18 | 2020-05-22 | 和铂医药(上海)有限责任公司 | 一种分离的结合抗原psma的蛋白及其用途 |
| CN111995681B (zh) * | 2020-05-09 | 2022-03-08 | 华博生物医药技术（上海）有限公司 | 抗tigit的抗体、其制备方法和应用 |
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2020
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- 2020-05-09 CN CN202210181241.5A patent/CN114507284B/zh active Active
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2021
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- 2021-05-07 CN CN202180033811.XA patent/CN115605511A/zh active Pending
- 2021-05-07 EP EP21804577.1A patent/EP4148068A1/en active Pending
- 2021-05-07 KR KR1020227042983A patent/KR20230009441A/ko active Search and Examination
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| EP4148068A1 (en) | 2023-03-15 |
| JP2023534588A (ja) | 2023-08-10 |
| AU2021273240A1 (en) | 2023-02-02 |
| TW202144428A (zh) | 2021-12-01 |
| KR20230009441A (ko) | 2023-01-17 |
| US20230183345A1 (en) | 2023-06-15 |
| TWI801862B (zh) | 2023-05-11 |
| CN111995681A (zh) | 2020-11-27 |
| WO2021227940A1 (zh) | 2021-11-18 |
| CN114507284B (zh) | 2023-05-26 |
| CN114507284A (zh) | 2022-05-17 |
| CN111995681B (zh) | 2022-03-08 |
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